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The map label for this gene is hisA [H]

Identifier: 91785376

GI number: 91785376

Start: 4434317

End: 4435069

Strand: Reverse

Name: hisA [H]

Synonym: Bxe_A0403

Alternate gene names: 91785376

Gene position: 4435069-4434317 (Counterclockwise)

Preceding gene: 91785377

Following gene: 91785375

Centisome position: 90.59

GC content: 63.48

Gene sequence:

>753_bases
ATGCTGCTGATTCCCGCCATCGACCTGAAAGACGGTCAGTGTGTACGCCTCAAACAGGGCGATATGGACCAGGCGACGAT
ATTTTCCGAGGAACCGGCGGCGATGGCCCGACATTGGGTCGATCGCGGGGCCCGGCGTCTGCACCTCGTCGACCTGAATG
GCGCGTTCGCCGGCAAGCCGAAGAACGAAGACGCGATTCGCGCGATCATCGCAGAGGTGGGCGGCGAGATTCCCGTTCAG
CTGGGCGGCGGCATTCGCGACCTGAACACGATCGAGCGCTATCTGGACGACGGTCTGTCGTACGTGATCATCGGCACGGC
GGCGGTGAAGAATCCCGGCTTTCTGCAAGATGCCTGCACGGCGTTCGGCGGCCATATCATCGTGGGGCTGGATGCGAAAG
ACGGCAAGGTCGCGACCGACGGCTGGAGCAAGCTCACCGGCCACGAAGTGGCCGACCTCGCGCGCAAGTTCGAGGACTAC
GGCTGCGAGTCGATCATCTATACCGACATCGGCCGTGACGGCATGCTGCAGGGCATCAACATCGAAGCGACGGTGCGTCT
CGCGCGCGCGGTGAAGATTCCGGTGATCGCGAGCGGCGGCTTGTCGAACCTTGCGGACATCGAATCGCTGTGCGAAGTCG
AAGACGAAGGCATCGAAGGCGTGATCTGCGGGCGGGCCATCTACTCGGGCGATCTCGACTTCGCGGCGGCGCAAACCCTC
GCGGACCGGCTGCGCGAATCGGACGACGCTTAA

Upstream 100 bases:

>100_bases
GAAAGAGTTGTACTAAACTAGCGAAACGGCGTCCCGGCGGGCTGAACCCTCAGCCGCTCGCGCCGACCTTCAACCCCTTC
CCAGACAACACCCGATTGCT

Downstream 100 bases:

>100_bases
AACGGGGAGGCGGGGTCGGCAGGCTTGCCGCTCGCGCCTCGTGCGTTCGGCGTCGCGGCGAGCGAATCGCCGGCGTCCGA
GCGGCGCGGCCTGACACCGG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEEPAAMARHWVDRGARRLHLVDLNGAFAGKPKNEDAIRAIIAEVGGEIPVQ
LGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKFEDY
GCESIIYTDIGRDGMLQGINIEATVRLARAVKIPVIASGGLSNLADIESLCEVEDEGIEGVICGRAIYSGDLDFAAAQTL
ADRLRESDDA

Sequences:

>Translated_250_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEEPAAMARHWVDRGARRLHLVDLNGAFAGKPKNEDAIRAIIAEVGGEIPVQ
LGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKFEDY
GCESIIYTDIGRDGMLQGINIEATVRLARAVKIPVIASGGLSNLADIESLCEVEDEGIEGVICGRAIYSGDLDFAAAQTL
ADRLRESDDA
>Mature_250_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEEPAAMARHWVDRGARRLHLVDLNGAFAGKPKNEDAIRAIIAEVGGEIPVQ
LGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKFEDY
GCESIIYTDIGRDGMLQGINIEATVRLARAVKIPVIASGGLSNLADIESLCEVEDEGIEGVICGRAIYSGDLDFAAAQTL
ADRLRESDDA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=31.6872427983539, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=25.3521126760563, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26697; Mature: 26697

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEEPAAMARHWVDRGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNEDAIRAIIAEVGGEIPVQLGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFLQDACT
CCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKFEDYGCESIIYTDIGRDGMLQGIN
HCCCEEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVRLARAVKIPVIASGGLSNLADIESLCEVEDEGIEGVICGRAIYSGDLDFAAAQTL
HHHHEEEEHHEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCEEECCCCCHHHHHHH
ADRLRESDDA
HHHHHHCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEEPAAMARHWVDRGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNEDAIRAIIAEVGGEIPVQLGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFLQDACT
CCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKFEDYGCESIIYTDIGRDGMLQGIN
HCCCEEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVRLARAVKIPVIASGGLSNLADIESLCEVEDEGIEGVICGRAIYSGDLDFAAAQTL
HHHHEEEEHHEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCEEECCCCCHHHHHHH
ADRLRESDDA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA