Click here to switch to the map view.

The map label for this gene is phhA [H]

Identifier: 91790053

GI number: 91790053

Start: 4433736

End: 4434614

Strand: Direct

Name: phhA [H]

Synonym: Bpro_4215

Alternate gene names: 91790053

Gene position: 4433736-4434614 (Clockwise)

Preceding gene: 91790052

Following gene: 91790054

Centisome position: 85.26

GC content: 64.28

Gene sequence:

>879_bases
ATGGCTGAAGTAGCAGGCGGCGCCCCCGAACCGGTGGTGTACGGTCAATCCGACCGGCCACCGCGGGGCGACTATTCACG
CGGCGGCCAGGTCAGGGCCGACTACACCTGCCCGCAAAACTACGCCGCCTATACCGCGGCAGACCACGACATCTACCACC
GCCTGTATCAGCGCCAGTCGGCGCTGGTGCCGGGCCTGGCCTGCGATGAATTCATTGCGGCACTGCCCTTGCTGGGAGCG
AAAGAGCGGATTCCGCGTTTTGAGGAAATCAACGAACGGCTGTACAAGGCCACCCGCTGGGAAATCGTCGCCGTGCCGGG
GCTGATCCCTGAAGTGCCGTTTTTTACCCTGCTGGCCAACCGCAAGTTCCCGGTGACCGACTGGCTGCGCACGCCGGCGG
AGTTTGACTACATCGTCGAGCCCGACGTGTTTCACGACCTGTTTGGCCATGTGCCGCTGCTGTTCAACCCGGTGTTTGCC
GACCACATGCAGGCCTACGGCGCCGGCGGGCTGAAGGCCCATGCCCTGGGCGCCTGCGAGCAGCTGTCGCGCCTGTACTG
GTACACGGTCGAGTTCGGCCTGATCCGCCAGGCGAACGGCCTGCGGGCCTATGGCGCCGGCATCCTGAGCTCGTCCGGCG
AGCTGGCCTACGCCGTGCAGAGCCCCGAGCCCCAGCGGATTGCGCTGAATCTGCTGCGCACCATGCGCACGCGCTACAAA
ATCGATAGCTATCAGCAAACCTATTTCGTGATTGACAGCTTCCAGCAGCTGTTCGACATGACGGCGCCCGACTTCACGCC
GCTGTACGCCCAGCTCAAGACCCTGCCCGAGCTGGCGGCCAACGCGCTTTTGGCGGAAGATGCGGTAATTCAGCGCTGA

Upstream 100 bases:

>100_bases
CCTATCTGCTGCCGCGTGGCGATGTGACCTTCAAGGCCTATGTAGACCAGTGGCTGCACCTGGCCAAGGCCAGCGGCGAG
TACCAGCGGGTGGAAGGACA

Downstream 100 bases:

>100_bases
AAAACAACAGTGTGTGGCGCTCTGGAGGCGCAGCCACCCATTCAATGTTTCGTTAGAGCGGTTCCTCCTCCAAAATGAGG
AGGCGAATAATTGTTACACC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAEVAGGAPEPVVYGQSDRPPRGDYSRGGQVRADYTCPQNYAAYTAADHDIYHRLYQRQSALVPGLACDEFIAALPLLGA
KERIPRFEEINERLYKATRWEIVAVPGLIPEVPFFTLLANRKFPVTDWLRTPAEFDYIVEPDVFHDLFGHVPLLFNPVFA
DHMQAYGAGGLKAHALGACEQLSRLYWYTVEFGLIRQANGLRAYGAGILSSSGELAYAVQSPEPQRIALNLLRTMRTRYK
IDSYQQTYFVIDSFQQLFDMTAPDFTPLYAQLKTLPELAANALLAEDAVIQR

Sequences:

>Translated_292_residues
MAEVAGGAPEPVVYGQSDRPPRGDYSRGGQVRADYTCPQNYAAYTAADHDIYHRLYQRQSALVPGLACDEFIAALPLLGA
KERIPRFEEINERLYKATRWEIVAVPGLIPEVPFFTLLANRKFPVTDWLRTPAEFDYIVEPDVFHDLFGHVPLLFNPVFA
DHMQAYGAGGLKAHALGACEQLSRLYWYTVEFGLIRQANGLRAYGAGILSSSGELAYAVQSPEPQRIALNLLRTMRTRYK
IDSYQQTYFVIDSFQQLFDMTAPDFTPLYAQLKTLPELAANALLAEDAVIQR
>Mature_291_residues
AEVAGGAPEPVVYGQSDRPPRGDYSRGGQVRADYTCPQNYAAYTAADHDIYHRLYQRQSALVPGLACDEFIAALPLLGAK
ERIPRFEEINERLYKATRWEIVAVPGLIPEVPFFTLLANRKFPVTDWLRTPAEFDYIVEPDVFHDLFGHVPLLFNPVFAD
HMQAYGAGGLKAHALGACEQLSRLYWYTVEFGLIRQANGLRAYGAGILSSSGELAYAVQSPEPQRIALNLLRTMRTRYKI
DSYQQTYFVIDSFQQLFDMTAPDFTPLYAQLKTLPELAANALLAEDAVIQR

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=217, Percent_Identity=34.1013824884793, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI88900501, Length=221, Percent_Identity=36.6515837104072, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI88900503, Length=221, Percent_Identity=36.6515837104072, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI88900505, Length=221, Percent_Identity=36.6515837104072, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI31795563, Length=218, Percent_Identity=33.9449541284404, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4759248, Length=217, Percent_Identity=34.5622119815668, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17531391, Length=217, Percent_Identity=35.9447004608295, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71980736, Length=220, Percent_Identity=34.0909090909091, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI115532103, Length=235, Percent_Identity=30.2127659574468, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533973, Length=235, Percent_Identity=30.2127659574468, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71980731, Length=152, Percent_Identity=30.9210526315789, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24660393, Length=229, Percent_Identity=36.2445414847162, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472054, Length=229, Percent_Identity=36.2445414847162, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17136776, Length=230, Percent_Identity=33.4782608695652, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17136774, Length=230, Percent_Identity=33.4782608695652, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24654994, Length=177, Percent_Identity=35.0282485875706, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 32802; Mature: 32670

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVAGGAPEPVVYGQSDRPPRGDYSRGGQVRADYTCPQNYAAYTAADHDIYHRLYQRQS
CCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCHHHHHHHHHHHH
ALVPGLACDEFIAALPLLGAKERIPRFEEINERLYKATRWEIVAVPGLIPEVPFFTLLAN
HCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHCC
RKFPVTDWLRTPAEFDYIVEPDVFHDLFGHVPLLFNPVFADHMQAYGAGGLKAHALGACE
CCCCHHHHHCCCCCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QLSRLYWYTVEFGLIRQANGLRAYGAGILSSSGELAYAVQSPEPQRIALNLLRTMRTRYK
HHHHHHHHEEEHHHHCCCCCCCHHCCHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
IDSYQQTYFVIDSFQQLFDMTAPDFTPLYAQLKTLPELAANALLAEDAVIQR
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEVAGGAPEPVVYGQSDRPPRGDYSRGGQVRADYTCPQNYAAYTAADHDIYHRLYQRQS
CCCCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCHHHHHHHHHHHH
ALVPGLACDEFIAALPLLGAKERIPRFEEINERLYKATRWEIVAVPGLIPEVPFFTLLAN
HCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHCC
RKFPVTDWLRTPAEFDYIVEPDVFHDLFGHVPLLFNPVFADHMQAYGAGGLKAHALGACE
CCCCHHHHHCCCCCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QLSRLYWYTVEFGLIRQANGLRAYGAGILSSSGELAYAVQSPEPQRIALNLLRTMRTRYK
HHHHHHHHEEEHHHHCCCCCCCHHCCHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
IDSYQQTYFVIDSFQQLFDMTAPDFTPLYAQLKTLPELAANALLAEDAVIQR
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]