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The map label for this gene is gcvT [H]

Identifier: 89055340

GI number: 89055340

Start: 2866818

End: 2869256

Strand: Direct

Name: gcvT [H]

Synonym: Jann_2849

Alternate gene names: 89055340

Gene position: 2866818-2869256 (Clockwise)

Preceding gene: 89055339

Following gene: 89055342

Centisome position: 66.39

GC content: 62.53

Gene sequence:

>2439_bases
ATGACCGAAATTCCCTCCCATGCGCGCGTCGTCATTGTCGGCGGCGGTGTTGCCGGGTGTTCCGTAGCCTATCACCTGAC
GAAACTTGGCTGGACCGATGTGGTGCTTTTGGAACGCAAGCGCCTGACAAGCGGCACCACATGGCATGCGGCAGGCCTGA
TCGCGCAATTGCGTGCGACGAAGAACATGACCCGCCTCGCGAAATATTCCCAGGAACTCTACGGCAATCTGGAGGCTGAG
ACCGGCGTCGCCACAGGCTTCCGCCGCTGCGGTTCCATCACCATGGCGCTGACCGATCACCGCGCGGAGGAGATCCGCAG
GCAGGCCTCCATGGCCCGCTCCTTCGGCGTGGAGGTGGAGGAAATCGACGCCGCCGCCGTCCTGAAACACTACCCCCACG
TGAACACCGACGGCATGACAGCCGCCGTCTGGCTGCCGCTGGATGGGCAAGGCGACCCGGCCAACATCGCGCTTTCGATG
GCCAAAGGCGCGCGCATGGGCGGGGCGACCGTGCTGGAAAACGTCAAGGTCACGGGCGTCGATACCGATGGCGGCAAGGT
GGGCGGCGTCAGCTGGGAAGCGGACGGAGACACGGGCACGATCAAAGCCGACATCGTCGTGAATTGCGCCGGCATGTGGG
CGCGCGACTTTGGCCAGATGGCCGGCGTGAACGTGCCGCTTCAGGCCTGCGAACACTTCTACATCGTCACAGAATCCATC
CCCAATCTCAGCCAGCTCCCCGTCCTTCGCGTGCCCGACGAATGCGCCTATTACAAGGAAGACGCAGGAAAAATGCTTCT
GGGCGCTTTCGAGCCGGTCTCCAAACCCTGGGGTCCGATCCCGGACGATTTTGAATTCGACCAATTGCCCGAGGATTTCG
ACCACTTCGAGCCGATCCTTGAAAACGCCATTGAGCGGATGCCGATGCTGGCGGAGGCGGGCATTCACACCTTCTTTAAT
GGTCCCGAAAGTTTTACTCCCGATGATGCCTATCACATGGGCCCCGCGCCGGAGGTGGACGGCTATTGGGTCTGCGCGGG
CTTCAACTCCATCGGCATCCAGTCGGCGGGCGGGGCCGGATGGGCCTTGGCGGAATGGATGGAAAACGGCATCCCCCCCT
TCGATGTGGGGGAGGTCGACATTCGCCGGATGCAGCCCTTCCAGCGCAACAAACGCTACCTGAAGGAACGCGCGTCCGAG
ACGCTCGGCCTGCTTTACGCCGACCATTACCCCAACCGTCAAAAGGCCACCGCACGCGGTGTGCGACGCTCGCCGTTGCA
TGAACATCTCAAGGCGCAGGGGGCCGTCTTCGGTGAATTGGCCGGGTGGGAACGGGCCAATTGGTTCGCCAATGAAGGTC
AGGAACGGGAATATAAATACGACTGGAAGGGTCAGAACTGGTTCGACAATCAGGCGCAGGAACACCGCGCGGTACGCGAG
ACGGTGGGCCTCTATGACATGTCGTCATTCGGCAAGATCCGCGTCGATGGCCCCGATGCGGAGGCGTTCCTGAACCGCAT
CGCGGCGGGCAACATGTCCGTGCCCGTGGGCAAGATCGTCTACACGCAATTCCTGAACATGCGTGGCGGGATTGAAGCCG
ACGTGACGATCACGCGGCTGGCGCAGGACAGTTATTTCATCGTCACCCCGGCGGCCACGCTGATCCGCGACATGGCGTGG
CTGAAGATGAACCGGCGCGACGAGGTGGTGATCCTGTCGGACATCACGGCATCGGAGGCGGTGATCTGCGTCATGGGCCC
GAATTCCCGCGCGCTGATGCAATCAGTCAGCCCGCATGATTGGTCGAATGCGGCCTTCCCCTTTGGCGTGGCGCAGCAGG
TGGACATCGGCCTCGGCATCGCCCGCGCCCACCGCGTCACTTATGTGGGCGAATTGGGGTGGGAGCTGTATGTCTCCGCC
GATCAGGCCGCCCATGTGTTTGAAACCTTGCATGAGGCGGGCGCCGATCACGGGTTGCGGCTCTGCGGCTTGCACATGAT
GGACAGCGCCCGGATCGAAAAGGCCTTCCGCCATTTTGGCCATGACATCACCGGCGAGGATCACGTGATCGAGGCCGGTC
TTGGGTTCGCAGTGTCCAAGACCAAGAACAATTTCATCGGGGCCGATGCCGTGGCCCGCAAGCGCGACGAGGGGCTGCAA
ATGCGGATGGTCCAGTTCAAACTGACGGATCCCGAAGCGATGCTGTTCCACGCAGAGCCGATCATTCGCAACGGAGAGGT
CGTCAGCTACATCACCTCCGGCAATTACGGCCACACTTTGGGCGGCGCGATTGGAATGGGCTACGTCCCCTGCCCCGGTG
AAACCCCGGCAGAGATGCTGGCCTCCGCGTACGAGATCGAGGTCGCGGGCACTCGCGTGGCGGCAGAGGCCAGCACCCGT
CCGATGTATGATCCAACGTCCGAGCGGGCACGCGGCTGA

Upstream 100 bases:

>100_bases
GCCGCTTCCGCAAGACCCTCGACCACATGCAGGCGAATGGGTAACGCTTCGGGGCGGGGGGACACCTCCGCCCTTTTTCC
TTCAGACCGGGTTTGCTCAC

Downstream 100 bases:

>100_bases
GGGCCACGCCCACCTCATCCGCGCCTCAGATCGCGTTCTGGGCGATGTGATTGGAGCGCGTTTGATCCCTCAAGGCGCCC
CAGCCCCGCGCGCGTTTTCG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 812; Mature: 811

Protein sequence:

>812_residues
MTEIPSHARVVIVGGGVAGCSVAYHLTKLGWTDVVLLERKRLTSGTTWHAAGLIAQLRATKNMTRLAKYSQELYGNLEAE
TGVATGFRRCGSITMALTDHRAEEIRRQASMARSFGVEVEEIDAAAVLKHYPHVNTDGMTAAVWLPLDGQGDPANIALSM
AKGARMGGATVLENVKVTGVDTDGGKVGGVSWEADGDTGTIKADIVVNCAGMWARDFGQMAGVNVPLQACEHFYIVTESI
PNLSQLPVLRVPDECAYYKEDAGKMLLGAFEPVSKPWGPIPDDFEFDQLPEDFDHFEPILENAIERMPMLAEAGIHTFFN
GPESFTPDDAYHMGPAPEVDGYWVCAGFNSIGIQSAGGAGWALAEWMENGIPPFDVGEVDIRRMQPFQRNKRYLKERASE
TLGLLYADHYPNRQKATARGVRRSPLHEHLKAQGAVFGELAGWERANWFANEGQEREYKYDWKGQNWFDNQAQEHRAVRE
TVGLYDMSSFGKIRVDGPDAEAFLNRIAAGNMSVPVGKIVYTQFLNMRGGIEADVTITRLAQDSYFIVTPAATLIRDMAW
LKMNRRDEVVILSDITASEAVICVMGPNSRALMQSVSPHDWSNAAFPFGVAQQVDIGLGIARAHRVTYVGELGWELYVSA
DQAAHVFETLHEAGADHGLRLCGLHMMDSARIEKAFRHFGHDITGEDHVIEAGLGFAVSKTKNNFIGADAVARKRDEGLQ
MRMVQFKLTDPEAMLFHAEPIIRNGEVVSYITSGNYGHTLGGAIGMGYVPCPGETPAEMLASAYEIEVAGTRVAAEASTR
PMYDPTSERARG

Sequences:

>Translated_812_residues
MTEIPSHARVVIVGGGVAGCSVAYHLTKLGWTDVVLLERKRLTSGTTWHAAGLIAQLRATKNMTRLAKYSQELYGNLEAE
TGVATGFRRCGSITMALTDHRAEEIRRQASMARSFGVEVEEIDAAAVLKHYPHVNTDGMTAAVWLPLDGQGDPANIALSM
AKGARMGGATVLENVKVTGVDTDGGKVGGVSWEADGDTGTIKADIVVNCAGMWARDFGQMAGVNVPLQACEHFYIVTESI
PNLSQLPVLRVPDECAYYKEDAGKMLLGAFEPVSKPWGPIPDDFEFDQLPEDFDHFEPILENAIERMPMLAEAGIHTFFN
GPESFTPDDAYHMGPAPEVDGYWVCAGFNSIGIQSAGGAGWALAEWMENGIPPFDVGEVDIRRMQPFQRNKRYLKERASE
TLGLLYADHYPNRQKATARGVRRSPLHEHLKAQGAVFGELAGWERANWFANEGQEREYKYDWKGQNWFDNQAQEHRAVRE
TVGLYDMSSFGKIRVDGPDAEAFLNRIAAGNMSVPVGKIVYTQFLNMRGGIEADVTITRLAQDSYFIVTPAATLIRDMAW
LKMNRRDEVVILSDITASEAVICVMGPNSRALMQSVSPHDWSNAAFPFGVAQQVDIGLGIARAHRVTYVGELGWELYVSA
DQAAHVFETLHEAGADHGLRLCGLHMMDSARIEKAFRHFGHDITGEDHVIEAGLGFAVSKTKNNFIGADAVARKRDEGLQ
MRMVQFKLTDPEAMLFHAEPIIRNGEVVSYITSGNYGHTLGGAIGMGYVPCPGETPAEMLASAYEIEVAGTRVAAEASTR
PMYDPTSERARG
>Mature_811_residues
TEIPSHARVVIVGGGVAGCSVAYHLTKLGWTDVVLLERKRLTSGTTWHAAGLIAQLRATKNMTRLAKYSQELYGNLEAET
GVATGFRRCGSITMALTDHRAEEIRRQASMARSFGVEVEEIDAAAVLKHYPHVNTDGMTAAVWLPLDGQGDPANIALSMA
KGARMGGATVLENVKVTGVDTDGGKVGGVSWEADGDTGTIKADIVVNCAGMWARDFGQMAGVNVPLQACEHFYIVTESIP
NLSQLPVLRVPDECAYYKEDAGKMLLGAFEPVSKPWGPIPDDFEFDQLPEDFDHFEPILENAIERMPMLAEAGIHTFFNG
PESFTPDDAYHMGPAPEVDGYWVCAGFNSIGIQSAGGAGWALAEWMENGIPPFDVGEVDIRRMQPFQRNKRYLKERASET
LGLLYADHYPNRQKATARGVRRSPLHEHLKAQGAVFGELAGWERANWFANEGQEREYKYDWKGQNWFDNQAQEHRAVRET
VGLYDMSSFGKIRVDGPDAEAFLNRIAAGNMSVPVGKIVYTQFLNMRGGIEADVTITRLAQDSYFIVTPAATLIRDMAWL
KMNRRDEVVILSDITASEAVICVMGPNSRALMQSVSPHDWSNAAFPFGVAQQVDIGLGIARAHRVTYVGELGWELYVSAD
QAAHVFETLHEAGADHGLRLCGLHMMDSARIEKAFRHFGHDITGEDHVIEAGLGFAVSKTKNNFIGADAVARKRDEGLQM
RMVQFKLTDPEAMLFHAEPIIRNGEVVSYITSGNYGHTLGGAIGMGYVPCPGETPAEMLASAYEIEVAGTRVAAEASTRP
MYDPTSERARG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI197927446, Length=859, Percent_Identity=35.3899883585565, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI21361378, Length=859, Percent_Identity=35.3899883585565, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI194306651, Length=839, Percent_Identity=35.1609058402861, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI24797151, Length=833, Percent_Identity=31.3325330132053, Blast_Score=418, Evalue=1e-116,
Organism=Homo sapiens, GI44662838, Length=394, Percent_Identity=23.0964467005076, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI257796258, Length=367, Percent_Identity=22.8882833787466, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI257796256, Length=326, Percent_Identity=23.6196319018405, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI257796254, Length=390, Percent_Identity=22.3076923076923, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789272, Length=317, Percent_Identity=25.2365930599369, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI32563613, Length=823, Percent_Identity=32.0777642770352, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI71994045, Length=796, Percent_Identity=27.0100502512563, Blast_Score=254, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71994052, Length=803, Percent_Identity=26.774595267746, Blast_Score=251, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=360, Percent_Identity=24.4444444444444, Blast_Score=94, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=254, Percent_Identity=24.8031496062992, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20130091, Length=861, Percent_Identity=33.4494773519164, Blast_Score=434, Evalue=1e-121,
Organism=Drosophila melanogaster, GI28571104, Length=840, Percent_Identity=31.6666666666667, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI20129441, Length=359, Percent_Identity=27.2980501392758, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 88940; Mature: 88808

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIPSHARVVIVGGGVAGCSVAYHLTKLGWTDVVLLERKRLTSGTTWHAAGLIAQLRAT
CCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHH
KNMTRLAKYSQELYGNLEAETGVATGFRRCGSITMALTDHRAEEIRRQASMARSFGVEVE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCHH
EIDAAAVLKHYPHVNTDGMTAAVWLPLDGQGDPANIALSMAKGARMGGATVLENVKVTGV
HHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCEEEEEE
DTDGGKVGGVSWEADGDTGTIKADIVVNCAGMWARDFGQMAGVNVPLQACEHFYIVTESI
ECCCCEECCEEEECCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCHHHCCEEEEEECCC
PNLSQLPVLRVPDECAYYKEDAGKMLLGAFEPVSKPWGPIPDDFEFDQLPEDFDHFEPIL
CCHHHCCEEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHH
ENAIERMPMLAEAGIHTFFNGPESFTPDDAYHMGPAPEVDGYWVCAGFNSIGIQSAGGAG
HHHHHHCCHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
WALAEWMENGIPPFDVGEVDIRRMQPFQRNKRYLKERASETLGLLYADHYPNRQKATARG
HHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHC
VRRSPLHEHLKAQGAVFGELAGWERANWFANEGQEREYKYDWKGQNWFDNQAQEHRAVRE
CCCCHHHHHHHHCCCEEHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
TVGLYDMSSFGKIRVDGPDAEAFLNRIAAGNMSVPVGKIVYTQFLNMRGGIEADVTITRL
HHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
AQDSYFIVTPAATLIRDMAWLKMNRRDEVVILSDITASEAVICVMGPNSRALMQSVSPHD
CCCCEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHCCCCCC
WSNAAFPFGVAQQVDIGLGIARAHRVTYVGELGWELYVSADQAAHVFETLHEAGADHGLR
CCCCCCCCCCCHHHCCCCEEHHHHEEEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCEE
LCGLHMMDSARIEKAFRHFGHDITGEDHVIEAGLGFAVSKTKNNFIGADAVARKRDEGLQ
EEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHCCCCE
MRMVQFKLTDPEAMLFHAEPIIRNGEVVSYITSGNYGHTLGGAIGMGYVPCPGETPAEML
EEEEEEEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHH
ASAYEIEVAGTRVAAEASTRPMYDPTSERARG
HHHEEEEECCCEEEECCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TEIPSHARVVIVGGGVAGCSVAYHLTKLGWTDVVLLERKRLTSGTTWHAAGLIAQLRAT
CCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHH
KNMTRLAKYSQELYGNLEAETGVATGFRRCGSITMALTDHRAEEIRRQASMARSFGVEVE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCHH
EIDAAAVLKHYPHVNTDGMTAAVWLPLDGQGDPANIALSMAKGARMGGATVLENVKVTGV
HHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCEEEEEE
DTDGGKVGGVSWEADGDTGTIKADIVVNCAGMWARDFGQMAGVNVPLQACEHFYIVTESI
ECCCCEECCEEEECCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCHHHCCEEEEEECCC
PNLSQLPVLRVPDECAYYKEDAGKMLLGAFEPVSKPWGPIPDDFEFDQLPEDFDHFEPIL
CCHHHCCEEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHH
ENAIERMPMLAEAGIHTFFNGPESFTPDDAYHMGPAPEVDGYWVCAGFNSIGIQSAGGAG
HHHHHHCCHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
WALAEWMENGIPPFDVGEVDIRRMQPFQRNKRYLKERASETLGLLYADHYPNRQKATARG
HHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHC
VRRSPLHEHLKAQGAVFGELAGWERANWFANEGQEREYKYDWKGQNWFDNQAQEHRAVRE
CCCCHHHHHHHHCCCEEHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
TVGLYDMSSFGKIRVDGPDAEAFLNRIAAGNMSVPVGKIVYTQFLNMRGGIEADVTITRL
HHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
AQDSYFIVTPAATLIRDMAWLKMNRRDEVVILSDITASEAVICVMGPNSRALMQSVSPHD
CCCCEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHCCCCCC
WSNAAFPFGVAQQVDIGLGIARAHRVTYVGELGWELYVSADQAAHVFETLHEAGADHGLR
CCCCCCCCCCCHHHCCCCEEHHHHEEEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCEE
LCGLHMMDSARIEKAFRHFGHDITGEDHVIEAGLGFAVSKTKNNFIGADAVARKRDEGLQ
EEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHCCCCE
MRMVQFKLTDPEAMLFHAEPIIRNGEVVSYITSGNYGHTLGGAIGMGYVPCPGETPAEML
EEEEEEEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHH
ASAYEIEVAGTRVAAEASTRPMYDPTSERARG
HHHEEEEECCCEEEECCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA