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The map label for this gene is bioA [H]

Identifier: 91781583

GI number: 91781583

Start: 231959

End: 233317

Strand: Reverse

Name: bioA [H]

Synonym: Bxe_A4263

Alternate gene names: 91781583

Gene position: 233317-231959 (Counterclockwise)

Preceding gene: 91781586

Following gene: 91781582

Centisome position: 4.77

GC content: 64.61

Gene sequence:

>1359_bases
TTGGAAAAATCAGCGCCACCACCCGCCCCCGAAGACTGGATCGCCCGCAGCCTGCGCGCCGTCTGGCACCCCTGCACCCA
GATGAAGCACCACGAACGCCTGCCGCTCGTCCCCGTCGCGCGCGGTCAAGGCGCGTGGCTCTACGACCGCGCCGGCCATC
GCTATCTGGATGCGATCAGCTCCTGGTGGGTCAACCTGTTCGGTCACGCCAATCCGCGCATCAACGCGGCACTGAAAGAC
CAGCTCGACACGCTCGAACACGCCATGCTCGCCGGCTGCACGCACGAACCGGCCATCGAACTCGCGGAGCGCCTCAGCGC
GCTCACCGGCAACACGCTCGGCCACGCATTCTTCGCATCGGATGGCGCGTCCGCCGTCGAAATCGCCCTGAAAATGAGCT
TCCACTCGTGGCGCAATCGCGGTTTCGCCGACAAGCAGGAATTCGTCTGCATCGCCAACAGTTACCACGGCGAAACCATC
GGCGCGCTCGGCGTCACGGATGTCGCACTCTTCAAAGACGCCTACGACCCGTTGATCCGCCACGCGCACGTCGTAGCGTC
TCCAGACGCCCGCCTCGCGCAAGCCGGCGAAACCGCCGCCGATGTCGCTCGCCGCGCGCTCGATCACGTCCGCTCGCTTT
TCGAAGCACGCGCCACGAAAATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCAGCCGGCATGGCCATGCACGAC
GCGTCGTATATCGCCGGACTACGCACGTTGTGCGATCAGTACGGCGTACATCTGATCGCCGATGAAATCGCCGTGGGCTG
CGGCCGCACCGGCACTTTCTTCGCGTGCGAACAGGCCGGTATCTGGCCGGACTTCATCTGTCTGTCGAAAGGCATCAGCG
GCGGCTATCTGCCGCTCTCGATCGTGCTGTCGCGCGACGAAATTTTCGAAGCCTTCTATCACGACGACACCGCGCGCGGC
TTCCTGCACTCGCACTCGTACACGGGCAATCCGCTCGCCTGTCGCGCGGCGCTCGCCACGCTCGATCTGTTCGCAGCCGA
CAACGTGATCGCCGTCAACGCACAAAAATCCGCGAAGCTGAAAGCCGCGCTCGCACCGCTCGCCGAACACGAACAAGTCC
GCAATCTGCGTCAGTGCGGCACGATCTTCGCGTTCGACGCCCTGATCGACGATGCTCAGCAGGCCAGAACATTCTCGCGC
CGCTTCTTCGAAAACGCGCTGCGGCGCGAACTGCTGCTGCGCCCAATCGGCACGACGGTGTATCTGATGCCGCCTTATAT
CCTCGACGACGAAGAACTCGCGCTGCTCGCCTCGCGCACGCGCGAGACCTTCGACGCCACGCTCGCGGAGACCCGCTAA

Upstream 100 bases:

>100_bases
GCCCGCGCGCAGCGCAAAAAAAGACGCGCAGCACGCCCCAAAATGGCCCCCAAAAAGCCACGCCCGCGCAGCGGCAAAAA
AAGCCCCCTGGAGCACCCCT

Downstream 100 bases:

>100_bases
TGCATCTGCTCGACACACTCGCCGAAGGGCTGAAGGAGATTGACGCGCGCGGCCTGCGCCGTCGCCGCCGCACCGCCGAC
ACGCCGTGCGCGGCCCACAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MEKSAPPPAPEDWIARSLRAVWHPCTQMKHHERLPLVPVARGQGAWLYDRAGHRYLDAISSWWVNLFGHANPRINAALKD
QLDTLEHAMLAGCTHEPAIELAERLSALTGNTLGHAFFASDGASAVEIALKMSFHSWRNRGFADKQEFVCIANSYHGETI
GALGVTDVALFKDAYDPLIRHAHVVASPDARLAQAGETAADVARRALDHVRSLFEARATKIAALIVEPLVQCAAGMAMHD
ASYIAGLRTLCDQYGVHLIADEIAVGCGRTGTFFACEQAGIWPDFICLSKGISGGYLPLSIVLSRDEIFEAFYHDDTARG
FLHSHSYTGNPLACRAALATLDLFAADNVIAVNAQKSAKLKAALAPLAEHEQVRNLRQCGTIFAFDALIDDAQQARTFSR
RFFENALRRELLLRPIGTTVYLMPPYILDDEELALLASRTRETFDATLAETR

Sequences:

>Translated_452_residues
MEKSAPPPAPEDWIARSLRAVWHPCTQMKHHERLPLVPVARGQGAWLYDRAGHRYLDAISSWWVNLFGHANPRINAALKD
QLDTLEHAMLAGCTHEPAIELAERLSALTGNTLGHAFFASDGASAVEIALKMSFHSWRNRGFADKQEFVCIANSYHGETI
GALGVTDVALFKDAYDPLIRHAHVVASPDARLAQAGETAADVARRALDHVRSLFEARATKIAALIVEPLVQCAAGMAMHD
ASYIAGLRTLCDQYGVHLIADEIAVGCGRTGTFFACEQAGIWPDFICLSKGISGGYLPLSIVLSRDEIFEAFYHDDTARG
FLHSHSYTGNPLACRAALATLDLFAADNVIAVNAQKSAKLKAALAPLAEHEQVRNLRQCGTIFAFDALIDDAQQARTFSR
RFFENALRRELLLRPIGTTVYLMPPYILDDEELALLASRTRETFDATLAETR
>Mature_452_residues
MEKSAPPPAPEDWIARSLRAVWHPCTQMKHHERLPLVPVARGQGAWLYDRAGHRYLDAISSWWVNLFGHANPRINAALKD
QLDTLEHAMLAGCTHEPAIELAERLSALTGNTLGHAFFASDGASAVEIALKMSFHSWRNRGFADKQEFVCIANSYHGETI
GALGVTDVALFKDAYDPLIRHAHVVASPDARLAQAGETAADVARRALDHVRSLFEARATKIAALIVEPLVQCAAGMAMHD
ASYIAGLRTLCDQYGVHLIADEIAVGCGRTGTFFACEQAGIWPDFICLSKGISGGYLPLSIVLSRDEIFEAFYHDDTARG
FLHSHSYTGNPLACRAALATLDLFAADNVIAVNAQKSAKLKAALAPLAEHEQVRNLRQCGTIFAFDALIDDAQQARTFSR
RFFENALRRELLLRPIGTTVYLMPPYILDDEELALLASRTRETFDATLAETR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=435, Percent_Identity=28.5057471264368, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=25.4807692307692, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=25.4807692307692, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI13994255, Length=381, Percent_Identity=25.7217847769029, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=25.1295336787565, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI284507298, Length=316, Percent_Identity=28.4810126582279, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24119277, Length=364, Percent_Identity=25.5494505494505, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786991, Length=441, Percent_Identity=36.734693877551, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI145693181, Length=405, Percent_Identity=29.6296296296296, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=28.743961352657, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789759, Length=315, Percent_Identity=28.8888888888889, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=27, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1787560, Length=426, Percent_Identity=27.6995305164319, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786349, Length=398, Percent_Identity=24.8743718592965, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=25.4237288135593, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=369, Percent_Identity=26.8292682926829, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=422, Percent_Identity=24.1706161137441, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=217, Percent_Identity=29.4930875576037, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324386, Length=448, Percent_Identity=28.125, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=371, Percent_Identity=26.9541778975741, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=27.8301886792453, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357415, Length=425, Percent_Identity=26.3529411764706, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI21356575, Length=432, Percent_Identity=24.7685185185185, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI161085790, Length=379, Percent_Identity=26.9129287598945, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574759, Length=379, Percent_Identity=26.9129287598945, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49629; Mature: 49629

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSAPPPAPEDWIARSLRAVWHPCTQMKHHERLPLVPVARGQGAWLYDRAGHRYLDAIS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCHHHHHHHH
SWWVNLFGHANPRINAALKDQLDTLEHAMLAGCTHEPAIELAERLSALTGNTLGHAFFAS
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHEECC
DGASAVEIALKMSFHSWRNRGFADKQEFVCIANSYHGETIGALGVTDVALFKDAYDPLIR
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHH
HAHVVASPDARLAQAGETAADVARRALDHVRSLFEARATKIAALIVEPLVQCAAGMAMHD
HHHEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ASYIAGLRTLCDQYGVHLIADEIAVGCGRTGTFFACEQAGIWPDFICLSKGISGGYLPLS
HHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCEEEE
IVLSRDEIFEAFYHDDTARGFLHSHSYTGNPLACRAALATLDLFAADNVIAVNAQKSAKL
EEECHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHH
KAALAPLAEHEQVRNLRQCGTIFAFDALIDDAQQARTFSRRFFENALRRELLLRPIGTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YLMPPYILDDEELALLASRTRETFDATLAETR
EEECCEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKSAPPPAPEDWIARSLRAVWHPCTQMKHHERLPLVPVARGQGAWLYDRAGHRYLDAIS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCHHHHHHHH
SWWVNLFGHANPRINAALKDQLDTLEHAMLAGCTHEPAIELAERLSALTGNTLGHAFFAS
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHEECC
DGASAVEIALKMSFHSWRNRGFADKQEFVCIANSYHGETIGALGVTDVALFKDAYDPLIR
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHH
HAHVVASPDARLAQAGETAADVARRALDHVRSLFEARATKIAALIVEPLVQCAAGMAMHD
HHHEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ASYIAGLRTLCDQYGVHLIADEIAVGCGRTGTFFACEQAGIWPDFICLSKGISGGYLPLS
HHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCEEEE
IVLSRDEIFEAFYHDDTARGFLHSHSYTGNPLACRAALATLDLFAADNVIAVNAQKSAKL
EEECHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHH
KAALAPLAEHEQVRNLRQCGTIFAFDALIDDAQQARTFSRRFFENALRRELLLRPIGTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YLMPPYILDDEELALLASRTRETFDATLAETR
EEECCEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]