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The map label for this gene is mutM [H]

Identifier: 91781717

GI number: 91781717

Start: 367882

End: 368712

Strand: Direct

Name: mutM [H]

Synonym: Bxe_A4129

Alternate gene names: 91781717

Gene position: 367882-368712 (Clockwise)

Preceding gene: 91781709

Following gene: 91781718

Centisome position: 7.51

GC content: 65.58

Gene sequence:

>831_bases
ATGCCAGAGTTGCCAGAAGTTGAGGTTACCCGACGGGGAATCGAACCGTATGTGTCCGGGCGCAAGGTTGAACGCGTCGA
AGTGCGTACGCCGGCGCTGCGCTGGCCGATTCCGGCCGATCTTGCGAAAACCTTGCGCGGCCGCGTGGTGCGTAAGGTCG
AGCGGCGCGGCAAGTACCTGTTGTTCGAGATCGACGCGGGCTGGTTCATTGTGCATCTTGGCATGACTGGGACGCTGCGG
GTGCTGCGCCACGTACCGCATCCGCCGGCCGCGGCGAAACACGATCACGTCGACTGGATCTTCGACGAGTTCATTTTGCG
CTATCGCGATCCGCGGCGCTTCGGCGCAGTGCTGTGGCATCCGCGTGAAGCCGGCGACGTGCTCGAGCATCCGCTGCTTG
CGGGCCTCGGCGTCGAACCGTTTTCGCCCGCGTTCTCCGGCGCGCTGATGCACCGGCTCACGCGCGGGCGCAAGGTGTCG
GTAAAGCAGGCGCTGCTGGCCGGTGAAATCGTCGTGGGCGTGGGCAATATCTATGCGTCGGAGAGTCTCTTTCGCGCCGG
CATCCGGCCGGCTACCGCGGCGGGGCGCGTCTCGCTCGTGCGCTACGACCTGCTGGCGGACGCCGTGCGCGTGACGCTCG
CCGCCGCGATCGAGAAGGGCGGCAGCACGCTGCGCGATTTCGTCGGCAGCAACGGCGAGAGCGGCTACTTCCAGCTCGAC
TATTTCGTCTATGATCGCGCGGGGCTGCCGTGCCGCGTGTGCGGAACGCCGATCAAACAGATCGTACAGGGGCAGCGTTC
AACGTATTTCTGTCCCACCTGCCAGCGCTAA

Upstream 100 bases:

>100_bases
AGGACAAGTTCATGGAAATCCGTTCAATGTTTCGGACGATTGTAACGCGCTCGCTACAATACGCGCACAACCACTCACGC
AAGTTGCAGACCAGTTAGAC

Downstream 100 bases:

>100_bases
ACCGTCCATGCCTTCTCGCTTAACTCCGCGTTCTACCTCGTCCGGCGCGCCTGCGGCGCCTGCTTTTCCTGTCATGTCCG
ATTTTTCCGCGCGCCTGATC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MPELPEVEVTRRGIEPYVSGRKVERVEVRTPALRWPIPADLAKTLRGRVVRKVERRGKYLLFEIDAGWFIVHLGMTGTLR
VLRHVPHPPAAAKHDHVDWIFDEFILRYRDPRRFGAVLWHPREAGDVLEHPLLAGLGVEPFSPAFSGALMHRLTRGRKVS
VKQALLAGEIVVGVGNIYASESLFRAGIRPATAAGRVSLVRYDLLADAVRVTLAAAIEKGGSTLRDFVGSNGESGYFQLD
YFVYDRAGLPCRVCGTPIKQIVQGQRSTYFCPTCQR

Sequences:

>Translated_276_residues
MPELPEVEVTRRGIEPYVSGRKVERVEVRTPALRWPIPADLAKTLRGRVVRKVERRGKYLLFEIDAGWFIVHLGMTGTLR
VLRHVPHPPAAAKHDHVDWIFDEFILRYRDPRRFGAVLWHPREAGDVLEHPLLAGLGVEPFSPAFSGALMHRLTRGRKVS
VKQALLAGEIVVGVGNIYASESLFRAGIRPATAAGRVSLVRYDLLADAVRVTLAAAIEKGGSTLRDFVGSNGESGYFQLD
YFVYDRAGLPCRVCGTPIKQIVQGQRSTYFCPTCQR
>Mature_275_residues
PELPEVEVTRRGIEPYVSGRKVERVEVRTPALRWPIPADLAKTLRGRVVRKVERRGKYLLFEIDAGWFIVHLGMTGTLRV
LRHVPHPPAAAKHDHVDWIFDEFILRYRDPRRFGAVLWHPREAGDVLEHPLLAGLGVEPFSPAFSGALMHRLTRGRKVSV
KQALLAGEIVVGVGNIYASESLFRAGIRPATAAGRVSLVRYDLLADAVRVTLAAAIEKGGSTLRDFVGSNGESGYFQLDY
FVYDRAGLPCRVCGTPIKQIVQGQRSTYFCPTCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=277, Percent_Identity=47.6534296028881, Blast_Score=254, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30808; Mature: 30677

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRRGIEPYVSGRKVERVEVRTPALRWPIPADLAKTLRGRVVRKVERRGKYL
CCCCCCCHHHHCCCCHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
LFEIDAGWFIVHLGMTGTLRVLRHVPHPPAAAKHDHVDWIFDEFILRYRDPRRFGAVLWH
EEEECCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHCCEEEC
PREAGDVLEHPLLAGLGVEPFSPAFSGALMHRLTRGRKVSVKQALLAGEIVVGVGNIYAS
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCHHHH
ESLFRAGIRPATAAGRVSLVRYDLLADAVRVTLAAAIEKGGSTLRDFVGSNGESGYFQLD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEE
YFVYDRAGLPCRVCGTPIKQIVQGQRSTYFCPTCQR
EEEEECCCCCEECCCCHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVEVTRRGIEPYVSGRKVERVEVRTPALRWPIPADLAKTLRGRVVRKVERRGKYL
CCCCCCHHHHCCCCHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
LFEIDAGWFIVHLGMTGTLRVLRHVPHPPAAAKHDHVDWIFDEFILRYRDPRRFGAVLWH
EEEECCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHCCEEEC
PREAGDVLEHPLLAGLGVEPFSPAFSGALMHRLTRGRKVSVKQALLAGEIVVGVGNIYAS
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCHHHH
ESLFRAGIRPATAAGRVSLVRYDLLADAVRVTLAAAIEKGGSTLRDFVGSNGESGYFQLD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEE
YFVYDRAGLPCRVCGTPIKQIVQGQRSTYFCPTCQR
EEEEECCCCCEECCCCHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA