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The map label for this gene is argH1 [H]

Identifier: 91790220

GI number: 91790220

Start: 4627855

End: 4629354

Strand: Reverse

Name: argH1 [H]

Synonym: Bpro_4386

Alternate gene names: 91790220

Gene position: 4629354-4627855 (Counterclockwise)

Preceding gene: 91790222

Following gene: 91790219

Centisome position: 89.02

GC content: 59.8

Gene sequence:

>1500_bases
ATGGAATCAAAAGTCAGTCGCCGGCTTAAAGAGCCAACCGCAAAGGAGATCTGCGAGCACATCACTGGTCCGCGCCTTGC
GCGCGATTTCCCGAGGCAGTTCCCCTATCTCACCGTCGTGAACCAGGCGCATTTGCTGATGCTGCACAAGACGGGTTTGA
TCTCGCCGGACGTGGCAAAGAAGCTCGCCAACGGTTTGGCGCAGATGGAAGCCGAAGGCCCTGAAGCCGTGGAACTGGAT
CCGGCCAAGGAGGAGCCCTACTTCAACTACGAATCGAAGCTGATGGAGATCGTCGGGCGCGACGTTGGAGGTCGACTGCA
TATGGCGCGCAGTCGAAACGACATTGGGGTGACGATTGATCGGCTGCGCGCACGGAGTGCCGTGCTCAATGTCCTAGAAG
CTCTTGGACGGGTGCGCAGGGTTGCCCTTGAGCGGGCGAGCAAGTTCACAAACGTCATCATGCCCGGGTATACCCATCTG
CAGCCCGCGCAGCCGATCACGTATGGCTTCTATCTGAGCGCTGTGGCGGAAGCGCTGGGGAGGGACATGGATCGTCTGCA
TGCCTCTTTGGCTCGCATCGATGAGTCGCCGCTTGGCGCGGGGGCGTTGGCGGGGACACGTTTCCCCATCGATAGGAGCG
TGACGGCTACGGCACTCGGCTTTAGCTCCGTCGCGCCCAACACCCTGGATGCGGTCGCCTCGCGAGACTTCGCGTGGGAG
GCGATGTCGGCGATGACCATCGTCGCGCTCACTTGGGGGAGGGTGGCGCAGGACTTTCAGGTCTGGTCCACGCTCGAATT
CGGGCTTGTGTCGTTCCCAGATCGAGTGGCCAGCACGTCGAGCATCATGCCGCAGAAGAAGAACCCCGTCGTACTTGAGT
ACCTTCGGGGCAAGAGCAGTCACATCATCGGACTGCTTACCGCTTCCCTTGTTGCAGTGAAGGGAACCCACTTCACCCAT
GCCGGCGATAGCAGCCGTGAAAGCATGCGCAGCTTTTGGGAGTGCGCTGAGGAGACTCTCCGATGCCTCGCACTGTTCGA
GTTGATCGTGAGCACGGCGGAGCCCAAAGAAAAGAACATGCTGCAGCATGTTCGATTCGATTTTTCGGTTGCAACCGACC
TTGCCGATGGGCTCGTGGCCGAGGCCGGCATGTCCTTTCGCGAGGCGCACCACGTGGTGGGTGGCCTCGTTCGCCTTGCA
CTGGACGAAGGCAAGTCTGCGAACGAGCTAACGAGCGCAATGCTGGATCGCGCAGCAGTCGACGTTATTGGATCCGCAAT
CGAGTGGCCCGAGCAGAAGCTGCGCAAGTACCTCGATCCCATTGAGTGTGTGAACATGCGGCACAACGGGGGGCCAGCGC
CTGCGGAGCTGTCCGGTGCAATCAAGAAGCAGCTCGGTAGTCTCGAAAATGTTCTGGCCAAAGTTCAGTCAACCAGAGAT
CACTTTACCGCAGCGCACGAACAGATGAAGCGCGACGTGGCCGCCATCGCAAGTCAATAA

Upstream 100 bases:

>100_bases
AGTCATATCAAATGCGTATTGAGTACTTGAAAACTGTCATTTGACGCCATGACGCTCTCTCTTGATACTTGCATTAACTT
AAAAAACGGATTTGAAAACA

Downstream 100 bases:

>100_bases
CCGTCCACTCACCGTAAAGGATCTGAACCATGAAGTTCCTTGTTAGAACTCTGATCGCGACCATCGCCGCTGTCTGCGTT
GCTACCAACGCATTCGCTGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MESKVSRRLKEPTAKEICEHITGPRLARDFPRQFPYLTVVNQAHLLMLHKTGLISPDVAKKLANGLAQMEAEGPEAVELD
PAKEEPYFNYESKLMEIVGRDVGGRLHMARSRNDIGVTIDRLRARSAVLNVLEALGRVRRVALERASKFTNVIMPGYTHL
QPAQPITYGFYLSAVAEALGRDMDRLHASLARIDESPLGAGALAGTRFPIDRSVTATALGFSSVAPNTLDAVASRDFAWE
AMSAMTIVALTWGRVAQDFQVWSTLEFGLVSFPDRVASTSSIMPQKKNPVVLEYLRGKSSHIIGLLTASLVAVKGTHFTH
AGDSSRESMRSFWECAEETLRCLALFELIVSTAEPKEKNMLQHVRFDFSVATDLADGLVAEAGMSFREAHHVVGGLVRLA
LDEGKSANELTSAMLDRAAVDVIGSAIEWPEQKLRKYLDPIECVNMRHNGGPAPAELSGAIKKQLGSLENVLAKVQSTRD
HFTAAHEQMKRDVAAIASQ

Sequences:

>Translated_499_residues
MESKVSRRLKEPTAKEICEHITGPRLARDFPRQFPYLTVVNQAHLLMLHKTGLISPDVAKKLANGLAQMEAEGPEAVELD
PAKEEPYFNYESKLMEIVGRDVGGRLHMARSRNDIGVTIDRLRARSAVLNVLEALGRVRRVALERASKFTNVIMPGYTHL
QPAQPITYGFYLSAVAEALGRDMDRLHASLARIDESPLGAGALAGTRFPIDRSVTATALGFSSVAPNTLDAVASRDFAWE
AMSAMTIVALTWGRVAQDFQVWSTLEFGLVSFPDRVASTSSIMPQKKNPVVLEYLRGKSSHIIGLLTASLVAVKGTHFTH
AGDSSRESMRSFWECAEETLRCLALFELIVSTAEPKEKNMLQHVRFDFSVATDLADGLVAEAGMSFREAHHVVGGLVRLA
LDEGKSANELTSAMLDRAAVDVIGSAIEWPEQKLRKYLDPIECVNMRHNGGPAPAELSGAIKKQLGSLENVLAKVQSTRD
HFTAAHEQMKRDVAAIASQ
>Mature_499_residues
MESKVSRRLKEPTAKEICEHITGPRLARDFPRQFPYLTVVNQAHLLMLHKTGLISPDVAKKLANGLAQMEAEGPEAVELD
PAKEEPYFNYESKLMEIVGRDVGGRLHMARSRNDIGVTIDRLRARSAVLNVLEALGRVRRVALERASKFTNVIMPGYTHL
QPAQPITYGFYLSAVAEALGRDMDRLHASLARIDESPLGAGALAGTRFPIDRSVTATALGFSSVAPNTLDAVASRDFAWE
AMSAMTIVALTWGRVAQDFQVWSTLEFGLVSFPDRVASTSSIMPQKKNPVVLEYLRGKSSHIIGLLTASLVAVKGTHFTH
AGDSSRESMRSFWECAEETLRCLALFELIVSTAEPKEKNMLQHVRFDFSVATDLADGLVAEAGMSFREAHHVVGGLVRLA
LDEGKSANELTSAMLDRAAVDVIGSAIEWPEQKLRKYLDPIECVNMRHNGGPAPAELSGAIKKQLGSLENVLAKVQSTRD
HFTAAHEQMKRDVAAIASQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=365, Percent_Identity=33.972602739726, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI68303542, Length=365, Percent_Identity=33.972602739726, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI68303547, Length=365, Percent_Identity=32.8767123287671, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI68303549, Length=365, Percent_Identity=30.6849315068493, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1790398, Length=383, Percent_Identity=37.3368146214099, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17553882, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32565146, Length=222, Percent_Identity=27.9279279279279, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321806, Length=355, Percent_Identity=39.1549295774648, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI221473854, Length=371, Percent_Identity=35.8490566037736, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI78706858, Length=371, Percent_Identity=35.8490566037736, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24640179, Length=247, Percent_Identity=26.7206477732794, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI78710009, Length=199, Percent_Identity=27.1356783919598, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640177, Length=247, Percent_Identity=26.7206477732794, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54664; Mature: 54664

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKVSRRLKEPTAKEICEHITGPRLARDFPRQFPYLTVVNQAHLLMLHKTGLISPDVAK
CCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCEEEEECCHHEEEEECCCCCCHHHHH
KLANGLAQMEAEGPEAVELDPAKEEPYFNYESKLMEIVGRDVGGRLHMARSRNDIGVTID
HHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCHHHH
RLRARSAVLNVLEALGRVRRVALERASKFTNVIMPGYTHLQPAQPITYGFYLSAVAEALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
RDMDRLHASLARIDESPLGAGALAGTRFPIDRSVTATALGFSSVAPNTLDAVASRDFAWE
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCCCHHHHHHHCCCHHHH
AMSAMTIVALTWGRVAQDFQVWSTLEFGLVSFPDRVASTSSIMPQKKNPVVLEYLRGKSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHCCCCC
HIIGLLTASLVAVKGTHFTHAGDSSRESMRSFWECAEETLRCLALFELIVSTAEPKEKNM
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LQHVRFDFSVATDLADGLVAEAGMSFREAHHVVGGLVRLALDEGKSANELTSAMLDRAAV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DVIGSAIEWPEQKLRKYLDPIECVNMRHNGGPAPAELSGAIKKQLGSLENVLAKVQSTRD
HHHHHHHCCHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HFTAAHEQMKRDVAAIASQ
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESKVSRRLKEPTAKEICEHITGPRLARDFPRQFPYLTVVNQAHLLMLHKTGLISPDVAK
CCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCEEEEECCHHEEEEECCCCCCHHHHH
KLANGLAQMEAEGPEAVELDPAKEEPYFNYESKLMEIVGRDVGGRLHMARSRNDIGVTID
HHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCHHHH
RLRARSAVLNVLEALGRVRRVALERASKFTNVIMPGYTHLQPAQPITYGFYLSAVAEALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
RDMDRLHASLARIDESPLGAGALAGTRFPIDRSVTATALGFSSVAPNTLDAVASRDFAWE
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCCCHHHHHHHCCCHHHH
AMSAMTIVALTWGRVAQDFQVWSTLEFGLVSFPDRVASTSSIMPQKKNPVVLEYLRGKSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHCCCCC
HIIGLLTASLVAVKGTHFTHAGDSSRESMRSFWECAEETLRCLALFELIVSTAEPKEKNM
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LQHVRFDFSVATDLADGLVAEAGMSFREAHHVVGGLVRLALDEGKSANELTSAMLDRAAV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DVIGSAIEWPEQKLRKYLDPIECVNMRHNGGPAPAELSGAIKKQLGSLENVLAKVQSTRD
HHHHHHHCCHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HFTAAHEQMKRDVAAIASQ
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA