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The map label for this gene is deoA [C]

Identifier: 91787091

GI number: 91787091

Start: 1234800

End: 1236335

Strand: Reverse

Name: deoA [C]

Synonym: Bpro_1194

Alternate gene names: 91787091

Gene position: 1236335-1234800 (Counterclockwise)

Preceding gene: 91787092

Following gene: 91787090

Centisome position: 23.77

GC content: 70.05

Gene sequence:

>1536_bases
ATGCAAACCCCGCCGACTCCGCTTTCTTCACTCACTCCGCACAAGCTGCGCCTGCGGCGGCTGGGCATAGACACCTACCA
GGAGCCGGTGCTCTACATGCATCGCGACTGCCGCGTCTGCCACTCGGAAGGCTTCGAGGCGCAATCCCGGGTGGAGCTCG
CGCTGGGCGACCGCACCATTGTCGCCACGCTGAATGTGGTGTCTGGTGACTTTCTGGCCCCCGACGAGGCCGGCCTGTCC
GAGGCGGCGTGGCGTCTGCTCGGGGCGCAAGAAGGTGACATGGTCTCGCCGCGCCACCCCGCACCGATCGAATCACTGGG
TCATGTGCGTGCCAAAGTCTATGGACGGCACCTCACCCAGGCCGCCATCACGGCCGTGATTGAAGACGTGACCGCGGGTC
GCTACTCGGACCTGCAGCTGGCGGCCTTTGTCACAGCCTGTGCCGGCGACCGGCTGGACCAGGAAGAGACCGTCTCGCTC
ACCCGCGCGATGGTCGCCGCCGGCGAGCGGATTGACTGGGGTGAGGGCCTGGTCATGGACAAACACTGCGTGGGCGGGCT
GCCGGGCAACCGAACGACCATGGTGATCGTGCCCATCGTGGCGGCCTGCGGACTGCGCATGCCCAAAACCTCGTCGCGCG
CCATCACCTCCCCCGCCGGTACGGCCGACACCATGGAGACACTGGCGCCGGTGGACCTGGATGTGGCGCAGATCCGCCGG
GTGGTGGAACGCACCGGCGGCTGCGTGGTGTGGGGCGGCGCGGTACGCCTGAGCCCGGCGGACGACATCCTGATCCGGGT
GGAACGCCCGCTGGACCTGGACAGCCAGGGCCAGCTGGTGGCGTCGATTTTGTCCAAGAAGGTGGCGGCGGGTTCCACCC
ACGTGCTGATCGACATGCCCGTGGGGCCCACCGCCAAGGTTCGCAGCGCCGAGGCGGCGGATTTGCTGGGCCGGCTGCTC
GGCCAGGTGGGGCAGACCCTCGGACTGCGGATGCGCGTGGTGCAGACTGACGGCCTGGCCCCGGTGGGCCGCGGCATAGG
CCCCGCGCTGGAGGCGCGCGACGTGCTGGCCGTGTTACGCAACCTGGCCACCGCGCCGGCCGACCTGGCCCAGCGCTCGC
TGCTGTTGGCCGGTGAAGTGCTCGAGTTCGGTGGTGCCGCGCCGGCCGGTGGCGGGCTGGCGCTGGCCAGCGCCGTGCTG
GCCGACGGGCGTGCCTGGCGCAAGTTCCAGGACATCTGTGCGGCTCAGGGTGGCCTGCGCGAGCCGCCCGTAGCCGCGCA
CCAGCAGGCGGTGCATGCCCTGCGCAGCGGCAGCGTTCTCGCCATCGACAACCGGCGCCTGGCCCGCATTGCCAAACTGG
CCGGTGCCCCCGGGGCGGCTTGCGCGGGCATCGACCTGCATGTTCGGCCGGGTGAGTTCGTCGAGCGCGGCCAGCCGCTG
TTCACGCTGCACGCAGCCACGCCGGGTGAGCTGGCCTATGCATTGGAATACGCGGCCTCGCAGGCTGAGACCGTGCATGT
GCTGGAGGATGCCTGA

