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The map label for this gene is xsc [H]

Identifier: 89055337

GI number: 89055337

Start: 2862448

End: 2864229

Strand: Direct

Name: xsc [H]

Synonym: Jann_2846

Alternate gene names: 89055337

Gene position: 2862448-2864229 (Clockwise)

Preceding gene: 89055336

Following gene: 89055338

Centisome position: 66.29

GC content: 62.74

Gene sequence:

>1782_bases
ATGAAAATGACCACCGAAGAAGCCTTCGTCAAAACACTGCAAATGCACGGCATCGACAATGCATTCGGCATTATCGGCTC
TGCGATGATGCCGATCTCGGATATCTTTCCCGATGCGGGCATCAAGTTCTGGGACTGTGCCCATGAAGGCTCCGCTGGCA
TGATGTCCGATGGCTACACCCGCGCCACCGGCAAGATCTCCATGATGATCGCGCAAAACGGCCCCGGCATCACCAACTTC
GTGACCGCCGTGAAGACCGCTTACTGGAACCACACGCCGCTGCTGCTGGTGACCCCGCAGGCGGCCAACAAGACCATCGG
TCAGGGCGGTTTTCAGGAAGTCGAGCAGATGAAACTGTTCGAAGACATGGTCGCCTACCAAGAAGAGGTGCGCGACCCGA
CCCGCGTGGCCGAAGTTCTGACCCGTGTGATTTCCCAGGCCAAGCGCCTGTCCGGCCCTGCCCAGATCAACATCCCGCGC
GATTTCTGGACGCAAGTGGTCGACATCGAAATCCCCGAACCGATCGAATTCGAAGCCTCCCCCGGCGGCGAAAACTCCGT
GGCCGAAGCCGCAGCCCTGCTGTCGCAGGCGAAGAACCCCGTCATCCTGAACGGCGCGGGCGTGGTCCTGTCCAAGGGCG
GGATCGACGCCTCCCAGGCCCTGGCCGAACGCCTGACCGCGCCGGTCTGTGTCGGCTACCAGCACAACGATGCGTTCCCC
GGAAACCACCCGCTTTTCGCAGGCCCGCTTGGCTATAACGGGTCCAAGGCGGGGATGGAGCTGATCAAGGACGCCGACGT
CGTTTTGTGCCTTGGCACACGCCTCAACCCCTTCTCCACCCTGCCCGGCTACGGGATTGAATACTGGCCCGCTGACGCCA
AGATCATTCAGGTCGACATCAACCCCGACCGCATCGGCCTGACCAAAAAGGTCACTGTGGGCATCGTGGGCGACGCCGCA
AAGGTGGCCAACGGCATCCTGAACCAGCTTGCCGAGGATGCGGGCGATGCGGGGCGTGAGGATCGCAAGAACCACATCGC
CCAGACCAAATCCGCCTGGGCGCAGGAGCTGTCGTCCATGACGGAAGAGGCCGACGATCCCGGCACCAACTGGAACGAGC
GGGCCCGCGCGGCGAAGCCCAACTGGATGGCCCCCCGCATGGCGTGGCGCGCGATCCAGGCCGCCCTGCCGGTGGAGGCG
ATCATCTCCAGCGATATCGGCAACAATTGCGCCATCGGCAACGCCTACCCGTCGTTCAATGAGGGCCGAAAGTACCTAGC
CCCCGGCCTCTTCGGTCCCTGCGGCTACGGCCTTCCGGCGATTGTCGGCGCAAAGATCGGCCAGCCGGACGTGCCCGTTG
TGGGCTTTGCCGGGGACGGCGCATTTGGCATCGCGGTCAATGAATTAACGGCCATCGGGCGCGGCGACTGGCCCGCCATC
ACGCAGATCGTCTTCCGCAACTACCAGTGGGGCGCGGAAAAGCGGAACTCCACGCTGTGGTTTGACGACAACTTCGTCGG
CACGGAACTGGATGAAGACGTATCCTACTCCGGCATCGCCAACGCGTGCGGTCTGAAGGGCGTGGTCGCCCGCACCCAGG
AGGAGCTGACGGCAGCGCTGGATCAGGCGATCAAGGACCAGATGGAAAATGGGATCACAACGCTGATCGAGGCGATGATC
AACCAGGAATTGGGCGATCCCTTCCGCCGCGATGCGATGAAGAAGCCCGTGGAAGTGGCCGGTATCTCGGCGTCGGACAT
GAAGCCGCAGAAGGTCGCCTGA

Upstream 100 bases:

>100_bases
TTATCCACTGAGATAATTGGCCCTACCGTTTTTGAGACTTCTGGGCTCATTAAGGCGCAATCGCGGACCCACGGGGGAGT
CCGCTCTCGGGAGATTCGCC

Downstream 100 bases:

>100_bases
TCATGGGCGGGGGGCCAGATGATCCGCTGGCCGCCATTGCCGCCCGTGCCGCGGCAGATATCAAGCACATCGTGCTGAGC
GAAGGCAGTGATCCGCGCGT

Product: sulfoacetaldehyde acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MKMTTEEAFVKTLQMHGIDNAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYTRATGKISMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPTRVAEVLTRVISQAKRLSGPAQINIPR
DFWTQVVDIEIPEPIEFEASPGGENSVAEAAALLSQAKNPVILNGAGVVLSKGGIDASQALAERLTAPVCVGYQHNDAFP
GNHPLFAGPLGYNGSKAGMELIKDADVVLCLGTRLNPFSTLPGYGIEYWPADAKIIQVDINPDRIGLTKKVTVGIVGDAA
KVANGILNQLAEDAGDAGREDRKNHIAQTKSAWAQELSSMTEEADDPGTNWNERARAAKPNWMAPRMAWRAIQAALPVEA
IISSDIGNNCAIGNAYPSFNEGRKYLAPGLFGPCGYGLPAIVGAKIGQPDVPVVGFAGDGAFGIAVNELTAIGRGDWPAI
TQIVFRNYQWGAEKRNSTLWFDDNFVGTELDEDVSYSGIANACGLKGVVARTQEELTAALDQAIKDQMENGITTLIEAMI
NQELGDPFRRDAMKKPVEVAGISASDMKPQKVA

Sequences:

>Translated_593_residues
MKMTTEEAFVKTLQMHGIDNAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYTRATGKISMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPTRVAEVLTRVISQAKRLSGPAQINIPR
DFWTQVVDIEIPEPIEFEASPGGENSVAEAAALLSQAKNPVILNGAGVVLSKGGIDASQALAERLTAPVCVGYQHNDAFP
GNHPLFAGPLGYNGSKAGMELIKDADVVLCLGTRLNPFSTLPGYGIEYWPADAKIIQVDINPDRIGLTKKVTVGIVGDAA
KVANGILNQLAEDAGDAGREDRKNHIAQTKSAWAQELSSMTEEADDPGTNWNERARAAKPNWMAPRMAWRAIQAALPVEA
IISSDIGNNCAIGNAYPSFNEGRKYLAPGLFGPCGYGLPAIVGAKIGQPDVPVVGFAGDGAFGIAVNELTAIGRGDWPAI
TQIVFRNYQWGAEKRNSTLWFDDNFVGTELDEDVSYSGIANACGLKGVVARTQEELTAALDQAIKDQMENGITTLIEAMI
NQELGDPFRRDAMKKPVEVAGISASDMKPQKVA
>Mature_593_residues
MKMTTEEAFVKTLQMHGIDNAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYTRATGKISMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPTRVAEVLTRVISQAKRLSGPAQINIPR
DFWTQVVDIEIPEPIEFEASPGGENSVAEAAALLSQAKNPVILNGAGVVLSKGGIDASQALAERLTAPVCVGYQHNDAFP
GNHPLFAGPLGYNGSKAGMELIKDADVVLCLGTRLNPFSTLPGYGIEYWPADAKIIQVDINPDRIGLTKKVTVGIVGDAA
KVANGILNQLAEDAGDAGREDRKNHIAQTKSAWAQELSSMTEEADDPGTNWNERARAAKPNWMAPRMAWRAIQAALPVEA
IISSDIGNNCAIGNAYPSFNEGRKYLAPGLFGPCGYGLPAIVGAKIGQPDVPVVGFAGDGAFGIAVNELTAIGRGDWPAI
TQIVFRNYQWGAEKRNSTLWFDDNFVGTELDEDVSYSGIANACGLKGVVARTQEELTAALDQAIKDQMENGITTLIEAMI
NQELGDPFRRDAMKKPVEVAGISASDMKPQKVA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=598, Percent_Identity=23.2441471571906, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI93004078, Length=569, Percent_Identity=25.1318101933216, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1790104, Length=553, Percent_Identity=28.2097649186257, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87081685, Length=567, Percent_Identity=24.3386243386243, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1787096, Length=558, Percent_Identity=25.089605734767, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1786717, Length=588, Percent_Identity=26.1904761904762, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1788716, Length=596, Percent_Identity=25.3355704697987, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17542570, Length=566, Percent_Identity=24.9116607773852, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17531299, Length=572, Percent_Identity=23.6013986013986, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17531301, Length=572, Percent_Identity=23.6013986013986, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323755, Length=567, Percent_Identity=24.3386243386243, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320816, Length=584, Percent_Identity=22.7739726027397, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19922626, Length=565, Percent_Identity=25.3097345132743, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017820
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.3.3.15 [H]

Molecular weight: Translated: 63530; Mature: 63530

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMTTEEAFVKTLQMHGIDNAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCCCCCCE
RATGKISMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLF
ECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
EDMVAYQEEVRDPTRVAEVLTRVISQAKRLSGPAQINIPRDFWTQVVDIEIPEPIEFEAS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCEEEEEECCCCCEECCC
PGGENSVAEAAALLSQAKNPVILNGAGVVLSKGGIDASQALAERLTAPVCVGYQHNDAFP
CCCCHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHCCCCEEECCCCCCCCC
GNHPLFAGPLGYNGSKAGMELIKDADVVLCLGTRLNPFSTLPGYGIEYWPADAKIIQVDI
CCCCEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCEEEEEEC
NPDRIGLTKKVTVGIVGDAAKVANGILNQLAEDAGDAGREDRKNHIAQTKSAWAQELSSM
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TEEADDPGTNWNERARAAKPNWMAPRMAWRAIQAALPVEAIISSDIGNNCAIGNAYPSFN
HHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCHH
EGRKYLAPGLFGPCGYGLPAIVGAKIGQPDVPVVGFAGDGAFGIAVNELTAIGRGDWPAI
CCCHHHCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEEEHHHHHHCCCCCCHHH
TQIVFRNYQWGAEKRNSTLWFDDNFVGTELDEDVSYSGIANACGLKGVVARTQEELTAAL
HHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHH
DQAIKDQMENGITTLIEAMINQELGDPFRRDAMKKPVEVAGISASDMKPQKVA
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure
MKMTTEEAFVKTLQMHGIDNAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCCCCCCE
RATGKISMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLF
ECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
EDMVAYQEEVRDPTRVAEVLTRVISQAKRLSGPAQINIPRDFWTQVVDIEIPEPIEFEAS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCEEEEEECCCCCEECCC
PGGENSVAEAAALLSQAKNPVILNGAGVVLSKGGIDASQALAERLTAPVCVGYQHNDAFP
CCCCHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHCCCCEEECCCCCCCCC
GNHPLFAGPLGYNGSKAGMELIKDADVVLCLGTRLNPFSTLPGYGIEYWPADAKIIQVDI
CCCCEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCEEEEEEC
NPDRIGLTKKVTVGIVGDAAKVANGILNQLAEDAGDAGREDRKNHIAQTKSAWAQELSSM
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TEEADDPGTNWNERARAAKPNWMAPRMAWRAIQAALPVEAIISSDIGNNCAIGNAYPSFN
HHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCHH
EGRKYLAPGLFGPCGYGLPAIVGAKIGQPDVPVVGFAGDGAFGIAVNELTAIGRGDWPAI
CCCHHHCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEEEHHHHHHCCCCCCHHH
TQIVFRNYQWGAEKRNSTLWFDDNFVGTELDEDVSYSGIANACGLKGVVARTQEELTAAL
HHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHH
DQAIKDQMENGITTLIEAMINQELGDPFRRDAMKKPVEVAGISASDMKPQKVA
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]