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The map label for this gene is adh [H]

Identifier: 89056455

GI number: 89056455

Start: 4062259

End: 4063293

Strand: Direct

Name: adh [H]

Synonym: Jann_3964

Alternate gene names: 89056455

Gene position: 4062259-4063293 (Clockwise)

Preceding gene: 89056454

Following gene: 89056457

Centisome position: 94.08

GC content: 65.99

Gene sequence:

>1035_bases
ATGCGCGCAGCGGTTGTCCGGGACTTCAACGCGGATCTGGCGCTGGAGCGCGTGCCTGACCCCGCCTGCCCCGAGACTGG
CGTGGTGCTGGAGGTTGCGGCCTGTGGCGTGTGCCGGTCCGATTACCACGGCTGGACGGGCGGGCACCCGAACGTCGTGA
ATGGCTCCATCCTCGGCCATGAATATTGCGGCACGGTGGTGGAGGCCGGGCCGCGTGCGCAACACAAGGTAGGTGATCGA
CTGATCGCGCCCTTTATCCTTGGCTGCGGAGCCTGCCCCGCTTGCCAAACGGGTGCGTCCAACACCTGCGCCCATCAGGT
CGTGCCGGGCTTCGGCGCGCCAGGTGCCTATGCCGAATGCGTCGCCGTGCCGTTTGATCACAATCTTGTCCATCTGCCCG
ATAGCCTGTCACCCGCCCTTGCCGCCGGGCTTGGCTGCCGGGTCACAACCGCCTGGCAAGCGCTGACGGACCGGGCGGAT
GTGAAGGCCGGCGAATGGGTCGCCGTCCATGGCACGGGCGGCATCGGTCTGTCGGTGCTGCTGCTGGCGAAGATGCTTGG
CGCGCGGGTTGTGGTGGTCGATATCGTTGACGAGAAGCTGGAGCACGCCGTGACCCACGGGGCTGACGCGACGGTCAACG
CGTCACAGGTTGATGCGGCGGCGGCGATCCGGGACATCACCGGCGGTGGCGCACACGTCTCGATCGAGGCTCTGGGGATT
GCGGCCACCACGAATGCGTCGGTGGAGTGTCTGGCCACGCTGGGTCGGCACGTCCATGTGGGGATGCCCGCAGGTGATGG
CATGATGGAGATCAACATGCGCGCGATCTACGCCAAGCAGCTTGCTTTCTATGGCACGCGCGGGATGCCGTCTTGGAAAT
ATCCAACGCTTCTGGGCATGATTGAACGCGGCGATGTGGATATTTCCCCCATGGTCGCCCGCGAAATCCCCCTGTCAGCC
GCAAGCGCCGAGTTGCGCGCGATGGGTGGCCCGACACCGCCCGGCACGGCGGTGATCACGGATTTTCTGGGGTAG

Upstream 100 bases:

>100_bases
TCGGCACCTCCACCGCGGCGGCGACGGGTGCAGTCATGGCGCTGCTGGTGGCGCGCCACATCGCGCGGGAAAAGATCGGC
GGATTGAGGGGAGAGGCGTG

Downstream 100 bases:

>100_bases
TCCTCACGTCAAATCGAACCCTATGGCGCGGATGTAGGCCCCGAAGTCTGCCCTCTCCGGCTGACTGTACTGGCGCACCT
TATCTTCGGACCAGCCATAG

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRAAVVRDFNADLALERVPDPACPETGVVLEVAACGVCRSDYHGWTGGHPNVVNGSILGHEYCGTVVEAGPRAQHKVGDR
LIAPFILGCGACPACQTGASNTCAHQVVPGFGAPGAYAECVAVPFDHNLVHLPDSLSPALAAGLGCRVTTAWQALTDRAD
VKAGEWVAVHGTGGIGLSVLLLAKMLGARVVVVDIVDEKLEHAVTHGADATVNASQVDAAAAIRDITGGGAHVSIEALGI
AATTNASVECLATLGRHVHVGMPAGDGMMEINMRAIYAKQLAFYGTRGMPSWKYPTLLGMIERGDVDISPMVAREIPLSA
ASAELRAMGGPTPPGTAVITDFLG

Sequences:

>Translated_344_residues
MRAAVVRDFNADLALERVPDPACPETGVVLEVAACGVCRSDYHGWTGGHPNVVNGSILGHEYCGTVVEAGPRAQHKVGDR
LIAPFILGCGACPACQTGASNTCAHQVVPGFGAPGAYAECVAVPFDHNLVHLPDSLSPALAAGLGCRVTTAWQALTDRAD
VKAGEWVAVHGTGGIGLSVLLLAKMLGARVVVVDIVDEKLEHAVTHGADATVNASQVDAAAAIRDITGGGAHVSIEALGI
AATTNASVECLATLGRHVHVGMPAGDGMMEINMRAIYAKQLAFYGTRGMPSWKYPTLLGMIERGDVDISPMVAREIPLSA
ASAELRAMGGPTPPGTAVITDFLG
>Mature_344_residues
MRAAVVRDFNADLALERVPDPACPETGVVLEVAACGVCRSDYHGWTGGHPNVVNGSILGHEYCGTVVEAGPRAQHKVGDR
LIAPFILGCGACPACQTGASNTCAHQVVPGFGAPGAYAECVAVPFDHNLVHLPDSLSPALAAGLGCRVTTAWQALTDRAD
VKAGEWVAVHGTGGIGLSVLLLAKMLGARVVVVDIVDEKLEHAVTHGADATVNASQVDAAAAIRDITGGGAHVSIEALGI
AATTNASVECLATLGRHVHVGMPAGDGMMEINMRAIYAKQLAFYGTRGMPSWKYPTLLGMIERGDVDISPMVAREIPLSA
ASAELRAMGGPTPPGTAVITDFLG

Specific function: Active with primary alcohols, including methanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=300, Percent_Identity=30, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI71743840, Length=344, Percent_Identity=26.1627906976744, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI262073058, Length=344, Percent_Identity=26.1627906976744, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI34577061, Length=300, Percent_Identity=29, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501929, Length=305, Percent_Identity=28.1967213114754, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=29.3413173652695, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI71565154, Length=274, Percent_Identity=26.6423357664234, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=24.9307479224377, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=24.9307479224377, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI71565152, Length=364, Percent_Identity=23.9010989010989, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI22538446, Length=259, Percent_Identity=30.1158301158301, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI22538444, Length=259, Percent_Identity=30.1158301158301, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194239674, Length=305, Percent_Identity=28.8524590163934, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI13236495, Length=305, Percent_Identity=28.8524590163934, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081918, Length=267, Percent_Identity=34.8314606741573, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786825, Length=271, Percent_Identity=31.3653136531365, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082125, Length=265, Percent_Identity=32.0754716981132, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788075, Length=346, Percent_Identity=28.0346820809249, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI226510992, Length=294, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790045, Length=322, Percent_Identity=25.776397515528, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788073, Length=306, Percent_Identity=30.0653594771242, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787863, Length=316, Percent_Identity=25.3164556962025, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786552, Length=345, Percent_Identity=27.8260869565217, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790718, Length=326, Percent_Identity=24.8466257668712, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788407, Length=341, Percent_Identity=24.9266862170088, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=345, Percent_Identity=31.8840579710145, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=319, Percent_Identity=31.974921630094, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=311, Percent_Identity=27.6527331189711, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=279, Percent_Identity=25.4480286738351, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=268, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=255, Percent_Identity=24.3137254901961, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=270, Percent_Identity=29.6296296296296, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=270, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=28.486646884273, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=28.486646884273, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=269, Percent_Identity=29.7397769516729, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=269, Percent_Identity=27.5092936802974, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=353, Percent_Identity=25.7790368271955, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=316, Percent_Identity=26.5822784810127, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=273, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=196, Percent_Identity=32.1428571428571, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=193, Percent_Identity=32.1243523316062, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=27.4238227146814, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17137530, Length=262, Percent_Identity=27.8625954198473, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737897, Length=225, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35365; Mature: 35365

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00059 ADH_ZINC ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVVRDFNADLALERVPDPACPETGVVLEVAACGVCRSDYHGWTGGHPNVVNGSILGH
CCCEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCH
EYCGTVVEAGPRAQHKVGDRLIAPFILGCGACPACQTGASNTCAHQVVPGFGAPGAYAEC
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEE
VAVPFDHNLVHLPDSLSPALAAGLGCRVTTAWQALTDRADVKAGEWVAVHGTGGIGLSVL
EEECCCCCEEECCCCCCHHHHHCCCCEEHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHH
LLAKMLGARVVVVDIVDEKLEHAVTHGADATVNASQVDAAAAIRDITGGGAHVSIEALGI
HHHHHHCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEE
AATTNASVECLATLGRHVHVGMPAGDGMMEINMRAIYAKQLAFYGTRGMPSWKYPTLLGM
EEECCCCHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
IERGDVDISPMVAREIPLSAASAELRAMGGPTPPGTAVITDFLG
HCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MRAAVVRDFNADLALERVPDPACPETGVVLEVAACGVCRSDYHGWTGGHPNVVNGSILGH
CCCEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCH
EYCGTVVEAGPRAQHKVGDRLIAPFILGCGACPACQTGASNTCAHQVVPGFGAPGAYAEC
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEE
VAVPFDHNLVHLPDSLSPALAAGLGCRVTTAWQALTDRADVKAGEWVAVHGTGGIGLSVL
EEECCCCCEEECCCCCCHHHHHCCCCEEHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHH
LLAKMLGARVVVVDIVDEKLEHAVTHGADATVNASQVDAAAAIRDITGGGAHVSIEALGI
HHHHHHCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEE
AATTNASVECLATLGRHVHVGMPAGDGMMEINMRAIYAKQLAFYGTRGMPSWKYPTLLGM
EEECCCCHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
IERGDVDISPMVAREIPLSAASAELRAMGGPTPPGTAVITDFLG
HCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]