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The map label for this gene is mutM

Identifier: 89056701

GI number: 89056701

Start: 4315345

End: 4316196

Strand: Direct

Name: mutM

Synonym: Jann_4210

Alternate gene names: 89056701

Gene position: 4315345-4316196 (Clockwise)

Preceding gene: 89056698

Following gene: 89056702

Centisome position: 99.94

GC content: 60.68

Gene sequence:

>852_bases
TTGCCCGAACTTCCAGAGGTAGAGACAGTGCGTCGCGGCCTGGCCCCGGTGTTGGAAGGGGCGCGGATCGCCCAAGCGGC
GGTGAACCGCCCCGATCTGCGCTGGCCGTTTCCGGACAACATGGCGCAGCGGCTGACTGGGGCGACGGTCACTGCCCTGC
GGCGTCGGTCAAAATACATCCTTGCCGATCTTGATACCGGGGAGACGTTGCTGATCCATCTGGGGATGTCCGGGCGCATG
CAGATCTCGGGCGATGTCATCGGCAGTTTTCACCACACTCATCCGGCAGCAGCGAAGCACGACCACGTTGTTCTTGATAC
CGACGCCGGCGCGCGGATCACCTTCAACGACGCACGCCGGTTCGGCGCGATGGACCTGATGGACACCGCCACGCAGGATC
AGCACTGGCTGCTCCGCGACCTGGGGCCGGAACCTTTGGGCAATGCGTTTAATGAAGCGCATCTGGTTGCTGCGTTCAAA
GGCAAGCGGTCACCGGTCAAAACAGCGCTGCTCGATCAACGCATCGTCTCGGGCCTTGGCAACATATATGTGTGTGAGGC
GCTATGGCGGGCCGGGATCAGTCCCCTGAGACAAGCGGGAAAGATCGCGGCGGTCCGAGTCGCCACCCTTGTTCCGATCA
TCCGCGATGTCCTAACGGAAGCTATCGAAGCCGGTGGCTCTTCCTTACGAGATCATCGGCAAGCAACCGGGGAACTGGGA
TATTTTCAACACACCTTTAGGGTGTATGGGCGGGAAGGCCAACGGTGCCAAACCCCAGATTGCGCTGAAAAAATCCTGCG
CAAGGTGCAGTCGGGACGCTCCAGTTTCTACTGTCCGGCCTGTCAGAGATAA

Upstream 100 bases:

>100_bases
GTCATTTGCCATGGGACTTGTCCTTTATTCGCCTCGCCCCCTCTTATAGGGCGGAGCCAAGGGGCCGCAACGGACCCTCT
GCGAGATAGGAAAGCCCGAT

Downstream 100 bases:

>100_bases
CTTGAACCCCGCGCCATCGGTGCTAACCCTCATGGCTCTGGTGCAACAGCGGATGAGCGCATTCCATGGCCTACGAGACC
CTGATCGTCGACGTTGAAGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPELPEVETVRRGLAPVLEGARIAQAAVNRPDLRWPFPDNMAQRLTGATVTALRRRSKYILADLDTGETLLIHLGMSGRM
QISGDVIGSFHHTHPAAAKHDHVVLDTDAGARITFNDARRFGAMDLMDTATQDQHWLLRDLGPEPLGNAFNEAHLVAAFK
GKRSPVKTALLDQRIVSGLGNIYVCEALWRAGISPLRQAGKIAAVRVATLVPIIRDVLTEAIEAGGSSLRDHRQATGELG
YFQHTFRVYGREGQRCQTPDCAEKILRKVQSGRSSFYCPACQR

Sequences:

>Translated_283_residues
MPELPEVETVRRGLAPVLEGARIAQAAVNRPDLRWPFPDNMAQRLTGATVTALRRRSKYILADLDTGETLLIHLGMSGRM
QISGDVIGSFHHTHPAAAKHDHVVLDTDAGARITFNDARRFGAMDLMDTATQDQHWLLRDLGPEPLGNAFNEAHLVAAFK
GKRSPVKTALLDQRIVSGLGNIYVCEALWRAGISPLRQAGKIAAVRVATLVPIIRDVLTEAIEAGGSSLRDHRQATGELG
YFQHTFRVYGREGQRCQTPDCAEKILRKVQSGRSSFYCPACQR
>Mature_282_residues
PELPEVETVRRGLAPVLEGARIAQAAVNRPDLRWPFPDNMAQRLTGATVTALRRRSKYILADLDTGETLLIHLGMSGRMQ
ISGDVIGSFHHTHPAAAKHDHVVLDTDAGARITFNDARRFGAMDLMDTATQDQHWLLRDLGPEPLGNAFNEAHLVAAFKG
KRSPVKTALLDQRIVSGLGNIYVCEALWRAGISPLRQAGKIAAVRVATLVPIIRDVLTEAIEAGGSSLRDHRQATGELGY
FQHTFRVYGREGQRCQTPDCAEKILRKVQSGRSSFYCPACQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=283, Percent_Identity=39.9293286219081, Blast_Score=200, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_JANSC (Q28JI5)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_512152.1
- HSSP:   P42371
- ProteinModelPortal:   Q28JI5
- SMR:   Q28JI5
- STRING:   Q28JI5
- GeneID:   3936699
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_4210
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q28JI5
- ProtClustDB:   PRK01103
- BioCyc:   JSP290400:JANN_4210-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31151; Mature: 31020

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 273-273 BINDING 100-100 BINDING 119-119 BINDING 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLAPVLEGARIAQAAVNRPDLRWPFPDNMAQRLTGATVTALRRRSKYI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
LADLDTGETLLIHLGMSGRMQISGDVIGSFHHTHPAAAKHDHVVLDTDAGARITFNDARR
EEECCCCCEEEEEECCCCCEEECCCHHCCHHCCCCCCCCCCEEEEECCCCCEEEEHHHHH
FGAMDLMDTATQDQHWLLRDLGPEPLGNAFNEAHLVAAFKGKRSPVKTALLDQRIVSGLG
HCCHHHHHHCCCCHHHHHHHCCCCCCCHHHCHHHEEEEECCCCCHHHHHHHHHHHHHHCC
NIYVCEALWRAGISPLRQAGKIAAVRVATLVPIIRDVLTEAIEAGGSSLRDHRQATGELG
CHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCH
YFQHTFRVYGREGQRCQTPDCAEKILRKVQSGRSSFYCPACQR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLAPVLEGARIAQAAVNRPDLRWPFPDNMAQRLTGATVTALRRRSKYI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
LADLDTGETLLIHLGMSGRMQISGDVIGSFHHTHPAAAKHDHVVLDTDAGARITFNDARR
EEECCCCCEEEEEECCCCCEEECCCHHCCHHCCCCCCCCCCEEEEECCCCCEEEEHHHHH
FGAMDLMDTATQDQHWLLRDLGPEPLGNAFNEAHLVAAFKGKRSPVKTALLDQRIVSGLG
HCCHHHHHHCCCCHHHHHHHCCCCCCCHHHCHHHEEEEECCCCCHHHHHHHHHHHHHHCC
NIYVCEALWRAGISPLRQAGKIAAVRVATLVPIIRDVLTEAIEAGGSSLRDHRQATGELG
CHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCH
YFQHTFRVYGREGQRCQTPDCAEKILRKVQSGRSSFYCPACQR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA