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The map label for this gene is creC [H]

Identifier: 91786147

GI number: 91786147

Start: 258922

End: 260319

Strand: Reverse

Name: creC [H]

Synonym: Bpro_0236

Alternate gene names: 91786147

Gene position: 260319-258922 (Counterclockwise)

Preceding gene: 91786148

Following gene: 91786140

Centisome position: 5.01

GC content: 64.23

Gene sequence:

>1398_bases
ATGCGTTTAGGTATTCGCCTGCTGTTCGGTTTTTTCCTGGTTACCGGGCTGGCGGCATTTTTTGTGCTGCGTGTCTTCAT
GGCTGAAGTCAAACCCAGCGTGCGCGAGGTGATGGAAGACATGATGGTGGACACCGCCAACATCCTGGCCGAGCTCGCCA
GCGACGATCTGTCCGCCGGCGCCATCGCTGACGGACGTTTTGCCGGACATGTGCGCAGCTATGCCAGGCGACCGATTGAT
GCGCAGATCTGGGGCATGACCAAGCAGTCGCTGGATTTCCGCGTGTATGTCACCGACATCAACGGCAAGGTCGTGTTTGA
TTCGGAAAACGTGGCGACCGGCCAGGACTATTCGCGCTGGCGCGACGTGGCCCGCACCCTGCGCGGCGAGTACGGCGCGC
GCGCCACCCGCGAAGTCCAGCGGGATGACCGCACCTCGGTGATGTATGTTGCGGCGCCGGTGCAGCACGATGGCAAAACC
ATTGGCGTGCTGACCGTCGCCAAGCCGATGTCCACCATCCAGGCCTTCATCGACCGGGCGGAGCGAAAAATTCTGCTGAG
CGGCCTGCTGCTATTGGTGTTGTCGCTGGCCATCGGTGTAGCGGTGACGCTGTGGGTGGTATGGAGCATTCGCAAGCTGC
GCCACTATGCCAACGCCGTCGGCCAGGGCGCCAAGCCCGCGGTGCCGCAAATACCGGGCGAGCTCGGTGAGCTGGCGATG
GCAGTGGATGCCATGCGCCTGAAGCTCGAGGGCCACGAGTACATAGAAGGTTATGTGCGCGCACTGACGCATGAACTCAA
GAGCCCGCTCGCGGCCATTCGCGGGGCGGGTGAGCTGCTGCAGGATGAACTGCCCGAAAACGCGCGCCGCGAATTTGCGG
GGCAGGTGCTCGACCAGTCCGCTCGCCTGCAGGCGCTGGTGGACCGCATGCTCGAGCTGACGAAGCTGGAGCAGCGCCAT
GCACAGGTACAGCGCGAGAGCCTTCTTTGGTGCGGCTTCCTCAAGCCTTTTGAGGCTGCACCCCTCGCCGGACGTGCGCA
ACATGCTGTGAAACTCATGGTTTCTCCGGAACATGCGGGTGTGCATGCCGAGCCCGGCTTGCTGGCCCTGGCGCTCAGCA
ACCTGCTGGAGAATGCGCGCTCGTTTGCGCCTCAAGCCTCCACCATCACGGTAGAGGCCGGCCAGGGTCACGTCGCTGTG
CAGGACCAGGGCCCCGGTGTGGCGGACTATGCCCTGCCCCGGCTGGGCGAGCGCTTCTTTTCGACCGTGCGTCCCGACGG
CCACACCAAGGGCTCCGGCCTCGGGCTGGCCATCGTGCGGCAGATCATGCTGCTGCACGGCGGCCGCATGGTGGTGCGCA
ACACCCACCCCGGGCTGCGGGTCGAGCTGCACTTCTAA

Upstream 100 bases:

>100_bases
CGCTTCGCTTCGCCTCCCCCCTTGCAGGGGGCGACGCCTGTGGTCTGGCAAAGCCAGTCCCACGGCGCCTGCTGGCAAAA
GCCTGTGTGCGGGAACAGGT

Downstream 100 bases:

>100_bases
GGCTGCTCGAATGCCTGGCGCGCGCATCAGCCGGCCACCTTTGCAGCTTCCGCCTGCCCGACGTGCCCCGCCTGCGTAAA
GCGTGCGTACCAGTCAACCC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRLGIRLLFGFFLVTGLAAFFVLRVFMAEVKPSVREVMEDMMVDTANILAELASDDLSAGAIADGRFAGHVRSYARRPID
AQIWGMTKQSLDFRVYVTDINGKVVFDSENVATGQDYSRWRDVARTLRGEYGARATREVQRDDRTSVMYVAAPVQHDGKT
IGVLTVAKPMSTIQAFIDRAERKILLSGLLLLVLSLAIGVAVTLWVVWSIRKLRHYANAVGQGAKPAVPQIPGELGELAM
AVDAMRLKLEGHEYIEGYVRALTHELKSPLAAIRGAGELLQDELPENARREFAGQVLDQSARLQALVDRMLELTKLEQRH
AQVQRESLLWCGFLKPFEAAPLAGRAQHAVKLMVSPEHAGVHAEPGLLALALSNLLENARSFAPQASTITVEAGQGHVAV
QDQGPGVADYALPRLGERFFSTVRPDGHTKGSGLGLAIVRQIMLLHGGRMVVRNTHPGLRVELHF

Sequences:

>Translated_465_residues
MRLGIRLLFGFFLVTGLAAFFVLRVFMAEVKPSVREVMEDMMVDTANILAELASDDLSAGAIADGRFAGHVRSYARRPID
AQIWGMTKQSLDFRVYVTDINGKVVFDSENVATGQDYSRWRDVARTLRGEYGARATREVQRDDRTSVMYVAAPVQHDGKT
IGVLTVAKPMSTIQAFIDRAERKILLSGLLLLVLSLAIGVAVTLWVVWSIRKLRHYANAVGQGAKPAVPQIPGELGELAM
AVDAMRLKLEGHEYIEGYVRALTHELKSPLAAIRGAGELLQDELPENARREFAGQVLDQSARLQALVDRMLELTKLEQRH
AQVQRESLLWCGFLKPFEAAPLAGRAQHAVKLMVSPEHAGVHAEPGLLALALSNLLENARSFAPQASTITVEAGQGHVAV
QDQGPGVADYALPRLGERFFSTVRPDGHTKGSGLGLAIVRQIMLLHGGRMVVRNTHPGLRVELHF
>Mature_465_residues
MRLGIRLLFGFFLVTGLAAFFVLRVFMAEVKPSVREVMEDMMVDTANILAELASDDLSAGAIADGRFAGHVRSYARRPID
AQIWGMTKQSLDFRVYVTDINGKVVFDSENVATGQDYSRWRDVARTLRGEYGARATREVQRDDRTSVMYVAAPVQHDGKT
IGVLTVAKPMSTIQAFIDRAERKILLSGLLLLVLSLAIGVAVTLWVVWSIRKLRHYANAVGQGAKPAVPQIPGELGELAM
AVDAMRLKLEGHEYIEGYVRALTHELKSPLAAIRGAGELLQDELPENARREFAGQVLDQSARLQALVDRMLELTKLEQRH
AQVQRESLLWCGFLKPFEAAPLAGRAQHAVKLMVSPEHAGVHAEPGLLALALSNLLENARSFAPQASTITVEAGQGHVAV
QDQGPGVADYALPRLGERFFSTVRPDGHTKGSGLGLAIVRQIMLLHGGRMVVRNTHPGLRVELHF

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=475, Percent_Identity=44.6315789473684, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1789403, Length=203, Percent_Identity=36.4532019704434, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=29.3333333333333, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=29.5546558704453, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=202, Percent_Identity=32.1782178217822, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=318, Percent_Identity=25.7861635220126, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=272, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51026; Mature: 51026

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGIRLLFGFFLVTGLAAFFVLRVFMAEVKPSVREVMEDMMVDTANILAELASDDLSAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIADGRFAGHVRSYARRPIDAQIWGMTKQSLDFRVYVTDINGKVVFDSENVATGQDYSRW
CCCCCHHHHHHHHHHCCCCCHHHHCCHHHCCEEEEEEEECCCEEEECCCCCCCCCHHHHH
RDVARTLRGEYGARATREVQRDDRTSVMYVAAPVQHDGKTIGVLTVAKPMSTIQAFIDRA
HHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHH
ERKILLSGLLLLVLSLAIGVAVTLWVVWSIRKLRHYANAVGQGAKPAVPQIPGELGELAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AVDAMRLKLEGHEYIEGYVRALTHELKSPLAAIRGAGELLQDELPENARREFAGQVLDQS
HHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHH
ARLQALVDRMLELTKLEQRHAQVQRESLLWCGFLKPFEAAPLAGRAQHAVKLMVSPEHAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEECCCCCC
VHAEPGLLALALSNLLENARSFAPQASTITVEAGQGHVAVQDQGPGVADYALPRLGERFF
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHH
STVRPDGHTKGSGLGLAIVRQIMLLHGGRMVVRNTHPGLRVELHF
HHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MRLGIRLLFGFFLVTGLAAFFVLRVFMAEVKPSVREVMEDMMVDTANILAELASDDLSAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIADGRFAGHVRSYARRPIDAQIWGMTKQSLDFRVYVTDINGKVVFDSENVATGQDYSRW
CCCCCHHHHHHHHHHCCCCCHHHHCCHHHCCEEEEEEEECCCEEEECCCCCCCCCHHHHH
RDVARTLRGEYGARATREVQRDDRTSVMYVAAPVQHDGKTIGVLTVAKPMSTIQAFIDRA
HHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHH
ERKILLSGLLLLVLSLAIGVAVTLWVVWSIRKLRHYANAVGQGAKPAVPQIPGELGELAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AVDAMRLKLEGHEYIEGYVRALTHELKSPLAAIRGAGELLQDELPENARREFAGQVLDQS
HHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHH
ARLQALVDRMLELTKLEQRHAQVQRESLLWCGFLKPFEAAPLAGRAQHAVKLMVSPEHAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEECCCCCC
VHAEPGLLALALSNLLENARSFAPQASTITVEAGQGHVAVQDQGPGVADYALPRLGERFF
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHH
STVRPDGHTKGSGLGLAIVRQIMLLHGGRMVVRNTHPGLRVELHF
HHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]