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The map label for this gene is mutY [H]

Identifier: 91781718

GI number: 91781718

Start: 368720

End: 369847

Strand: Direct

Name: mutY [H]

Synonym: Bxe_A4128

Alternate gene names: 91781718

Gene position: 368720-369847 (Clockwise)

Preceding gene: 91781717

Following gene: 91781730

Centisome position: 7.53

GC content: 66.58

Gene sequence:

>1128_bases
ATGCCTTCTCGCTTAACTCCGCGTTCTACCTCGTCCGGCGCGCCTGCGGCGCCTGCTTTTCCTGTCATGTCCGATTTTTC
CGCGCGCCTGATCGCGTGGCAGCGTCAGCATGGCCGGCATGATTTGCCGTGGCAGAACACGCGCGACCCGTATCGCATCT
GGCTGTCGGAAATCATGCTCCAGCAGACCCAGGTGTCGACGGTGATTCCGTATTACGCGAAGTTCCTCGCGCGTTTCCCG
AGCGTCGCCGCGCTCGCCGCCGCGCCGTCCGACGACGTAATGGCGCTGTGGGCCGGTCTTGGCTACTACACGCGCGCGCG
CAACCTGCATCGCTGCGCGCAGGTCGTGGTCGAGCAGCATGGCGGCGGGTTTCCGACGTCGGTCGAGGAACTGGCCGAAC
TGCCGGGTATCGGCCGTTCGACGGCGGCGGCGATTGCGTCGTTCGCGTTCGGCGCGCGCGCGACGATTCTCGACGGCAAT
GTGAAGCGCGTGCTGGCGCGCGTGTTCGGCGTCGAAGGTTTCCCCGGCGAAAAGAAAGTCGAAAACGCGATGTGGACGCT
GGCGGAGTCGCTGCTTCCGTCGAATGCATCGGATGCCGAAGTCAGCGCATACACGCAAGGCTTGATGGACCTCGGCGCGA
CCCTGTGCGTGCGCGGCAAGCCCGACTGCCTGCGTTGCCCGTTCGCCGTCGACTGCGTGGCGAACGTGACGGGACGTCAG
CGCCTGCTGCCCACTGCACGTCCGAAAAAGACCGTGCCGACGCGCCGCACGTGGATGCTGGTGCTGCGTGACGGCAACGC
GGTGATGCTGGAGAAGCGGCCGCCGTCGGGTATCTGGGGCGGCTTGTGGAGCCTGCCCGAAGCCGCCGACGAAACCGCGC
TCGCCGAGCGTGCGCGCGCCTTCGGCGGCGACGGTGCGGTCTCGCCGCTCGCGCCGCTCACACATGTGTTCACGCATTTC
AAACTGGATATCGAGCCGCGGCTCGCGGAACTGGATCGCGGTGTGGGCGCGTTGGCCGCGTTAGGCGATGCGGACACGGC
GTGGGTCGCGCTCAGCGATCTCGATTCGTTCGGTGTGCCCGCGCCGGTGCGCAAACTGCTGGACAGTTTGCAGGGTTCGC
TGATCTGA

Upstream 100 bases:

>100_bases
GCGGGGCTGCCGTGCCGCGTGTGCGGAACGCCGATCAAACAGATCGTACAGGGGCAGCGTTCAACGTATTTCTGTCCCAC
CTGCCAGCGCTAAACCGTCC

Downstream 100 bases:

>100_bases
GCAATCCGGCGCGGAGTACGGCGGCCGCCGTCAGAGCAATTGATGTTGCTGCATGTAGTGGTGAACCACATCGATCCGCG
CGCCGGCGTCCTGCAACTCC

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MPSRLTPRSTSSGAPAAPAFPVMSDFSARLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVIPYYAKFLARFP
SVAALAAAPSDDVMALWAGLGYYTRARNLHRCAQVVVEQHGGGFPTSVEELAELPGIGRSTAAAIASFAFGARATILDGN
VKRVLARVFGVEGFPGEKKVENAMWTLAESLLPSNASDAEVSAYTQGLMDLGATLCVRGKPDCLRCPFAVDCVANVTGRQ
RLLPTARPKKTVPTRRTWMLVLRDGNAVMLEKRPPSGIWGGLWSLPEAADETALAERARAFGGDGAVSPLAPLTHVFTHF
KLDIEPRLAELDRGVGALAALGDADTAWVALSDLDSFGVPAPVRKLLDSLQGSLI

Sequences:

>Translated_375_residues
MPSRLTPRSTSSGAPAAPAFPVMSDFSARLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVIPYYAKFLARFP
SVAALAAAPSDDVMALWAGLGYYTRARNLHRCAQVVVEQHGGGFPTSVEELAELPGIGRSTAAAIASFAFGARATILDGN
VKRVLARVFGVEGFPGEKKVENAMWTLAESLLPSNASDAEVSAYTQGLMDLGATLCVRGKPDCLRCPFAVDCVANVTGRQ
RLLPTARPKKTVPTRRTWMLVLRDGNAVMLEKRPPSGIWGGLWSLPEAADETALAERARAFGGDGAVSPLAPLTHVFTHF
KLDIEPRLAELDRGVGALAALGDADTAWVALSDLDSFGVPAPVRKLLDSLQGSLI
>Mature_374_residues
PSRLTPRSTSSGAPAAPAFPVMSDFSARLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVIPYYAKFLARFPS
VAALAAAPSDDVMALWAGLGYYTRARNLHRCAQVVVEQHGGGFPTSVEELAELPGIGRSTAAAIASFAFGARATILDGNV
KRVLARVFGVEGFPGEKKVENAMWTLAESLLPSNASDAEVSAYTQGLMDLGATLCVRGKPDCLRCPFAVDCVANVTGRQR
LLPTARPKKTVPTRRTWMLVLRDGNAVMLEKRPPSGIWGGLWSLPEAADETALAERARAFGGDGAVSPLAPLTHVFTHFK
LDIEPRLAELDRGVGALAALGDADTAWVALSDLDSFGVPAPVRKLLDSLQGSLI

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=422, Percent_Identity=30.8056872037915, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI190358497, Length=422, Percent_Identity=30.8056872037915, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI115298654, Length=422, Percent_Identity=30.8056872037915, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI115298652, Length=422, Percent_Identity=30.8056872037915, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI115298650, Length=422, Percent_Identity=30.8056872037915, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI115298648, Length=422, Percent_Identity=30.8056872037915, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1789331, Length=350, Percent_Identity=46.8571428571429, Blast_Score=337, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40412; Mature: 40281

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRLTPRSTSSGAPAAPAFPVMSDFSARLIAWQRQHGRHDLPWQNTRDPYRIWLSEIML
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QQTQVSTVIPYYAKFLARFPSVAALAAAPSDDVMALWAGLGYYTRARNLHRCAQVVVEQH
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGGFPTSVEELAELPGIGRSTAAAIASFAFGARATILDGNVKRVLARVFGVEGFPGEKKV
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCCHHHH
ENAMWTLAESLLPSNASDAEVSAYTQGLMDLGATLCVRGKPDCLRCPFAVDCVANVTGRQ
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHEEECCCCCCEECCHHHHHHHCCCCCH
RLLPTARPKKTVPTRRTWMLVLRDGNAVMLEKRPPSGIWGGLWSLPEAADETALAERARA
HCCCCCCCCCCCCCCEEEEEEEECCCEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHH
FGGDGAVSPLAPLTHVFTHFKLDIEPRLAELDRGVGALAALGDADTAWVALSDLDSFGVP
CCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCCC
APVRKLLDSLQGSLI
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSRLTPRSTSSGAPAAPAFPVMSDFSARLIAWQRQHGRHDLPWQNTRDPYRIWLSEIML
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QQTQVSTVIPYYAKFLARFPSVAALAAAPSDDVMALWAGLGYYTRARNLHRCAQVVVEQH
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGGFPTSVEELAELPGIGRSTAAAIASFAFGARATILDGNVKRVLARVFGVEGFPGEKKV
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCCHHHH
ENAMWTLAESLLPSNASDAEVSAYTQGLMDLGATLCVRGKPDCLRCPFAVDCVANVTGRQ
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHEEECCCCCCEECCHHHHHHHCCCCCH
RLLPTARPKKTVPTRRTWMLVLRDGNAVMLEKRPPSGIWGGLWSLPEAADETALAERARA
HCCCCCCCCCCCCCCEEEEEEEECCCEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHH
FGGDGAVSPLAPLTHVFTHFKLDIEPRLAELDRGVGALAALGDADTAWVALSDLDSFGVP
CCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCCC
APVRKLLDSLQGSLI
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]