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The map label for this gene is bioA [C]

Identifier: 89055339

GI number: 89055339

Start: 2865430

End: 2866761

Strand: Direct

Name: bioA [C]

Synonym: Jann_2848

Alternate gene names: 89055339

Gene position: 2865430-2866761 (Clockwise)

Preceding gene: 89055338

Following gene: 89055340

Centisome position: 66.36

GC content: 62.54

Gene sequence:

>1332_bases
ATGGCCTATGATGCAACGAACTCGCTGGAAGCGCATTGGATGCCATTCTCGGACAACCGGGGTTTCAAGGAAGATCCGCG
TCTGGTTGTCCGCGCGGAAGGCGTGCACCTTTATGACCATCGTGGCGGACAATTGCTGGACGGGTCATCGGGCCTCTTCT
GCTCGCCCGCCGGTCACTGCCACCCGAAAATCGCAGAGGCCGTCGCCAAGCAGATGATGGAATACACCTACGTCATGCCG
TTCCAGGCCGGCCACCCGGGATCTTTCAAGCTGGCGGAGAAGATCAGCCGCATGTTGCCCGAGCAGATGAACCACGTGTT
CTTCACCAATTCCGGCTCTGAATCGGTGGACACGGCGATGAAGATCGTCATGGCCTACTGGAATGCGCGCGGCGAGTCCC
GCCCCCGTTTCGTGAGCCGCGAGCGCGCCTACCACGGCGTGAACATCGGCGGCGTCAGCCTCAGCGGCATGGTCAAGAAC
CGCGACATCTTCCACGCCACGGTTCCCGGCGTCATGATGCTGCGCCACACCTATGACCCGTCGGAAAAATTCATCCCCGG
CGGCCATTCCCAGCACAACGGCGTTGAACTCGCCAATGATCTGGAACGGATGGCCCAGACCTACGGCGGCGCCAACATCG
CGGCCGTCTTCGTGGAACCCGTCGCAGGCTCCACCGGCGCGCTTCCGCCGCCCAAAGGCTACCTGCAACAGCTTCGCAAG
ATCTGTGACCAATACGGCATCCTGCTGGTGTTTGACGAAGTGATCACCGGGTTTGGCCGCATGGGCACGGCCTTCGCGGC
GCAAAAATACGGCGTGGAGCCCGACATCATCACCATGGCCAAGGCGCTCACCAACGGCTCGATCCCCATGGGCGCGGTCG
CCTGCCGCGATGACATCTACGAGACGGTCGTGGGAAGCAGCAAGCGCGGCCTGACCGAATTCTTCCACGGCTACACCTAT
TCCGGCCACCCCGCGGCCTGCGCGGCGGGCAACGCGATGATGGACATCCTTGAAGAGGAAGACCTGATCACCCGTGCCGC
CGACCTGATCCCCTATTTCGAGGCCGCCCTGATGGACGGCCTGAAGCAACATCCGATGATCAAGGACATCCGCGTCGCGG
GCCTGATGGCGGGCGTCGAAGTCCACGCCGAAGGTGGGCCCGGCATGCGCGGGACCGAGCTGCAAAAGCGCATGTTCTGG
GATGGTCTGTCGGTCAAGTTCACCGGCGACAATGCGATCCTCGCGCCGCAGTTCATCGCCACCCGCGACAATGTTGACGA
GATCGTGGGCCGCTTCCGCAAGACCCTCGACCACATGCAGGCGAATGGGTAA

Upstream 100 bases:

>100_bases
TTACTCAACGTCCCTTCTGGCCCTACTCCGACTCTGTCAGCGGAGCGATTTTCGCGCATCGTTTTACGGTCCCGCGGGGC
TCAATTGGGGAGGGTCCACC

Downstream 100 bases:

>100_bases
CGCTTCGGGGCGGGGGGACACCTCCGCCCTTTTTCCTTCAGACCGGGTTTGCTCACATGACCGAAATTCCCTCCCATGCG
CGCGTCGTCATTGTCGGCGG

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAYDATNSLEAHWMPFSDNRGFKEDPRLVVRAEGVHLYDHRGGQLLDGSSGLFCSPAGHCHPKIAEAVAKQMMEYTYVMP
FQAGHPGSFKLAEKISRMLPEQMNHVFFTNSGSESVDTAMKIVMAYWNARGESRPRFVSRERAYHGVNIGGVSLSGMVKN
RDIFHATVPGVMMLRHTYDPSEKFIPGGHSQHNGVELANDLERMAQTYGGANIAAVFVEPVAGSTGALPPPKGYLQQLRK
ICDQYGILLVFDEVITGFGRMGTAFAAQKYGVEPDIITMAKALTNGSIPMGAVACRDDIYETVVGSSKRGLTEFFHGYTY
SGHPAACAAGNAMMDILEEEDLITRAADLIPYFEAALMDGLKQHPMIKDIRVAGLMAGVEVHAEGGPGMRGTELQKRMFW
DGLSVKFTGDNAILAPQFIATRDNVDEIVGRFRKTLDHMQANG

Sequences:

>Translated_443_residues
MAYDATNSLEAHWMPFSDNRGFKEDPRLVVRAEGVHLYDHRGGQLLDGSSGLFCSPAGHCHPKIAEAVAKQMMEYTYVMP
FQAGHPGSFKLAEKISRMLPEQMNHVFFTNSGSESVDTAMKIVMAYWNARGESRPRFVSRERAYHGVNIGGVSLSGMVKN
RDIFHATVPGVMMLRHTYDPSEKFIPGGHSQHNGVELANDLERMAQTYGGANIAAVFVEPVAGSTGALPPPKGYLQQLRK
ICDQYGILLVFDEVITGFGRMGTAFAAQKYGVEPDIITMAKALTNGSIPMGAVACRDDIYETVVGSSKRGLTEFFHGYTY
SGHPAACAAGNAMMDILEEEDLITRAADLIPYFEAALMDGLKQHPMIKDIRVAGLMAGVEVHAEGGPGMRGTELQKRMFW
DGLSVKFTGDNAILAPQFIATRDNVDEIVGRFRKTLDHMQANG
>Mature_442_residues
AYDATNSLEAHWMPFSDNRGFKEDPRLVVRAEGVHLYDHRGGQLLDGSSGLFCSPAGHCHPKIAEAVAKQMMEYTYVMPF
QAGHPGSFKLAEKISRMLPEQMNHVFFTNSGSESVDTAMKIVMAYWNARGESRPRFVSRERAYHGVNIGGVSLSGMVKNR
DIFHATVPGVMMLRHTYDPSEKFIPGGHSQHNGVELANDLERMAQTYGGANIAAVFVEPVAGSTGALPPPKGYLQQLRKI
CDQYGILLVFDEVITGFGRMGTAFAAQKYGVEPDIITMAKALTNGSIPMGAVACRDDIYETVVGSSKRGLTEFFHGYTYS
GHPAACAAGNAMMDILEEEDLITRAADLIPYFEAALMDGLKQHPMIKDIRVAGLMAGVEVHAEGGPGMRGTELQKRMFWD
GLSVKFTGDNAILAPQFIATRDNVDEIVGRFRKTLDHMQANG

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=451, Percent_Identity=28.6031042128603, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI37574042, Length=370, Percent_Identity=30.8108108108108, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI24119277, Length=437, Percent_Identity=28.3752860411899, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=27.536231884058, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI226442705, Length=372, Percent_Identity=29.0322580645161, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI226442709, Length=334, Percent_Identity=30.8383233532934, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=27.6595744680851, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786991, Length=414, Percent_Identity=31.8840579710145, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI145693181, Length=421, Percent_Identity=29.6912114014252, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789016, Length=362, Percent_Identity=29.5580110497238, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=26.6666666666667, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=28.8834951456311, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=30.6282722513089, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=29.3948126801153, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=377, Percent_Identity=32.0954907161804, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32564660, Length=393, Percent_Identity=27.9898218829517, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=426, Percent_Identity=26.5258215962441, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=244, Percent_Identity=30.7377049180328, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=28.1323877068558, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=418, Percent_Identity=26.555023923445, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=26.2910798122066, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI161085790, Length=366, Percent_Identity=30.8743169398907, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574759, Length=366, Percent_Identity=30.8743169398907, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=29.0322580645161, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21357415, Length=425, Percent_Identity=25.4117647058824, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281366494, Length=368, Percent_Identity=21.7391304347826, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667139, Length=368, Percent_Identity=21.7391304347826, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667143, Length=368, Percent_Identity=21.7391304347826, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48491; Mature: 48360

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDATNSLEAHWMPFSDNRGFKEDPRLVVRAEGVHLYDHRGGQLLDGSSGLFCSPAGHC
CCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCEEEEECCCCEEEECCCCEEECCCCCC
HPKIAEAVAKQMMEYTYVMPFQAGHPGSFKLAEKISRMLPEQMNHVFFTNSGSESVDTAM
CHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHH
KIVMAYWNARGESRPRFVSRERAYHGVNIGGVSLSGMVKNRDIFHATVPGVMMLRHTYDP
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEECEEECCCEEEECCCHHHHHHCCCCC
SEKFIPGGHSQHNGVELANDLERMAQTYGGANIAAVFVEPVAGSTGALPPPKGYLQQLRK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
ICDQYGILLVFDEVITGFGRMGTAFAAQKYGVEPDIITMAKALTNGSIPMGAVACRDDIY
HHHHCCEEEEEHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
ETVVGSSKRGLTEFFHGYTYSGHPAACAAGNAMMDILEEEDLITRAADLIPYFEAALMDG
HHHHCCCCCCHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQHPMIKDIRVAGLMAGVEVHAEGGPGMRGTELQKRMFWDGLSVKFTGDNAILAPQFIA
HHHCCCHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCCEECCHHHH
TRDNVDEIVGRFRKTLDHMQANG
CCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYDATNSLEAHWMPFSDNRGFKEDPRLVVRAEGVHLYDHRGGQLLDGSSGLFCSPAGHC
CCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCEEEEECCCCEEEECCCCEEECCCCCC
HPKIAEAVAKQMMEYTYVMPFQAGHPGSFKLAEKISRMLPEQMNHVFFTNSGSESVDTAM
CHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHH
KIVMAYWNARGESRPRFVSRERAYHGVNIGGVSLSGMVKNRDIFHATVPGVMMLRHTYDP
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEECEEECCCEEEECCCHHHHHHCCCCC
SEKFIPGGHSQHNGVELANDLERMAQTYGGANIAAVFVEPVAGSTGALPPPKGYLQQLRK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
ICDQYGILLVFDEVITGFGRMGTAFAAQKYGVEPDIITMAKALTNGSIPMGAVACRDDIY
HHHHCCEEEEEHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
ETVVGSSKRGLTEFFHGYTYSGHPAACAAGNAMMDILEEEDLITRAADLIPYFEAALMDG
HHHHCCCCCCHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQHPMIKDIRVAGLMAGVEVHAEGGPGMRGTELQKRMFWDGLSVKFTGDNAILAPQFIA
HHHCCCHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCCEECCHHHH
TRDNVDEIVGRFRKTLDHMQANG
CCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]