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The map label for this gene is gpt

Identifier: 89054968

GI number: 89054968

Start: 2474210

End: 2474728

Strand: Direct

Name: gpt

Synonym: Jann_2477

Alternate gene names: 89054968

Gene position: 2474210-2474728 (Clockwise)

Preceding gene: 89054967

Following gene: 89054977

Centisome position: 57.3

GC content: 60.89

Gene sequence:

>519_bases
ATGACCACGCAACTCCCCCACGAAAAAGGCTTTCATATCTCCTGGGATCAGATCCACCGTGACAGCCGCGCCTTGGCGTG
GCGGCTGGACAATCACGGGCCCGATGATGGCGCGTGGAAGGCCGTTGTGGCGATCACCCGGGGCGGCATGGCGCCCGCGA
TGATCGTTGCGCGCGAATTGGACATTCGCACCGTCGATACGATTTCCGTGGTGTCCTACCATTCCGGCGGCGGCAAGGCC
GATGAACGGCGCGAAGCGAAGGTGCTCAAGGGCCCCGATGCGGATCTGATGGGCGATGGAGAGGGAGTTTTGATCATCGA
CGATCTGGTGGATTCGGGCAAAACACTGGAGCTTGTCCGCACCCTCTACCCCAAGGCGCATTTCGCCACCGTCTATGCCA
AGCCCGAGGGCGAACCGATGGTCGACACCTTCATCACCGGCGTCAGCCAAGACACCTGGATTTTCTTCCCCTGGGACATG
GCGCTGCAATATGTCGACCCGTATCGCGGCAAGGATTGA

Upstream 100 bases:

>100_bases
CGTGACGGGAGAGGTGCACCATGTGGATGCGGGCTACCACGTCATCGGCATGAAAAACCCCGAGGCCCCGGATATGTCTT
TGGAAAAGAAGGACTAAGCC

Downstream 100 bases:

>100_bases
CCGCGGCGCGACCACAACACTGACCCAAATCCCGTATGCGGAACATCGCTGACCCGTGCGGTTGCGATATCAAATGGCAA
TTGCAGCGACGCGGGCAATG

Product: xanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: Xanthine-guanine phosphoribosyltransferase; XGPRT

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MTTQLPHEKGFHISWDQIHRDSRALAWRLDNHGPDDGAWKAVVAITRGGMAPAMIVARELDIRTVDTISVVSYHSGGGKA
DERREAKVLKGPDADLMGDGEGVLIIDDLVDSGKTLELVRTLYPKAHFATVYAKPEGEPMVDTFITGVSQDTWIFFPWDM
ALQYVDPYRGKD

Sequences:

>Translated_172_residues
MTTQLPHEKGFHISWDQIHRDSRALAWRLDNHGPDDGAWKAVVAITRGGMAPAMIVARELDIRTVDTISVVSYHSGGGKA
DERREAKVLKGPDADLMGDGEGVLIIDDLVDSGKTLELVRTLYPKAHFATVYAKPEGEPMVDTFITGVSQDTWIFFPWDM
ALQYVDPYRGKD
>Mature_171_residues
TTQLPHEKGFHISWDQIHRDSRALAWRLDNHGPDDGAWKAVVAITRGGMAPAMIVARELDIRTVDTISVVSYHSGGGKAD
ERREAKVLKGPDADLMGDGEGVLIIDDLVDSGKTLELVRTLYPKAHFATVYAKPEGEPMVDTFITGVSQDTWIFFPWDMA
LQYVDPYRGKD

Specific function: Acts on guanine, xanthine and to a lesser extent hypoxanthine

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily

Homologues:

Organism=Escherichia coli, GI1786433, Length=161, Percent_Identity=45.3416149068323, Blast_Score=144, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XGPT_JANSC (Q28PG8)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510419.1
- ProteinModelPortal:   Q28PG8
- SMR:   Q28PG8
- STRING:   Q28PG8
- GeneID:   3934935
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2477
- eggNOG:   COG0503
- HOGENOM:   HBG503428
- OMA:   LVDTFIT
- PhylomeDB:   Q28PG8
- ProtClustDB:   PRK09177
- BioCyc:   JSP290400:JANN_2477-MONOMER
- HAMAP:   MF_01903
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 19125; Mature: 18994

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 84-84 BINDING 111-111 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQLPHEKGFHISWDQIHRDSRALAWRLDNHGPDDGAWKAVVAITRGGMAPAMIVAREL
CCCCCCCCCCCEEEHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEEEC
DIRTVDTISVVSYHSGGGKADERREAKVLKGPDADLMGDGEGVLIIDDLVDSGKTLELVR
CCEEECEEEEEEEECCCCCCCCHHCHHEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHH
TLYPKAHFATVYAKPEGEPMVDTFITGVSQDTWIFFPWDMALQYVDPYRGKD
HHCCCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTQLPHEKGFHISWDQIHRDSRALAWRLDNHGPDDGAWKAVVAITRGGMAPAMIVAREL
CCCCCCCCCCEEEHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEEEC
DIRTVDTISVVSYHSGGGKADERREAKVLKGPDADLMGDGEGVLIIDDLVDSGKTLELVR
CCEEECEEEEEEEECCCCCCCCHHCHHEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHH
TLYPKAHFATVYAKPEGEPMVDTFITGVSQDTWIFFPWDMALQYVDPYRGKD
HHCCCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA