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The map label for this gene is hbd [H]

Identifier: 89056318

GI number: 89056318

Start: 3919210

End: 3920610

Strand: Direct

Name: hbd [H]

Synonym: Jann_3827

Alternate gene names: 89056318

Gene position: 3919210-3920610 (Clockwise)

Preceding gene: 89056317

Following gene: 89056319

Centisome position: 90.76

GC content: 64.45

Gene sequence:

>1401_bases
ATGAAAACCGCAATCATCGGCGGGGGCGTCATTGGCGGCGGATGGGCCGCGCGCTTCCTTCTCAACGGCTGGAATGTGGC
GATCTATGACCCTGATCCGGAGGCCGAGCGCAAGATCGGCGAGGTGATGGACAACGCCCGACGCGCCCTGCCCGGCCTTT
ACGACACGGCCCTGCCGCCCGAGGGCACGCTGCGGTTTACCGATGACCTGGGCGACGCGGTTGGCGACGCCGATTGGGTG
CAGGAAAGCGTGCCGGAGCGGCTCGACATCAAGCACAAGGTCCACGCGGAGCTGACCACGCTGGCCCCAGGCCGCGCCGT
TATCGGCTCCTCCACGTCGGGATTCAAACCGTCGGAGCTCACGGAAAAAGGTGCGCGCGTGATCGTGGCGCATCCGTTCA
ACCCGGTCTACCTGCTGCCGCTGATCGAATTGGTCGGCGACACGGACCACTGCGCCAAAGCCGCCGAAATCCTGCGCGGT
ATTGGCATGTACCCGCTGCATGTCCGCAAGGAGATCGACGCCCATATCGCGGACCGTTTTCTGGAGGCCGTCTGGCGTGA
GGCCCTTTGGCTGGTCAAGGACGGCATCGCCACGACCGAAGAAATCGACGAGGCAATTCGTATGGGCTTTGGCCTGCGGT
GGGCGCAGATGGGCCTGTTCGAGACCTATCGTGTGGCCGGTGGCGAAGCGGGCATGAAGCACTTCATGGCGCAGTTTGGG
CCTTGCCTGACCTGGCCCTGGACCAAACTGATGGATGTGCCGGAGTTCACCGACGAGCTTGTGGACCTGATCGCCGGGCA
ATCGGACGCGCAATCAGGCCACCTCAGCATCCGGGAGCTGGAACGCCTGCGCGACGACAATCTGGTGGGGATCCTGCGCG
GGCTCAAACACTCGGGCGCGGGCGCGGGCGGAGTGGTCGCACGCCATGAGGCCGCACTACCCAAGGCGGATCAACCGATC
ACGCTCGACCGTCAGGTGCCCCAGGGCTGGACCGACTACAACGGCCACATGAATGAGATGCACTACCTGGAGGCCGGGTC
CAAAGCGACGGATCGGTTCATGGAAATGGTCGGCGCGGACGCGGCTTACATCGCGCAGGGCCTCAGCTATTTCACGGTGG
AGAACCATGTCCGCTATCTGGATGAGGTCCACGCGGGCGACAGGTTGCGGGCGGAGACGCGGTTGCTGGGGGGTGAAGGC
AAGAAACTGCATGTATTCCACACGCTCTATCGAGGCGATGGCACCCTTGCTGCGACCGTTGAAAGCCTGCTGTTACATGT
CGATCTGGCGACGCGTAGGACGTGCCTGCCCGGTGAGGCCGTGGCCTCAGCCCTTGCGCAGGTGGCCGCAGATCAAGCCG
GGCTGCCAATGCCCGACGGCGCAGGCAAAGTCGGGCGCTAG

Upstream 100 bases:

>100_bases
ACCGGGAGCCGGACATCCCCGCAGACCGCCTCGCCGCCGCCCGGGAGGTCCTGGACTTCAACGGCTACGACCTGGGCCAA
CTGACCCGGAGTGTGACACC

Downstream 100 bases:

>100_bases
GGTGGAGAACGATGGCGCGTGACCAAATCGACATTTAACCCGAGATCATAGCCTGACCAGAAGGTCTCGGTGCCGCTTCG
GGCCATCGCGTCAAGCACTG

Product: bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKTAIIGGGVIGGGWAARFLLNGWNVAIYDPDPEAERKIGEVMDNARRALPGLYDTALPPEGTLRFTDDLGDAVGDADWV
QESVPERLDIKHKVHAELTTLAPGRAVIGSSTSGFKPSELTEKGARVIVAHPFNPVYLLPLIELVGDTDHCAKAAEILRG
IGMYPLHVRKEIDAHIADRFLEAVWREALWLVKDGIATTEEIDEAIRMGFGLRWAQMGLFETYRVAGGEAGMKHFMAQFG
PCLTWPWTKLMDVPEFTDELVDLIAGQSDAQSGHLSIRELERLRDDNLVGILRGLKHSGAGAGGVVARHEAALPKADQPI
TLDRQVPQGWTDYNGHMNEMHYLEAGSKATDRFMEMVGADAAYIAQGLSYFTVENHVRYLDEVHAGDRLRAETRLLGGEG
KKLHVFHTLYRGDGTLAATVESLLLHVDLATRRTCLPGEAVASALAQVAADQAGLPMPDGAGKVGR

Sequences:

>Translated_466_residues
MKTAIIGGGVIGGGWAARFLLNGWNVAIYDPDPEAERKIGEVMDNARRALPGLYDTALPPEGTLRFTDDLGDAVGDADWV
QESVPERLDIKHKVHAELTTLAPGRAVIGSSTSGFKPSELTEKGARVIVAHPFNPVYLLPLIELVGDTDHCAKAAEILRG
IGMYPLHVRKEIDAHIADRFLEAVWREALWLVKDGIATTEEIDEAIRMGFGLRWAQMGLFETYRVAGGEAGMKHFMAQFG
PCLTWPWTKLMDVPEFTDELVDLIAGQSDAQSGHLSIRELERLRDDNLVGILRGLKHSGAGAGGVVARHEAALPKADQPI
TLDRQVPQGWTDYNGHMNEMHYLEAGSKATDRFMEMVGADAAYIAQGLSYFTVENHVRYLDEVHAGDRLRAETRLLGGEG
KKLHVFHTLYRGDGTLAATVESLLLHVDLATRRTCLPGEAVASALAQVAADQAGLPMPDGAGKVGR
>Mature_466_residues
MKTAIIGGGVIGGGWAARFLLNGWNVAIYDPDPEAERKIGEVMDNARRALPGLYDTALPPEGTLRFTDDLGDAVGDADWV
QESVPERLDIKHKVHAELTTLAPGRAVIGSSTSGFKPSELTEKGARVIVAHPFNPVYLLPLIELVGDTDHCAKAAEILRG
IGMYPLHVRKEIDAHIADRFLEAVWREALWLVKDGIATTEEIDEAIRMGFGLRWAQMGLFETYRVAGGEAGMKHFMAQFG
PCLTWPWTKLMDVPEFTDELVDLIAGQSDAQSGHLSIRELERLRDDNLVGILRGLKHSGAGAGGVVARHEAALPKADQPI
TLDRQVPQGWTDYNGHMNEMHYLEAGSKATDRFMEMVGADAAYIAQGLSYFTVENHVRYLDEVHAGDRLRAETRLLGGEG
KKLHVFHTLYRGDGTLAATVESLLLHVDLATRRTCLPGEAVASALAQVAADQAGLPMPDGAGKVGR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=280, Percent_Identity=31.0714285714286, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI296179429, Length=233, Percent_Identity=26.1802575107296, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787661, Length=222, Percent_Identity=28.3783783783784, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=275, Percent_Identity=26.1818181818182, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI193203623, Length=275, Percent_Identity=26.1818181818182, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17549919, Length=233, Percent_Identity=28.755364806867, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45549573, Length=253, Percent_Identity=31.2252964426877, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI20129993, Length=255, Percent_Identity=29.0196078431373, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 50719; Mature: 50719

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAIIGGGVIGGGWAARFLLNGWNVAIYDPDPEAERKIGEVMDNARRALPGLYDTALPP
CCCEEECCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHCCCCC
EGTLRFTDDLGDAVGDADWVQESVPERLDIKHKVHAELTTLAPGRAVIGSSTSGFKPSEL
CCCEEECHHHHHHCCCHHHHHHHCCHHHCCHHHHHHHHHCCCCCCEEECCCCCCCCCHHH
TEKGARVIVAHPFNPVYLLPLIELVGDTDHCAKAAEILRGIGMYPLHVRKEIDAHIADRF
HHCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LEAVWREALWLVKDGIATTEEIDEAIRMGFGLRWAQMGLFETYRVAGGEAGMKHFMAQFG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHC
PCLTWPWTKLMDVPEFTDELVDLIAGQSDAQSGHLSIRELERLRDDNLVGILRGLKHSGA
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
GAGGVVARHEAALPKADQPITLDRQVPQGWTDYNGHMNEMHYLEAGSKATDRFMEMVGAD
CCCCCHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCC
AAYIAQGLSYFTVENHVRYLDEVHAGDRLRAETRLLGGEGKKLHVFHTLYRGDGTLAATV
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHH
ESLLLHVDLATRRTCLPGEAVASALAQVAADQAGLPMPDGAGKVGR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTAIIGGGVIGGGWAARFLLNGWNVAIYDPDPEAERKIGEVMDNARRALPGLYDTALPP
CCCEEECCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHCCCCC
EGTLRFTDDLGDAVGDADWVQESVPERLDIKHKVHAELTTLAPGRAVIGSSTSGFKPSEL
CCCEEECHHHHHHCCCHHHHHHHCCHHHCCHHHHHHHHHCCCCCCEEECCCCCCCCCHHH
TEKGARVIVAHPFNPVYLLPLIELVGDTDHCAKAAEILRGIGMYPLHVRKEIDAHIADRF
HHCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LEAVWREALWLVKDGIATTEEIDEAIRMGFGLRWAQMGLFETYRVAGGEAGMKHFMAQFG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHC
PCLTWPWTKLMDVPEFTDELVDLIAGQSDAQSGHLSIRELERLRDDNLVGILRGLKHSGA
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
GAGGVVARHEAALPKADQPITLDRQVPQGWTDYNGHMNEMHYLEAGSKATDRFMEMVGAD
CCCCCHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCC
AAYIAQGLSYFTVENHVRYLDEVHAGDRLRAETRLLGGEGKKLHVFHTLYRGDGTLAATV
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHH
ESLLLHVDLATRRTCLPGEAVASALAQVAADQAGLPMPDGAGKVGR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA