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The map label for this gene is folC [H]

Identifier: 91787488

GI number: 91787488

Start: 1655275

End: 1656780

Strand: Direct

Name: folC [H]

Synonym: Bpro_1604

Alternate gene names: 91787488

Gene position: 1655275-1656780 (Clockwise)

Preceding gene: 91787487

Following gene: 91787489

Centisome position: 31.83

GC content: 66.0

Gene sequence:

>1506_bases
ATGGCTTGCGCGACAATGCGGGCCTGTATGGAACAACTCAAGACACTGCAAGACTGGCTGGCCCACTGCGAGCGCCTGCA
CCCCAAAAGCATCGACATGGGGCTGGAGCGGGTGCAGGCCGTGGCCAGGCGCATGGGGCTGGCGTTTGCCTGCCCCGTCA
TCACGGTCGCCGGAACCAATGGCAAGGGCTCGACCTGCGCGATGCTCGAAGCCATCCTGCTCGAGGCGGGCTACCGCACC
GGCGTTTACACCTCGCCGCACCTGGTGCATTTTGAAGAACGCTGCAGGGTCCGCGGCGACATCGTCAATGCGACTGATTT
GGTCGCAAACTTTGCCCGTGTTGAAGCGGCCAGGGTCCAGAACGGCGATGAAATCTCGCTGACCTACTTTGAATTCACCA
CGCTGGCTATCCTGCAGCTGCTGGCCGATGCGAAGCTGGACGTTGTCATCCTGGAAGTGGGGCTGGGCGGCCGGCTGGAC
GCTGTCAACATCCTGGACACCGACTGCGCCGTGATCACCAGCATCGACCTGGACCACATGGAGTTTCTGGGCAACGACCG
CGAGAGCATAGGCCGGGAGAAAGCCGGCATCATGCGCGCCGGCAAGCCGGTGGTGGTGAGCGACCCGGTGCCGCCGCAAA
GCATTCTTGACCATGCCGCCGCACTGGGCGCTGACCTGTGGCGCTTCGGCCAGGACTTCAATTTTTCGGGCGACAAGCAG
CAATGGAGCTGGGTGGGGCGTGCGGACACCGGGCCGCCCCAAGGCAGCACAGCCCCCTCGGGGGGCAGCGCAGTACACGA
AGTGACAAGCGTGGGGGCCAAAGTGCGCCGCGCCGGGCCGCCCCAAGCAAGCACAGCCCCCTCGGGGGGCAGCGCAGCAC
ACGAAGTGGCAAGCGTGGGGGCCAAAACATACCGCAGGTATGCCGGGCTGGCTTACCCGGCACTGCGCGGCGCCAACCAG
CTGGTCAATGCCTCTGGTGTGCTGGCGGCGCTGACGGCCCTGCGCGATCGCCTGCCGGTGACGGCCCAGGCGGTGCGCAA
TGGCCTGTCCATGGTCGAGCTGCCAGGGCGTTTCCAGATCGTTCCGGGCCAGCCCACGCTGGTGCTGGACGTGGCGCACA
ACCCGCATTCGGTGGCGGCCCTGGCCGAAAACCTGGACGCCATGGGCTTTTACCCCTGCACCCATGCGGTGTTTGGCGCC
ATGGCCGACAAGGACCTGGCACCCATGCTGGCGCGGGTCGGCCCGCTGATCGATAAATGGTATTTCACTGATTTGCCCAC
GGCCCGGGCCGCGAGCGGCGAAGAGCTGGCGGCGAAATGGCAGGCGGTGGAAAGCCGGCCCGACGTGACCGCCACCACGC
ACAAAGACCCCGAACTGGCGCTGCAGGCCGCCGTGAGGGCTGCAGGGCCCGCTGATAGAATTGTGGTGTTCGGCTCGTTC
TACACGGTGGGCGGTGTTTTGAAGGGCGGGGTGCCGCGCCTCATGGCCCCGCACCTGGCTTCTTGA

Upstream 100 bases:

>100_bases
GCGTTAGCAGGGGCCGCCGGTCCGGCTTTGCCGGCCGCAGGCGCCGCCCCCTGCAAGGGGGGAGGACCCTACACGCAGTG
AGGGTCAACGGGGGTGTGCC

Downstream 100 bases:

>100_bases
TGCCGGATAAACCTGTCTGACCCGGGGCCTGTGATGCCTGGAAATGCAGACCGACAGCCCACGTTAACCGTCAACGGATT
CAAGCCACACCATGCCGTTT

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MACATMRACMEQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLAFACPVITVAGTNGKGSTCAMLEAILLEAGYRT
GVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQNGDEISLTYFEFTTLAILQLLADAKLDVVILEVGLGGRLD
AVNILDTDCAVITSIDLDHMEFLGNDRESIGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQ
QWSWVGRADTGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVGAKTYRRYAGLAYPALRGANQ
LVNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQIVPGQPTLVLDVAHNPHSVAALAENLDAMGFYPCTHAVFGA
MADKDLAPMLARVGPLIDKWYFTDLPTARAASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSF
YTVGGVLKGGVPRLMAPHLAS

Sequences:

>Translated_501_residues
MACATMRACMEQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLAFACPVITVAGTNGKGSTCAMLEAILLEAGYRT
GVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQNGDEISLTYFEFTTLAILQLLADAKLDVVILEVGLGGRLD
AVNILDTDCAVITSIDLDHMEFLGNDRESIGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQ
QWSWVGRADTGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVGAKTYRRYAGLAYPALRGANQ
LVNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQIVPGQPTLVLDVAHNPHSVAALAENLDAMGFYPCTHAVFGA
MADKDLAPMLARVGPLIDKWYFTDLPTARAASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSF
YTVGGVLKGGVPRLMAPHLAS
>Mature_500_residues
ACATMRACMEQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLAFACPVITVAGTNGKGSTCAMLEAILLEAGYRTG
VYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQNGDEISLTYFEFTTLAILQLLADAKLDVVILEVGLGGRLDA
VNILDTDCAVITSIDLDHMEFLGNDRESIGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQQ
WSWVGRADTGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVGAKTYRRYAGLAYPALRGANQL
VNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQIVPGQPTLVLDVAHNPHSVAALAENLDAMGFYPCTHAVFGAM
ADKDLAPMLARVGPLIDKWYFTDLPTARAASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSFY
TVGGVLKGGVPRLMAPHLAS

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=181, Percent_Identity=35.3591160220994, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI66932990, Length=181, Percent_Identity=35.3591160220994, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788654, Length=230, Percent_Identity=56.5217391304348, Blast_Score=248, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17553150, Length=208, Percent_Identity=36.0576923076923, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71984923, Length=208, Percent_Identity=36.0576923076923, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17553148, Length=208, Percent_Identity=36.0576923076923, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323760, Length=205, Percent_Identity=33.6585365853659, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324815, Length=236, Percent_Identity=28.3898305084746, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24641571, Length=178, Percent_Identity=37.6404494382022, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24581568, Length=155, Percent_Identity=35.4838709677419, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 53113; Mature: 52982

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACATMRACMEQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLAFACPVITVAGTN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCEEEEECCC
GKGSTCAMLEAILLEAGYRTGVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQ
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
NGDEISLTYFEFTTLAILQLLADAKLDVVILEVGLGGRLDAVNILDTDCAVITSIDLDHM
CCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCEEEEECCHHHH
EFLGNDRESIGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQ
HHHCCCHHHHCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
QWSWVGRADTGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVG
HHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AKTYRRYAGLAYPALRGANQLVNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQI
HHHHHHHHCCHHHHHHCHHHHHCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCEEE
VPGQPTLVLDVAHNPHSVAALAENLDAMGFYPCTHAVFGAMADKDLAPMLARVGPLIDKW
ECCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YFTDLPTARAASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSF
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCEEEEEECH
YTVGGVLKGGVPRLMAPHLAS
HHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure 
ACATMRACMEQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLAFACPVITVAGTN
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCEEEEECCC
GKGSTCAMLEAILLEAGYRTGVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQ
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
NGDEISLTYFEFTTLAILQLLADAKLDVVILEVGLGGRLDAVNILDTDCAVITSIDLDHM
CCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCEEEEECCHHHH
EFLGNDRESIGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQ
HHHCCCHHHHCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
QWSWVGRADTGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVG
HHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AKTYRRYAGLAYPALRGANQLVNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQI
HHHHHHHHCCHHHHHHCHHHHHCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCEEE
VPGQPTLVLDVAHNPHSVAALAENLDAMGFYPCTHAVFGAMADKDLAPMLARVGPLIDKW
ECCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YFTDLPTARAASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSF
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCEEEEEECH
YTVGGVLKGGVPRLMAPHLAS
HHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]