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The map label for this gene is upp [H]

Identifier: 91787839

GI number: 91787839

Start: 2029912

End: 2030553

Strand: Reverse

Name: upp [H]

Synonym: Bpro_1963

Alternate gene names: 91787839

Gene position: 2030553-2029912 (Counterclockwise)

Preceding gene: 91787840

Following gene: 91787838

Centisome position: 39.05

GC content: 62.31

Gene sequence:

>642_bases
ATGACCACTCGCAACGACAAAGTCCACGTCATTGACCATCCGCTCGTGCAGCACAAGCTCACGCTGATGCGGCGCAAGGA
CGCCTCCACCAACACCTTTCGCACGCTGCTCAACGAGTTGAGCATGCTGATGGCCTACGAGGTCACGCGCGACATGCCGA
TGCAGGAGATCGAAATCGAAACGCCGCTGGAAACAACGACGTCCCGGGTGATCGATGGCAAAAAGCTGGTCTTCGTCTCC
ATCCTGCGTGCCGGCAACGGCATCCTGGAAGGCATGCTCAGCGTGGTGCCAGGCGCGCGCGTCGGCCACGTGGGCCTGTA
CCGCGACCCCAAAACGCTGACCGCGGTCGAGTACTACTTCAAGATGCCGCACGACATGCAGGAACGCGACGTCGTCATCG
TCGATCCGATGCTGGCCACCGGCAATTCCGCCATTGCGGCCGTCGACCGGCTCAAGGAACTCAACCCGAAGTCCATCAAG
TTCGTCTGCCTGCTGACCTGCCCGGAAGGCATTGCCGCCCTGCAAAAAGCCCACCCCGACGTGGCCATCTACACCGCGGC
CATCGACCGCCAGCTCAACGACCACGGCTACATCCTGCCCGGTCTGGGTGACGCGGGCGACCGGATCTTCGGCACCAAGT
AG

Upstream 100 bases:

>100_bases
GGCACTGGCACAGCAACTGCACGGCGGCAAGCCGCCCCTGAACATCCAGAGCGACGGCACCGTTTTTTGAACACCGCTTT
TGAATAAAGCACATCGCAAC

Downstream 100 bases:

>100_bases
CCGTCAGGCAATCGCTAGCAATCGCCAGGCAACCGGTAGGCAGCCGCTACACTCCCCGCATGTTTTTACCTACGTATGCA
CGGCGCGCCGCCGGCGCCGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTTRNDKVHVIDHPLVQHKLTLMRRKDASTNTFRTLLNELSMLMAYEVTRDMPMQEIEIETPLETTTSRVIDGKKLVFVS
ILRAGNGILEGMLSVVPGARVGHVGLYRDPKTLTAVEYYFKMPHDMQERDVVIVDPMLATGNSAIAAVDRLKELNPKSIK
FVCLLTCPEGIAALQKAHPDVAIYTAAIDRQLNDHGYILPGLGDAGDRIFGTK

Sequences:

>Translated_213_residues
MTTRNDKVHVIDHPLVQHKLTLMRRKDASTNTFRTLLNELSMLMAYEVTRDMPMQEIEIETPLETTTSRVIDGKKLVFVS
ILRAGNGILEGMLSVVPGARVGHVGLYRDPKTLTAVEYYFKMPHDMQERDVVIVDPMLATGNSAIAAVDRLKELNPKSIK
FVCLLTCPEGIAALQKAHPDVAIYTAAIDRQLNDHGYILPGLGDAGDRIFGTK
>Mature_212_residues
TTRNDKVHVIDHPLVQHKLTLMRRKDASTNTFRTLLNELSMLMAYEVTRDMPMQEIEIETPLETTTSRVIDGKKLVFVSI
LRAGNGILEGMLSVVPGARVGHVGLYRDPKTLTAVEYYFKMPHDMQERDVVIVDPMLATGNSAIAAVDRLKELNPKSIKF
VCLLTCPEGIAALQKAHPDVAIYTAAIDRQLNDHGYILPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=29.7029702970297, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=29.7029702970297, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI21450816, Length=194, Percent_Identity=28.8659793814433, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=52.6570048309179, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=26.3681592039801, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=26.3681592039801, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=35.4166666666667, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=29.6116504854369, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=29.6116504854369, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=29.6116504854369, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=29.6116504854369, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358379, Length=199, Percent_Identity=26.6331658291457, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23670; Mature: 23539

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRNDKVHVIDHPLVQHKLTLMRRKDASTNTFRTLLNELSMLMAYEVTRDMPMQEIEIE
CCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEC
TPLETTTSRVIDGKKLVFVSILRAGNGILEGMLSVVPGARVGHVGLYRDPKTLTAVEYYF
CCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHH
KMPHDMQERDVVIVDPMLATGNSAIAAVDRLKELNPKSIKFVCLLTCPEGIAALQKAHPD
CCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCC
VAIYTAAIDRQLNDHGYILPGLGDAGDRIFGTK
EEEEEEEHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TTRNDKVHVIDHPLVQHKLTLMRRKDASTNTFRTLLNELSMLMAYEVTRDMPMQEIEIE
CCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEC
TPLETTTSRVIDGKKLVFVSILRAGNGILEGMLSVVPGARVGHVGLYRDPKTLTAVEYYF
CCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHH
KMPHDMQERDVVIVDPMLATGNSAIAAVDRLKELNPKSIKFVCLLTCPEGIAALQKAHPD
CCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCC
VAIYTAAIDRQLNDHGYILPGLGDAGDRIFGTK
EEEEEEEHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA