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The map label for this gene is bioF [H]

Identifier: 91781582

GI number: 91781582

Start: 230775

End: 231959

Strand: Reverse

Name: bioF [H]

Synonym: Bxe_A4264

Alternate gene names: 91781582

Gene position: 231959-230775 (Counterclockwise)

Preceding gene: 91781583

Following gene: 91781581

Centisome position: 4.74

GC content: 68.35

Gene sequence:

>1185_bases
ATGCATCTGCTCGACACACTCGCCGAAGGGCTGAAGGAGATTGACGCGCGCGGCCTGCGCCGTCGCCGCCGCACCGCCGA
CACGCCGTGCGCGGCCCACATGACCGTCGACGGCCGCGCGATCATCGGCTTCGCCAGCAACGACTATCTCGGCCTCGCCG
CGCATCCGCAACTGATCGCGGCCATCGCTGAAGGCGCGCAGCGCTATGGCGCGGGCAGCGGCGGCTCGCATCTGCTCGGC
GGCCACTCGCGCGCGCATGCGCAACTCGAAGACGATCTCGCCGAATTCGTCGGCGGCTTCGTCGAGAATGCGCGCGCGCT
CTACTTCAGCACGGGCTACATGGCGAATCTCGCCACGCTCACCGCGCTCGCGGGCCGCGGCACGACGCTCTTCTCCGACG
CGCTGAATCACGCGTCGCTGATCGACGGCGCGCGTTTGTCCCGCGCCGACGTGCAGATCTACCCGCACTGCGATACCGAC
GCGCTGAGCGCGATGCTCGAAGCCTCGGACGCCGACGTCAAGGTGATCGTCTCCGACACCGTCTTCAGCATGGACGGCGA
TATCGCGCCGCTCCCACGTCTGCTCGAACTCGCGGAACAACACGGCGCCTGGCTGATCGTCGACGACGCGCACGGTTTCG
GCGTGCTCGGCCCGCAAGGCCGCGGCGCGATCGCGCAAGCCGCGCTGCGTTCGCCGAATCTCATTTCGATCGGCACGCTC
GGCAAAGCGGCAGGCGTCTCCGGCGCGTTCGTCGCGGCGCATGAGACGGTGATCGAATGGCTCGTGCAGCGCGCTCGCCC
GTACATTTTCACCACGGCGTCGGTGCCGGCTGCGGCACATGCGGTGTCGGCGAGTCTGCGCATCATCGGCGGCGAGGAAG
GCGATGCGCGGCGCGCGCATCTTCAGCAATTGATCGGGCGCACGCGCGCCATGCTCAAGGCAACGCCGTGGCTACCGGTC
GATTCGCATACGGCCGTGCAGCCGCTCATCATCGGCGCGAACGACGCCACACTCGAGATCGCGGCCACGCTCGATCGCGC
GGGCCTGTGGGTGCCGGCGATCCGTCCGCCCACCGTGCCCACCGGCACGTCGCGTTTGCGCATTTCGTTATCGGCCGCGC
ACTCGCAGGCGGATCTGGATCGTCTTGAAGCAGGCTTGCAGCAACTCGGAGCGAAAGCGGCATGA

Upstream 100 bases:

>100_bases
TGTATCTGATGCCGCCTTATATCCTCGACGACGAAGAACTCGCGCTGCTCGCCTCGCGCACGCGCGAGACCTTCGACGCC
ACGCTCGCGGAGACCCGCTA

Downstream 100 bases:

>100_bases
GTAGCACGAGTCAAAACGCACTGTCCTTATTCATCACCGGCACCGATACGGAAATCGGCAAGACGTTCGTCTCAGCGGCG
CTGTTGCGCGGCTTCGTCCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MHLLDTLAEGLKEIDARGLRRRRRTADTPCAAHMTVDGRAIIGFASNDYLGLAAHPQLIAAIAEGAQRYGAGSGGSHLLG
GHSRAHAQLEDDLAEFVGGFVENARALYFSTGYMANLATLTALAGRGTTLFSDALNHASLIDGARLSRADVQIYPHCDTD
ALSAMLEASDADVKVIVSDTVFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTL
GKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLIGRTRAMLKATPWLPV
DSHTAVQPLIIGANDATLEIAATLDRAGLWVPAIRPPTVPTGTSRLRISLSAAHSQADLDRLEAGLQQLGAKAA

Sequences:

>Translated_394_residues
MHLLDTLAEGLKEIDARGLRRRRRTADTPCAAHMTVDGRAIIGFASNDYLGLAAHPQLIAAIAEGAQRYGAGSGGSHLLG
GHSRAHAQLEDDLAEFVGGFVENARALYFSTGYMANLATLTALAGRGTTLFSDALNHASLIDGARLSRADVQIYPHCDTD
ALSAMLEASDADVKVIVSDTVFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTL
GKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLIGRTRAMLKATPWLPV
DSHTAVQPLIIGANDATLEIAATLDRAGLWVPAIRPPTVPTGTSRLRISLSAAHSQADLDRLEAGLQQLGAKAA
>Mature_394_residues
MHLLDTLAEGLKEIDARGLRRRRRTADTPCAAHMTVDGRAIIGFASNDYLGLAAHPQLIAAIAEGAQRYGAGSGGSHLLG
GHSRAHAQLEDDLAEFVGGFVENARALYFSTGYMANLATLTALAGRGTTLFSDALNHASLIDGARLSRADVQIYPHCDTD
ALSAMLEASDADVKVIVSDTVFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTL
GKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLIGRTRAMLKATPWLPV
DSHTAVQPLIIGANDATLEIAATLDRAGLWVPAIRPPTVPTGTSRLRISLSAAHSQADLDRLEAGLQQLGAKAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=382, Percent_Identity=36.1256544502618, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI83977440, Length=382, Percent_Identity=36.1256544502618, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI83977442, Length=382, Percent_Identity=36.1256544502618, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=32.03125, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI284448556, Length=363, Percent_Identity=32.2314049586777, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=34.1040462427746, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=34.1040462427746, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4758668, Length=361, Percent_Identity=29.9168975069252, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI119220554, Length=372, Percent_Identity=28.7634408602151, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI5454084, Length=305, Percent_Identity=26.8852459016393, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=45.2722063037249, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=35.264483627204, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71994529, Length=359, Percent_Identity=34.2618384401114, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=390, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=26.3586956521739, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=26.3586956521739, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=318, Percent_Identity=22.9559748427673, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982617, Length=318, Percent_Identity=22.9559748427673, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=387, Percent_Identity=30.2325581395349, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320267, Length=375, Percent_Identity=28.2666666666667, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=302, Percent_Identity=27.8145695364238, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=32.9896907216495, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI17137420, Length=356, Percent_Identity=32.8651685393258, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=27.2486772486773, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653280, Length=329, Percent_Identity=24.6200607902736, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653276, Length=329, Percent_Identity=24.6200607902736, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653278, Length=329, Percent_Identity=24.6200607902736, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41282; Mature: 41282

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLDTLAEGLKEIDARGLRRRRRTADTPCAAHMTVDGRAIIGFASNDYLGLAAHPQLIA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEECCCCEEEECCCHHHHH
AIAEGAQRYGAGSGGSHLLGGHSRAHAQLEDDLAEFVGGFVENARALYFSTGYMANLATL
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHH
TALAGRGTTLFSDALNHASLIDGARLSRADVQIYPHCDTDALSAMLEASDADVKVIVSDT
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEECE
VFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTL
EEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAH
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCEEEEEECCCCCHHHHH
LQQLIGRTRAMLKATPWLPVDSHTAVQPLIIGANDATLEIAATLDRAGLWVPAIRPPTVP
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEECCCCCCCCC
TGTSRLRISLSAAHSQADLDRLEAGLQQLGAKAA
CCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHLLDTLAEGLKEIDARGLRRRRRTADTPCAAHMTVDGRAIIGFASNDYLGLAAHPQLIA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEECCCCEEEECCCHHHHH
AIAEGAQRYGAGSGGSHLLGGHSRAHAQLEDDLAEFVGGFVENARALYFSTGYMANLATL
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHH
TALAGRGTTLFSDALNHASLIDGARLSRADVQIYPHCDTDALSAMLEASDADVKVIVSDT
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEECE
VFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTL
EEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAH
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCEEEEEECCCCCHHHHH
LQQLIGRTRAMLKATPWLPVDSHTAVQPLIIGANDATLEIAATLDRAGLWVPAIRPPTVP
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEECCCCCCCCC
TGTSRLRISLSAAHSQADLDRLEAGLQQLGAKAA
CCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA