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The map label for this gene is gcvT [H]

Identifier: 89055296

GI number: 89055296

Start: 2817661

End: 2820069

Strand: Direct

Name: gcvT [H]

Synonym: Jann_2805

Alternate gene names: 89055296

Gene position: 2817661-2820069 (Clockwise)

Preceding gene: 89055295

Following gene: 89055297

Centisome position: 65.25

GC content: 60.65

Gene sequence:

>2409_bases
ATGAAGACCCATGCACAGGCCGTTGTGATCGGCGGCGGTGTCGTCGGATGCTCCATTCTGTATCACCTCGCGAAGGCCGG
CTGGACCGATGTGGTCTTGCTGGAGCGAGATGAGCTGACGTCGGGGTCCACCTGGCACGCGGCGGCCAATATCCACGGCC
TGCATGACAGCACCAATATCTCTCGCCTCCAGCATTACACGATGAACCTTTACAAAGAGTTAGAGGAAGAAACCGGCCAA
TCCTGCGGCGTGTTTCAGCCCGGCTCGCTCTATCTGGCGCAGACCGAGGACCGGGAACATCAGTTGCGCCTGCAAGAGGC
AAAGGCACGGCGCTATGGCATGAATTTCCACGACATCACGCGGGCGGAGGCCGAACGCCTGCATCCACTGGTCGACTTCG
ATGGCATCCGCTGCATCATGTTCGAGCCCGACGGCGGCAATGTCGACCCTTCGGGCGTCACCAACGCCTATGCGCTTGGG
GCCCGGCAACGCGGCGCTGAGATCATTCGGTTTTGCCCCGTTGTCGGCACCGATGCGCAGCCCGACGGCTCATGGATTGT
CCGCACGGAAAAGGGCGACATTCGCACGCCATGGGTCGTGAACGCGGCCGGTCTCTGGGCCCGAGAAGTGGCTGCTATGG
CCGGTGTCGACCTGCCGCTTTTGCCGACAGAACACCAGTATTTCGTCACCGAAACCATTGCGGATATCGCGGCAATGGAT
CGCCGCCTGCCCTCCGTCGCCGATCGCGATGGCGAGTATTATTTGCGCCAGGAAGGCCAGGGTTTGTTGGTCGGCGCCTA
TGAAAAAGACATGCGCTTCTGGGCCGAACATGGCACGCCGCCAGATTTCGGTCATGAGTTGTTCGCCGATGATCTGGAGC
GGATCGAGCCCAACATGATGCGCGCCATCGACCGGGTGCCAGCCGTGGGACTGGCCGGGATCAAACGGGTGATCAATGGC
CCGATGATCTGGTCGCCGGATTCGAGCGCATTGGTCGGGCCCGTCCCTGAGCGAACGGGTTATTTTTGCTGTTGCGGCAT
CATTCCGGGCTTTTCCCAGAACGGGGGGCTTGGACGTCTCGCCGCCGAATGGATGGTCGAAGGGGAGCCGTCGCTTGACC
TGTTCGGCTGGGATCTCGCGCGCTACGGCCAGTGGGCGAGCAAGAGCTTCATCAAAGCGCGGGTAGCGGATCAATATGCC
AATCGGTTCGCGATCCACTTCCCCGGCGAAGAACGCCCAGCCGGACGTCCGGTGCGCAAGCGGCCAGCTTACGACATGCA
AGCCGCAATGGGCGCGAAATTTGGCATGAACTACGGCTGGGAACATCCTGCTTTCTTTGATAAATCGGTGAATGATAGTG
CAGGCTACGCACGCCAACCCTGGTGGGATGTTGTGGGCCGGGAAGCTCGCATGTTGCGCGAGTGCGCGGGCCTGATCGAC
ATCTCAAACTTCGCCAAATACCGGGTCGCGGGGCCCGGGGCGGAGGGTTGGCTCAATGCGCTGTTTGCCAACCGAATGCC
CAATTTAGTCGGCCGATCCTGCCTGACGCCCTTGATCGGCAAACGCGGCGGCGTCGTGGGCGATTTTACGGTCACGAAGC
TGGCAGACGATGAGTTCTGGATCTTGGGCGGTGGCGCGGCTGAGCGCTATCATCAGCGCTTCTTCCGCCAAATTCCCTTG
CCCGATGACACGACGCTCCACAGCCTGACAGACGCCACCTGCGGCTTCAACATAGCTGGTCCTGAATCACGCAACATCCT
AAATCAATTGACAGATTCAGACCTCTCCAACTCCGCTTTTCCATTCTTTCGGTCTGCGCGGATCCGCGTGGCGGAGGTCG
ATTGTGTGGCCATTCGCGTGTCTTTCACGGGTGATCTGGGGTGGGAGCTGCACTGCGCGGAGACTGATCAAATCTCGCTC
TACACCGCTCTGCTGGAGGCTGGCGCAGGTTTCGGCGCCGGTCCTGTCGGAAGCCGCGCCCTGATGTCATTGCGGCTTGA
GAAGGGCTACGGGTCATGGGGCCGCGATTATTCGCCAGAATACTGGCCACAGGAATCGGGGCTTGCCGGGTTGATCAAGC
GAGACAAGGACTTCCTGAACAAAGACAGTTGGTTGGAGATCGAAGCTCAACCGGCGCGTGAGGAGATGGTTCTGCTATCC
ATCGACGCGGACACAGCCGATGCCTCCGGAACAGAGCCGGTCTTCCTGCCCGATGGCACGCCCATTGGACAGGTTTCATC
CGGCGGCTACGGCTATACAGTCGAGAAATCTCTTGCCTTGGCCTACATCAAAGCTGGCTCCGTCCAGCCAGGCGACACGC
TTCACGTCGCCATTCTTGGCCGTCCACACACCGCCCGCATCTTGCCCGAGCCGCCCTTTGACCCCCAGGGCCTGCGTCTT
CGACAGTAA

Upstream 100 bases:

>100_bases
CGGCAGGCCTCCGAAAACAGACCCCCGTGTGTCGCCGTCAGACCAGAATCACGCGCGTCACCCCGCCACTCTCATCCCAT
CGGACCGAGGGAGAGCGACC

Downstream 100 bases:

>100_bases
TTTTTGCGGTGTCCGAACGTCGGTCCCTCGTGACGCGCCGGTCTGTTTCCCGCTATAGTCGTCGAAAATTGAGCAGCGGG
ACGTAACCATGGCGCGCAAA

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 802; Mature: 802

Protein sequence:

>802_residues
MKTHAQAVVIGGGVVGCSILYHLAKAGWTDVVLLERDELTSGSTWHAAANIHGLHDSTNISRLQHYTMNLYKELEEETGQ
SCGVFQPGSLYLAQTEDREHQLRLQEAKARRYGMNFHDITRAEAERLHPLVDFDGIRCIMFEPDGGNVDPSGVTNAYALG
ARQRGAEIIRFCPVVGTDAQPDGSWIVRTEKGDIRTPWVVNAAGLWAREVAAMAGVDLPLLPTEHQYFVTETIADIAAMD
RRLPSVADRDGEYYLRQEGQGLLVGAYEKDMRFWAEHGTPPDFGHELFADDLERIEPNMMRAIDRVPAVGLAGIKRVING
PMIWSPDSSALVGPVPERTGYFCCCGIIPGFSQNGGLGRLAAEWMVEGEPSLDLFGWDLARYGQWASKSFIKARVADQYA
NRFAIHFPGEERPAGRPVRKRPAYDMQAAMGAKFGMNYGWEHPAFFDKSVNDSAGYARQPWWDVVGREARMLRECAGLID
ISNFAKYRVAGPGAEGWLNALFANRMPNLVGRSCLTPLIGKRGGVVGDFTVTKLADDEFWILGGGAAERYHQRFFRQIPL
PDDTTLHSLTDATCGFNIAGPESRNILNQLTDSDLSNSAFPFFRSARIRVAEVDCVAIRVSFTGDLGWELHCAETDQISL
YTALLEAGAGFGAGPVGSRALMSLRLEKGYGSWGRDYSPEYWPQESGLAGLIKRDKDFLNKDSWLEIEAQPAREEMVLLS
IDADTADASGTEPVFLPDGTPIGQVSSGGYGYTVEKSLALAYIKAGSVQPGDTLHVAILGRPHTARILPEPPFDPQGLRL
RQ

Sequences:

>Translated_802_residues
MKTHAQAVVIGGGVVGCSILYHLAKAGWTDVVLLERDELTSGSTWHAAANIHGLHDSTNISRLQHYTMNLYKELEEETGQ
SCGVFQPGSLYLAQTEDREHQLRLQEAKARRYGMNFHDITRAEAERLHPLVDFDGIRCIMFEPDGGNVDPSGVTNAYALG
ARQRGAEIIRFCPVVGTDAQPDGSWIVRTEKGDIRTPWVVNAAGLWAREVAAMAGVDLPLLPTEHQYFVTETIADIAAMD
RRLPSVADRDGEYYLRQEGQGLLVGAYEKDMRFWAEHGTPPDFGHELFADDLERIEPNMMRAIDRVPAVGLAGIKRVING
PMIWSPDSSALVGPVPERTGYFCCCGIIPGFSQNGGLGRLAAEWMVEGEPSLDLFGWDLARYGQWASKSFIKARVADQYA
NRFAIHFPGEERPAGRPVRKRPAYDMQAAMGAKFGMNYGWEHPAFFDKSVNDSAGYARQPWWDVVGREARMLRECAGLID
ISNFAKYRVAGPGAEGWLNALFANRMPNLVGRSCLTPLIGKRGGVVGDFTVTKLADDEFWILGGGAAERYHQRFFRQIPL
PDDTTLHSLTDATCGFNIAGPESRNILNQLTDSDLSNSAFPFFRSARIRVAEVDCVAIRVSFTGDLGWELHCAETDQISL
YTALLEAGAGFGAGPVGSRALMSLRLEKGYGSWGRDYSPEYWPQESGLAGLIKRDKDFLNKDSWLEIEAQPAREEMVLLS
IDADTADASGTEPVFLPDGTPIGQVSSGGYGYTVEKSLALAYIKAGSVQPGDTLHVAILGRPHTARILPEPPFDPQGLRL
RQ
>Mature_802_residues
MKTHAQAVVIGGGVVGCSILYHLAKAGWTDVVLLERDELTSGSTWHAAANIHGLHDSTNISRLQHYTMNLYKELEEETGQ
SCGVFQPGSLYLAQTEDREHQLRLQEAKARRYGMNFHDITRAEAERLHPLVDFDGIRCIMFEPDGGNVDPSGVTNAYALG
ARQRGAEIIRFCPVVGTDAQPDGSWIVRTEKGDIRTPWVVNAAGLWAREVAAMAGVDLPLLPTEHQYFVTETIADIAAMD
RRLPSVADRDGEYYLRQEGQGLLVGAYEKDMRFWAEHGTPPDFGHELFADDLERIEPNMMRAIDRVPAVGLAGIKRVING
PMIWSPDSSALVGPVPERTGYFCCCGIIPGFSQNGGLGRLAAEWMVEGEPSLDLFGWDLARYGQWASKSFIKARVADQYA
NRFAIHFPGEERPAGRPVRKRPAYDMQAAMGAKFGMNYGWEHPAFFDKSVNDSAGYARQPWWDVVGREARMLRECAGLID
ISNFAKYRVAGPGAEGWLNALFANRMPNLVGRSCLTPLIGKRGGVVGDFTVTKLADDEFWILGGGAAERYHQRFFRQIPL
PDDTTLHSLTDATCGFNIAGPESRNILNQLTDSDLSNSAFPFFRSARIRVAEVDCVAIRVSFTGDLGWELHCAETDQISL
YTALLEAGAGFGAGPVGSRALMSLRLEKGYGSWGRDYSPEYWPQESGLAGLIKRDKDFLNKDSWLEIEAQPAREEMVLLS
IDADTADASGTEPVFLPDGTPIGQVSSGGYGYTVEKSLALAYIKAGSVQPGDTLHVAILGRPHTARILPEPPFDPQGLRL
RQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=802, Percent_Identity=36.0349127182045, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI197927446, Length=863, Percent_Identity=33.0243337195828, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI21361378, Length=863, Percent_Identity=33.0243337195828, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI194306651, Length=792, Percent_Identity=27.7777777777778, Blast_Score=324, Evalue=2e-88,
Organism=Homo sapiens, GI44662838, Length=387, Percent_Identity=25.0645994832041, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI257796258, Length=374, Percent_Identity=25.1336898395722, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1789272, Length=399, Percent_Identity=22.5563909774436, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994045, Length=839, Percent_Identity=28.2479141835518, Blast_Score=298, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71994052, Length=846, Percent_Identity=28.0141843971631, Blast_Score=295, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI32563613, Length=832, Percent_Identity=26.5625, Blast_Score=248, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6320222, Length=397, Percent_Identity=23.4256926952141, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20130091, Length=858, Percent_Identity=30.5361305361305, Blast_Score=354, Evalue=1e-97,
Organism=Drosophila melanogaster, GI28571104, Length=803, Percent_Identity=28.1444582814446, Blast_Score=307, Evalue=2e-83,
Organism=Drosophila melanogaster, GI20129441, Length=332, Percent_Identity=24.0963855421687, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 88250; Mature: 88250

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHAQAVVIGGGVVGCSILYHLAKAGWTDVVLLERDELTSGSTWHAAANIHGLHDSTNI
CCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCH
SRLQHYTMNLYKELEEETGQSCGVFQPGSLYLAQTEDREHQLRLQEAKARRYGMNFHDIT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHH
RAEAERLHPLVDFDGIRCIMFEPDGGNVDPSGVTNAYALGARQRGAEIIRFCPVVGTDAQ
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCHHHCCHHHHCCCCCCCCCC
PDGSWIVRTEKGDIRTPWVVNAAGLWAREVAAMAGVDLPLLPTEHQYFVTETIADIAAMD
CCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
RRLPSVADRDGEYYLRQEGQGLLVGAYEKDMRFWAEHGTPPDFGHELFADDLERIEPNMM
HHCCCCCCCCCCEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHH
RAIDRVPAVGLAGIKRVINGPMIWSPDSSALVGPVPERTGYFCCCGIIPGFSQNGGLGRL
HHHHHCCCCHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHH
AAEWMVEGEPSLDLFGWDLARYGQWASKSFIKARVADQYANRFAIHFPGEERPAGRPVRK
HHHHEECCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCC
RPAYDMQAAMGAKFGMNYGWEHPAFFDKSVNDSAGYARQPWWDVVGREARMLRECAGLID
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
ISNFAKYRVAGPGAEGWLNALFANRMPNLVGRSCLTPLIGKRGGVVGDFTVTKLADDEFW
CCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECEEEEEECCCCEE
ILGGGAAERYHQRFFRQIPLPDDTTLHSLTDATCGFNIAGPESRNILNQLTDSDLSNSAF
EEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
PFFRSARIRVAEVDCVAIRVSFTGDLGWELHCAETDQISLYTALLEAGAGFGAGPVGSRA
CHHHCCEEEEEEEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHH
LMSLRLEKGYGSWGRDYSPEYWPQESGLAGLIKRDKDFLNKDSWLEIEAQPAREEMVLLS
HHEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEE
IDADTADASGTEPVFLPDGTPIGQVSSGGYGYTVEKSLALAYIKAGSVQPGDTLHVAILG
ECCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCEEEEEEEC
RPHTARILPEPPFDPQGLRLRQ
CCCCEEECCCCCCCCCCCEECC
>Mature Secondary Structure
MKTHAQAVVIGGGVVGCSILYHLAKAGWTDVVLLERDELTSGSTWHAAANIHGLHDSTNI
CCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCH
SRLQHYTMNLYKELEEETGQSCGVFQPGSLYLAQTEDREHQLRLQEAKARRYGMNFHDIT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHH
RAEAERLHPLVDFDGIRCIMFEPDGGNVDPSGVTNAYALGARQRGAEIIRFCPVVGTDAQ
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCHHHCCHHHHCCCCCCCCCC
PDGSWIVRTEKGDIRTPWVVNAAGLWAREVAAMAGVDLPLLPTEHQYFVTETIADIAAMD
CCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
RRLPSVADRDGEYYLRQEGQGLLVGAYEKDMRFWAEHGTPPDFGHELFADDLERIEPNMM
HHCCCCCCCCCCEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHH
RAIDRVPAVGLAGIKRVINGPMIWSPDSSALVGPVPERTGYFCCCGIIPGFSQNGGLGRL
HHHHHCCCCHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHH
AAEWMVEGEPSLDLFGWDLARYGQWASKSFIKARVADQYANRFAIHFPGEERPAGRPVRK
HHHHEECCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCC
RPAYDMQAAMGAKFGMNYGWEHPAFFDKSVNDSAGYARQPWWDVVGREARMLRECAGLID
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
ISNFAKYRVAGPGAEGWLNALFANRMPNLVGRSCLTPLIGKRGGVVGDFTVTKLADDEFW
CCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECEEEEEECCCCEE
ILGGGAAERYHQRFFRQIPLPDDTTLHSLTDATCGFNIAGPESRNILNQLTDSDLSNSAF
EEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
PFFRSARIRVAEVDCVAIRVSFTGDLGWELHCAETDQISLYTALLEAGAGFGAGPVGSRA
CHHHCCEEEEEEEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHH
LMSLRLEKGYGSWGRDYSPEYWPQESGLAGLIKRDKDFLNKDSWLEIEAQPAREEMVLLS
HHEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEE
IDADTADASGTEPVFLPDGTPIGQVSSGGYGYTVEKSLALAYIKAGSVQPGDTLHVAILG
ECCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCEEEEEEEC
RPHTARILPEPPFDPQGLRLRQ
CCCCEEECCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]