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The map label for this gene is hpd [H]

Identifier: 91790051

GI number: 91790051

Start: 4431761

End: 4432891

Strand: Direct

Name: hpd [H]

Synonym: Bpro_4213

Alternate gene names: 91790051

Gene position: 4431761-4432891 (Clockwise)

Preceding gene: 91790048

Following gene: 91790052

Centisome position: 85.22

GC content: 60.83

Gene sequence:

>1131_bases
ATGAACGCACCCCTATCTTTCGAAACAGGCGCCGCCTGGGACAACCCCATGGGCACCGACGGTTTCGAGTTCATCGAATA
CGCCGCGCCGGACCCCCAGGCCATGGGCGCGCTGTTCGAGCGCATGGGCTTCAAGCCGATTGCCAGGCATCGCCATAAAG
ATGTGACGCTGTACCGCCAGGGCGGCATCAACTTCATCCTCAATGCCGAGCCCGATTCATTTGCGCAGCGCTTTGCACGC
CAGCACGGTCCCAGCGTCTGCGCCATTGCGTTCAGGGTGCGGGATGCCAAGGCCGCTTACGAGCGCGCGATTGCGCTGGG
CGCCTGGGGTTATGCCCACACCGCCGGCCCGGGCGAGCTGAACATCCCGGCCATCAAGGGCATTGGCGACTCCATCATCT
ATTTCATTGACCGCTGGCGCGGCAAGAACGGCGCCCGGGAAGGCGATATCGGCAACATCGGTTTTTACGATGTTGACTTC
GAGCCCCTGCCGGGCGTGAGCGGCGCCGAGGCGCTGAATCCCACGGGCCATGGGCTGACCTACATTGACCACCTGACGCA
CAACGTGCACCGCGGCCGCATGGACGAGTGGGCCGGCTTCTACGAGCGCCTGTTCAACTTCCGCGAGATCCGCTACTTCG
ACATCGAAGGCCTGGTGACCGGCGTGAAAAGCAAGGCCATGACCAGCCCCTGCGGCAAGATCCGCATCCCGATCAACGAG
GAAGGCAATGAGAAAGCCGGCCAGATCCAGGAGTACCTGGACCGTTACCAGGGCGAGGGCATCCAGCACATCGCCATGGG
CAGCGGCAATTTGCCAGCCACCGTGGACAAGCTACGCGCCAGCGGCATCAAGCTGCTGGACACGGTAGACACCTACTACG
AACTGATCGACAAGCGCATTCCAGGCCATGGCGAAAATGTGGCGGAACTGCACAAGCGAAAAATTTTGGTGGACGGCAAG
AAAGGCGCGCTTCTGCTGCAGATCTTCAGTGAAAACCAGCTCGGCCCGATCTTCTTTGAATTCATCCAGCGCAAGGGCGA
CGAGGGTTTTGGCGAAGGCAACTTCAAGGCACTGTTCGAAAGCATCGAGCTGGACCAGATGCGCCGAGGGGTTTTGGCGA
GTGCACAATAA

Upstream 100 bases:

>100_bases
GTCAGTGAATGGACTCCGTAACCAGTCACACGCCAACAGCCGGGCCAGGCCAAGCCGAACCAAGTCAGCCCATCGTCAAT
CCAATATTTCTGGAGACTCC

Downstream 100 bases:

>100_bases
AGTCCGTCCATTTACCCACCCTCCCGGAGATTGCCATGTCATTTCGTCAGAAACTGCAGCCCCGCCTGGTCGCACTCGGC
CTTGTTTCGGCCGCGTCCTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNAPLSFETGAAWDNPMGTDGFEFIEYAAPDPQAMGALFERMGFKPIARHRHKDVTLYRQGGINFILNAEPDSFAQRFAR
QHGPSVCAIAFRVRDAKAAYERAIALGAWGYAHTAGPGELNIPAIKGIGDSIIYFIDRWRGKNGAREGDIGNIGFYDVDF
EPLPGVSGAEALNPTGHGLTYIDHLTHNVHRGRMDEWAGFYERLFNFREIRYFDIEGLVTGVKSKAMTSPCGKIRIPINE
EGNEKAGQIQEYLDRYQGEGIQHIAMGSGNLPATVDKLRASGIKLLDTVDTYYELIDKRIPGHGENVAELHKRKILVDGK
KGALLLQIFSENQLGPIFFEFIQRKGDEGFGEGNFKALFESIELDQMRRGVLASAQ

Sequences:

>Translated_376_residues
MNAPLSFETGAAWDNPMGTDGFEFIEYAAPDPQAMGALFERMGFKPIARHRHKDVTLYRQGGINFILNAEPDSFAQRFAR
QHGPSVCAIAFRVRDAKAAYERAIALGAWGYAHTAGPGELNIPAIKGIGDSIIYFIDRWRGKNGAREGDIGNIGFYDVDF
EPLPGVSGAEALNPTGHGLTYIDHLTHNVHRGRMDEWAGFYERLFNFREIRYFDIEGLVTGVKSKAMTSPCGKIRIPINE
EGNEKAGQIQEYLDRYQGEGIQHIAMGSGNLPATVDKLRASGIKLLDTVDTYYELIDKRIPGHGENVAELHKRKILVDGK
KGALLLQIFSENQLGPIFFEFIQRKGDEGFGEGNFKALFESIELDQMRRGVLASAQ
>Mature_376_residues
MNAPLSFETGAAWDNPMGTDGFEFIEYAAPDPQAMGALFERMGFKPIARHRHKDVTLYRQGGINFILNAEPDSFAQRFAR
QHGPSVCAIAFRVRDAKAAYERAIALGAWGYAHTAGPGELNIPAIKGIGDSIIYFIDRWRGKNGAREGDIGNIGFYDVDF
EPLPGVSGAEALNPTGHGLTYIDHLTHNVHRGRMDEWAGFYERLFNFREIRYFDIEGLVTGVKSKAMTSPCGKIRIPINE
EGNEKAGQIQEYLDRYQGEGIQHIAMGSGNLPATVDKLRASGIKLLDTVDTYYELIDKRIPGHGENVAELHKRKILVDGK
KGALLLQIFSENQLGPIFFEFIQRKGDEGFGEGNFKALFESIELDQMRRGVLASAQ

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=372, Percent_Identity=26.6129032258064, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI285002264, Length=363, Percent_Identity=26.7217630853994, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI14249394, Length=384, Percent_Identity=24.7395833333333, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=334, Percent_Identity=33.2335329341317, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17550752, Length=204, Percent_Identity=27.9411764705882, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667510, Length=374, Percent_Identity=31.5508021390374, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356105, Length=311, Percent_Identity=33.4405144694534, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41772; Mature: 41772

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLSFETGAAWDNPMGTDGFEFIEYAAPDPQAMGALFERMGFKPIARHRHKDVTLYRQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCEEEEEE
GGINFILNAEPDSFAQRFARQHGPSVCAIAFRVRDAKAAYERAIALGAWGYAHTAGPGEL
CCCEEEEECCCHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCC
NIPAIKGIGDSIIYFIDRWRGKNGAREGDIGNIGFYDVDFEPLPGVSGAEALNPTGHGLT
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHH
YIDHLTHNVHRGRMDEWAGFYERLFNFREIRYFDIEGLVTGVKSKAMTSPCGKIRIPINE
HHHHHHHHHHCCCHHHHHHHHHHHHCHHHEEEEEHHHHHHHHHHHHHCCCCCEEEEECCC
EGNEKAGQIQEYLDRYQGEGIQHIAMGSGNLPATVDKLRASGIKLLDTVDTYYELIDKRI
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHC
PGHGENVAELHKRKILVDGKKGALLLQIFSENQLGPIFFEFIQRKGDEGFGEGNFKALFE
CCCCCCHHHHHHCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIELDQMRRGVLASAQ
HHHHHHHHHCHHCCCC
>Mature Secondary Structure
MNAPLSFETGAAWDNPMGTDGFEFIEYAAPDPQAMGALFERMGFKPIARHRHKDVTLYRQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCEEEEEE
GGINFILNAEPDSFAQRFARQHGPSVCAIAFRVRDAKAAYERAIALGAWGYAHTAGPGEL
CCCEEEEECCCHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCC
NIPAIKGIGDSIIYFIDRWRGKNGAREGDIGNIGFYDVDFEPLPGVSGAEALNPTGHGLT
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHH
YIDHLTHNVHRGRMDEWAGFYERLFNFREIRYFDIEGLVTGVKSKAMTSPCGKIRIPINE
HHHHHHHHHHCCCHHHHHHHHHHHHCHHHEEEEEHHHHHHHHHHHHHCCCCCEEEEECCC
EGNEKAGQIQEYLDRYQGEGIQHIAMGSGNLPATVDKLRASGIKLLDTVDTYYELIDKRI
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHC
PGHGENVAELHKRKILVDGKKGALLLQIFSENQLGPIFFEFIQRKGDEGFGEGNFKALFE
CCCCCCHHHHHHCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIELDQMRRGVLASAQ
HHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]