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The map label for this gene is proA [H]

Identifier: 91785200

GI number: 91785200

Start: 4246168

End: 4247439

Strand: Reverse

Name: proA [H]

Synonym: Bxe_A0579

Alternate gene names: 91785200

Gene position: 4247439-4246168 (Counterclockwise)

Preceding gene: 91785201

Following gene: 91785199

Centisome position: 86.76

GC content: 65.25

Gene sequence:

>1272_bases
ATGGATATCGACCAGTACATGACCGACCTCGGCCGTCGCGCCCGCCAGGCATCGCGGGCTATGGCGCGGGCGTCGACGGC
GGCGAAGAACGCCGCGCTCGCCGCCGTCGCCGAGGCGATCGAGCGCGACGCCGCCTCGCTGAAAGAAGCGAATGCGCGTG
ACGTGGCCAAGGCTCGCGAGAAAGGCCACGACGCCGCGTTCATCGACCGTTTGACGCTGTCGGACAAAGCGCTGAAGACG
ATGGTGGAAGGTCTGCGGCAAGTCGCCGCGCTGGCCGATCCGATCGGCGAGATCAGCAATCTGAAGTACCGGCCGAGCGG
CATTCAGGTCGGTCAGATGCGCGTGCCGCTCGGCGTGATCGGCATCATCTACGAATCGCGTCCGAACGTGACGATCGACG
CCGCGGCGCTCTGCCTCAAGTCGGGCAACGCCACCATTCTGCGCGGCGGTTCCGAAGCGCTCGAATGCAATACGGCGCTG
GCGAAGCTGATCGGCGAAGGGCTGGAAGCCGCCGGTTTGCCGCAGGACGCCGTGCAGGTGGTGGCCACCTCGGACCGCGC
GGCGGTCGGCAAGCTGATCACCATGACTGAATATGTCGACGTGATCGTGCCGCGCGGCGGCAAGAGCCTGATCGAGCGCC
TGATGAACGAAGCGCGCGTGCCGATGATCAAGCACCTCGACGGCATCTGCCACGTGTACGTGGACGATCGCGCGGATCTG
ACCAAGGCGCTGACGGTCTGCGACAACGCCAAGACGCACCGCTACGGCACCTGCAATACGATGGAAACGCTGCTGGTTGC
GCGCGGCATTGCAGCCGAAGTGCTGCCGCCGTTGGGCAAGCTGTATCGCGACAAGCAAGTTGAACTGCGGGTGGATGCGG
CGGCGCGCGCGGTGCTGGCGGATGCGGGCGTGGGACCGCTCGGCGATGCGACCGAGGAAGACTGGCGCACCGAATATCTC
GCGCCGGTGCTGGCGATCAAGGTGGTGGACGATCTCGATGCGGCGATCGAGCACATCAACGAGTACAGCTCGCAGCACAC
CGACGCGATCGTCACGGAAGACCACGATCGCGCGATGCGCTTCCTGCGCGAAGTGGATTCGGCGAGCGTGATGGTCAACG
CGTCGACGCGTTTTGCCGATGGTTTCGAATTCGGTCTGGGCGCGGAGATCGGCATCTCGAACGACAAGCTGCATGCGCGC
GGGCCGGTGGGACTCGAAGGGCTGACGTCGTTGAAATACGTCGTGCTCGGGCACGGCGAAGGCCGTCAATAA

Upstream 100 bases:

>100_bases
CGACAAGCAAAGCGCCTTCGCCCGACTTACAATCGCTGAATCATTCGCTCATTCTGTCCGTCCGCCGCACCTCGACGTGC
GCGGCACCACGAGAATTTCA

Downstream 100 bases:

>100_bases
GGGCGCCTTCGCGGGCTCGTTCTTCCCCAGGGGCGCGCTGATACGCGCGCTTCTTTTTACGCCAATACGCTGCACAAGGA
TCGCCGATGCTTTGGGTCAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIDQYMTDLGRRARQASRAMARASTAAKNAALAAVAEAIERDAASLKEANARDVAKAREKGHDAAFIDRLTLSDKALKT
MVEGLRQVAALADPIGEISNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTAL
AKLIGEGLEAAGLPQDAVQVVATSDRAAVGKLITMTEYVDVIVPRGGKSLIERLMNEARVPMIKHLDGICHVYVDDRADL
TKALTVCDNAKTHRYGTCNTMETLLVARGIAAEVLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLGDATEEDWRTEYL
APVLAIKVVDDLDAAIEHINEYSSQHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Sequences:

>Translated_423_residues
MDIDQYMTDLGRRARQASRAMARASTAAKNAALAAVAEAIERDAASLKEANARDVAKAREKGHDAAFIDRLTLSDKALKT
MVEGLRQVAALADPIGEISNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTAL
AKLIGEGLEAAGLPQDAVQVVATSDRAAVGKLITMTEYVDVIVPRGGKSLIERLMNEARVPMIKHLDGICHVYVDDRADL
TKALTVCDNAKTHRYGTCNTMETLLVARGIAAEVLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLGDATEEDWRTEYL
APVLAIKVVDDLDAAIEHINEYSSQHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ
>Mature_423_residues
MDIDQYMTDLGRRARQASRAMARASTAAKNAALAAVAEAIERDAASLKEANARDVAKAREKGHDAAFIDRLTLSDKALKT
MVEGLRQVAALADPIGEISNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTAL
AKLIGEGLEAAGLPQDAVQVVATSDRAAVGKLITMTEYVDVIVPRGGKSLIERLMNEARVPMIKHLDGICHVYVDDRADL
TKALTVCDNAKTHRYGTCNTMETLLVARGIAAEVLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLGDATEEDWRTEYL
APVLAIKVVDDLDAAIEHINEYSSQHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=36.8292682926829, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=36.8292682926829, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=45.4987834549878, Blast_Score=355, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=33.8129496402878, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=33.8129496402878, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=37.5576036866359, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21357643, Length=416, Percent_Identity=37.0192307692308, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45304; Mature: 45304

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDQYMTDLGRRARQASRAMARASTAAKNAALAAVAEAIERDAASLKEANARDVAKARE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KGHDAAFIDRLTLSDKALKTMVEGLRQVAALADPIGEISNLKYRPSGIQVGQMRVPLGVI
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTALAKLIGEGLEAAGLPQDAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
VATSDRAAVGKLITMTEYVDVIVPRGGKSLIERLMNEARVPMIKHLDGICHVYVDDRADL
HCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
TKALTVCDNAKTHRYGTCNTMETLLVARGIAAEVLPPLGKLYRDKQVELRVDAAARAVLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
DAGVGPLGDATEEDWRTEYLAPVLAIKVVDDLDAAIEHINEYSSQHTDAIVTEDHDRAMR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEECCC
GRQ
CCC
>Mature Secondary Structure
MDIDQYMTDLGRRARQASRAMARASTAAKNAALAAVAEAIERDAASLKEANARDVAKARE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KGHDAAFIDRLTLSDKALKTMVEGLRQVAALADPIGEISNLKYRPSGIQVGQMRVPLGVI
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALECNTALAKLIGEGLEAAGLPQDAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
VATSDRAAVGKLITMTEYVDVIVPRGGKSLIERLMNEARVPMIKHLDGICHVYVDDRADL
HCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
TKALTVCDNAKTHRYGTCNTMETLLVARGIAAEVLPPLGKLYRDKQVELRVDAAARAVLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
DAGVGPLGDATEEDWRTEYLAPVLAIKVVDDLDAAIEHINEYSSQHTDAIVTEDHDRAMR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEECCC
GRQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA