Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 91788551

GI number: 91788551

Start: 2830745

End: 2831932

Strand: Reverse

Name: dxr [H]

Synonym: Bpro_2689

Alternate gene names: 91788551

Gene position: 2831932-2830745 (Counterclockwise)

Preceding gene: 91788552

Following gene: 91788550

Centisome position: 54.46

GC content: 62.12

Gene sequence:

>1188_bases
ATGTCTTTCAAAAAACAGCGTATCACCGTTCTGGGTTCAACCGGCTCCATTGGCGTCAACACACTTGACGTGATTGCCAG
CCATCCGGAGCGCTTTGAGGTGTTTGCGCTCAGTGCGGCAACCCAGGTCGACCTGATGCTGGCGCAGTGCATGCAGTTCA
GGCCGCAATATGCCGTGATGGTGAGCGAGCCGCATGCCCGCCTGCTGGCTGAAAAGGTCAAGGAAAATCAGCTTCCTGTC
CAGGTTTTATGGGTGCCTGATGCTCTCGAAATGATAGCGTCTCATGAGCTGGTGGACACCGTGATGGCCGCCATTGTGGG
TGCGGCTGGCCTGGCGCCCTGTATGGCCGCCGCCAGGGCGGGCAAACGCCTGTTGCTGGCCAACAAGGAAGCGCTCGTGG
TCGGCGGAGAGGTCTTCATGCAGGCGGTTCGTGCGGGCGGCGCGCAGCTGCTGCCCATCGACAGCGAGCATTCGGCCATT
TTCCAGTCCCTGCCGGAGGATCCGGCCAGCTGGCCGCAGCGTGTCGAGAAAATCATCCTGACAGCGTCCGGCGGGCCTTT
CCGGACCCGGGAGCCGGGCAGCCTGCGGCATGTGACGCCCGATGAAGCGTGCGCGCACCCGAACTGGGTGATGGGGCGCA
AGATATCGGTTGATTCCGCCACCATGATGAACAAGGCCCTGGAGGTCATCGAGGCCAAGTACCTGTTCGGCCTGACGCCG
CAGCAGATCGAGGTGGTGATCCATCCGCAGAGCATCATTCACTCCATGGTGCAGTACCGCGATACGTCGGTCGTGGCGCA
ACTGGGGACGCCCGACATGCGCGTGCCCATCGCCTATGGCCTGGCCTGGCCGGACCGCATTACCTCGGGGGCCCGGGCGC
TGGATTTCACCGCGTTGGCGACCATGACTTTTGAGGTGCCCGATCATGAGCGGTTTCCTGGACTGCCGCTGGCCTGGGAG
GTCCTCAATGCACCGGTGGGCAGCACGGCGGTGCTCAATGCGGCCAACGAGGCGGCGGTGGCCGCATTTCTGGACCGGCG
CATCCGCTTTGACCACATCCACCATGTAAATCATGCAACTTTGGATGCCATGGCGGTCTCAGATGTGAACGATATCGAGG
GATTGCTGGCACTGGACGCGCGGGCGCGCCTTGTTGCCGGTCAAATCATTGAACGTCTGGAGCCATGA

Upstream 100 bases:

>100_bases
CGCCTTGCTGCCGGGCCACGGCGGGGTGCTTGACCGTGTCGATGCGCTGTTGCCGACCTTGCCGCTGGCCATGATGCTGG
CCACTCTTTAGGCTTGTTGA

Downstream 100 bases:

>100_bases
CATGTTGACGCTGCTTGCCTTTGTGGTCGCTCTCGGCATCCTGATTGCCGTGCACGAATACGGTCATTACCGGGTGGCCG
TCGCCTGCGGCATCAAGGTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSFKKQRITVLGSTGSIGVNTLDVIASHPERFEVFALSAATQVDLMLAQCMQFRPQYAVMVSEPHARLLAEKVKENQLPV
QVLWVPDALEMIASHELVDTVMAAIVGAAGLAPCMAAARAGKRLLLANKEALVVGGEVFMQAVRAGGAQLLPIDSEHSAI
FQSLPEDPASWPQRVEKIILTASGGPFRTREPGSLRHVTPDEACAHPNWVMGRKISVDSATMMNKALEVIEAKYLFGLTP
QQIEVVIHPQSIIHSMVQYRDTSVVAQLGTPDMRVPIAYGLAWPDRITSGARALDFTALATMTFEVPDHERFPGLPLAWE
VLNAPVGSTAVLNAANEAAVAAFLDRRIRFDHIHHVNHATLDAMAVSDVNDIEGLLALDARARLVAGQIIERLEP

Sequences:

>Translated_395_residues
MSFKKQRITVLGSTGSIGVNTLDVIASHPERFEVFALSAATQVDLMLAQCMQFRPQYAVMVSEPHARLLAEKVKENQLPV
QVLWVPDALEMIASHELVDTVMAAIVGAAGLAPCMAAARAGKRLLLANKEALVVGGEVFMQAVRAGGAQLLPIDSEHSAI
FQSLPEDPASWPQRVEKIILTASGGPFRTREPGSLRHVTPDEACAHPNWVMGRKISVDSATMMNKALEVIEAKYLFGLTP
QQIEVVIHPQSIIHSMVQYRDTSVVAQLGTPDMRVPIAYGLAWPDRITSGARALDFTALATMTFEVPDHERFPGLPLAWE
VLNAPVGSTAVLNAANEAAVAAFLDRRIRFDHIHHVNHATLDAMAVSDVNDIEGLLALDARARLVAGQIIERLEP
>Mature_394_residues
SFKKQRITVLGSTGSIGVNTLDVIASHPERFEVFALSAATQVDLMLAQCMQFRPQYAVMVSEPHARLLAEKVKENQLPVQ
VLWVPDALEMIASHELVDTVMAAIVGAAGLAPCMAAARAGKRLLLANKEALVVGGEVFMQAVRAGGAQLLPIDSEHSAIF
QSLPEDPASWPQRVEKIILTASGGPFRTREPGSLRHVTPDEACAHPNWVMGRKISVDSATMMNKALEVIEAKYLFGLTPQ
QIEVVIHPQSIIHSMVQYRDTSVVAQLGTPDMRVPIAYGLAWPDRITSGARALDFTALATMTFEVPDHERFPGLPLAWEV
LNAPVGSTAVLNAANEAAVAAFLDRRIRFDHIHHVNHATLDAMAVSDVNDIEGLLALDARARLVAGQIIERLEP

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=52.6582278481013, Blast_Score=384, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42868; Mature: 42737

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKKQRITVLGSTGSIGVNTLDVIASHPERFEVFALSAATQVDLMLAQCMQFRPQYAVM
CCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEE
VSEPHARLLAEKVKENQLPVQVLWVPDALEMIASHELVDTVMAAIVGAAGLAPCMAAARA
ECCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKRLLLANKEALVVGGEVFMQAVRAGGAQLLPIDSEHSAIFQSLPEDPASWPQRVEKIIL
CCEEEEECCCEEEECHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCHHHHHHHHEEE
TASGGPFRTREPGSLRHVTPDEACAHPNWVMGRKISVDSATMMNKALEVIEAKYLFGLTP
EECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCC
QQIEVVIHPQSIIHSMVQYRDTSVVAQLGTPDMRVPIAYGLAWPDRITSGARALDFTALA
CCEEEEECCHHHHHHHHHHCCCHHEEECCCCCCEEEEEECCCCHHHHCCCCHHHEEEEEE
TMTFEVPDHERFPGLPLAWEVLNAPVGSTAVLNAANEAAVAAFLDRRIRFDHIHHVNHAT
EEEEECCCCCCCCCCCHHHHHHCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHCCCCHH
LDAMAVSDVNDIEGLLALDARARLVAGQIIERLEP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFKKQRITVLGSTGSIGVNTLDVIASHPERFEVFALSAATQVDLMLAQCMQFRPQYAVM
CCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEE
VSEPHARLLAEKVKENQLPVQVLWVPDALEMIASHELVDTVMAAIVGAAGLAPCMAAARA
ECCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKRLLLANKEALVVGGEVFMQAVRAGGAQLLPIDSEHSAIFQSLPEDPASWPQRVEKIIL
CCEEEEECCCEEEECHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCHHHHHHHHEEE
TASGGPFRTREPGSLRHVTPDEACAHPNWVMGRKISVDSATMMNKALEVIEAKYLFGLTP
EECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCC
QQIEVVIHPQSIIHSMVQYRDTSVVAQLGTPDMRVPIAYGLAWPDRITSGARALDFTALA
CCEEEEECCHHHHHHHHHHCCCHHEEECCCCCCEEEEEECCCCHHHHCCCCHHHEEEEEE
TMTFEVPDHERFPGLPLAWEVLNAPVGSTAVLNAANEAAVAAFLDRRIRFDHIHHVNHAT
EEEEECCCCCCCCCCCHHHHHHCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHCCCCHH
LDAMAVSDVNDIEGLLALDARARLVAGQIIERLEP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA