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The map label for this gene is coxN [H]

Identifier: 91786629

GI number: 91786629

Start: 742181

End: 743947

Strand: Direct

Name: coxN [H]

Synonym: Bpro_0727

Alternate gene names: 91786629

Gene position: 742181-743947 (Clockwise)

Preceding gene: 91786628

Following gene: 91786630

Centisome position: 14.27

GC content: 63.38

Gene sequence:

>1767_bases
ATGGCCTACGCTGAAGATACTTCGCATCACCCGCAGAGCTTCTGGACCCGCTATGTCTGGAGCCAGGACCACAAGGTGAT
TGCCGTGCAGTACGCCTGCGTCGCCATCGCGGTGGGGCTGGTGGGCGTCATGCTGTCCAACCTGATGCGGCTGCAACTGG
GTTTCCCGGGGCAGTTCCAGTTCATCAACGCCGAGCGCTACTACCAGTTCGTCACCATGCACGGAATGATCATGGTGATC
TATCTGCTCACGGCGCTGTTCCTTGGCGGTTTCGGCAATTACCTGATCCCGCTGATGATAGGGGCGCGCGACATGGTGTT
CCCCTACATGAACATGCTGAGCTTTTGGGTCTACCTGCTGTCGGTGCTGGTGCTGATGGCAAGCTTCTTCGTGCCCGGCG
GTCCGACCGGCGCCGGCTGGACGCTGTACCCGCCGCAGGCCATCCTGCCCGGCACGCCAGGGCATGACTGGGGCATCATC
CTGATGCTGGTGTCGCTGGTGATCTTCATTGTCGCCACCACGATGGGCGGCCTGAATTACGTGACCACGGTGCTGCAGGC
GCGCTGCGAGGGCATGACGCTGCTGCGCATGCCGCTGTCGGTCTGGGGCATTTTCGTCGCGACGATTCTCGCGCTGCTGG
CCTTCCCGGCGCTGTTCGTAAGCGGCGTGATGATGCTGCTCGACAAGACGCTGGGCACCAGCTTCTTCATGCCGGCGCTG
GTGTCGATGGGACAGGTGACCGGCTACAAGGGTGGCAGTCCGCTGCTGTTCCAGCACCTGTTCTGGTTCTTCGGCCACCC
CGAGGTCTACATCGTGGCGCTGCCGGCTTTCGGCGTCGTGTCCGACCTGATCAGCGTGCATGCGCGCAAGGCCATCTTCG
GCTACCGCATGATGGTCTGGGCCATCGTCATCATCGGGGCGCTGAGCTTCGTCGTGTGGGCACACCATATGTTCGTGAGC
GGCATGAATCCGTGGTTCGGCTTCTTCTTTGCCACCAGCACGCTGATCATCGCGGTACCCACCGCCATCAAGGTCTACAA
CTGGGTGCTGACGCTGTGGCGTGGCGACATTCACCTGACCGTGCCCATGCTGTTCACGCTGGCCTTCATCCTGACCTTTC
TGGCCGGCGGACTGACCGGGCTGTTCCTGGGCAATGTCAGCGTCGACATCCCGCTGTCAGGCACCTACTTCGTGGTGGCG
CACTTCCACATGGTGATGGGCGTGGCGCCGCTGCTGGTGGTGTTTGGCGGCATCTACCACTGGTTCCCCAAGGTGACCGG
CCGCATGCTCGACGACCGGATCGGCAAGCTGCATTTCTGGATCACCTTCATCGGCACCTACCTGATCTACTTCCCGATGC
ACTACCTGGGCGTGCTGGGCATGCCGCGGCGCTACTACAATTTTGACGGCTACCAGTTCATCCCGGCCTCGGCGCACGCG
CTGAACACCTTCATCACCGTGGCCGCACTGATCGTCGGTGCGGCGCAGCTGTTGTTCATCTTCAACCTGGCCTGGAGCAC
CTTCCGTGGCCGGCGGGCCAGTGCCAACCCCTGGCGCGCGGCCTCGCTGGAATGGCAGACGCCCGAGACGCCGCCGCTGC
ACGGCAACTGGGGGCCACAGCTGCCGGTGGTTTACCGCTGGGCCTACGCCTACAGTGTGCCGGGCGCGCCGCAGGACTTC
ATTGCACAAAACGCACCCCCCGAGGACGGCGGCCAGGAGCCTGAGCCGCACCCCCGCCCCGACAGAGCCACAGGAGCGAT
CGCATGA

Upstream 100 bases:

>100_bases
CTACATCCAGTCGCTGGGCGGCGTCACTCCGGCTGCACCAGCTCCCGCAGCCGGGCAGAAGGCGCAGCAGTGAACGCCAC
GCCACACAACGAGGAACTCC

Downstream 100 bases:

>100_bases
GTGCCGCCGTGGCATCTGGCGCCTGGCCGCCCGACCGCCGCGCCGCCAGCACGGGTACCGGCCTGTGGACGTTCATGGGT
GTTGCCACCGCCTTGTTCAC

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MAYAEDTSHHPQSFWTRYVWSQDHKVIAVQYACVAIAVGLVGVMLSNLMRLQLGFPGQFQFINAERYYQFVTMHGMIMVI
YLLTALFLGGFGNYLIPLMIGARDMVFPYMNMLSFWVYLLSVLVLMASFFVPGGPTGAGWTLYPPQAILPGTPGHDWGII
LMLVSLVIFIVATTMGGLNYVTTVLQARCEGMTLLRMPLSVWGIFVATILALLAFPALFVSGVMMLLDKTLGTSFFMPAL
VSMGQVTGYKGGSPLLFQHLFWFFGHPEVYIVALPAFGVVSDLISVHARKAIFGYRMMVWAIVIIGALSFVVWAHHMFVS
GMNPWFGFFFATSTLIIAVPTAIKVYNWVLTLWRGDIHLTVPMLFTLAFILTFLAGGLTGLFLGNVSVDIPLSGTYFVVA
HFHMVMGVAPLLVVFGGIYHWFPKVTGRMLDDRIGKLHFWITFIGTYLIYFPMHYLGVLGMPRRYYNFDGYQFIPASAHA
LNTFITVAALIVGAAQLLFIFNLAWSTFRGRRASANPWRAASLEWQTPETPPLHGNWGPQLPVVYRWAYAYSVPGAPQDF
IAQNAPPEDGGQEPEPHPRPDRATGAIA

Sequences:

>Translated_588_residues
MAYAEDTSHHPQSFWTRYVWSQDHKVIAVQYACVAIAVGLVGVMLSNLMRLQLGFPGQFQFINAERYYQFVTMHGMIMVI
YLLTALFLGGFGNYLIPLMIGARDMVFPYMNMLSFWVYLLSVLVLMASFFVPGGPTGAGWTLYPPQAILPGTPGHDWGII
LMLVSLVIFIVATTMGGLNYVTTVLQARCEGMTLLRMPLSVWGIFVATILALLAFPALFVSGVMMLLDKTLGTSFFMPAL
VSMGQVTGYKGGSPLLFQHLFWFFGHPEVYIVALPAFGVVSDLISVHARKAIFGYRMMVWAIVIIGALSFVVWAHHMFVS
GMNPWFGFFFATSTLIIAVPTAIKVYNWVLTLWRGDIHLTVPMLFTLAFILTFLAGGLTGLFLGNVSVDIPLSGTYFVVA
HFHMVMGVAPLLVVFGGIYHWFPKVTGRMLDDRIGKLHFWITFIGTYLIYFPMHYLGVLGMPRRYYNFDGYQFIPASAHA
LNTFITVAALIVGAAQLLFIFNLAWSTFRGRRASANPWRAASLEWQTPETPPLHGNWGPQLPVVYRWAYAYSVPGAPQDF
IAQNAPPEDGGQEPEPHPRPDRATGAIA
>Mature_587_residues
AYAEDTSHHPQSFWTRYVWSQDHKVIAVQYACVAIAVGLVGVMLSNLMRLQLGFPGQFQFINAERYYQFVTMHGMIMVIY
LLTALFLGGFGNYLIPLMIGARDMVFPYMNMLSFWVYLLSVLVLMASFFVPGGPTGAGWTLYPPQAILPGTPGHDWGIIL
MLVSLVIFIVATTMGGLNYVTTVLQARCEGMTLLRMPLSVWGIFVATILALLAFPALFVSGVMMLLDKTLGTSFFMPALV
SMGQVTGYKGGSPLLFQHLFWFFGHPEVYIVALPAFGVVSDLISVHARKAIFGYRMMVWAIVIIGALSFVVWAHHMFVSG
MNPWFGFFFATSTLIIAVPTAIKVYNWVLTLWRGDIHLTVPMLFTLAFILTFLAGGLTGLFLGNVSVDIPLSGTYFVVAH
FHMVMGVAPLLVVFGGIYHWFPKVTGRMLDDRIGKLHFWITFIGTYLIYFPMHYLGVLGMPRRYYNFDGYQFIPASAHAL
NTFITVAALIVGAAQLLFIFNLAWSTFRGRRASANPWRAASLEWQTPETPPLHGNWGPQLPVVYRWAYAYSVPGAPQDFI
AQNAPPEDGGQEPEPHPRPDRATGAIA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=525, Percent_Identity=41.1428571428571, Blast_Score=354, Evalue=2e-97,
Organism=Escherichia coli, GI1786634, Length=526, Percent_Identity=35.7414448669202, Blast_Score=314, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6226519, Length=501, Percent_Identity=38.5229540918164, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6226524, Length=336, Percent_Identity=39.8809523809524, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6226523, Length=258, Percent_Identity=37.2093023255814, Blast_Score=153, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 65460; Mature: 65329

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCEEEEEHHEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYAEDTSHHPQSFWTRYVWSQDHKVIAVQYACVAIAVGLVGVMLSNLMRLQLGFPGQFQ
CCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE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CCCEEEEEHHEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]