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The map label for this gene is dsbC [H]

Identifier: 91789359

GI number: 91789359

Start: 3703376

End: 3704089

Strand: Direct

Name: dsbC [H]

Synonym: Bpro_3505

Alternate gene names: 91789359

Gene position: 3703376-3704089 (Clockwise)

Preceding gene: 91789358

Following gene: 91789360

Centisome position: 71.22

GC content: 63.17

Gene sequence:

>714_bases
ATGATGGAGCGTCTGCTGATGGTCATCGCGGCGGCGACCGTGGCAACGGTTGCCCGCAGCGACGACGCCGCGGTGCGCGC
CACGTTGCAGCGCACCTTCCCGCAAAGCCCGATCCAGAGCCCTTCGAAGACCCCGGTTCCGGGCGTTCTCGAAGCGGCGA
TCGAAGGCCAGATCATCTACATCACGGAGGACGGCCAATACGTTCTTGGCGGTCCGCTACTCGACGTCAAAGCGAGCCGC
AACCTCACCGAAGTCCGGCTCGAACAGATCAATGCGATTCCCTTCGACAGCCTTCCCCTCGATTGGGCCTTCAAGCGGGT
CAAGGGCACCGGTGCGCGCAGGATCGCGATCTTCGAGGATCCCGACTGTCCGTACTGCAAGATGCTGGAGCAGACGCTTG
AGGGCATGGACAACTTGACGGTGTATGTCTTTCTGTATCCCATCGACCAGATCCACCCCGACGCTGTGGCCAAGTCCAAG
GCGGTCTGGTGCGCGAAAGACCGGGTCAAGGCGTGGGACGATGCCATGCGTCCCGGCACCGTGCCCACTGGCGCGGCGAA
CTGCGACAACCCGATTGCGAAAATCATCGACTTCGCGAAGCGGCACCGTATCACCGGCACCCCGACGACAATACTCGCGG
ATGGGCGCCGATTGGTCGGCGCCGTCCCTCGCGCCGAGCTGGAAGCGCAGCTGCAGAAAGCGGCAAAACGATGA

Upstream 100 bases:

>100_bases
GGGCTTCACCGACTACCCGGGGCTGTTTCCCTACCACTGCCACATGCTGGAGCACGAGGACTCCGGCTTGATGCGCAACT
ACCTCGTCAAGGAGTAGACG

Downstream 100 bases:

>100_bases
CCTCACGATCATTGCGCTGCACCTCGGCTCGCGTCGCACGCTGCCTTCCTGGACTGCTGCTTGCCGCGTCTGCTGCGGCC
TATGCCCAATCCGATGCATC

Product: thiol:disulfide interchange protein DsbC

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MMERLLMVIAAATVATVARSDDAAVRATLQRTFPQSPIQSPSKTPVPGVLEAAIEGQIIYITEDGQYVLGGPLLDVKASR
NLTEVRLEQINAIPFDSLPLDWAFKRVKGTGARRIAIFEDPDCPYCKMLEQTLEGMDNLTVYVFLYPIDQIHPDAVAKSK
AVWCAKDRVKAWDDAMRPGTVPTGAANCDNPIAKIIDFAKRHRITGTPTTILADGRRLVGAVPRAELEAQLQKAAKR

Sequences:

>Translated_237_residues
MMERLLMVIAAATVATVARSDDAAVRATLQRTFPQSPIQSPSKTPVPGVLEAAIEGQIIYITEDGQYVLGGPLLDVKASR
NLTEVRLEQINAIPFDSLPLDWAFKRVKGTGARRIAIFEDPDCPYCKMLEQTLEGMDNLTVYVFLYPIDQIHPDAVAKSK
AVWCAKDRVKAWDDAMRPGTVPTGAANCDNPIAKIIDFAKRHRITGTPTTILADGRRLVGAVPRAELEAQLQKAAKR
>Mature_237_residues
MMERLLMVIAAATVATVARSDDAAVRATLQRTFPQSPIQSPSKTPVPGVLEAAIEGQIIYITEDGQYVLGGPLLDVKASR
NLTEVRLEQINAIPFDSLPLDWAFKRVKGTGARRIAIFEDPDCPYCKMLEQTLEGMDNLTVYVFLYPIDQIHPDAVAKSK
AVWCAKDRVKAWDDAMRPGTVPTGAANCDNPIAKIIDFAKRHRITGTPTTILADGRRLVGAVPRAELEAQLQKAAKR

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=241, Percent_Identity=29.045643153527, Blast_Score=104, Evalue=5e-24,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 25981; Mature: 25981

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMERLLMVIAAATVATVARSDDAAVRATLQRTFPQSPIQSPSKTPVPGVLEAAIEGQIIY
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCEEEE
ITEDGQYVLGGPLLDVKASRNLTEVRLEQINAIPFDSLPLDWAFKRVKGTGARRIAIFED
EECCCCEEECCCEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEEEC
PDCPYCKMLEQTLEGMDNLTVYVFLYPIDQIHPDAVAKSKAVWCAKDRVKAWDDAMRPGT
CCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHCCCEEEHHHHHHHHHHHCCCCC
VPTGAANCDNPIAKIIDFAKRHRITGTPTTILADGRRLVGAVPRAELEAQLQKAAKR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMERLLMVIAAATVATVARSDDAAVRATLQRTFPQSPIQSPSKTPVPGVLEAAIEGQIIY
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCEEEE
ITEDGQYVLGGPLLDVKASRNLTEVRLEQINAIPFDSLPLDWAFKRVKGTGARRIAIFED
EECCCCEEECCCEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEEEC
PDCPYCKMLEQTLEGMDNLTVYVFLYPIDQIHPDAVAKSKAVWCAKDRVKAWDDAMRPGT
CCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHCCCEEEHHHHHHHHHHHCCCCC
VPTGAANCDNPIAKIIDFAKRHRITGTPTTILADGRRLVGAVPRAELEAQLQKAAKR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]