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The map label for this gene is purK [H]

Identifier: 91785086

GI number: 91785086

Start: 4117640

End: 4118836

Strand: Reverse

Name: purK [H]

Synonym: Bxe_A0694

Alternate gene names: 91785086

Gene position: 4118836-4117640 (Counterclockwise)

Preceding gene: 91785087

Following gene: 91785085

Centisome position: 84.13

GC content: 66.83

Gene sequence:

>1197_bases
ATGAACCCAGACAACAACCCGGTTTCACCGATTCTGCCCGGCGCATGGCTTGGCATGGTCGGTGGCGGCCAGCTCGGCCG
CATGTTCTGCTTTGCCGCTCAGGCTATGGGCTATCGCGTCGCCGTGCTCGATCCCGACGAAAACAGTCCGGCGGGCGCCG
TTGCCGATCGGCATCTGCGCGCGGCGTACAACGACGAAGCGTCGCTCACCGAGCTCGCGCGGCTGTGCGCGGCGGTGTCC
ACGGAGTTCGAGAACGTGCCTGCCGCGAGCCTCGACTTCCTCGCGCGGACCACCTTCGTGAGTCCGGCTGGCCGCTGCGT
CGCCGTGGCGCAGGACCGCATTGCCGAGAAGCGCTTCATTGCGTCATCGGGCGTGACGGTCGCGCCGCATGTGGTGATCG
AATCGTCGGATGCGCTCGCCGCGCTCGACGACGCCAAACTCGAAGCCGTGCTGCCGGGCATTCTCAAGACCGCCCGCATG
GGCTACGACGGCAAAGGCCAGATTCGCGTGCGCAACGCCGAGGAAGTGCGCGAGGCGCATGCTTCGCTCGCCGGAGTGCC
GTGCGTGCTGGAAAAGCGGTTGCCGCTGAAGTTCGAAGTGTCCGCGCTGATTGCGCGGGCAGCGAGCGGCGCCTCGGTGG
TCTATCCGCTCGCGCAGAACACGCATCGCGACGGCGTGCTGTCGCACACCATTGTCCCGGCGCCGGACGCGAGCCCGACG
CTCGTTCAGCAGGCGCAGCAGGCCGCGCTGCAAATCGCCGACAAACTCGGTTACGTGGGCGTGCTGTGCGTCGAGTTTTT
CATTCTTGAAGACGGCTCGCTGGTCGCCAATGAAATGGCGCCGCGTCCGCACAACTCCGGCCATTACACGGTCGACGCCT
GCGCGACCAGCCAGTTCGAGCAGCAGGTGCGCGCCATGACCGGCATGCCGTTGGGCGATACACGTCAGCATTCGCCGGCG
GTGATGCTCAACATTCTCGGCGACGTGTGGTTTCCGGACGGCCCGAAGCGCCCGGCGGTCACGCCGCCCTGGCAGGAGGT
CGCCGCGATGCCGGCGGCGCGTTTGCATCTGTACGGCAAGGAAGAGGCGCGTTGCGGCCGCAAGATGGGCCACGTGAACT
TCACGGCGGCTACGCTCGAAGAAGCCCGCACCGCTGCGCGCGATTGCGCACGGCTTCTGCACATCATCACGAGCTGA

Upstream 100 bases:

>100_bases
AAGCGCACAGACTGATTGCTTCAAGACGTCCCCCTGTCCGACCCCCGGCCGGGTGCCTGCCATCGCATTGCATGCACACC
GGCCGCGACCGACCACTAAG

Downstream 100 bases:

>100_bases
CACGAGAGCCATGCCGGATCAACAGAAAGCCGCCGAAGGCGCATTGCCTGTGAGCGCCGCGCAGATCGAACACGCGGCGG
CGCTGCTGGACGCGGGAGAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNPDNNPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDENSPAGAVADRHLRAAYNDEASLTELARLCAAVS
TEFENVPAASLDFLARTTFVSPAGRCVAVAQDRIAEKRFIASSGVTVAPHVVIESSDALAALDDAKLEAVLPGILKTARM
GYDGKGQIRVRNAEEVREAHASLAGVPCVLEKRLPLKFEVSALIARAASGASVVYPLAQNTHRDGVLSHTIVPAPDASPT
LVQQAQQAALQIADKLGYVGVLCVEFFILEDGSLVANEMAPRPHNSGHYTVDACATSQFEQQVRAMTGMPLGDTRQHSPA
VMLNILGDVWFPDGPKRPAVTPPWQEVAAMPAARLHLYGKEEARCGRKMGHVNFTAATLEEARTAARDCARLLHIITS

Sequences:

>Translated_398_residues
MNPDNNPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDENSPAGAVADRHLRAAYNDEASLTELARLCAAVS
TEFENVPAASLDFLARTTFVSPAGRCVAVAQDRIAEKRFIASSGVTVAPHVVIESSDALAALDDAKLEAVLPGILKTARM
GYDGKGQIRVRNAEEVREAHASLAGVPCVLEKRLPLKFEVSALIARAASGASVVYPLAQNTHRDGVLSHTIVPAPDASPT
LVQQAQQAALQIADKLGYVGVLCVEFFILEDGSLVANEMAPRPHNSGHYTVDACATSQFEQQVRAMTGMPLGDTRQHSPA
VMLNILGDVWFPDGPKRPAVTPPWQEVAAMPAARLHLYGKEEARCGRKMGHVNFTAATLEEARTAARDCARLLHIITS
>Mature_398_residues
MNPDNNPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDENSPAGAVADRHLRAAYNDEASLTELARLCAAVS
TEFENVPAASLDFLARTTFVSPAGRCVAVAQDRIAEKRFIASSGVTVAPHVVIESSDALAALDDAKLEAVLPGILKTARM
GYDGKGQIRVRNAEEVREAHASLAGVPCVLEKRLPLKFEVSALIARAASGASVVYPLAQNTHRDGVLSHTIVPAPDASPT
LVQQAQQAALQIADKLGYVGVLCVEFFILEDGSLVANEMAPRPHNSGHYTVDACATSQFEQQVRAMTGMPLGDTRQHSPA
VMLNILGDVWFPDGPKRPAVTPPWQEVAAMPAARLHLYGKEEARCGRKMGHVNFTAATLEEARTAARDCARLLHIITS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=357, Percent_Identity=33.6134453781513, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788155, Length=383, Percent_Identity=26.3707571801567, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=392, Percent_Identity=32.1428571428571, Blast_Score=206, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006115
- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp; PF03446 NAD_binding_2 [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42401; Mature: 42401

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPDNNPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDENSPAGAVADRHLR
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHH
AAYNDEASLTELARLCAAVSTEFENVPAASLDFLARTTFVSPAGRCVAVAQDRIAEKRFI
HHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHH
ASSGVTVAPHVVIESSDALAALDDAKLEAVLPGILKTARMGYDGKGQIRVRNAEEVREAH
HCCCCEEECEEEEECCCCEEHHCHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHH
ASLAGVPCVLEKRLPLKFEVSALIARAASGASVVYPLAQNTHRDGVLSHTIVPAPDASPT
HHHCCCCHHECCCCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEECCCCCCHH
LVQQAQQAALQIADKLGYVGVLCVEFFILEDGSLVANEMAPRPHNSGHYTVDACATSQFE
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCCEEEEHHHHHHHH
QQVRAMTGMPLGDTRQHSPAVMLNILGDVWFPDGPKRPAVTPPWQEVAAMPAARLHLYGK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHEEECCC
EEARCGRKMGHVNFTAATLEEARTAARDCARLLHIITS
HHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPDNNPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDENSPAGAVADRHLR
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHH
AAYNDEASLTELARLCAAVSTEFENVPAASLDFLARTTFVSPAGRCVAVAQDRIAEKRFI
HHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHH
ASSGVTVAPHVVIESSDALAALDDAKLEAVLPGILKTARMGYDGKGQIRVRNAEEVREAH
HCCCCEEECEEEEECCCCEEHHCHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHH
ASLAGVPCVLEKRLPLKFEVSALIARAASGASVVYPLAQNTHRDGVLSHTIVPAPDASPT
HHHCCCCHHECCCCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEECCCCCCHH
LVQQAQQAALQIADKLGYVGVLCVEFFILEDGSLVANEMAPRPHNSGHYTVDACATSQFE
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCCEEEEHHHHHHHH
QQVRAMTGMPLGDTRQHSPAVMLNILGDVWFPDGPKRPAVTPPWQEVAAMPAARLHLYGK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHEEECCC
EEARCGRKMGHVNFTAATLEEARTAARDCARLLHIITS
HHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]