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The map label for this gene is purE [H]

Identifier: 91790456

GI number: 91790456

Start: 4907638

End: 4908144

Strand: Reverse

Name: purE [H]

Synonym: Bpro_4627

Alternate gene names: 91790456

Gene position: 4908144-4907638 (Counterclockwise)

Preceding gene: 91790458

Following gene: 91790455

Centisome position: 94.38

GC content: 69.63

Gene sequence:

>507_bases
ATGACAACGCACAATCCGGTCGGCCCCCTCGTGGGCGTGGTGATGGGCTCCAGCAGCGACTGGACCACCATGCAGCATGC
CGTGCAAATCCTGCAGCAGTTCGGCGTGGCGCACGAGGCCCGCGTGGTGTCGGCCCACCGCATGCCCGACGAGCTGTTTG
CCTATGCCGAGCAGGCTGCCGGGCGCGGCCTGCGGGCCATCATTGCCGGTGCCGGCGGTGCGGCGCACCTGCCCGGCATG
CTGGCCGCCAAAACCGCGGTGCCCATCCTGGGCGTGCCGGTGGCCAGCAACCACCTGCAGGGCGTTGATTCGCTGCACAG
CATCGTGCAGATGCCCAGGGGAGTGCCGGTGGCGACGTTTGCCATCGGCAATGCCGGGGCGGCCAATGCGGCGCTGTTTG
CGGTGGCCATGCTGGCGACGAACGACAAATCCCTGGCCGACAAGCTGCAGGCTTTCCGCGCCGAGCAGACCGCCGCCGCG
CGCGCCATGACGCTGCCTCCCGCATGA

Upstream 100 bases:

>100_bases
GATAGCATGCATCGCGGCATGGCCCGAGCCCTTAAAATCAAAGGTTCCGGGCGCGCAGTCGCCCGCAGAACTTGCAGAAT
TCTTGGCTTGAAAGTCCACT

Downstream 100 bases:

>100_bases
GCGCGGCACCGTTGTTGCCTGTGCTTCCCGGTACGGTGTCGGCCGACGGCCGTCCGGCCACGCTTGGCGTGATGGGTGGC
GGCCAGCTGGGCCGCATGTT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTTHNPVGPLVGVVMGSSSDWTTMQHAVQILQQFGVAHEARVVSAHRMPDELFAYAEQAAGRGLRAIIAGAGGAAHLPGM
LAAKTAVPILGVPVASNHLQGVDSLHSIVQMPRGVPVATFAIGNAGAANAALFAVAMLATNDKSLADKLQAFRAEQTAAA
RAMTLPPA

Sequences:

>Translated_168_residues
MTTHNPVGPLVGVVMGSSSDWTTMQHAVQILQQFGVAHEARVVSAHRMPDELFAYAEQAAGRGLRAIIAGAGGAAHLPGM
LAAKTAVPILGVPVASNHLQGVDSLHSIVQMPRGVPVATFAIGNAGAANAALFAVAMLATNDKSLADKLQAFRAEQTAAA
RAMTLPPA
>Mature_167_residues
TTHNPVGPLVGVVMGSSSDWTTMQHAVQILQQFGVAHEARVVSAHRMPDELFAYAEQAAGRGLRAIIAGAGGAAHLPGML
AAKTAVPILGVPVASNHLQGVDSLHSIVQMPRGVPVATFAIGNAGAANAALFAVAMLATNDKSLADKLQAFRAEQTAAAR
AMTLPPA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=147, Percent_Identity=63.9455782312925, Blast_Score=159, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=57.3333333333333, Blast_Score=165, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17177; Mature: 17046

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHNPVGPLVGVVMGSSSDWTTMQHAVQILQQFGVAHEARVVSAHRMPDELFAYAEQAA
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHH
GRGLRAIIAGAGGAAHLPGMLAAKTAVPILGVPVASNHLQGVDSLHSIVQMPRGVPVATF
CCCEEEEEECCCCHHHCCHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
AIGNAGAANAALFAVAMLATNDKSLADKLQAFRAEQTAAARAMTLPPA
ECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTHNPVGPLVGVVMGSSSDWTTMQHAVQILQQFGVAHEARVVSAHRMPDELFAYAEQAA
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHH
GRGLRAIIAGAGGAAHLPGMLAAKTAVPILGVPVASNHLQGVDSLHSIVQMPRGVPVATF
CCCEEEEEECCCCHHHCCHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
AIGNAGAANAALFAVAMLATNDKSLADKLQAFRAEQTAAARAMTLPPA
ECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]