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The map label for this gene is pcaR [H]

Identifier: 91789536

GI number: 91789536

Start: 3901698

End: 3902534

Strand: Reverse

Name: pcaR [H]

Synonym: Bpro_3689

Alternate gene names: 91789536

Gene position: 3902534-3901698 (Counterclockwise)

Preceding gene: 91789537

Following gene: 91789535

Centisome position: 75.04

GC content: 66.91

Gene sequence:

>837_bases
ATGAGTGACAACACCGCCGAAGAAAACGGCAACGACAAATACATCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCTCGG
AGAATTCAGCCGCGACAGCCGCACGCTGAGCGCGCCCGAACTGGCACGCCGACTTGACCTGCCGCGCTCCACGGTGTTTC
GCCTGCTCAACACGCTGGAGGCCATGGGCTTCATCGAGCGCACCAGCGGCGGCAGCGACTACCGCCTTGGCATGGCCGTG
CTGCGCCTGGGCTTTGAATACCTGTCCTCGCTGGAGCTCACCGAACTGGGTCAGCCATTGCTGGCGCGGCTGTGCGACGA
AATTCACTACTCGTGCAACCTGGTGGTGCGGGACGGGCGTTCGATCGTCTATGTGGCCAAGGTCGCGCCGCCGACGCCGT
TCGCCAGCTCGGTGCGCGTCGGCACGCGCCTGCCGGCCCACGCGACCGTTCTGGGCCGGGTACTGCTGCAGGACCTGACC
CTGCCCGAGTTGCGCGCGATCTACCCCGAGGATCACCTCGAAGCGTTTTCCGCCAGCACGCCCAAGACCGTGCTGGAACT
GTTCAACCTGCTGGAGGCGGACCGCCAGCGCGGCTACGTGATGGGCGAGGGCTATTACGAGGCCAGCATCTCCACCATTG
CGGCCCCGGTGCGCGACGACAGCGGCCGCATCATCGCCGCGCTGGGAACCACCATTCCCTCGGCCCACATCGAGACCGGG
CTGGTCGACGACATGGTGCGGCATGTGCGCCTGTCGGCCGACGAGTTGTCCCGCCTCCTGAATTACCAACCGCGCAGCGA
CAGCCTCAACACGGTCGTCGCCCTGCGCCTGCGCTGA

Upstream 100 bases:

>100_bases
TTGATCAAGGGAGCCGGCCATGCCAGCCCTGTGGAGCAACCTGAAGCGGTCGCGCGCCTGATCACGCGCGCCGCGATGCA
ACCAAACGGAGCCACGCACC

Downstream 100 bases:

>100_bases
GTGCCTTCGCGATGAACCTGATTGACCTGAACCATACCGTGGCCGTGGTCACGGGCGGCTCGTCCGGCATCGGCCTGGCG
ACAGTCGAGCTGTTGCTGCA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSDNTAEENGNDKYIVPALERGLRLLGEFSRDSRTLSAPELARRLDLPRSTVFRLLNTLEAMGFIERTSGGSDYRLGMAV
LRLGFEYLSSLELTELGQPLLARLCDEIHYSCNLVVRDGRSIVYVAKVAPPTPFASSVRVGTRLPAHATVLGRVLLQDLT
LPELRAIYPEDHLEAFSASTPKTVLELFNLLEADRQRGYVMGEGYYEASISTIAAPVRDDSGRIIAALGTTIPSAHIETG
LVDDMVRHVRLSADELSRLLNYQPRSDSLNTVVALRLR

Sequences:

>Translated_278_residues
MSDNTAEENGNDKYIVPALERGLRLLGEFSRDSRTLSAPELARRLDLPRSTVFRLLNTLEAMGFIERTSGGSDYRLGMAV
LRLGFEYLSSLELTELGQPLLARLCDEIHYSCNLVVRDGRSIVYVAKVAPPTPFASSVRVGTRLPAHATVLGRVLLQDLT
LPELRAIYPEDHLEAFSASTPKTVLELFNLLEADRQRGYVMGEGYYEASISTIAAPVRDDSGRIIAALGTTIPSAHIETG
LVDDMVRHVRLSADELSRLLNYQPRSDSLNTVVALRLR
>Mature_277_residues
SDNTAEENGNDKYIVPALERGLRLLGEFSRDSRTLSAPELARRLDLPRSTVFRLLNTLEAMGFIERTSGGSDYRLGMAVL
RLGFEYLSSLELTELGQPLLARLCDEIHYSCNLVVRDGRSIVYVAKVAPPTPFASSVRVGTRLPAHATVLGRVLLQDLTL
PELRAIYPEDHLEAFSASTPKTVLELFNLLEADRQRGYVMGEGYYEASISTIAAPVRDDSGRIIAALGTTIPSAHIETGL
VDDMVRHVRLSADELSRLLNYQPRSDSLNTVVALRLR

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=248, Percent_Identity=27.4193548387097, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786715, Length=220, Percent_Identity=28.6363636363636, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082359, Length=244, Percent_Identity=25.4098360655738, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788131, Length=244, Percent_Identity=26.2295081967213, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789999, Length=254, Percent_Identity=25.1968503937008, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788581, Length=257, Percent_Identity=25.6809338521401, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30743; Mature: 30611

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNTAEENGNDKYIVPALERGLRLLGEFSRDSRTLSAPELARRLDLPRSTVFRLLNTLE
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
AMGFIERTSGGSDYRLGMAVLRLGFEYLSSLELTELGQPLLARLCDEIHYSCNLVVRDGR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCEEEEEECCC
SIVYVAKVAPPTPFASSVRVGTRLPAHATVLGRVLLQDLTLPELRAIYPEDHLEAFSAST
EEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHCCCC
PKTVLELFNLLEADRQRGYVMGEGYYEASISTIAAPVRDDSGRIIAALGTTIPSAHIETG
HHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHH
LVDDMVRHVRLSADELSRLLNYQPRSDSLNTVVALRLR
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
SDNTAEENGNDKYIVPALERGLRLLGEFSRDSRTLSAPELARRLDLPRSTVFRLLNTLE
CCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
AMGFIERTSGGSDYRLGMAVLRLGFEYLSSLELTELGQPLLARLCDEIHYSCNLVVRDGR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCEEEEEECCC
SIVYVAKVAPPTPFASSVRVGTRLPAHATVLGRVLLQDLTLPELRAIYPEDHLEAFSAST
EEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHCCCC
PKTVLELFNLLEADRQRGYVMGEGYYEASISTIAAPVRDDSGRIIAALGTTIPSAHIETG
HHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHH
LVDDMVRHVRLSADELSRLLNYQPRSDSLNTVVALRLR
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]