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The map label for this gene is bioF1

Identifier: 91786800

GI number: 91786800

Start: 916163

End: 917380

Strand: Reverse

Name: bioF1

Synonym: Bpro_0898

Alternate gene names: 91786800

Gene position: 917380-916163 (Counterclockwise)

Preceding gene: 91786801

Following gene: 91786799

Centisome position: 17.64

GC content: 67.24

Gene sequence:

>1218_bases
ATGGCAATCAACACCCCACTGACAAATTCCTGGCTCGATGAATTTCCGGCGCGCATTGCCGAGCTGGACCGCGCGCATTT
GCGCCGCCGGCGTCGCGTCGTCGTGCCTGAAGATGGCGCCCACCTGCAGGTTGACGGGCAGCGCATGCTGGCGTTTTGCA
GCAACGACTACCTGGGCCTGGCCGGCCACCCCGCGCTGGTGCAAGCCGCCTGCGACGGTGCCCGGGCTTTCGGCGTGGGT
GCGGCGGCCTCGCCACTGGTGAGCGGCCACAGCGCCGCCAACGAGGCGCTGGAAGCCGCCCTGGCCCGCTTTGTCGGCCA
GCCGCGCGCCCTGTACTTTTACGCCGGTTATGCCACCAACATCGGCATCGTGCCCGCGCTGGTGGGCAAAGGCGATGCGA
TTTTTTCAGACGCGCTGAACCACGCCTGCCTGATTGACGGCGCAAGGCTGTCAAGCGCACAGATTCACCGCTACCCGCAT
GCCGACCTGGCCGCACTGGAGCAGGAGCTCATCAGCAGCCCGGCGCGGCGCAAGCTCATCATCAGTGACGCCGTGTTCAG
CATGGACGGCGATGTGGCCGATGTGCCTGCGCTGCTGGCATTGTGCGAGCGCCATGACGCCCTGCTGCTGCTCGACGACG
CACACGGTTTTGGCGTGCTGGGCCCGCAGGGGCGGGGTTGCCTGGCCCACTTTGGCCTGTCCGGTGAAAATGCTTCACCG
CGCGTGCTCTACATGGCCACGCTGGGCAAGGCCGCGGGCGTGGCCGGGGCGTTTGTGGCGGGCAGCGAGGCACTGGTTGA
ATGGCTGCTGCAAAAAACCCGCAGTTACATTTTTGCCACCGCCGCCCCTGCCTTGCTGGCCACCGCCTTGCAAACCAGCC
TGCAACTGATTGAGCAGGACGAGTGGCGGCGCGAGCACCTGCAGCGCCTCATTGCCCGCTTGAGGAGCGGCCTGGCTCAA
GGCCTGCAAGGCAGCTCATGGCGGCTCGGCGAGTCACCCACCGCCATTCAGCCCGTGGTGATTGGCCCCAACGACGCGGC
GCTGGCCGTGATGGAAGGCCTGCGCACACGCGGACTGTGGGTCCCCGCCATTCGCCCGCCCACCGTGGCTGAGGGCACGG
CCCGTTTGCGCATTGCCCTGTCGGCCGCGCACACCGAGGCAGATATTGACCGGCTGGTGCAGGCCCTGACCGAGCTGGCA
AAGCCCGGCAGTCTCTGA

Upstream 100 bases:

>100_bases
TCGCCTTTTTGCAGCACCAGCTGGCCGCACCGCTGCTGGCCAGCATTGCGCACCAGTCGCAGCCCGACCCCAAAACCCTG
AACCTGGAACTCCCCCTGGC

Downstream 100 bases:

>100_bases
ACCCGGCCTCGTCAGTGCTGGGTAAAATTGGCGGCCGAAGACGATGGCCCCGAATCGTCATGCACAAGCCGTGCGAGCAA
GCGCATCGAACAGACTGACA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS 1; 7-keto-8-amino-pelargonic acid synthase 1; 7-KAP synthase 1; KAPA synthase 1; 8-amino-7-ketopelargonate synthase 1; L-alanine--pimeloyl-CoA ligase 1

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MAINTPLTNSWLDEFPARIAELDRAHLRRRRRVVVPEDGAHLQVDGQRMLAFCSNDYLGLAGHPALVQAACDGARAFGVG
AAASPLVSGHSAANEALEAALARFVGQPRALYFYAGYATNIGIVPALVGKGDAIFSDALNHACLIDGARLSSAQIHRYPH
ADLAALEQELISSPARRKLIISDAVFSMDGDVADVPALLALCERHDALLLLDDAHGFGVLGPQGRGCLAHFGLSGENASP
RVLYMATLGKAAGVAGAFVAGSEALVEWLLQKTRSYIFATAAPALLATALQTSLQLIEQDEWRREHLQRLIARLRSGLAQ
GLQGSSWRLGESPTAIQPVVIGPNDAALAVMEGLRTRGLWVPAIRPPTVAEGTARLRIALSAAHTEADIDRLVQALTELA
KPGSL

Sequences:

>Translated_405_residues
MAINTPLTNSWLDEFPARIAELDRAHLRRRRRVVVPEDGAHLQVDGQRMLAFCSNDYLGLAGHPALVQAACDGARAFGVG
AAASPLVSGHSAANEALEAALARFVGQPRALYFYAGYATNIGIVPALVGKGDAIFSDALNHACLIDGARLSSAQIHRYPH
ADLAALEQELISSPARRKLIISDAVFSMDGDVADVPALLALCERHDALLLLDDAHGFGVLGPQGRGCLAHFGLSGENASP
RVLYMATLGKAAGVAGAFVAGSEALVEWLLQKTRSYIFATAAPALLATALQTSLQLIEQDEWRREHLQRLIARLRSGLAQ
GLQGSSWRLGESPTAIQPVVIGPNDAALAVMEGLRTRGLWVPAIRPPTVAEGTARLRIALSAAHTEADIDRLVQALTELA
KPGSL
>Mature_404_residues
AINTPLTNSWLDEFPARIAELDRAHLRRRRRVVVPEDGAHLQVDGQRMLAFCSNDYLGLAGHPALVQAACDGARAFGVGA
AASPLVSGHSAANEALEAALARFVGQPRALYFYAGYATNIGIVPALVGKGDAIFSDALNHACLIDGARLSSAQIHRYPHA
DLAALEQELISSPARRKLIISDAVFSMDGDVADVPALLALCERHDALLLLDDAHGFGVLGPQGRGCLAHFGLSGENASPR
VLYMATLGKAAGVAGAFVAGSEALVEWLLQKTRSYIFATAAPALLATALQTSLQLIEQDEWRREHLQRLIARLRSGLAQG
LQGSSWRLGESPTAIQPVVIGPNDAALAVMEGLRTRGLWVPAIRPPTVAEGTARLRIALSAAHTEADIDRLVQALTELAK
PGSL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=377, Percent_Identity=33.6870026525199, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI284448556, Length=403, Percent_Identity=31.5136476426799, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=31.4207650273224, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI119220554, Length=360, Percent_Identity=30.8333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977442, Length=404, Percent_Identity=28.960396039604, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI83977440, Length=404, Percent_Identity=28.960396039604, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4502025, Length=398, Percent_Identity=28.1407035175879, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40316939, Length=398, Percent_Identity=28.1407035175879, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI83977444, Length=404, Percent_Identity=28.960396039604, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI5454084, Length=389, Percent_Identity=23.9074550128535, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786993, Length=361, Percent_Identity=42.9362880886427, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1790046, Length=382, Percent_Identity=36.6492146596859, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=33.25, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=29.2011019283747, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=363, Percent_Identity=29.2011019283747, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI32566772, Length=375, Percent_Identity=25.6, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=305, Percent_Identity=25.2459016393443, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982617, Length=305, Percent_Identity=25.2459016393443, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320438, Length=387, Percent_Identity=31.5245478036176, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=26.9754768392371, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=289, Percent_Identity=24.9134948096886, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=33.4190231362468, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=30.1408450704225, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=29.3010752688172, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653280, Length=301, Percent_Identity=27.2425249169435, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24653276, Length=301, Percent_Identity=27.2425249169435, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24653278, Length=301, Percent_Identity=27.2425249169435, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF1_POLSJ (Q12F38)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547752.1
- ProteinModelPortal:   Q12F38
- STRING:   Q12F38
- GeneID:   4011206
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_0898
- NMPDR:   fig|296591.1.peg.3034
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   CASAPVV
- PhylomeDB:   Q12F38
- ProtClustDB:   CLSK953000
- BioCyc:   PSP296591:BPRO_0898-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 42930; Mature: 42798

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 29-29 BINDING 141-141 BINDING 187-187 BINDING 368-368

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINTPLTNSWLDEFPARIAELDRAHLRRRRRVVVPEDGAHLQVDGQRMLAFCSNDYLGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEECHHHHEEECCCCCCCC
AGHPALVQAACDGARAFGVGAAASPLVSGHSAANEALEAALARFVGQPRALYFYAGYATN
CCCHHHHHHHHCCCHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
IGIVPALVGKGDAIFSDALNHACLIDGARLSSAQIHRYPHADLAALEQELISSPARRKLI
CCHHHHHHCCCCHHHHHHCCCEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCCCHHCEEE
ISDAVFSMDGDVADVPALLALCERHDALLLLDDAHGFGVLGPQGRGCLAHFGLSGENASP
EEHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCC
RVLYMATLGKAAGVAGAFVAGSEALVEWLLQKTRSYIFATAAPALLATALQTSLQLIEQD
EEEEEEECCCHHCCHHHHHCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHH
EWRREHLQRLIARLRSGLAQGLQGSSWRLGESPTAIQPVVIGPNDAALAVMEGLRTRGLW
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEE
VPAIRPPTVAEGTARLRIALSAAHTEADIDRLVQALTELAKPGSL
ECCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AINTPLTNSWLDEFPARIAELDRAHLRRRRRVVVPEDGAHLQVDGQRMLAFCSNDYLGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEECHHHHEEECCCCCCCC
AGHPALVQAACDGARAFGVGAAASPLVSGHSAANEALEAALARFVGQPRALYFYAGYATN
CCCHHHHHHHHCCCHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
IGIVPALVGKGDAIFSDALNHACLIDGARLSSAQIHRYPHADLAALEQELISSPARRKLI
CCHHHHHHCCCCHHHHHHCCCEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCCCHHCEEE
ISDAVFSMDGDVADVPALLALCERHDALLLLDDAHGFGVLGPQGRGCLAHFGLSGENASP
EEHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCC
RVLYMATLGKAAGVAGAFVAGSEALVEWLLQKTRSYIFATAAPALLATALQTSLQLIEQD
EEEEEEECCCHHCCHHHHHCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHH
EWRREHLQRLIARLRSGLAQGLQGSSWRLGESPTAIQPVVIGPNDAALAVMEGLRTRGLW
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEE
VPAIRPPTVAEGTARLRIALSAAHTEADIDRLVQALTELAKPGSL
ECCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA