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The map label for this gene is hyi [H]

Identifier: 91790392

GI number: 91790392

Start: 4827521

End: 4828300

Strand: Direct

Name: hyi [H]

Synonym: Bpro_4562

Alternate gene names: 91790392

Gene position: 4827521-4828300 (Clockwise)

Preceding gene: 91790391

Following gene: 91790393

Centisome position: 92.83

GC content: 64.36

Gene sequence:

>780_bases
ATGCCAAGATTTTCCGCCAACCTCAGCATGCTCTTCACCGAGCATGCTTTCCTCGACCGCTTTGAGCCTGCCGCGAAAGC
CGGCTTCAAGGCCGTGGAGTTTCTTTTCCCCTATGCCTTCAGCATCGAAGACATCAAGTCCAGGCTGGACCGCCACGGCC
TGAAGCTGGTGCTGCACAACCTGCCGGCCGGCAACTGGGAGGCCGGCGAGCGCGGCATCGCCTGCCACCCCGATCGCGTC
GAGGAGTTTCGCGCCGGTGTGGCGCAGGCCATCACCTATGCCCAGGCGCTGGGCGTGCGCCAGCTCAACTGCCTGGCGGG
CAAGGCGCCCGCGGGTGTCGACAACGCGCTGCTGCGGCAGACCTTTGTGGACAACCTGCGCCATGCGGCGGCGGCGTTGA
AGAAGGCAGGTCTCAAGCTGCTGATCGAACCGATCAATACCTTTGACATCCCGGGCTTTTACCTGAACCGCACGGCGCAG
GCGCTCGAAATTCTGGACGAAGTGCGGGCCGACAACGCCTTCGTGCAGTACGACATCTACCACGCGCAGCGCATGGAGGG
CGAGCTGGCGGCGACCATGCAAAAGCATTTGCCGCGCATTGGCCACATCCAGCTGGCCGACAATCCGGGCCGCAACGAGC
CGGGCACGGGCGAGATCAATTACGCGTTTCTGTTCGCGCACCTGGACCGCATCGGCTACGACGGCTGGATTGGCTGCGAA
TACAAGCCTGCGGGCACCACGGAAGCCGGCCTCGGCTGGCGCGAACGCCTGGCAGCCTGA

Upstream 100 bases:

>100_bases
GGCCGCGAGGGCCTGGAACTGGCCGGCCTGCTGGAGTAAGGCCGCGGCAACGCAGTCATCAACGCCCCCCTACTCACTTA
TACCCACCCACAGACAAGAC

Downstream 100 bases:

>100_bases
CCTTCATTTTTTTCGACAAGTTTTCGACAAGGACTTTCTGATGACTTCCCAACCCCTGAAAATCGGTTTTATCGGCCTCG
GCATCATGGGCGCGCCCATG

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPRFSANLSMLFTEHAFLDRFEPAAKAGFKAVEFLFPYAFSIEDIKSRLDRHGLKLVLHNLPAGNWEAGERGIACHPDRV
EEFRAGVAQAITYAQALGVRQLNCLAGKAPAGVDNALLRQTFVDNLRHAAAALKKAGLKLLIEPINTFDIPGFYLNRTAQ
ALEILDEVRADNAFVQYDIYHAQRMEGELAATMQKHLPRIGHIQLADNPGRNEPGTGEINYAFLFAHLDRIGYDGWIGCE
YKPAGTTEAGLGWRERLAA

Sequences:

>Translated_259_residues
MPRFSANLSMLFTEHAFLDRFEPAAKAGFKAVEFLFPYAFSIEDIKSRLDRHGLKLVLHNLPAGNWEAGERGIACHPDRV
EEFRAGVAQAITYAQALGVRQLNCLAGKAPAGVDNALLRQTFVDNLRHAAAALKKAGLKLLIEPINTFDIPGFYLNRTAQ
ALEILDEVRADNAFVQYDIYHAQRMEGELAATMQKHLPRIGHIQLADNPGRNEPGTGEINYAFLFAHLDRIGYDGWIGCE
YKPAGTTEAGLGWRERLAA
>Mature_258_residues
PRFSANLSMLFTEHAFLDRFEPAAKAGFKAVEFLFPYAFSIEDIKSRLDRHGLKLVLHNLPAGNWEAGERGIACHPDRVE
EFRAGVAQAITYAQALGVRQLNCLAGKAPAGVDNALLRQTFVDNLRHAAAALKKAGLKLLIEPINTFDIPGFYLNRTAQA
LEILDEVRADNAFVQYDIYHAQRMEGELAATMQKHLPRIGHIQLADNPGRNEPGTGEINYAFLFAHLDRIGYDGWIGCEY
KPAGTTEAGLGWRERLAA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=258, Percent_Identity=43.7984496124031, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=42.798353909465, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786718, Length=255, Percent_Identity=60, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI1789095, Length=253, Percent_Identity=45.8498023715415, Blast_Score=233, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17552022, Length=257, Percent_Identity=38.9105058365759, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17530883, Length=259, Percent_Identity=36.6795366795367, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28732; Mature: 28601

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFSANLSMLFTEHAFLDRFEPAAKAGFKAVEFLFPYAFSIEDIKSRLDRHGLKLVLHN
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LPAGNWEAGERGIACHPDRVEEFRAGVAQAITYAQALGVRQLNCLAGKAPAGVDNALLRQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHH
TFVDNLRHAAAALKKAGLKLLIEPINTFDIPGFYLNRTAQALEILDEVRADNAFVQYDIY
HHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHH
HAQRMEGELAATMQKHLPRIGHIQLADNPGRNEPGTGEINYAFLFAHLDRIGYDGWIGCE
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCC
YKPAGTTEAGLGWRERLAA
CCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
PRFSANLSMLFTEHAFLDRFEPAAKAGFKAVEFLFPYAFSIEDIKSRLDRHGLKLVLHN
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LPAGNWEAGERGIACHPDRVEEFRAGVAQAITYAQALGVRQLNCLAGKAPAGVDNALLRQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHH
TFVDNLRHAAAALKKAGLKLLIEPINTFDIPGFYLNRTAQALEILDEVRADNAFVQYDIY
HHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHH
HAQRMEGELAATMQKHLPRIGHIQLADNPGRNEPGTGEINYAFLFAHLDRIGYDGWIGCE
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCC
YKPAGTTEAGLGWRERLAA
CCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]