Upstream 100 bases:

>100_bases
GTCTCGTCCCGCCCGGCCACCGGAACCGGCGCCCCGCGTTGAGCTTTGTCAAGGCCGCGCGCACCTGCCTTGCCTACAGT
AACCGGAACAGGCCCCCATC

Downstream 100 bases:

>100_bases
TGCTGATCGTTGCCCTTCCAGGTGAGGCCCGGCTCGCGGGCAGGCTGGCGCGCCTGCTGCGCTGCGGCTGGAGCGAGCTG
CGGCTGCACCGTTTTCCCGA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MQTPPTPLSSLTPHKLRLRRLGIDTYQEPVLYMHRDCRVCHSEGFEAQSRVELALGDRTIVATLNVVSGDFLAPDEAGLS
EAAWRLLGAQEGDMVSPRHPAPIESLGHVRAKVYGRHLTQAAITAVIEDVTAGRYSDLQLAAFVTACAGDRLDQEETVSL
TRAMVAAGERIDWGEGLVMDKHCVGGLPGNRTTMVIVPIVAACGLRMPKTSSRAITSPAGTADTMETLAPVDLDVAQIRR
VVERTGGCVVWGGAVRLSPADDILIRVERPLDLDSQGQLVASILSKKVAAGSTHVLIDMPVGPTAKVRSAEAADLLGRLL
GQVGQTLGLRMRVVQTDGLAPVGRGIGPALEARDVLAVLRNLATAPADLAQRSLLLAGEVLEFGGAAPAGGGLALASAVL
ADGRAWRKFQDICAAQGGLREPPVAAHQQAVHALRSGSVLAIDNRRLARIAKLAGAPGAACAGIDLHVRPGEFVERGQPL
FTLHAATPGELAYALEYAASQAETVHVLEDA

Sequences:

>Translated_511_residues
MQTPPTPLSSLTPHKLRLRRLGIDTYQEPVLYMHRDCRVCHSEGFEAQSRVELALGDRTIVATLNVVSGDFLAPDEAGLS
EAAWRLLGAQEGDMVSPRHPAPIESLGHVRAKVYGRHLTQAAITAVIEDVTAGRYSDLQLAAFVTACAGDRLDQEETVSL
TRAMVAAGERIDWGEGLVMDKHCVGGLPGNRTTMVIVPIVAACGLRMPKTSSRAITSPAGTADTMETLAPVDLDVAQIRR
VVERTGGCVVWGGAVRLSPADDILIRVERPLDLDSQGQLVASILSKKVAAGSTHVLIDMPVGPTAKVRSAEAADLLGRLL
GQVGQTLGLRMRVVQTDGLAPVGRGIGPALEARDVLAVLRNLATAPADLAQRSLLLAGEVLEFGGAAPAGGGLALASAVL
ADGRAWRKFQDICAAQGGLREPPVAAHQQAVHALRSGSVLAIDNRRLARIAKLAGAPGAACAGIDLHVRPGEFVERGQPL
FTLHAATPGELAYALEYAASQAETVHVLEDA
>Mature_511_residues
MQTPPTPLSSLTPHKLRLRRLGIDTYQEPVLYMHRDCRVCHSEGFEAQSRVELALGDRTIVATLNVVSGDFLAPDEAGLS
EAAWRLLGAQEGDMVSPRHPAPIESLGHVRAKVYGRHLTQAAITAVIEDVTAGRYSDLQLAAFVTACAGDRLDQEETVSL
TRAMVAAGERIDWGEGLVMDKHCVGGLPGNRTTMVIVPIVAACGLRMPKTSSRAITSPAGTADTMETLAPVDLDVAQIRR
VVERTGGCVVWGGAVRLSPADDILIRVERPLDLDSQGQLVASILSKKVAAGSTHVLIDMPVGPTAKVRSAEAADLLGRLL
GQVGQTLGLRMRVVQTDGLAPVGRGIGPALEARDVLAVLRNLATAPADLAQRSLLLAGEVLEFGGAAPAGGGLALASAVL
ADGRAWRKFQDICAAQGGLREPPVAAHQQAVHALRSGSVLAIDNRRLARIAKLAGAPGAACAGIDLHVRPGEFVERGQPL
FTLHAATPGELAYALEYAASQAETVHVLEDA

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=419, Percent_Identity=30.5489260143198, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI4503445, Length=419, Percent_Identity=30.5489260143198, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI166158922, Length=419, Percent_Identity=30.5489260143198, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1790842, Length=400, Percent_Identity=29, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_POLSJ (Q12E97)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548043.1
- STRING:   Q12E97
- GeneID:   4012163
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1194
- NMPDR:   fig|296591.1.peg.3206
- eggNOG:   COG0213
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- PhylomeDB:   Q12E97
- ProtClustDB:   PRK04350
- BioCyc:   PSP296591:BPRO_1194-MONOMER
- HAMAP:   MF_00703
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 53699; Mature: 53699

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPPTPLSSLTPHKLRLRRLGIDTYQEPVLYMHRDCRVCHSEGFEAQSRVELALGDRTI
CCCCCCCCCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCHHEEEEEECCEEE
VATLNVVSGDFLAPDEAGLSEAAWRLLGAQEGDMVSPRHPAPIESLGHVRAKVYGRHLTQ
EEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AAITAVIEDVTAGRYSDLQLAAFVTACAGDRLDQEETVSLTRAMVAAGERIDWGEGLVMD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEC
KHCVGGLPGNRTTMVIVPIVAACGLRMPKTSSRAITSPAGTADTMETLAPVDLDVAQIRR
CHHCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHH
VVERTGGCVVWGGAVRLSPADDILIRVERPLDLDSQGQLVASILSKKVAAGSTHVLIDMP
HHHHCCCEEEECCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
VGPTAKVRSAEAADLLGRLLGQVGQTLGLRMRVVQTDGLAPVGRGIGPALEARDVLAVLR
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
NLATAPADLAQRSLLLAGEVLEFGGAAPAGGGLALASAVLADGRAWRKFQDICAAQGGLR
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
EPPVAAHQQAVHALRSGSVLAIDNRRLARIAKLAGAPGAACAGIDLHVRPGEFVERGQPL
CCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCEEECEEEEECCCHHHHCCCCE
FTLHAATPGELAYALEYAASQAETVHVLEDA
EEEECCCCHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MQTPPTPLSSLTPHKLRLRRLGIDTYQEPVLYMHRDCRVCHSEGFEAQSRVELALGDRTI
CCCCCCCCCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCHHEEEEEECCEEE
VATLNVVSGDFLAPDEAGLSEAAWRLLGAQEGDMVSPRHPAPIESLGHVRAKVYGRHLTQ
EEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AAITAVIEDVTAGRYSDLQLAAFVTACAGDRLDQEETVSLTRAMVAAGERIDWGEGLVMD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEC
KHCVGGLPGNRTTMVIVPIVAACGLRMPKTSSRAITSPAGTADTMETLAPVDLDVAQIRR
CHHCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHH
VVERTGGCVVWGGAVRLSPADDILIRVERPLDLDSQGQLVASILSKKVAAGSTHVLIDMP
HHHHCCCEEEECCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
VGPTAKVRSAEAADLLGRLLGQVGQTLGLRMRVVQTDGLAPVGRGIGPALEARDVLAVLR
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
NLATAPADLAQRSLLLAGEVLEFGGAAPAGGGLALASAVLADGRAWRKFQDICAAQGGLR
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
EPPVAAHQQAVHALRSGSVLAIDNRRLARIAKLAGAPGAACAGIDLHVRPGEFVERGQPL
CCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCEEECEEEEECCCHHHHCCCCE
FTLHAATPGELAYALEYAASQAETVHVLEDA
EEEECCCCHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA