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The map label for this gene is holA [H]

Identifier: 91785201

GI number: 91785201

Start: 4247695

End: 4248813

Strand: Reverse

Name: holA [H]

Synonym: Bxe_A0578

Alternate gene names: 91785201

Gene position: 4248813-4247695 (Counterclockwise)

Preceding gene: 91785202

Following gene: 91785200

Centisome position: 86.78

GC content: 68.19

Gene sequence:

>1119_bases
ATGCAACTGCGACTTGACGCGCTCGAAGCGCATCTCGCCAAGGGACTCGCCGGACTGTACGTCGTGTACGGCGACGAGCA
CCTGCTCGCGCAGGAAGCGTGCGACCGGATTCGCGCCACCGCGCGCGCGGCCGGCTTCACCGATCGCTCGGTGTTCACCG
TGGAGCGGGGTTTCGACTGGAGTTCGCTGCTGGGCGCGAGCCAGTCGATGTCGCTGTTCGGCGACCGCCAACTGGTCGAG
TTGCGCATTCCGTCGGGCAAGCCCGGCAAGGAAGGCGCGGACGCGCTGAAAGCGCTGGCCGCCGCCGTGAATGACGATGT
GCTCACCATGATCACGCTGCCGCGGCTCGATGCGGCCACGCAAAAGTCGGCGTGGTTCACGGCGTTGTCCGATGCCGGCG
TCGCGTTGAAAATCGATCCGGTCGAGCGTGCGCAGTTGCCCAATTGGGTGGGCCAGCGGCTCGCCGCGCAGGGTCAGCGC
GTGGCTGCCGGTGAAGAAGGGCGGCGCGCGCTGGCCTTCATCGCCGAGCGTGTGGAGGGCAATCTGCTCGCCGCGCATCA
GGAAATCCAGAAGCTCGGGCTGCTGTATCCGGCCGGGTCGCTGAGCTTCGAGCAGGTTCAGGACGCTGTGCTCAACGTCG
CCCGTTACGACGTTTTCAAGCTGAATGAAGCGATGCTGGCCGGCGATGTCGGCCGCCTGTCGCGCATGCTCGACGGCTTG
CGCGGCGAAGGCGAGGCCGCGGTGCTGGTGCTGTGGGCGGTGGTGGAAGAAGTCCGCACGCTGCTGCGCATCAAACGCGG
CGTCGCGGCCGGCAAGCCGCTTGCCATGCTGGTGCGCGAGAACCGCGTGTGGGGTCCGCGCGAACGGTTGATCGGGCCGG
CGTTGTCGCGGGTCAGCGAAGGCACGCTGGAAAAGGCGCTTGCGCTGGCGGCGCGGCTGGATCGGCAGGTGAAGGGTTTG
TCGGGCGGCACGCCGGGCAATCATCGCAACGATCCGCCGCCTGATCCGTGGGATGGCCTGTTCGAATTGGCCATGACGGT
GGCGGCGCCGAAAACGTCGCCCGTGCCACCGCCGCGACCTCGGGCCGGGACTGCTGCACCGGCACGAAGGCCGGCCTGA

Upstream 100 bases:

>100_bases
GCCGGCGATCGTGCCGCGTGCGCCGCTGCCGCCGCCGCCTCTGTGAGCGTCGTGTTTCGTTCAATGTGCCGCACCTGTTC
AACTTCGCCGATCGGTAGCC

Downstream 100 bases:

>100_bases
ACGGCAACGCCAGGCTAGCCGGCACCTTGTGAGGGCGTTTGTGGGTCGGTCTTAAGGCGCTCTTGAGTTGCATCGTGATG
CGCTCCTGTGTCGCAAGCGA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MQLRLDALEAHLAKGLAGLYVVYGDEHLLAQEACDRIRATARAAGFTDRSVFTVERGFDWSSLLGASQSMSLFGDRQLVE
LRIPSGKPGKEGADALKALAAAVNDDVLTMITLPRLDAATQKSAWFTALSDAGVALKIDPVERAQLPNWVGQRLAAQGQR
VAAGEEGRRALAFIAERVEGNLLAAHQEIQKLGLLYPAGSLSFEQVQDAVLNVARYDVFKLNEAMLAGDVGRLSRMLDGL
RGEGEAAVLVLWAVVEEVRTLLRIKRGVAAGKPLAMLVRENRVWGPRERLIGPALSRVSEGTLEKALALAARLDRQVKGL
SGGTPGNHRNDPPPDPWDGLFELAMTVAAPKTSPVPPPRPRAGTAAPARRPA

Sequences:

>Translated_372_residues
MQLRLDALEAHLAKGLAGLYVVYGDEHLLAQEACDRIRATARAAGFTDRSVFTVERGFDWSSLLGASQSMSLFGDRQLVE
LRIPSGKPGKEGADALKALAAAVNDDVLTMITLPRLDAATQKSAWFTALSDAGVALKIDPVERAQLPNWVGQRLAAQGQR
VAAGEEGRRALAFIAERVEGNLLAAHQEIQKLGLLYPAGSLSFEQVQDAVLNVARYDVFKLNEAMLAGDVGRLSRMLDGL
RGEGEAAVLVLWAVVEEVRTLLRIKRGVAAGKPLAMLVRENRVWGPRERLIGPALSRVSEGTLEKALALAARLDRQVKGL
SGGTPGNHRNDPPPDPWDGLFELAMTVAAPKTSPVPPPRPRAGTAAPARRPA
>Mature_372_residues
MQLRLDALEAHLAKGLAGLYVVYGDEHLLAQEACDRIRATARAAGFTDRSVFTVERGFDWSSLLGASQSMSLFGDRQLVE
LRIPSGKPGKEGADALKALAAAVNDDVLTMITLPRLDAATQKSAWFTALSDAGVALKIDPVERAQLPNWVGQRLAAQGQR
VAAGEEGRRALAFIAERVEGNLLAAHQEIQKLGLLYPAGSLSFEQVQDAVLNVARYDVFKLNEAMLAGDVGRLSRMLDGL
RGEGEAAVLVLWAVVEEVRTLLRIKRGVAAGKPLAMLVRENRVWGPRERLIGPALSRVSEGTLEKALALAARLDRQVKGL
SGGTPGNHRNDPPPDPWDGLFELAMTVAAPKTSPVPPPRPRAGTAAPARRPA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=319, Percent_Identity=33.2288401253918, Blast_Score=164, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39911; Mature: 39911

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEAHLAKGLAGLYVVYGDEHLLAQEACDRIRATARAAGFTDRSVFTVERGFDW
CCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
SSLLGASQSMSLFGDRQLVELRIPSGKPGKEGADALKALAAAVNDDVLTMITLPRLDAAT
HHHHCCCCHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
QKSAWFTALSDAGVALKIDPVERAQLPNWVGQRLAAQGQRVAAGEEGRRALAFIAERVEG
HHHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPAGSLSFEQVQDAVLNVARYDVFKLNEAMLAGDVGRLSRMLDGL
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RGEGEAAVLVLWAVVEEVRTLLRIKRGVAAGKPLAMLVRENRVWGPRERLIGPALSRVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
GTLEKALALAARLDRQVKGLSGGTPGNHRNDPPPDPWDGLFELAMTVAAPKTSPVPPPRP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
RAGTAAPARRPA
CCCCCCCCCCCC
>Mature Secondary Structure
MQLRLDALEAHLAKGLAGLYVVYGDEHLLAQEACDRIRATARAAGFTDRSVFTVERGFDW
CCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
SSLLGASQSMSLFGDRQLVELRIPSGKPGKEGADALKALAAAVNDDVLTMITLPRLDAAT
HHHHCCCCHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
QKSAWFTALSDAGVALKIDPVERAQLPNWVGQRLAAQGQRVAAGEEGRRALAFIAERVEG
HHHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPAGSLSFEQVQDAVLNVARYDVFKLNEAMLAGDVGRLSRMLDGL
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RGEGEAAVLVLWAVVEEVRTLLRIKRGVAAGKPLAMLVRENRVWGPRERLIGPALSRVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
GTLEKALALAARLDRQVKGLSGGTPGNHRNDPPPDPWDGLFELAMTVAAPKTSPVPPPRP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
RAGTAAPARRPA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]