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The map label for this gene is emrY [H]

Identifier: 91784638

GI number: 91784638

Start: 3628048

End: 3629622

Strand: Reverse

Name: emrY [H]

Synonym: Bxe_A1156

Alternate gene names: 91784638

Gene position: 3629622-3628048 (Counterclockwise)

Preceding gene: 91784639

Following gene: 91784637

Centisome position: 74.14

GC content: 63.87

Gene sequence:

>1575_bases
ATGAGCGCCGCAGCGTCGCAGTCGTCGACGGCGCCGCCGCCCGCGGCAACCGCTGCGGCAGCCCCTCCGAAGCGGGCGAT
TGCGGGACTGGTCGGCATCCTCATCGCGGCCATGATGGCCGGACTGAACAACCGCGTGGGCGCGCTGGCACTGGCCGACG
TGCGTGGCGCGCTGGGCTTCGGCCTGGACGATGCCTCCTGGCTCACCACCGTCTATAGCGCGGGCGAAGTGATCGCCATG
CCATTTTCAGCGTGGTTCGCCGTCACGCTTTCAGTGCGCCGCTTCGAGTTGTGGATGATTGGCACGTGCACTTTGCTGGC
GGTGTGCATCCCCTTCATCCATGACCTCGATCTGCTGCTGGCCATGCGGTTTCTGCAGGGCATCGCCAGCGGCACAATGA
TTCCCGTGCTGATGATGGCGGCGTTGAAGTTTCTGCCGCCCCCCATCCGACTGCACGGACTGGCGCTGTATGCACTGACG
GCCACCTTCTCGCCCAATCTCTCGATCTGGCTGGCGGGGCAATGGACGGATGGCCTGTTCGATTGGCGCTGGGTGTACTG
GCAGATTCTTCCGCTCGCGGCGATTGCCGCCTTGACGATCGGATGGGGCCTGCCCAAAGACCCCATCCAGACAGACCGTT
TCCCGCAGGCCAACTGGCCCGGTATGGCCTTCGGCGCACCGGCATTCGGCCTGATTGCCGTCGCCTTGGATCAGGGCGTT
CGGCTGGACTGGTTCAATTCACCCCTCATCGTCGTCTCGCTGGTGGCCGGGCTGACGCTGCTGGGGGCCTATCTGCTAAC
GGAGTGGTATCACCCCACGCCGTTCATCAAGTTGCAGATGCTCAGCCGCCGCAACCTGGCGCTGGGCTTCACCTTGTTCA
TCTGCCTTCTGGTCGTGCTGACCTCCGGCGTGATGTTGCCAATGACCTTTCTCGGGCCACTGCAGAGCTACCGACCGCTT
CAGATGGCACCGATCGGGCTGATCGTCGCGCTGCCTCAACTCGCCCTGGGTTCCGTGGTGGCGCTGTTCCTGTACCGGAA
ATGGGTCGATGCCCGATTCGTGTTCGCGGGCGGCCTGCTATTGATCGGCCTGGCGTGCTTCCTTGGCGCGCAACTGACTT
CCGACTGGAACCGCGACCAGTTCGTGCTGACGCAGACGCTGCAAGCCTTTGGCCAGCCCATGGCGGTCGTCTCGCTGCTG
TTCCTGGGTACCAGTGTCGTGCACCCCAGCGAAGGCCCGTATGTGTCGGGGAACATCAACACGCTGCGCGCCCTGGGGTC
GCTAATCGGGGGCGCCGTGGTTGGGCAACTTGTGACCGTGAGTCAGCGGGTCCACGCGGAAATGCTGCTGGATCACGCTG
CATTGGTAGGCAACTCCGTTCCGCTTGCCCTGGAGCCCGCTCAACTGATGGGAGTCATCGCCCAGCAGGCACTGGTACTG
TCGGTCGCGGATGCCTATCGCGTCCTGGGCGTCTTGGCGCTGGTGATGGTCCCCTTCGTATTGCGACTGACCTACATTCC
CGCTCCCATTTTGCAGGCCCCCGCTTCGCAATCCACATCGTCGTCCCAAGGATAG

Upstream 100 bases:

>100_bases
GCTGGGACCCCGGCGCATTCTCTTCCGAGCAGCAGACCGGCGGCGACGCGTCGCTGACGACCGCTGTGTCGTCGGCCACC
TCGCAATCGAAGGTTGACCA

Downstream 100 bases:

>100_bases
TTCCGCCATGGCCATGCCGAAAAAAGCCAAGATCACCAGTGCCGTGCTGCTCCTCGCAGTGGCAGTGGGCTGTGTCATTT
ATCTGAATCGCCCCGAATCC

Product: major facilitator superfamily multidrug efflux transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSAAASQSSTAPPPAATAAAAPPKRAIAGLVGILIAAMMAGLNNRVGALALADVRGALGFGLDDASWLTTVYSAGEVIAM
PFSAWFAVTLSVRRFELWMIGTCTLLAVCIPFIHDLDLLLAMRFLQGIASGTMIPVLMMAALKFLPPPIRLHGLALYALT
ATFSPNLSIWLAGQWTDGLFDWRWVYWQILPLAAIAALTIGWGLPKDPIQTDRFPQANWPGMAFGAPAFGLIAVALDQGV
RLDWFNSPLIVVSLVAGLTLLGAYLLTEWYHPTPFIKLQMLSRRNLALGFTLFICLLVVLTSGVMLPMTFLGPLQSYRPL
QMAPIGLIVALPQLALGSVVALFLYRKWVDARFVFAGGLLLIGLACFLGAQLTSDWNRDQFVLTQTLQAFGQPMAVVSLL
FLGTSVVHPSEGPYVSGNINTLRALGSLIGGAVVGQLVTVSQRVHAEMLLDHAALVGNSVPLALEPAQLMGVIAQQALVL
SVADAYRVLGVLALVMVPFVLRLTYIPAPILQAPASQSTSSSQG

Sequences:

>Translated_524_residues
MSAAASQSSTAPPPAATAAAAPPKRAIAGLVGILIAAMMAGLNNRVGALALADVRGALGFGLDDASWLTTVYSAGEVIAM
PFSAWFAVTLSVRRFELWMIGTCTLLAVCIPFIHDLDLLLAMRFLQGIASGTMIPVLMMAALKFLPPPIRLHGLALYALT
ATFSPNLSIWLAGQWTDGLFDWRWVYWQILPLAAIAALTIGWGLPKDPIQTDRFPQANWPGMAFGAPAFGLIAVALDQGV
RLDWFNSPLIVVSLVAGLTLLGAYLLTEWYHPTPFIKLQMLSRRNLALGFTLFICLLVVLTSGVMLPMTFLGPLQSYRPL
QMAPIGLIVALPQLALGSVVALFLYRKWVDARFVFAGGLLLIGLACFLGAQLTSDWNRDQFVLTQTLQAFGQPMAVVSLL
FLGTSVVHPSEGPYVSGNINTLRALGSLIGGAVVGQLVTVSQRVHAEMLLDHAALVGNSVPLALEPAQLMGVIAQQALVL
SVADAYRVLGVLALVMVPFVLRLTYIPAPILQAPASQSTSSSQG
>Mature_523_residues
SAAASQSSTAPPPAATAAAAPPKRAIAGLVGILIAAMMAGLNNRVGALALADVRGALGFGLDDASWLTTVYSAGEVIAMP
FSAWFAVTLSVRRFELWMIGTCTLLAVCIPFIHDLDLLLAMRFLQGIASGTMIPVLMMAALKFLPPPIRLHGLALYALTA
TFSPNLSIWLAGQWTDGLFDWRWVYWQILPLAAIAALTIGWGLPKDPIQTDRFPQANWPGMAFGAPAFGLIAVALDQGVR
LDWFNSPLIVVSLVAGLTLLGAYLLTEWYHPTPFIKLQMLSRRNLALGFTLFICLLVVLTSGVMLPMTFLGPLQSYRPLQ
MAPIGLIVALPQLALGSVVALFLYRKWVDARFVFAGGLLLIGLACFLGAQLTSDWNRDQFVLTQTLQAFGQPMAVVSLLF
LGTSVVHPSEGPYVSGNINTLRALGSLIGGAVVGQLVTVSQRVHAEMLLDHAALVGNSVPLALEPAQLMGVIAQQALVLS
VADAYRVLGVLALVMVPFVLRLTYIPAPILQAPASQSTSSSQG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=477, Percent_Identity=24.3186582809224, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789042, Length=466, Percent_Identity=22.7467811158798, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55834; Mature: 55703

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAASQSSTAPPPAATAAAAPPKRAIAGLVGILIAAMMAGLNNRVGALALADVRGALGF
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCC
GLDDASWLTTVYSAGEVIAMPFSAWFAVTLSVRRFELWMIGTCTLLAVCIPFIHDLDLLL
CCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHH
AMRFLQGIASGTMIPVLMMAALKFLPPPIRLHGLALYALTATFSPNLSIWLAGQWTDGLF
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHEEEEHEEEECCCCEEEEEEECCCCCCH
DWRWVYWQILPLAAIAALTIGWGLPKDPIQTDRFPQANWPGMAFGAPAFGLIAVALDQGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
RLDWFNSPLIVVSLVAGLTLLGAYLLTEWYHPTPFIKLQMLSRRNLALGFTLFICLLVVL
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHH
TSGVMLPMTFLGPLQSYRPLQMAPIGLIVALPQLALGSVVALFLYRKWVDARFVFAGGLL
HCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGLACFLGAQLTSDWNRDQFVLTQTLQAFGQPMAVVSLLFLGTSVVHPSEGPYVSGNIN
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEECCCHH
TLRALGSLIGGAVVGQLVTVSQRVHAEMLLDHAALVGNSVPLALEPAQLMGVIAQQALVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHH
SVADAYRVLGVLALVMVPFVLRLTYIPAPILQAPASQSTSSSQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAAASQSSTAPPPAATAAAAPPKRAIAGLVGILIAAMMAGLNNRVGALALADVRGALGF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCC
GLDDASWLTTVYSAGEVIAMPFSAWFAVTLSVRRFELWMIGTCTLLAVCIPFIHDLDLLL
CCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHH
AMRFLQGIASGTMIPVLMMAALKFLPPPIRLHGLALYALTATFSPNLSIWLAGQWTDGLF
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHEEEEHEEEECCCCEEEEEEECCCCCCH
DWRWVYWQILPLAAIAALTIGWGLPKDPIQTDRFPQANWPGMAFGAPAFGLIAVALDQGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
RLDWFNSPLIVVSLVAGLTLLGAYLLTEWYHPTPFIKLQMLSRRNLALGFTLFICLLVVL
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHH
TSGVMLPMTFLGPLQSYRPLQMAPIGLIVALPQLALGSVVALFLYRKWVDARFVFAGGLL
HCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGLACFLGAQLTSDWNRDQFVLTQTLQAFGQPMAVVSLLFLGTSVVHPSEGPYVSGNIN
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEECCCHH
TLRALGSLIGGAVVGQLVTVSQRVHAEMLLDHAALVGNSVPLALEPAQLMGVIAQQALVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHH
SVADAYRVLGVLALVMVPFVLRLTYIPAPILQAPASQSTSSSQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]