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The map label for this gene is prs [H]

Identifier: 91787090

GI number: 91787090

Start: 1233895

End: 1234800

Strand: Reverse

Name: prs [H]

Synonym: Bpro_1193

Alternate gene names: 91787090

Gene position: 1234800-1233895 (Counterclockwise)

Preceding gene: 91787091

Following gene: 91787089

Centisome position: 23.74

GC content: 69.43

Gene sequence:

>906_bases
ATGCTGATCGTTGCCCTTCCAGGTGAGGCCCGGCTCGCGGGCAGGCTGGCGCGCCTGCTGCGCTGCGGCTGGAGCGAGCT
GCGGCTGCACCGTTTTCCCGACGGGGAAACCCTGGTGCGCATTGACGCGCCGGTGATGGGCCGCTGCGTCGTGCTGGCCG
GCAGCCTGAACCAGCCCGACGGCAAGACCCTGCCCCTGCTGTTTGCCGCCGACGCGGCACGCGAGCTGGGCGCCTCGCGG
GTCGGCCTGGTGGCGCCCTACCTGGCCTACATGCGGCAGGACCACCGCTTTAACGCTGGCGAGGCGGTCACTTCGCGCAG
CTATGCACGGCTGCTCTCGGCATCACTTGACTTCCTCGTCACGGTCGACCCGCACCTGCATCGCTGGCGCAATCTGGGCG
ATATCTATCCGATCCGCACGCAGGCGGTCGCGGCAGCCCCCATGATCGCGCGCTGGCTGCGCAGCCATGTCGACCATCCG
CTGGTGATCGGACCTGACCAGGAAAGCGGGCAATGGGTTGCCGAGGTGGCCCGGCTGACGGATGCCCCCTGGACGGTGCT
GGGCAAGACCCGCCTGGGCGACCGCGATGTGCAGGTCACGCTGGCCGATGGCGGCCCCTGGCCCGGCAAGACGCCGGTGC
TGCTGGACGACATCATCTCCACCGGCCAGACCCTGGTCGCCGCTGCCACGGCGCTGACGCAGGCCGGCATGGCCGCACCC
CTGTGCATTGGCGTGCATGCCCTGTTTGACAGCGGCGCACTGCAACGGCTGCAGGACGCGGGCGTGACACGCGTGGTGAC
CTGCGATACGATTTCCCACACCTCCAATGCCATCCGCCTGGCGCCGCTGCTGGCCAGGGCCGTGCTCGCCGTCTCACACC
ACAGTACACAGGGCAAGCCACCATGA

Upstream 100 bases:

>100_bases
CGCTGTTCACGCTGCACGCAGCCACGCCGGGTGAGCTGGCCTATGCATTGGAATACGCGGCCTCGCAGGCTGAGACCGTG
CATGTGCTGGAGGATGCCTG

Downstream 100 bases:

>100_bases
CGTCCAAACAGGTCCTGCTGATCCAGGGTCACCCCGACACGTCCGCTCACCACCTGTGCCATGCCCTGGCCGCGGCCTAC
GCCAGCGGCGCGCAAGAGGG

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MLIVALPGEARLAGRLARLLRCGWSELRLHRFPDGETLVRIDAPVMGRCVVLAGSLNQPDGKTLPLLFAADAARELGASR
VGLVAPYLAYMRQDHRFNAGEAVTSRSYARLLSASLDFLVTVDPHLHRWRNLGDIYPIRTQAVAAAPMIARWLRSHVDHP
LVIGPDQESGQWVAEVARLTDAPWTVLGKTRLGDRDVQVTLADGGPWPGKTPVLLDDIISTGQTLVAAATALTQAGMAAP
LCIGVHALFDSGALQRLQDAGVTRVVTCDTISHTSNAIRLAPLLARAVLAVSHHSTQGKPP

Sequences:

>Translated_301_residues
MLIVALPGEARLAGRLARLLRCGWSELRLHRFPDGETLVRIDAPVMGRCVVLAGSLNQPDGKTLPLLFAADAARELGASR
VGLVAPYLAYMRQDHRFNAGEAVTSRSYARLLSASLDFLVTVDPHLHRWRNLGDIYPIRTQAVAAAPMIARWLRSHVDHP
LVIGPDQESGQWVAEVARLTDAPWTVLGKTRLGDRDVQVTLADGGPWPGKTPVLLDDIISTGQTLVAAATALTQAGMAAP
LCIGVHALFDSGALQRLQDAGVTRVVTCDTISHTSNAIRLAPLLARAVLAVSHHSTQGKPP
>Mature_301_residues
MLIVALPGEARLAGRLARLLRCGWSELRLHRFPDGETLVRIDAPVMGRCVVLAGSLNQPDGKTLPLLFAADAARELGASR
VGLVAPYLAYMRQDHRFNAGEAVTSRSYARLLSASLDFLVTVDPHLHRWRNLGDIYPIRTQAVAAAPMIARWLRSHVDHP
LVIGPDQESGQWVAEVARLTDAPWTVLGKTRLGDRDVQVTLADGGPWPGKTPVLLDDIISTGQTLVAAATALTQAGMAAP
LCIGVHALFDSGALQRLQDAGVTRVVTCDTISHTSNAIRLAPLLARAVLAVSHHSTQGKPP

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=290, Percent_Identity=25.8620689655172, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI84875539, Length=279, Percent_Identity=25.8064516129032, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI4506129, Length=276, Percent_Identity=25.3623188405797, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4506127, Length=290, Percent_Identity=25.5172413793103, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=299, Percent_Identity=29.0969899665552, Blast_Score=107, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI25149168, Length=294, Percent_Identity=26.530612244898, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554702, Length=294, Percent_Identity=26.530612244898, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17554704, Length=294, Percent_Identity=26.530612244898, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71989924, Length=294, Percent_Identity=26.530612244898, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321776, Length=279, Percent_Identity=23.6559139784946, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320946, Length=293, Percent_Identity=23.2081911262799, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319403, Length=289, Percent_Identity=22.8373702422145, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355239, Length=265, Percent_Identity=26.4150943396226, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551540, Length=288, Percent_Identity=24.6527777777778, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 32312; Mature: 32312

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVALPGEARLAGRLARLLRCGWSELRLHRFPDGETLVRIDAPVMGRCVVLAGSLNQPD
CEEEECCCCHHHHHHHHHHHHCCHHHHEEEECCCCCEEEEECCCCCCEEEEEECCCCCCC
GKTLPLLFAADAARELGASRVGLVAPYLAYMRQDHRFNAGEAVTSRSYARLLSASLDFLV
CCEEEEEEECHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEE
TVDPHLHRWRNLGDIYPIRTQAVAAAPMIARWLRSHVDHPLVIGPDQESGQWVAEVARLT
EECHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHC
DAPWTVLGKTRLGDRDVQVTLADGGPWPGKTPVLLDDIISTGQTLVAAATALTQAGMAAP
CCCEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCH
LCIGVHALFDSGALQRLQDAGVTRVVTCDTISHTSNAIRLAPLLARAVLAVSHHSTQGKP
HHHHHHHHHCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
P
C
>Mature Secondary Structure
MLIVALPGEARLAGRLARLLRCGWSELRLHRFPDGETLVRIDAPVMGRCVVLAGSLNQPD
CEEEECCCCHHHHHHHHHHHHCCHHHHEEEECCCCCEEEEECCCCCCEEEEEECCCCCCC
GKTLPLLFAADAARELGASRVGLVAPYLAYMRQDHRFNAGEAVTSRSYARLLSASLDFLV
CCEEEEEEECHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEE
TVDPHLHRWRNLGDIYPIRTQAVAAAPMIARWLRSHVDHPLVIGPDQESGQWVAEVARLT
EECHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHC
DAPWTVLGKTRLGDRDVQVTLADGGPWPGKTPVLLDDIISTGQTLVAAATALTQAGMAAP
CCCEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCH
LCIGVHALFDSGALQRLQDAGVTRVVTCDTISHTSNAIRLAPLLARAVLAVSHHSTQGKP
HHHHHHHHHCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]