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The map label for this gene is purK [H]

Identifier: 91790455

GI number: 91790455

Start: 4906412

End: 4907641

Strand: Reverse

Name: purK [H]

Synonym: Bpro_4626

Alternate gene names: 91790455

Gene position: 4907641-4906412 (Counterclockwise)

Preceding gene: 91790456

Following gene: 91790454

Centisome position: 94.37

GC content: 66.83

Gene sequence:

>1230_bases
ATGAGCGCGGCACCGTTGTTGCCTGTGCTTCCCGGTACGGTGTCGGCCGACGGCCGTCCGGCCACGCTTGGCGTGATGGG
TGGCGGCCAGCTGGGCCGCATGTTTGTGCATGCCGCCCAGCGGCTGGGTTACTTCACTACCGTGCTCGACCCGGACCCGC
ACAGCCCGGCTGGCTATGTGAGCCACCACTTCATTCAAACCGCCTACGACGATGCCGACGGGCTGGCGCAGCTGGCCGCG
CAGTGCGACGCCATCACCACCGAATTTGAAAACGTGCCCGCCCAGGCGCTGACCGCGCTGGCCGCCACGCGGCCGGTGGC
ACCGGGTGCCGCCGCCGTGGCGATTGCGCAGGACCGCATCGCCGAAAAAGACCACTTCGTGGCCTGCGCCGGCATTTCGG
GCGTGAGCTGCGCGCCCTTCGCGGTGATCGACAGTGCGGCCGCGGTCGAGGCGGTGCCCGATGCCCTGTTGCCCGGCATT
TTGAAAACCGCCCGCCTGGGCTACGACGGCAAGGGCCAGATGCGCATCAGGACCCGCGAGGAACTTCTGGCCGCCTGGAC
GGCGCTCAAGCAGGTGCCCTGCGTGCTCGAACAGTTGCTGCCGCTCAAGGCCGAATGCTCGGTGCTGGTGGCACGAGGCT
GGGACGGCAGCATCGTCAGCTTCCCGCCGCAGCGCAATGTGCATGTCGACGGCATTCTGGCCGTGACCCATGCCTATGCG
TCAAACATGTCTTCGGCTCTTGCCGTACAGGCGCTTGCGGCGACCAAATCCATAGCGGATCATGTGGGCTATGTCGGCAT
CCTGTGCGTCGAGTTTTTCGTGATTGACGACGGCAGCGAGCATGGCGCGCTGGTGGTCAATGAAATGGCGCCGCGCCCGC
ACAACAGCGGCCATTACACGCTGGACGCCTGCGATGTCTCGCAGTTTGACTTGCAGGTGCATGCGATGGCCGGCCTGCCC
CTGCCGCAACCGCGTCAGCATTCGCCCGCCATCATGCTCAATCTGTTGGGCGACCTGTGGTTCGATGCCCAGGGCAAGGA
GCACACACCCGATTGGCAGGCCGTGCTGGCGCTGCCCGGTGCCCATCTGCACCTGTACGGCAAGCTGCACGCGCGTGCGG
GCCGCAAGATGGGCCACCTCAACATCACGGGTGCCGATGTCGCGGGCGTGCAGGCCACGGCGCGCAAGGCGGCTGCCATC
CTCGGCCTGCCGGGCCTCGAAGACCACTGA

Upstream 100 bases:

>100_bases
TGGCCATGCTGGCGACGAACGACAAATCCCTGGCCGACAAGCTGCAGGCTTTCCGCGCCGAGCAGACCGCCGCCGCGCGC
GCCATGACGCTGCCTCCCGC

Downstream 100 bases:

>100_bases
TGATCCTGCCCGGCACCGACCCCCAAGCCATTCATGAAGCCGCCCGCCGCATCCAGGCCGGCGGGCTGGTGGGTTTTCCG
ACCGAAACGGTGTATGGCTT

Product: phosphoribosylaminoimidazole carboxylase ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSAAPLLPVLPGTVSADGRPATLGVMGGGQLGRMFVHAAQRLGYFTTVLDPDPHSPAGYVSHHFIQTAYDDADGLAQLAA
QCDAITTEFENVPAQALTALAATRPVAPGAAAVAIAQDRIAEKDHFVACAGISGVSCAPFAVIDSAAAVEAVPDALLPGI
LKTARLGYDGKGQMRIRTREELLAAWTALKQVPCVLEQLLPLKAECSVLVARGWDGSIVSFPPQRNVHVDGILAVTHAYA
SNMSSALAVQALAATKSIADHVGYVGILCVEFFVIDDGSEHGALVVNEMAPRPHNSGHYTLDACDVSQFDLQVHAMAGLP
LPQPRQHSPAIMLNLLGDLWFDAQGKEHTPDWQAVLALPGAHLHLYGKLHARAGRKMGHLNITGADVAGVQATARKAAAI
LGLPGLEDH

Sequences:

>Translated_409_residues
MSAAPLLPVLPGTVSADGRPATLGVMGGGQLGRMFVHAAQRLGYFTTVLDPDPHSPAGYVSHHFIQTAYDDADGLAQLAA
QCDAITTEFENVPAQALTALAATRPVAPGAAAVAIAQDRIAEKDHFVACAGISGVSCAPFAVIDSAAAVEAVPDALLPGI
LKTARLGYDGKGQMRIRTREELLAAWTALKQVPCVLEQLLPLKAECSVLVARGWDGSIVSFPPQRNVHVDGILAVTHAYA
SNMSSALAVQALAATKSIADHVGYVGILCVEFFVIDDGSEHGALVVNEMAPRPHNSGHYTLDACDVSQFDLQVHAMAGLP
LPQPRQHSPAIMLNLLGDLWFDAQGKEHTPDWQAVLALPGAHLHLYGKLHARAGRKMGHLNITGADVAGVQATARKAAAI
LGLPGLEDH
>Mature_408_residues
SAAPLLPVLPGTVSADGRPATLGVMGGGQLGRMFVHAAQRLGYFTTVLDPDPHSPAGYVSHHFIQTAYDDADGLAQLAAQ
CDAITTEFENVPAQALTALAATRPVAPGAAAVAIAQDRIAEKDHFVACAGISGVSCAPFAVIDSAAAVEAVPDALLPGIL
KTARLGYDGKGQMRIRTREELLAAWTALKQVPCVLEQLLPLKAECSVLVARGWDGSIVSFPPQRNVHVDGILAVTHAYAS
NMSSALAVQALAATKSIADHVGYVGILCVEFFVIDDGSEHGALVVNEMAPRPHNSGHYTLDACDVSQFDLQVHAMAGLPL
PQPRQHSPAIMLNLLGDLWFDAQGKEHTPDWQAVLALPGAHLHLYGKLHARAGRKMGHLNITGADVAGVQATARKAAAIL
GLPGLEDH

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=378, Percent_Identity=34.6560846560847, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1788155, Length=403, Percent_Identity=27.7915632754342, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324702, Length=382, Percent_Identity=34.0314136125654, Blast_Score=214, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42838; Mature: 42707

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPLLPVLPGTVSADGRPATLGVMGGGQLGRMFVHAAQRLGYFTTVLDPDPHSPAGYV
CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHH
SHHFIQTAYDDADGLAQLAAQCDAITTEFENVPAQALTALAATRPVAPGAAAVAIAQDRI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHEEEEHHHHH
AEKDHFVACAGISGVSCAPFAVIDSAAAVEAVPDALLPGILKTARLGYDGKGQMRIRTRE
CCCCCEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHH
ELLAAWTALKQVPCVLEQLLPLKAECSVLVARGWDGSIVSFPPQRNVHVDGILAVTHAYA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCCEECHHHHHHHHHH
SNMSSALAVQALAATKSIADHVGYVGILCVEFFVIDDGSEHGALVVNEMAPRPHNSGHYT
HCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCEEEECCCCCCCCCCCEE
LDACDVSQFDLQVHAMAGLPLPQPRQHSPAIMLNLLGDLWFDAQGKEHTPDWQAVLALPG
EEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
AHLHLYGKLHARAGRKMGHLNITGADVAGVQATARKAAAILGLPGLEDH
CEEEEEEEEHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SAAPLLPVLPGTVSADGRPATLGVMGGGQLGRMFVHAAQRLGYFTTVLDPDPHSPAGYV
CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHH
SHHFIQTAYDDADGLAQLAAQCDAITTEFENVPAQALTALAATRPVAPGAAAVAIAQDRI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHEEEEHHHHH
AEKDHFVACAGISGVSCAPFAVIDSAAAVEAVPDALLPGILKTARLGYDGKGQMRIRTRE
CCCCCEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHH
ELLAAWTALKQVPCVLEQLLPLKAECSVLVARGWDGSIVSFPPQRNVHVDGILAVTHAYA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCCEECHHHHHHHHHH
SNMSSALAVQALAATKSIADHVGYVGILCVEFFVIDDGSEHGALVVNEMAPRPHNSGHYT
HCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCEEEECCCCCCCCCCCEE
LDACDVSQFDLQVHAMAGLPLPQPRQHSPAIMLNLLGDLWFDAQGKEHTPDWQAVLALPG
EEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
AHLHLYGKLHARAGRKMGHLNITGADVAGVQATARKAAAILGLPGLEDH
CEEEEEEEEHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA