Click here to switch to the map view.

The map label for this gene is rtcA [H]

Identifier: 91787368

GI number: 91787368

Start: 1526171

End: 1527229

Strand: Direct

Name: rtcA [H]

Synonym: Bpro_1474

Alternate gene names: 91787368

Gene position: 1526171-1527229 (Clockwise)

Preceding gene: 91787367

Following gene: 91787373

Centisome position: 29.35

GC content: 66.76

Gene sequence:

>1059_bases
ATGATTGAACTCGATGGCTCGCAAGGCGAAGGCGGCGGGCAGATTTTGCGCACGGCGCTGGCGCTCAGCCTGGTGACGGG
CAAGCCGTTTCGCATGGACAACATCCGCGCCAAACGGCCCAAGCCTGGCCTGATGCGCCAGCATCTGGCCTGTGTGAACG
CCGCTATGGCCGTGGGCGGCGGCCCGGGCCATAGCGCTGCCGTCAACGCCGCCGGCCAGCCCGTGCAGATTGGTGAAACT
ACGCTGCTGTTCACGCCCGGTGAGGTGCGCGCGGGCGACTACGAGTTTGCGGTCGGCTCGGCAGGCAGTTGCACGCTGGT
GCTGCAAACCGTGCTGTGGCCGCTGCTGCACGCCAAGGAGGCCTCAACGCTGCTGCTCAGCGGCGGGACGCATAACCCAA
TGGCGCCGTCGATTTCGTTTCTGACCCTGCTGGCGCCTTATTTCTCCGGCAACGGCGAGGCGCTATTTGACATTGAACTG
CGCCGCCACGGCTTTTACCCGGCGGGAGGCGGAGAGGCCCGCGTGCGCTTGCGTCCACCCGCCCAGGGCTTTGCCGCCCT
CCACCTCATGGAGCGCGGCGCGCTGCTGGAGGCTTATGCCGAGTGCCTGCATGCGGGCCTGCCCCGAGGCGTGGCTGAGC
GGGAACTGGCCGTGCTGCGCAAGGGGCTTGGCTGGGACGAAGACTGCTTGCGCGACCGCGGACTGCGCAGCAACGAGGGG
CCGGGCAACGCGCTGCTGGCCGTCCTGCGCTATGAGCACATCACCGAGGTGTTTGCAGCCTATGGCGACAAAGGCATCGG
TGCCGAGCAGGTCGCCCGCCGCGTGCTGCAGGAGGTGAGGGACTACCAGACTCACCGGGCGCCGGTGGGGCCGCATCTGG
CGGACCAACTGATGATCCCCATGGCCCTGGCGAGCCTGCAGGGAAGGGTGGGACGCTACTGGGCGACGGAACTCACCGAG
CACACCCGCACCAACGCGCGGACCATTGAAACCTTTCTGCCGGTGAAGTTTTCATGCGAGCCATTGGATGGCGGTACGGT
GATTTCGCTGGAAGGCTGA

Upstream 100 bases:

>100_bases
TCAAGCAGGTAGTGTGTGTGAAGGGCTAGCGTGAGACTCTCCCGAGAGGAAGGTTGCCTTGGCTCCCGGTAAGTAAGAAC
AAAAAAAGAAAGCAAAAAAA

Downstream 100 bases:

>100_bases
TGCGCTGACCGGAGCGATTCCGGTGGCCCTATTGATTTTGTAGCTGCACAGGCCCTCATGCAAAAGCAGCTCGCCCGCGA
GGGCTTTGACCTGCAGGCCT

Product: RNA-3'-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MIELDGSQGEGGGQILRTALALSLVTGKPFRMDNIRAKRPKPGLMRQHLACVNAAMAVGGGPGHSAAVNAAGQPVQIGET
TLLFTPGEVRAGDYEFAVGSAGSCTLVLQTVLWPLLHAKEASTLLLSGGTHNPMAPSISFLTLLAPYFSGNGEALFDIEL
RRHGFYPAGGGEARVRLRPPAQGFAALHLMERGALLEAYAECLHAGLPRGVAERELAVLRKGLGWDEDCLRDRGLRSNEG
PGNALLAVLRYEHITEVFAAYGDKGIGAEQVARRVLQEVRDYQTHRAPVGPHLADQLMIPMALASLQGRVGRYWATELTE
HTRTNARTIETFLPVKFSCEPLDGGTVISLEG

Sequences:

>Translated_352_residues
MIELDGSQGEGGGQILRTALALSLVTGKPFRMDNIRAKRPKPGLMRQHLACVNAAMAVGGGPGHSAAVNAAGQPVQIGET
TLLFTPGEVRAGDYEFAVGSAGSCTLVLQTVLWPLLHAKEASTLLLSGGTHNPMAPSISFLTLLAPYFSGNGEALFDIEL
RRHGFYPAGGGEARVRLRPPAQGFAALHLMERGALLEAYAECLHAGLPRGVAERELAVLRKGLGWDEDCLRDRGLRSNEG
PGNALLAVLRYEHITEVFAAYGDKGIGAEQVARRVLQEVRDYQTHRAPVGPHLADQLMIPMALASLQGRVGRYWATELTE
HTRTNARTIETFLPVKFSCEPLDGGTVISLEG
>Mature_352_residues
MIELDGSQGEGGGQILRTALALSLVTGKPFRMDNIRAKRPKPGLMRQHLACVNAAMAVGGGPGHSAAVNAAGQPVQIGET
TLLFTPGEVRAGDYEFAVGSAGSCTLVLQTVLWPLLHAKEASTLLLSGGTHNPMAPSISFLTLLAPYFSGNGEALFDIEL
RRHGFYPAGGGEARVRLRPPAQGFAALHLMERGALLEAYAECLHAGLPRGVAERELAVLRKGLGWDEDCLRDRGLRSNEG
PGNALLAVLRYEHITEVFAAYGDKGIGAEQVARRVLQEVRDYQTHRAPVGPHLADQLMIPMALASLQGRVGRYWATELTE
HTRTNARTIETFLPVKFSCEPLDGGTVISLEG

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=351, Percent_Identity=31.6239316239316, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI195927044, Length=355, Percent_Identity=30.1408450704225, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI48994937, Length=352, Percent_Identity=46.875, Blast_Score=270, Evalue=7e-74,
Organism=Drosophila melanogaster, GI18543269, Length=359, Percent_Identity=30.9192200557103, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013791
- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 37687; Mature: 37687

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELDGSQGEGGGQILRTALALSLVTGKPFRMDNIRAKRPKPGLMRQHLACVNAAMAVGG
CEEECCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
GPGHSAAVNAAGQPVQIGETTLLFTPGEVRAGDYEFAVGSAGSCTLVLQTVLWPLLHAKE
CCCCCCEECCCCCCEEECCEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCC
ASTLLLSGGTHNPMAPSISFLTLLAPYFSGNGEALFDIELRRHGFYPAGGGEARVRLRPP
CCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCCCCCEEEEECCC
AQGFAALHLMERGALLEAYAECLHAGLPRGVAERELAVLRKGLGWDEDCLRDRGLRSNEG
CHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
PGNALLAVLRYEHITEVFAAYGDKGIGAEQVARRVLQEVRDYQTHRAPVGPHLADQLMIP
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MALASLQGRVGRYWATELTEHTRTNARTIETFLPVKFSCEPLDGGTVISLEG
HHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCCCCEEEEECC
>Mature Secondary Structure
MIELDGSQGEGGGQILRTALALSLVTGKPFRMDNIRAKRPKPGLMRQHLACVNAAMAVGG
CEEECCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
GPGHSAAVNAAGQPVQIGETTLLFTPGEVRAGDYEFAVGSAGSCTLVLQTVLWPLLHAKE
CCCCCCEECCCCCCEEECCEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCC
ASTLLLSGGTHNPMAPSISFLTLLAPYFSGNGEALFDIELRRHGFYPAGGGEARVRLRPP
CCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCCCCCEEEEECCC
AQGFAALHLMERGALLEAYAECLHAGLPRGVAERELAVLRKGLGWDEDCLRDRGLRSNEG
CHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
PGNALLAVLRYEHITEVFAAYGDKGIGAEQVARRVLQEVRDYQTHRAPVGPHLADQLMIP
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MALASLQGRVGRYWATELTEHTRTNARTIETFLPVKFSCEPLDGGTVISLEG
HHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]