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The map label for this gene is ppx [H]

Identifier: 91788120

GI number: 91788120

Start: 2335539

End: 2337038

Strand: Reverse

Name: ppx [H]

Synonym: Bpro_2249

Alternate gene names: 91788120

Gene position: 2337038-2335539 (Counterclockwise)

Preceding gene: 91788121

Following gene: 91788119

Centisome position: 44.94

GC content: 62.2

Gene sequence:

>1500_bases
ATGCAAAACGGAACACTGCTCGCGGCTGTAGATCTGGGATCCAACAGTTTTCGCCTTGAAATTGGCCGCCTTGATCATGG
CCGGGTCCACCGCACGGAATACATCAAGGAAACGGTCCGCCAGGGCAACGGACTGGACGGCGACCGCAACCTGACGCCGG
ACGCCATGCAGCGCGGCTGGGACTGCCTGGCCCGCTTCGCCGAACGGCTGGCCGGGTTCAAAAAAACGCAGGTCAGGGCC
GTCGCCACGCAAACCTTGCGGGAGGCACGCAACCGGGAAGAATTTCTGGCGCAGGCCTTCCGGATTCTGGAATTCCCCAT
TGATGTCATTTCAGGCAGCGAAGAAGCCCGACTGATTTACCAGGGTGTGGCCCATCTGCTGCCCCAGTCGGATGAGCGCC
GGCTGGTTGTGGACATTGGGGGCCGCTCCACAGAAATGATCCTGGGCAAGGGCTTCGATGCACGCACGATGGAGTCCTAC
CGCGTCGGCAGCGTGGCTTGGTCCATGAAGTACTTTCCGGACGGCCAGTTCACGCCGCGGGCTTTCGAGATGGCTGAAAT
TGCGGCCAAAGCGGTGCTTGATGAAGCGGTCAATGCCTACCAGCCGGGCGTCTGGGATGTCGCCTATGGTTCGTCCGGCA
CGATTGGCGCCGTCAGCGATGTACTGACTGCCGCGGGCTGGCCTGCCGGCCTTGTCACGCGTGATGGCCTCGACTGGCTG
CTCGATCGCCTGCTCAAGGCGCAACATGCCGACCGCGTGAAGCTCGACGGCATGAAAGATGACCGGCGCGCCGTCATTGG
CGGTGGCGTCAGCGTGCTGAGGGCTGTGTTCGGGCTGCTGGGCATTGAACAGATGGAAGCCGCCCAGGGCGCGCTGCGCC
ACGGCGTTCTTTATGACCTCCTCGACCGGGAGCAGGACTCCACCGATTTGCGCTCAACCAGCGTCCAGCGCCTGGCGAGC
AAATTCAACTCAGATGCAGCACAGGCCCAGCGGGTCAGCAGAGTTTCGCAGCACCTGTTCCGGATGGCTGGCGCAGGCCT
CCCAGGCGAGGCACTGGAGCGTTTCCAGCGCAAGCTGCAGTGGGCTGCGCAGCTTCATGAGATTGGCAGCCAGATTTCAC
ACAGCGACTACCACAAGCATGGCGCCTATATTCTGGACAACGCCGACGCGCCCGGTTTTGCGCTCCCCGAGCTGCACCGG
CTGAGCCTGCTCGTGCTGGGTCATCGCGGGAAACTGCGCAAGCTGGAAGTTGACTTCGAAGACCGGGTGTTTGTCCAGCA
ACTGCTGTGCCTGCGCATGGCGGTCATTTTGTGCCACGCCCGGCGAGACCCTGACCTCAAGGGACTGCAACTCGAATGCA
GCGCGGAACCCGGCAGGATTTTTGTGCTGAACTGCAGGCCGGGCTGGGCTGAAGCCTTTCCTCAATCGGCGCACTTGCTG
CGCGAAGAAGTGCTGGCCTGGCAAAAAACGCCATGGACCCTGATTGTCTCCGGTCTGTAG

Upstream 100 bases:

>100_bases
ACGATAGATGGCCGGCTGATTGGCTAAGCAGCAGGAATGCCGGGGTGAGTGCCGATGCCCGCGTGAATGCTATGCTGGGC
CCGGACAAAGAAACTCAGAC

Downstream 100 bases:

>100_bases
ACAGCAGGAACCCTGTGGCAGCCAGGAGGCTTGACGGTTCATTTTCAAACGATATAAACTATATATACGGTTTATATCGT
TTATTGAAAAGGACATTCTC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MQNGTLLAAVDLGSNSFRLEIGRLDHGRVHRTEYIKETVRQGNGLDGDRNLTPDAMQRGWDCLARFAERLAGFKKTQVRA
VATQTLREARNREEFLAQAFRILEFPIDVISGSEEARLIYQGVAHLLPQSDERRLVVDIGGRSTEMILGKGFDARTMESY
RVGSVAWSMKYFPDGQFTPRAFEMAEIAAKAVLDEAVNAYQPGVWDVAYGSSGTIGAVSDVLTAAGWPAGLVTRDGLDWL
LDRLLKAQHADRVKLDGMKDDRRAVIGGGVSVLRAVFGLLGIEQMEAAQGALRHGVLYDLLDREQDSTDLRSTSVQRLAS
KFNSDAAQAQRVSRVSQHLFRMAGAGLPGEALERFQRKLQWAAQLHEIGSQISHSDYHKHGAYILDNADAPGFALPELHR
LSLLVLGHRGKLRKLEVDFEDRVFVQQLLCLRMAVILCHARRDPDLKGLQLECSAEPGRIFVLNCRPGWAEAFPQSAHLL
REEVLAWQKTPWTLIVSGL

Sequences:

>Translated_499_residues
MQNGTLLAAVDLGSNSFRLEIGRLDHGRVHRTEYIKETVRQGNGLDGDRNLTPDAMQRGWDCLARFAERLAGFKKTQVRA
VATQTLREARNREEFLAQAFRILEFPIDVISGSEEARLIYQGVAHLLPQSDERRLVVDIGGRSTEMILGKGFDARTMESY
RVGSVAWSMKYFPDGQFTPRAFEMAEIAAKAVLDEAVNAYQPGVWDVAYGSSGTIGAVSDVLTAAGWPAGLVTRDGLDWL
LDRLLKAQHADRVKLDGMKDDRRAVIGGGVSVLRAVFGLLGIEQMEAAQGALRHGVLYDLLDREQDSTDLRSTSVQRLAS
KFNSDAAQAQRVSRVSQHLFRMAGAGLPGEALERFQRKLQWAAQLHEIGSQISHSDYHKHGAYILDNADAPGFALPELHR
LSLLVLGHRGKLRKLEVDFEDRVFVQQLLCLRMAVILCHARRDPDLKGLQLECSAEPGRIFVLNCRPGWAEAFPQSAHLL
REEVLAWQKTPWTLIVSGL
>Mature_499_residues
MQNGTLLAAVDLGSNSFRLEIGRLDHGRVHRTEYIKETVRQGNGLDGDRNLTPDAMQRGWDCLARFAERLAGFKKTQVRA
VATQTLREARNREEFLAQAFRILEFPIDVISGSEEARLIYQGVAHLLPQSDERRLVVDIGGRSTEMILGKGFDARTMESY
RVGSVAWSMKYFPDGQFTPRAFEMAEIAAKAVLDEAVNAYQPGVWDVAYGSSGTIGAVSDVLTAAGWPAGLVTRDGLDWL
LDRLLKAQHADRVKLDGMKDDRRAVIGGGVSVLRAVFGLLGIEQMEAAQGALRHGVLYDLLDREQDSTDLRSTSVQRLAS
KFNSDAAQAQRVSRVSQHLFRMAGAGLPGEALERFQRKLQWAAQLHEIGSQISHSDYHKHGAYILDNADAPGFALPELHR
LSLLVLGHRGKLRKLEVDFEDRVFVQQLLCLRMAVILCHARRDPDLKGLQLECSAEPGRIFVLNCRPGWAEAFPQSAHLL
REEVLAWQKTPWTLIVSGL

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=440, Percent_Identity=37.5, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI48994966, Length=499, Percent_Identity=36.0721442885772, Blast_Score=272, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55498; Mature: 55498

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNGTLLAAVDLGSNSFRLEIGRLDHGRVHRTEYIKETVRQGNGLDGDRNLTPDAMQRGW
CCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
DCLARFAERLAGFKKTQVRAVATQTLREARNREEFLAQAFRILEFPIDVISGSEEARLIY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QGVAHLLPQSDERRLVVDIGGRSTEMILGKGFDARTMESYRVGSVAWSMKYFPDGQFTPR
HHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCH
AFEMAEIAAKAVLDEAVNAYQPGVWDVAYGSSGTIGAVSDVLTAAGWPAGLVTRDGLDWL
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHH
LDRLLKAQHADRVKLDGMKDDRRAVIGGGVSVLRAVFGLLGIEQMEAAQGALRHGVLYDL
HHHHHHHHCCCCEEECCCCCCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
LDREQDSTDLRSTSVQRLASKFNSDAAQAQRVSRVSQHLFRMAGAGLPGEALERFQRKLQ
HCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
WAAQLHEIGSQISHSDYHKHGAYILDNADAPGFALPELHRLSLLVLGHRGKLRKLEVDFE
HHHHHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCHHHHHEEEEECCCCCCEEEECCHH
DRVFVQQLLCLRMAVILCHARRDPDLKGLQLECSAEPGRIFVLNCRPGWAEAFPQSAHLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHCCHHHHHH
REEVLAWQKTPWTLIVSGL
HHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MQNGTLLAAVDLGSNSFRLEIGRLDHGRVHRTEYIKETVRQGNGLDGDRNLTPDAMQRGW
CCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
DCLARFAERLAGFKKTQVRAVATQTLREARNREEFLAQAFRILEFPIDVISGSEEARLIY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QGVAHLLPQSDERRLVVDIGGRSTEMILGKGFDARTMESYRVGSVAWSMKYFPDGQFTPR
HHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCH
AFEMAEIAAKAVLDEAVNAYQPGVWDVAYGSSGTIGAVSDVLTAAGWPAGLVTRDGLDWL
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHH
LDRLLKAQHADRVKLDGMKDDRRAVIGGGVSVLRAVFGLLGIEQMEAAQGALRHGVLYDL
HHHHHHHHCCCCEEECCCCCCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
LDREQDSTDLRSTSVQRLASKFNSDAAQAQRVSRVSQHLFRMAGAGLPGEALERFQRKLQ
HCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
WAAQLHEIGSQISHSDYHKHGAYILDNADAPGFALPELHRLSLLVLGHRGKLRKLEVDFE
HHHHHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCHHHHHEEEEECCCCCCEEEECCHH
DRVFVQQLLCLRMAVILCHARRDPDLKGLQLECSAEPGRIFVLNCRPGWAEAFPQSAHLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHCCHHHHHH
REEVLAWQKTPWTLIVSGL
HHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]