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The map label for this gene is lig [H]

Identifier: 89055158

GI number: 89055158

Start: 2677458

End: 2679056

Strand: Direct

Name: lig [H]

Synonym: Jann_2667

Alternate gene names: 89055158

Gene position: 2677458-2679056 (Clockwise)

Preceding gene: 89055157

Following gene: 89055161

Centisome position: 62.01

GC content: 62.48

Gene sequence:

>1599_bases
ATGAAGGCCTTCGCCGCCCTTTTCACGACGCTGGATCAGACCACCAAGACCAGCGTGAAGACGGCCGCGCTGGCCGACTA
TTTCCGCACGGCGCCCGAGGATGACCGGATCTGGACCATCGCATTGCTTTCGGGCCGACGTCCGCGCCGCACCATCACCA
CCACAAAACTGCGCGAATGGGCGGCGGAGCGGGCGGGCATTCCGCTGTGGCTGTTTGAGGCCTGTTATCCGGTCGTGGGT
GACCTGAGCGAGACCATTGCCCTTGTTTTGCCGGAGCCCGAGACCCGGATCGACAAAAGCCTGAGCGCCTGGATCGCCAC
GCTGCGCGGCCTCGACAATGCGGAGGAGGATGCGCGCAAGGCCGCGATTCTGGAGGCCTGGAACGGTCTGCCCCCGATCG
AACGGTTTGTTTTCAATAAGTTGATTACCGGCGGCTGGCGCATGGGGGTGAGTCAAAAGCTGATGACCCGCGCGCTGTCG
AAGGCCACTGACATCGATGAGGCGGAACTGACACACCGCCTGATGGGCGATTGGTCGCCCGACACGGTCAGTTGGGACGG
CCTGATCGAAGCGCCCGATCCAACAACGAACCTTAGCCGACCCTACCCGTTCTATCTGGCTTATCAGCTGGAGGGCGACG
CGGAGGACCAGGGAGGCGTCGGCGATTGGGTGGCGGAGCGGAAATGGGACGGCATTCGCGGCCAGCTGATCATGCGCGGA
GGCGAGCGCTATCTGTGGTCGCGTGGCGAAGACCTGATGACGGACCGGTTCCCGGAGTTTGCGCAGCTGCTGGACTACCT
GCCCTCGGGGACGGTTCTTGACGGCGAGGTTTTGGCGTATGACTTTGTTAACAACACCCCGCTTTCGTTCAATAAGTTGC
AACCGCGTATAGGGCGCAAAACTGTGCCCAAGAAGCTTCTGGCCGAGGCCCCGTGCATCCTGATGGCCTATGATCTGCTG
GAATGGCAGGGCGCGGACATTCGGCACAGGCCGTTGGCCGAGCGGCGCGCTTTGTTGGAGGAGGCCACCGACAATATGCC
ACCCGACGCCCCCCTCCGCCTGTCGCCGAGGGTGGAGGCCGAGAGTTGGGACGACCTGCGCGCCGCACGCGCCATCAGCC
GCGACATAGGGGCAGAGGGGTTGATGCTGAAGCGTCTTTCGGCACCCTATCTAGCCGGGCGCAAAAAGGGCGATTGGTGG
AAATGGAAGGTCGATCCACTGACCATCGACGCGGTGATGATCTATGCGCAGGCGGGTTCCGGCCGGCGGGCAACGCTCTA
CACCGATTTCACATTCGCGGTCTGGAACGGCCCCGATCTGGTGCCCTTCACCAAGGCCTATTCCGGCCTCACCGACAAGG
AATTCCGCGAGATCACGGCCTGGGTTCGCAAGAACACGACGGACCGGTTCGGCCCCGTCCGCGCGGTCACGCCGCACCAT
GTGTTTGAGATTGCGTTCGAAGGCATTCAACCCTCACCGCGCCACAAATCCGGCGTTGCCCTGCGCTTTCCCCGCATGTT
GCGCTGGCGCAAAGACAAGCCGTTGGAAGAGGCCAATACATTGGACGACCTCAACCAGATGCTGGAACAATACGGCTAA

Upstream 100 bases:

>100_bases
AATGGCCCGGCCTGCAACATGTCTGGCACCTCAAGGCAGGGGTCATGCCCGCCGCAACCCAAGCCTGCGCGGAGCTTGGG
GCGTTTTTGCGGACGCACAC

Downstream 100 bases:

>100_bases
GGCGTCACATTAACTTCGCACCACAATACTCTGTAATCGCTACTGAAATATATAGCTTCTCGGCCAGGCCGTATAGTCGG
CTGTCGTCACACCGTTGCGG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MKAFAALFTTLDQTTKTSVKTAALADYFRTAPEDDRIWTIALLSGRRPRRTITTTKLREWAAERAGIPLWLFEACYPVVG
DLSETIALVLPEPETRIDKSLSAWIATLRGLDNAEEDARKAAILEAWNGLPPIERFVFNKLITGGWRMGVSQKLMTRALS
KATDIDEAELTHRLMGDWSPDTVSWDGLIEAPDPTTNLSRPYPFYLAYQLEGDAEDQGGVGDWVAERKWDGIRGQLIMRG
GERYLWSRGEDLMTDRFPEFAQLLDYLPSGTVLDGEVLAYDFVNNTPLSFNKLQPRIGRKTVPKKLLAEAPCILMAYDLL
EWQGADIRHRPLAERRALLEEATDNMPPDAPLRLSPRVEAESWDDLRAARAISRDIGAEGLMLKRLSAPYLAGRKKGDWW
KWKVDPLTIDAVMIYAQAGSGRRATLYTDFTFAVWNGPDLVPFTKAYSGLTDKEFREITAWVRKNTTDRFGPVRAVTPHH
VFEIAFEGIQPSPRHKSGVALRFPRMLRWRKDKPLEEANTLDDLNQMLEQYG

Sequences:

>Translated_532_residues
MKAFAALFTTLDQTTKTSVKTAALADYFRTAPEDDRIWTIALLSGRRPRRTITTTKLREWAAERAGIPLWLFEACYPVVG
DLSETIALVLPEPETRIDKSLSAWIATLRGLDNAEEDARKAAILEAWNGLPPIERFVFNKLITGGWRMGVSQKLMTRALS
KATDIDEAELTHRLMGDWSPDTVSWDGLIEAPDPTTNLSRPYPFYLAYQLEGDAEDQGGVGDWVAERKWDGIRGQLIMRG
GERYLWSRGEDLMTDRFPEFAQLLDYLPSGTVLDGEVLAYDFVNNTPLSFNKLQPRIGRKTVPKKLLAEAPCILMAYDLL
EWQGADIRHRPLAERRALLEEATDNMPPDAPLRLSPRVEAESWDDLRAARAISRDIGAEGLMLKRLSAPYLAGRKKGDWW
KWKVDPLTIDAVMIYAQAGSGRRATLYTDFTFAVWNGPDLVPFTKAYSGLTDKEFREITAWVRKNTTDRFGPVRAVTPHH
VFEIAFEGIQPSPRHKSGVALRFPRMLRWRKDKPLEEANTLDDLNQMLEQYG
>Mature_532_residues
MKAFAALFTTLDQTTKTSVKTAALADYFRTAPEDDRIWTIALLSGRRPRRTITTTKLREWAAERAGIPLWLFEACYPVVG
DLSETIALVLPEPETRIDKSLSAWIATLRGLDNAEEDARKAAILEAWNGLPPIERFVFNKLITGGWRMGVSQKLMTRALS
KATDIDEAELTHRLMGDWSPDTVSWDGLIEAPDPTTNLSRPYPFYLAYQLEGDAEDQGGVGDWVAERKWDGIRGQLIMRG
GERYLWSRGEDLMTDRFPEFAQLLDYLPSGTVLDGEVLAYDFVNNTPLSFNKLQPRIGRKTVPKKLLAEAPCILMAYDLL
EWQGADIRHRPLAERRALLEEATDNMPPDAPLRLSPRVEAESWDDLRAARAISRDIGAEGLMLKRLSAPYLAGRKKGDWW
KWKVDPLTIDAVMIYAQAGSGRRATLYTDFTFAVWNGPDLVPFTKAYSGLTDKEFREITAWVRKNTTDRFGPVRAVTPHH
VFEIAFEGIQPSPRHKSGVALRFPRMLRWRKDKPLEEANTLDDLNQMLEQYG

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=331, Percent_Identity=29.3051359516616, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71985269, Length=342, Percent_Identity=26.9005847953216, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320038, Length=343, Percent_Identity=27.4052478134111, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24762424, Length=350, Percent_Identity=28, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI85815841, Length=338, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 60315; Mature: 60315

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFAALFTTLDQTTKTSVKTAALADYFRTAPEDDRIWTIALLSGRRPRRTITTTKLREW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
AAERAGIPLWLFEACYPVVGDLSETIALVLPEPETRIDKSLSAWIATLRGLDNAEEDARK
HHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
AAILEAWNGLPPIERFVFNKLITGGWRMGVSQKLMTRALSKATDIDEAELTHRLMGDWSP
HHHHHHHCCCCHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
DTVSWDGLIEAPDPTTNLSRPYPFYLAYQLEGDAEDQGGVGDWVAERKWDGIRGQLIMRG
CCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEEC
GERYLWSRGEDLMTDRFPEFAQLLDYLPSGTVLDGEVLAYDFVNNTPLSFNKLQPRIGRK
CCHHHHCCCCHHHHHCCHHHHHHHHHCCCCCEECCCEEEEECCCCCCCCHHCCCCCCCCH
TVPKKLLAEAPCILMAYDLLEWQGADIRHRPLAERRALLEEATDNMPPDAPLRLSPRVEA
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCC
ESWDDLRAARAISRDIGAEGLMLKRLSAPYLAGRKKGDWWKWKVDPLTIDAVMIYAQAGS
CCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHCCCCCCCEEEEEECCEEEEEEEEEEECCC
GRRATLYTDFTFAVWNGPDLVPFTKAYSGLTDKEFREITAWVRKNTTDRFGPVRAVTPHH
CCEEEEEEEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHH
VFEIAFEGIQPSPRHKSGVALRFPRMLRWRKDKPLEEANTLDDLNQMLEQYG
HHHHHHCCCCCCCCCCCCCEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAFAALFTTLDQTTKTSVKTAALADYFRTAPEDDRIWTIALLSGRRPRRTITTTKLREW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
AAERAGIPLWLFEACYPVVGDLSETIALVLPEPETRIDKSLSAWIATLRGLDNAEEDARK
HHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
AAILEAWNGLPPIERFVFNKLITGGWRMGVSQKLMTRALSKATDIDEAELTHRLMGDWSP
HHHHHHHCCCCHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
DTVSWDGLIEAPDPTTNLSRPYPFYLAYQLEGDAEDQGGVGDWVAERKWDGIRGQLIMRG
CCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEEC
GERYLWSRGEDLMTDRFPEFAQLLDYLPSGTVLDGEVLAYDFVNNTPLSFNKLQPRIGRK
CCHHHHCCCCHHHHHCCHHHHHHHHHCCCCCEECCCEEEEECCCCCCCCHHCCCCCCCCH
TVPKKLLAEAPCILMAYDLLEWQGADIRHRPLAERRALLEEATDNMPPDAPLRLSPRVEA
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCC
ESWDDLRAARAISRDIGAEGLMLKRLSAPYLAGRKKGDWWKWKVDPLTIDAVMIYAQAGS
CCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHCCCCCCCEEEEEECCEEEEEEEEEEECCC
GRRATLYTDFTFAVWNGPDLVPFTKAYSGLTDKEFREITAWVRKNTTDRFGPVRAVTPHH
CCEEEEEEEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHH
VFEIAFEGIQPSPRHKSGVALRFPRMLRWRKDKPLEEANTLDDLNQMLEQYG
HHHHHHCCCCCCCCCCCCCEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA