Click here to switch to the map view.

The map label for this gene is kefC [H]

Identifier: 89055795

GI number: 89055795

Start: 3358334

End: 3360373

Strand: Direct

Name: kefC [H]

Synonym: Jann_3304

Alternate gene names: 89055795

Gene position: 3358334-3360373 (Clockwise)

Preceding gene: 89055793

Following gene: 89055797

Centisome position: 77.78

GC content: 63.38

Gene sequence:

>2040_bases
ATGCCCCTAACGCCGCGCCGCAACACCCGCTACACTCGCCGCACTCCCACCCCAAACCGGAACAGGTCCATGGACGAAGC
CCTTCTCCAGATCACCATCTACCTGACCGCCATGCTGATCGCTGTCCCGATCTCCATTCGCTTTGGTCTGGGCTCTGTCC
TTGGCTACCTGCTGGCGGGCATCGCCATCGGTCCGGTTCTGGGCCTTGTCGGATCGGAAACGCAAGACCTTCAGCATTAC
GCGGAATTCGGCGTTGTCCTGATGCTGTTTCTCATCGGGCTGGAGTTGGACCCCCGGACGCTGTGGGACATGCGCAAGCG
GCTGGTCGGGCTTGGGGGCAGTCAGATTCTGCTGTCGACCGCCATCCTGACCGGCGGCGCGATGATCCTGGGCCTTTCCA
CGTCGCTTTCTCTGGCCATCGGGATCACGCTGGCGCTCAGCTCGACGGCTATCGTGCTGACAACATTGTCGGAAAAAGGG
CTGATGGGAACGACCGGCGGGCGGGGGGCGTTCTCGGTTCTGCTCACCCAGGACATCGCCGTGATCCCGGCGCTGGCCCT
TCTTCCGCTGCTGGCGACGGGCGCGGGCATACGCTTCACGGAAGACGGCGCGATTGAGCGGACGGCGGAGGACGCGCATC
ATTCGCTGTCCCTGGTCGAGGGGTTGCCCGCATGGGGTGTCACGCTGGTCACCATTGCGGCTGTGATCGCGGTGATTCTG
GCGGGGCGCTACCTCTCGCCCTTCGTGTTCCGCGTGATCCACAACGCGAAACTGAAGGAACTCTATACCGTCGCCGCCCT
CGCCTTTGTGGTGGGCATCGCAGAGCTGATGATCCTCGTGGGTCTCTCGCCCGCGCTCGGCGCATTCCTTGCGGGTGTGG
TTCTGGCCAATTCCGAGTTCAAGCATGAGCTGGAGGCGGATATCGAGCCGTTCAAGGGCCTTCTCCTTGGCCTCTTTTTC
ATCACGGTCGGTGCGGGCATCAACTTTGCCACGCTGTTTGCCAACCCGTTCCTGATCATCGGCCTGACCCTTGCCATCAT
GGTGATCAAAGGTGTCGTTCTCTATGCCATCGCGCGGGTCACGCGGATGGAGGGGCGGGACCGCTGGCTCTTTACCCTCA
GCCTCGCGCAGGCCGGGGAGTTCGGCTTCGTGCTGGTGGCGTTCGGCGTCAGCCAAGCGGTTTTCCCGACTTATATCGCC
CAGATCCTTTTGCTGGTCGTGGCGCTGTCGATGTTGTTGACCCCGCTCAGTTTTATTCTCTACGAGGCCATTGGGGCGCG
GCTCGGCACCGGCGTGGAGGACGCGCCCGAGCATGATGAAATTGATGAGGAGGCCCCCGTCATCATCGCCGGTATCGGGC
GGTTCGGGCAGTCGGTCCACCGGATGGTGCGGGCGTCGGGCTTCAAGACGGTGGTGCTTGATTCGAACCTGGAGACGATC
CAGCTGATGCGCCGGTTCGGCCTCAAGAGCTTCTTTGGCGACCCCACCCGGCCCGAACTTCTGAAAGCCGCGGGCCTCGA
CAAGGCGCGGGTCCTTGTCGTCTGCGTCGATAACAAACAGGCCGCCGTCAAGCTGGTGCGCTATGCCAAACGGACGCGGC
CTGACATCTCGGTCGTGGCCCGCGCCCATGATCTGCTCCACGTCTATGAGCTGTACGCAGCCGGCGCTGACCACATCATC
CGAGAGGTCTTCGACAGTTCCCTACGCGCCGCGCGCTATGTGCTGGAGGATATGGGCCTGTCGGATTACGAGGCCCACGC
GATGGAAATCGCCTTTTATCGCCATGATCGCCACAACCTGCGCGCCCTGGCCGAGGTCTGGAAGCCCGGCATTCCGGTGA
CCGAGAATGAAGACTACATGCGCCTGACCCGCGAGATGGCGGACAACCTTGAAAGCGCGGTGATGACCCATCTCGACGCG
ATGGAGGATGAAGGGGGAGGCTCGACGGCCCATACCCGTGGCGATGTCGGCGCGCTCAGCGGGATCAGCCGCACGCCGGG
CGGCACACCGCGCCGCCCCGATGGCAAGGCAGACGGCTAG

Upstream 100 bases:

>100_bases
CAAGGGCACTCTGCGCTAAAACGGGCCGAAACCTGCATTCTTGGCTCAAAGATATTTCCGCCGTGGGCACGGCCCCCAAC
TTACGGCCAGCGCCCGCGCA

Downstream 100 bases:

>100_bases
CCGCCCGCCACGCCCGCCTCCGCGAAGGTCGCCATGCCGGAATGGCAGGCAATCGCGCCGCGTAGGATCTGGATCGCAAG
CGCCCCGCCCGAGCCTTCGC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MPLTPRRNTRYTRRTPTPNRNRSMDEALLQITIYLTAMLIAVPISIRFGLGSVLGYLLAGIAIGPVLGLVGSETQDLQHY
AEFGVVLMLFLIGLELDPRTLWDMRKRLVGLGGSQILLSTAILTGGAMILGLSTSLSLAIGITLALSSTAIVLTTLSEKG
LMGTTGGRGAFSVLLTQDIAVIPALALLPLLATGAGIRFTEDGAIERTAEDAHHSLSLVEGLPAWGVTLVTIAAVIAVIL
AGRYLSPFVFRVIHNAKLKELYTVAALAFVVGIAELMILVGLSPALGAFLAGVVLANSEFKHELEADIEPFKGLLLGLFF
ITVGAGINFATLFANPFLIIGLTLAIMVIKGVVLYAIARVTRMEGRDRWLFTLSLAQAGEFGFVLVAFGVSQAVFPTYIA
QILLLVVALSMLLTPLSFILYEAIGARLGTGVEDAPEHDEIDEEAPVIIAGIGRFGQSVHRMVRASGFKTVVLDSNLETI
QLMRRFGLKSFFGDPTRPELLKAAGLDKARVLVVCVDNKQAAVKLVRYAKRTRPDISVVARAHDLLHVYELYAAGADHII
REVFDSSLRAARYVLEDMGLSDYEAHAMEIAFYRHDRHNLRALAEVWKPGIPVTENEDYMRLTREMADNLESAVMTHLDA
MEDEGGGSTAHTRGDVGALSGISRTPGGTPRRPDGKADG

Sequences:

>Translated_679_residues
MPLTPRRNTRYTRRTPTPNRNRSMDEALLQITIYLTAMLIAVPISIRFGLGSVLGYLLAGIAIGPVLGLVGSETQDLQHY
AEFGVVLMLFLIGLELDPRTLWDMRKRLVGLGGSQILLSTAILTGGAMILGLSTSLSLAIGITLALSSTAIVLTTLSEKG
LMGTTGGRGAFSVLLTQDIAVIPALALLPLLATGAGIRFTEDGAIERTAEDAHHSLSLVEGLPAWGVTLVTIAAVIAVIL
AGRYLSPFVFRVIHNAKLKELYTVAALAFVVGIAELMILVGLSPALGAFLAGVVLANSEFKHELEADIEPFKGLLLGLFF
ITVGAGINFATLFANPFLIIGLTLAIMVIKGVVLYAIARVTRMEGRDRWLFTLSLAQAGEFGFVLVAFGVSQAVFPTYIA
QILLLVVALSMLLTPLSFILYEAIGARLGTGVEDAPEHDEIDEEAPVIIAGIGRFGQSVHRMVRASGFKTVVLDSNLETI
QLMRRFGLKSFFGDPTRPELLKAAGLDKARVLVVCVDNKQAAVKLVRYAKRTRPDISVVARAHDLLHVYELYAAGADHII
REVFDSSLRAARYVLEDMGLSDYEAHAMEIAFYRHDRHNLRALAEVWKPGIPVTENEDYMRLTREMADNLESAVMTHLDA
MEDEGGGSTAHTRGDVGALSGISRTPGGTPRRPDGKADG
>Mature_678_residues
PLTPRRNTRYTRRTPTPNRNRSMDEALLQITIYLTAMLIAVPISIRFGLGSVLGYLLAGIAIGPVLGLVGSETQDLQHYA
EFGVVLMLFLIGLELDPRTLWDMRKRLVGLGGSQILLSTAILTGGAMILGLSTSLSLAIGITLALSSTAIVLTTLSEKGL
MGTTGGRGAFSVLLTQDIAVIPALALLPLLATGAGIRFTEDGAIERTAEDAHHSLSLVEGLPAWGVTLVTIAAVIAVILA
GRYLSPFVFRVIHNAKLKELYTVAALAFVVGIAELMILVGLSPALGAFLAGVVLANSEFKHELEADIEPFKGLLLGLFFI
TVGAGINFATLFANPFLIIGLTLAIMVIKGVVLYAIARVTRMEGRDRWLFTLSLAQAGEFGFVLVAFGVSQAVFPTYIAQ
ILLLVVALSMLLTPLSFILYEAIGARLGTGVEDAPEHDEIDEEAPVIIAGIGRFGQSVHRMVRASGFKTVVLDSNLETIQ
LMRRFGLKSFFGDPTRPELLKAAGLDKARVLVVCVDNKQAAVKLVRYAKRTRPDISVVARAHDLLHVYELYAAGADHIIR
EVFDSSLRAARYVLEDMGLSDYEAHAMEIAFYRHDRHNLRALAEVWKPGIPVTENEDYMRLTREMADNLESAVMTHLDAM
EDEGGGSTAHTRGDVGALSGISRTPGGTPRRPDGKADG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=410, Percent_Identity=26.5853658536585, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786232, Length=582, Percent_Identity=43.298969072165, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1789749, Length=618, Percent_Identity=37.0550161812298, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786685, Length=532, Percent_Identity=28.7593984962406, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 73147; Mature: 73015

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTPRRNTRYTRRTPTPNRNRSMDEALLQITIYLTAMLIAVPISIRFGLGSVLGYLLAG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIGPVLGLVGSETQDLQHYAEFGVVLMLFLIGLELDPRTLWDMRKRLVGLGGSQILLST
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHH
AILTGGAMILGLSTSLSLAIGITLALSSTAIVLTTLSEKGLMGTTGGRGAFSVLLTQDIA
HHHHCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
VIPALALLPLLATGAGIRFTEDGAIERTAEDAHHSLSLVEGLPAWGVTLVTIAAVIAVIL
HHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGRYLSPFVFRVIHNAKLKELYTVAALAFVVGIAELMILVGLSPALGAFLAGVVLANSEF
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHH
KHELEADIEPFKGLLLGLFFITVGAGINFATLFANPFLIIGLTLAIMVIKGVVLYAIARV
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
TRMEGRDRWLFTLSLAQAGEFGFVLVAFGVSQAVFPTYIAQILLLVVALSMLLTPLSFIL
HHHCCCCCEEEEEEECCCCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEAIGARLGTGVEDAPEHDEIDEEAPVIIAGIGRFGQSVHRMVRASGFKTVVLDSNLETI
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHH
QLMRRFGLKSFFGDPTRPELLKAAGLDKARVLVVCVDNKQAAVKLVRYAKRTRPDISVVA
HHHHHHCHHHHCCCCCCHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHH
RAHDLLHVYELYAAGADHIIREVFDSSLRAARYVLEDMGLSDYEAHAMEIAFYRHDRHNL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEHHHHCCHHHH
RALAEVWKPGIPVTENEDYMRLTREMADNLESAVMTHLDAMEDEGGGSTAHTRGDVGALS
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHC
GISRTPGGTPRRPDGKADG
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PLTPRRNTRYTRRTPTPNRNRSMDEALLQITIYLTAMLIAVPISIRFGLGSVLGYLLAG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIGPVLGLVGSETQDLQHYAEFGVVLMLFLIGLELDPRTLWDMRKRLVGLGGSQILLST
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHH
AILTGGAMILGLSTSLSLAIGITLALSSTAIVLTTLSEKGLMGTTGGRGAFSVLLTQDIA
HHHHCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
VIPALALLPLLATGAGIRFTEDGAIERTAEDAHHSLSLVEGLPAWGVTLVTIAAVIAVIL
HHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGRYLSPFVFRVIHNAKLKELYTVAALAFVVGIAELMILVGLSPALGAFLAGVVLANSEF
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHH
KHELEADIEPFKGLLLGLFFITVGAGINFATLFANPFLIIGLTLAIMVIKGVVLYAIARV
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
TRMEGRDRWLFTLSLAQAGEFGFVLVAFGVSQAVFPTYIAQILLLVVALSMLLTPLSFIL
HHHCCCCCEEEEEEECCCCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEAIGARLGTGVEDAPEHDEIDEEAPVIIAGIGRFGQSVHRMVRASGFKTVVLDSNLETI
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHH
QLMRRFGLKSFFGDPTRPELLKAAGLDKARVLVVCVDNKQAAVKLVRYAKRTRPDISVVA
HHHHHHCHHHHCCCCCCHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHH
RAHDLLHVYELYAAGADHIIREVFDSSLRAARYVLEDMGLSDYEAHAMEIAFYRHDRHNL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEHHHHCCHHHH
RALAEVWKPGIPVTENEDYMRLTREMADNLESAVMTHLDAMEDEGGGSTAHTRGDVGALS
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHC
GISRTPGGTPRRPDGKADG
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA