BacMap

Definition	Polaromonas sp. JS666 chromosome, complete genome.
Accession	NC_007948
Length	5,200,264

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The map label for this gene is kduD [H]

Identifier: 91789198

GI number: 91789198

Start: 3538900

End: 3539619

Strand: Reverse

Name: kduD [H]

Synonym: Bpro_3342

Alternate gene names: 91789198

Gene position: 3539619-3538900 (Counterclockwise)

Preceding gene: 91789199

Following gene: 91789197

Centisome position: 68.07

GC content: 70.0

Gene sequence:

>720_bases
ATGACTTATCAGGCAGAACTCTTCAAAGGCAAGCGGGCGCTGGTCGCCGGTGCAACACAGGGCATAGGCGCCGTGATTGC
CAACCACCTCGCAGCGCTGGGCGCCGAGGTCACGGCTCTCGGGCTGGGGCCGGGCGACGGCACGCTGGACGCGGCGGTCG
CCGTGCGGCAGGCCGATGTGACGTCGGCGCAGAGCCTGGACGCGGCGCTGGCCGGCATGGACCAGCTCGACATCGTCTTC
AACTGCGCAGGCATCATCAAGCGCGGCGCCGAGCACGACCTGGACGTGTTCGAGCAGGTGCTGGCCGTGAACCTGACCGG
CACCATGCGGGTCTGCACCGCGACGCGCGAGCGGCTCAAAGCCAGTCGCGGCTGCATCGTCAACACCGCCTCCATGCTGA
GCTTTTTTGGCGGCGGCCTCGTGCCGGGCTATGCGGCCAGCAAGGGCGGAGTGGCGCAGCTCACCAAGTCGCTGGCCATT
GCCTATGCTGCAGACGGCATCCGTGTCAACGCCATCGCGCCCGGCTGGATTGCCACACCGCTCACGCAGGCGCTGCAGGA
CGACCCGGCACGCGCCGGCCCGATCCTGGCGCGCACGCCGCTGGGCCGCTGGGGCACGCCGGCCGATGTGGCCCAGGCCG
CCATGTTCCTGTGCACGCCGGCGGCGGCGTTCATGACCGGCGTGATCCTGCCGGTCGACGGGGGCTACCTGGTGTCCTGA

Upstream 100 bases:

>100_bases
GCAGGAAGGGTGCGTGCAGCTATTATTTTGATAGCGTAACGGTGGCTGTCCTGCGCTGGCGAGGCCGCTTTTACACCTAT
TCGACAACCCAGGAATCCTC

Downstream 100 bases:

>100_bases
TGAATTGCGGGCCGGGCCAGCAGGGATAATCCTTTTTTGCTCATCAGCCCTCACCGCACATCGCCCTGCCCATGCCCGCT
TCCCGACCACCTTCCGCTGT

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTYQAELFKGKRALVAGATQGIGAVIANHLAALGAEVTALGLGPGDGTLDAAVAVRQADVTSAQSLDAALAGMDQLDIVF
NCAGIIKRGAEHDLDVFEQVLAVNLTGTMRVCTATRERLKASRGCIVNTASMLSFFGGGLVPGYAASKGGVAQLTKSLAI
AYAADGIRVNAIAPGWIATPLTQALQDDPARAGPILARTPLGRWGTPADVAQAAMFLCTPAAAFMTGVILPVDGGYLVS

Sequences:

>Translated_239_residues
MTYQAELFKGKRALVAGATQGIGAVIANHLAALGAEVTALGLGPGDGTLDAAVAVRQADVTSAQSLDAALAGMDQLDIVF
NCAGIIKRGAEHDLDVFEQVLAVNLTGTMRVCTATRERLKASRGCIVNTASMLSFFGGGLVPGYAASKGGVAQLTKSLAI
AYAADGIRVNAIAPGWIATPLTQALQDDPARAGPILARTPLGRWGTPADVAQAAMFLCTPAAAFMTGVILPVDGGYLVS
>Mature_238_residues
TYQAELFKGKRALVAGATQGIGAVIANHLAALGAEVTALGLGPGDGTLDAAVAVRQADVTSAQSLDAALAGMDQLDIVFN
CAGIIKRGAEHDLDVFEQVLAVNLTGTMRVCTATRERLKASRGCIVNTASMLSFFGGGLVPGYAASKGGVAQLTKSLAIA
YAADGIRVNAIAPGWIATPLTQALQDDPARAGPILARTPLGRWGTPADVAQAAMFLCTPAAAFMTGVILPVDGGYLVS

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=35.0194552529183, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=31.9672131147541, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=33.596837944664, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI59889578, Length=170, Percent_Identity=40.5882352941176, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI40254992, Length=217, Percent_Identity=33.6405529953917, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=30.7392996108949, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI66933014, Length=195, Percent_Identity=28.7179487179487, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=26.6932270916335, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=31.1023622047244, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=30.327868852459, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI5031737, Length=237, Percent_Identity=25.3164556962025, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=35.6862745098039, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=34.9593495934959, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=38.1147540983607, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=31.5573770491803, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=33.59375, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI2367175, Length=193, Percent_Identity=33.6787564766839, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=33.0645161290323, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786812, Length=241, Percent_Identity=30.2904564315353, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=29.9610894941634, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=248, Percent_Identity=31.0483870967742, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=32.5301204819277, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=244, Percent_Identity=31.5573770491803, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=31.3253012048193, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=259, Percent_Identity=29.7297297297297, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=32.1428571428571, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=27.027027027027, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=28.2442748091603, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=260, Percent_Identity=27.3076923076923, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=28.3524904214559, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=28.5171102661597, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=27.6859504132231, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=26.9961977186312, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=27.7992277992278, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=29.6875, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=27.5193798449612, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=27.3764258555133, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=267, Percent_Identity=26.5917602996255, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=27.4131274131274, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=28.3524904214559, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=30.5555555555556, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=26.5384615384615, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=27.2373540856031, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=27.9693486590038, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=270, Percent_Identity=27.4074074074074, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=30.8880308880309, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=149, Percent_Identity=32.2147651006711, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=245, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=25.4752851711027, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=28.740157480315, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=32.6612903225806, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=35.5102040816327, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=34.5381526104418, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=33.8912133891213, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=33.6, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=32.8063241106719, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24644337, Length=170, Percent_Identity=35.8823529411765, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=30.3149606299213, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 24281; Mature: 24150

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQAELFKGKRALVAGATQGIGAVIANHLAALGAEVTALGLGPGDGTLDAAVAVRQADV
CCCCHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH
TSAQSLDAALAGMDQLDIVFNCAGIIKRGAEHDLDVFEQVLAVNLTGTMRVCTATRERLK
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
ASRGCIVNTASMLSFFGGGLVPGYAASKGGVAQLTKSLAIAYAADGIRVNAIAPGWIATP
HHCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEECCCEEEEEECCCHHHHH
LTQALQDDPARAGPILARTPLGRWGTPADVAQAAMFLCTPAAAFMTGVILPVDGGYLVS
HHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEECC
>Mature Secondary Structure 
TYQAELFKGKRALVAGATQGIGAVIANHLAALGAEVTALGLGPGDGTLDAAVAVRQADV
CCCHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH
TSAQSLDAALAGMDQLDIVFNCAGIIKRGAEHDLDVFEQVLAVNLTGTMRVCTATRERLK
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
ASRGCIVNTASMLSFFGGGLVPGYAASKGGVAQLTKSLAIAYAADGIRVNAIAPGWIATP
HHCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEECCCEEEEEECCCHHHHH
LTQALQDDPARAGPILARTPLGRWGTPADVAQAAMFLCTPAAAFMTGVILPVDGGYLVS
HHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]