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The map label for this gene is norM [H]

Identifier: 89056454

GI number: 89056454

Start: 4060886

End: 4062259

Strand: Direct

Name: norM [H]

Synonym: Jann_3963

Alternate gene names: 89056454

Gene position: 4060886-4062259 (Clockwise)

Preceding gene: 89056453

Following gene: 89056455

Centisome position: 94.05

GC content: 64.48

Gene sequence:

>1374_bases
GTGGCGGCCCATATCGATCAGGACCTGACGAAAGGTCCCATCCCGAAGCATTTCTGGGCGCTGGCCATCCCTGCCGCCGT
GGGGATGCTGTTCAACACGCTCTATAACGTCGTGGATGTCTACTTCGCGGGGCTCGTGTCCACCGCGGCGCAGGCGGGTC
TGTCGTTGGGATTTCAGATCCTGTTCGTCAGCATGGCACTGGGTGTGGGCCTTGGGGCGGCCATGGGCGCGCTGGTGGGC
AACGCGCTGGGGGAAGGCGATAAACGGCTGGCGCGGCGATACTGCGCCCAGGGCATCAGCTATGGCCTGTTGGGGGCGGT
GATCCTTGCGGTCGCCGGTCAGGCCTACGGGCCGGGCCTGATCAGGTTCGTGTCGGCCGAGGCGGAATATCAGAACACGG
CTATCACCTATTACCGCCTGCTGACGCTGGCGCTGCCGGGCTTCATCCTGGCCGCAGGATGCAACGGCATCTTGCAGGCC
CACGGCGACGGCAAATCCATGCGGCGCGCGCTGATGGTCGCTTTCTTCGTCAATATTGGCCTGAACCCGCTGCTGATGTT
TGGCATTCCGGGCGTCTGGGGCGGCCTGGGCTTTCCGGGGCTCGCCGTGTCGACCATCATCAGCCAGACCGGCGTGATGG
CCTATCTGATCCGGCAGGTGATCCGCCTCGACACGATGGAGGCGACGGAGCCGCGCCATTTCGCCCCCGACTGGCCGCGC
TACAAGGAGATCACCGAACAGGTCGTGCCGTCGGGCTTCGCCTTCCTGATCATGATCCTTGCGGGCGTCGTGGTGCAATT
CGCGCTGAAAGATTTCGGAGAGCACGCGGTGGCGGGCTTCGGCATCGGCATCCGGCTGGAACAACTGGTGATCCTGCCGC
TCATCGGCATGTCGAGCGCGCTTCTGCCCATCGCCGCGCAAAACCTCGGCGCGGGCAACCCCGACCGGGTGCGGGAGGCG
ATCTTCTATTGCTGGAAGGCGGGCGCAGTGATCGCGCTGATCGCGGGCCCGATCCTGTTTTTGGGCGCCCCTTATTTCGT
GCGCCTGTTCACCAACGACGCGGACGTCATTCTTGTGGGCCGCGACTACCTGCGGGTGGGGGCGTTCATGCTCTATGTCT
ACCTCATCCACTTCTCGATCACGTCGTTCCTGCAAGCGGCCAAACGCCCGATCTGGTCGCTCTGGATCAGCCTTTACCGG
CAGGCCTTTGGCGTCGCGTTCTTCGTCTGGCTTTATGTCGGGGTCTTCGGGATGCCGGTGATCGGTGTCTGGTTCGGCAC
CTCCACCGCGGCGGCGACGGGTGCAGTCATGGCGCTGCTGGTGGCGCGCCACATCGCGCGGGAAAAGATCGGCGGATTGA
GGGGAGAGGCGTGA

Upstream 100 bases:

>100_bases
CAACCAGATCGTCGGATATTTTTGTTACGTGAACCGCCTGCTCAACGGGCTCGGCGTCACCACTGACGGCGATGTCGTCG
GATATTACGCGGAGAGTTGA

Downstream 100 bases:

>100_bases
TGCGCGCAGCGGTTGTCCGGGACTTCAACGCGGATCTGGCGCTGGAGCGCGTGCCTGACCCCGCCTGCCCCGAGACTGGC
GTGGTGCTGGAGGTTGCGGC

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MAAHIDQDLTKGPIPKHFWALAIPAAVGMLFNTLYNVVDVYFAGLVSTAAQAGLSLGFQILFVSMALGVGLGAAMGALVG
NALGEGDKRLARRYCAQGISYGLLGAVILAVAGQAYGPGLIRFVSAEAEYQNTAITYYRLLTLALPGFILAAGCNGILQA
HGDGKSMRRALMVAFFVNIGLNPLLMFGIPGVWGGLGFPGLAVSTIISQTGVMAYLIRQVIRLDTMEATEPRHFAPDWPR
YKEITEQVVPSGFAFLIMILAGVVVQFALKDFGEHAVAGFGIGIRLEQLVILPLIGMSSALLPIAAQNLGAGNPDRVREA
IFYCWKAGAVIALIAGPILFLGAPYFVRLFTNDADVILVGRDYLRVGAFMLYVYLIHFSITSFLQAAKRPIWSLWISLYR
QAFGVAFFVWLYVGVFGMPVIGVWFGTSTAAATGAVMALLVARHIAREKIGGLRGEA

Sequences:

>Translated_457_residues
MAAHIDQDLTKGPIPKHFWALAIPAAVGMLFNTLYNVVDVYFAGLVSTAAQAGLSLGFQILFVSMALGVGLGAAMGALVG
NALGEGDKRLARRYCAQGISYGLLGAVILAVAGQAYGPGLIRFVSAEAEYQNTAITYYRLLTLALPGFILAAGCNGILQA
HGDGKSMRRALMVAFFVNIGLNPLLMFGIPGVWGGLGFPGLAVSTIISQTGVMAYLIRQVIRLDTMEATEPRHFAPDWPR
YKEITEQVVPSGFAFLIMILAGVVVQFALKDFGEHAVAGFGIGIRLEQLVILPLIGMSSALLPIAAQNLGAGNPDRVREA
IFYCWKAGAVIALIAGPILFLGAPYFVRLFTNDADVILVGRDYLRVGAFMLYVYLIHFSITSFLQAAKRPIWSLWISLYR
QAFGVAFFVWLYVGVFGMPVIGVWFGTSTAAATGAVMALLVARHIAREKIGGLRGEA
>Mature_456_residues
AAHIDQDLTKGPIPKHFWALAIPAAVGMLFNTLYNVVDVYFAGLVSTAAQAGLSLGFQILFVSMALGVGLGAAMGALVGN
ALGEGDKRLARRYCAQGISYGLLGAVILAVAGQAYGPGLIRFVSAEAEYQNTAITYYRLLTLALPGFILAAGCNGILQAH
GDGKSMRRALMVAFFVNIGLNPLLMFGIPGVWGGLGFPGLAVSTIISQTGVMAYLIRQVIRLDTMEATEPRHFAPDWPRY
KEITEQVVPSGFAFLIMILAGVVVQFALKDFGEHAVAGFGIGIRLEQLVILPLIGMSSALLPIAAQNLGAGNPDRVREAI
FYCWKAGAVIALIAGPILFLGAPYFVRLFTNDADVILVGRDYLRVGAFMLYVYLIHFSITSFLQAAKRPIWSLWISLYRQ
AFGVAFFVWLYVGVFGMPVIGVWFGTSTAAATGAVMALLVARHIAREKIGGLRGEA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=440, Percent_Identity=23.6363636363636, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48932; Mature: 48800

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHIDQDLTKGPIPKHFWALAIPAAVGMLFNTLYNVVDVYFAGLVSTAAQAGLSLGFQI
CCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVSMALGVGLGAAMGALVGNALGEGDKRLARRYCAQGISYGLLGAVILAVAGQAYGPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHH
IRFVSAEAEYQNTAITYYRLLTLALPGFILAAGCNGILQAHGDGKSMRRALMVAFFVNIG
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHCC
LNPLLMFGIPGVWGGLGFPGLAVSTIISQTGVMAYLIRQVIRLDTMEATEPRHFAPDWPR
CCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
YKEITEQVVPSGFAFLIMILAGVVVQFALKDFGEHAVAGFGIGIRLEQLVILPLIGMSSA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHH
LLPIAAQNLGAGNPDRVREAIFYCWKAGAVIALIAGPILFLGAPYFVRLFTNDADVILVG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCEEEEC
RDYLRVGAFMLYVYLIHFSITSFLQAAKRPIWSLWISLYRQAFGVAFFVWLYVGVFGMPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVWFGTSTAAATGAVMALLVARHIAREKIGGLRGEA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AAHIDQDLTKGPIPKHFWALAIPAAVGMLFNTLYNVVDVYFAGLVSTAAQAGLSLGFQI
CCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVSMALGVGLGAAMGALVGNALGEGDKRLARRYCAQGISYGLLGAVILAVAGQAYGPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHH
IRFVSAEAEYQNTAITYYRLLTLALPGFILAAGCNGILQAHGDGKSMRRALMVAFFVNIG
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHCC
LNPLLMFGIPGVWGGLGFPGLAVSTIISQTGVMAYLIRQVIRLDTMEATEPRHFAPDWPR
CCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
YKEITEQVVPSGFAFLIMILAGVVVQFALKDFGEHAVAGFGIGIRLEQLVILPLIGMSSA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHH
LLPIAAQNLGAGNPDRVREAIFYCWKAGAVIALIAGPILFLGAPYFVRLFTNDADVILVG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCEEEEC
RDYLRVGAFMLYVYLIHFSITSFLQAAKRPIWSLWISLYRQAFGVAFFVWLYVGVFGMPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVWFGTSTAAATGAVMALLVARHIAREKIGGLRGEA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]