Click here to switch to the map view.

The map label for this gene is glxR [H]

Identifier: 91790393

GI number: 91790393

Start: 4828341

End: 4829270

Strand: Direct

Name: glxR [H]

Synonym: Bpro_4563

Alternate gene names: 91790393

Gene position: 4828341-4829270 (Clockwise)

Preceding gene: 91790392

Following gene: 91790397

Centisome position: 92.85

GC content: 63.55

Gene sequence:

>930_bases
ATGACTTCCCAACCCCTGAAAATCGGTTTTATCGGCCTCGGCATCATGGGCGCGCCCATGGCGGGCCACCTGATCAACGC
AGGCCACCAGCTGTTTGTATTCTCGCAGGCCAAACTGCCCGCCAGCATTGCCAACAGCAACGCCACCCAGTGCCTGAACG
CCCGCGGTGTGGCCGAACGCGCCGACGTCATCATCGTCATGGTGCCCGACACACCCGATGTGGAAGCCGTGCTGTTCGGC
GAGACCGGCGTGGCCAGCGGGCTCGCCATGCCGCCTCACGCATCGGACGCTCCCCGCAAGACGGTGGTGGACATGAGCTC
CATCTCGCCGATCGCCACCAAAACCTTTGCGCAAAAGATCAACGCGCTGGGCTGCGATTACCTCGATGCGCCGGTCTCGG
GCGGGGAGGTCGGCGCCAAAAATGCCACGCTCTCCATCATGGTGGGGGGTGACGAGGCGGTCTTCGGGCGCATCAAGCCG
CTGTTTGACCTCATGGGCAAGAACATCACGCTGGTGGGCGGCAACGGCGATGGCCAGACCGCAAAAGTCGCCAACCAGAT
CATCGTCGCGCTCAACATCGAGGCCGTGGCCGAAGCGTTGCTGTTTGCCGCCCGTGCCGGTGCCGACCCGGCGCGTGTGC
GCCAGGCGTTGATGGGAGGTTTCGCCTCGTCAAAAATCCTGGAAGTGCATGGCGAACGCATGGTCAAACGCACGTTTGAC
CCAGGCTTTCGCATTGAGCTGCACCAGAAGGATTTGAACCTGGCTCTGTCCAGTGCCCGCGCGCTCGGCGTCTCGCTGCC
CAACACCGCCACAGCCCAGGAGCTCTTCAACTCCTGCGTGGCGCATGGCGGCAAAGCCTGGGACCATTCGGCCATGGTCC
GCGCGCTGGAGAAGCTGGCCAACTTCGAGATCGGGCAAAAGGCGGAGTGA

Upstream 100 bases:

>100_bases
TACAAGCCTGCGGGCACCACGGAAGCCGGCCTCGGCTGGCGCGAACGCCTGGCAGCCTGACCTTCATTTTTTTCGACAAG
TTTTCGACAAGGACTTTCTG

Downstream 100 bases:

>100_bases
TGGGGCGGGCCGCGCAGGAAGCCGTCAACTCGATGGCATCTTGCGCCCCAGCCATGACGTTCCCCAACCGCTGCTCACTC
CTCACTACTGACCACTGACT

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTSQPLKIGFIGLGIMGAPMAGHLINAGHQLFVFSQAKLPASIANSNATQCLNARGVAERADVIIVMVPDTPDVEAVLFG
ETGVASGLAMPPHASDAPRKTVVDMSSISPIATKTFAQKINALGCDYLDAPVSGGEVGAKNATLSIMVGGDEAVFGRIKP
LFDLMGKNITLVGGNGDGQTAKVANQIIVALNIEAVAEALLFAARAGADPARVRQALMGGFASSKILEVHGERMVKRTFD
PGFRIELHQKDLNLALSSARALGVSLPNTATAQELFNSCVAHGGKAWDHSAMVRALEKLANFEIGQKAE

Sequences:

>Translated_309_residues
MTSQPLKIGFIGLGIMGAPMAGHLINAGHQLFVFSQAKLPASIANSNATQCLNARGVAERADVIIVMVPDTPDVEAVLFG
ETGVASGLAMPPHASDAPRKTVVDMSSISPIATKTFAQKINALGCDYLDAPVSGGEVGAKNATLSIMVGGDEAVFGRIKP
LFDLMGKNITLVGGNGDGQTAKVANQIIVALNIEAVAEALLFAARAGADPARVRQALMGGFASSKILEVHGERMVKRTFD
PGFRIELHQKDLNLALSSARALGVSLPNTATAQELFNSCVAHGGKAWDHSAMVRALEKLANFEIGQKAE
>Mature_308_residues
TSQPLKIGFIGLGIMGAPMAGHLINAGHQLFVFSQAKLPASIANSNATQCLNARGVAERADVIIVMVPDTPDVEAVLFGE
TGVASGLAMPPHASDAPRKTVVDMSSISPIATKTFAQKINALGCDYLDAPVSGGEVGAKNATLSIMVGGDEAVFGRIKPL
FDLMGKNITLVGGNGDGQTAKVANQIIVALNIEAVAEALLFAARAGADPARVRQALMGGFASSKILEVHGERMVKRTFDP
GFRIELHQKDLNLALSSARALGVSLPNTATAQELFNSCVAHGGKAWDHSAMVRALEKLANFEIGQKAE

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=313, Percent_Identity=28.7539936102236, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI40556376, Length=291, Percent_Identity=26.4604810996564, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786719, Length=299, Percent_Identity=67.2240802675585, Blast_Score=406, Evalue=1e-115,
Organism=Escherichia coli, GI145693186, Length=302, Percent_Identity=43.046357615894, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=34.020618556701, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789092, Length=304, Percent_Identity=30.5921052631579, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=288, Percent_Identity=31.9444444444444, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24655230, Length=301, Percent_Identity=35.5481727574751, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI19922568, Length=301, Percent_Identity=35.5481727574751, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574115, Length=286, Percent_Identity=28.6713286713287, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32194; Mature: 32062

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQPLKIGFIGLGIMGAPMAGHLINAGHQLFVFSQAKLPASIANSNATQCLNARGVAER
CCCCCEEEEEEEECHHCCCHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHCCCCCCCC
ADVIIVMVPDTPDVEAVLFGETGVASGLAMPPHASDAPRKTVVDMSSISPIATKTFAQKI
CCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHCCCHHHHHHHHHHH
NALGCDYLDAPVSGGEVGAKNATLSIMVGGDEAVFGRIKPLFDLMGKNITLVGGNGDGQT
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCH
AKVANQIIVALNIEAVAEALLFAARAGADPARVRQALMGGFASSKILEVHGERMVKRTFD
HHHHCEEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
PGFRIELHQKDLNLALSSARALGVSLPNTATAQELFNSCVAHGGKAWDHSAMVRALEKLA
CCCEEEEECCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
NFEIGQKAE
CCCCCCCCC
>Mature Secondary Structure 
TSQPLKIGFIGLGIMGAPMAGHLINAGHQLFVFSQAKLPASIANSNATQCLNARGVAER
CCCCEEEEEEEECHHCCCHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHCCCCCCCC
ADVIIVMVPDTPDVEAVLFGETGVASGLAMPPHASDAPRKTVVDMSSISPIATKTFAQKI
CCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHCCCHHHHHHHHHHH
NALGCDYLDAPVSGGEVGAKNATLSIMVGGDEAVFGRIKPLFDLMGKNITLVGGNGDGQT
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCH
AKVANQIIVALNIEAVAEALLFAARAGADPARVRQALMGGFASSKILEVHGERMVKRTFD
HHHHCEEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
PGFRIELHQKDLNLALSSARALGVSLPNTATAQELFNSCVAHGGKAWDHSAMVRALEKLA
CCCEEEEECCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
NFEIGQKAE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]