BacMap

Definition	Jannaschia sp. CCS1 chromosome, complete genome.
Accession	NC_007802
Length	4,317,977

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The map label for this gene is gra-orf6 [H]

Identifier: 89054760

GI number: 89054760

Start: 2276251

End: 2277015

Strand: Reverse

Name: gra-orf6 [H]

Synonym: Jann_2269

Alternate gene names: 89054760

Gene position: 2277015-2276251 (Counterclockwise)

Preceding gene: 89054761

Following gene: 89054759

Centisome position: 52.73

GC content: 64.84

Gene sequence:

>765_bases
ATGCAATCGATTGAGGGATATTCGGTCCTGATCACCGGTGGCGGCTCGGGCCTCGGGCGCGGCGTGGCCGAAGATATGGC
CGCTCGTGGCGCGAAAGTAACGATCACCGGGCGGCGGGCTGAGAAACTGGAAGACGTAGCGGGCGCCATCGGGCCGAGCT
GCGCCATCGCTGCGGGCGACGTGTCCATCGAAGAAGACCGCCGACGCATGATCGACACAGCCGTCGCCCACGGCGGCGGC
CTTCAGGGGCTGTTCAACAATGCGGGCAACATGCTGCGCGGGCCGATCACAGACCTGGCGGCCGAAGACATCCTCGAGGT
GATGAACGTCAACGTCGTGGCAGGAATGCGACTGACAGGTCTTGCTGCACCACATCTGGAGGAACACGGCGGCGCAGTGG
TGTTTGTCGGCTCTGGCCACACCCGCCGCGCTTTTCCCGGTGCATCACCCTACGCGGCCTCCAAGGGCGCGGTAGAAGTT
CTCGCGCAGGTTCTCGCGGCAGAGCTTGGCCCCAAAGGTATCCGCGTCAATTGCATCGTTCCGGGGGCGGTGCCGACCGA
GATCAACGTGCGCGCCGGGATCGCCGCAAGCTTCGAGGACAACAAAGTGCGCCTCAACTCCATGGTTGACGACCACCCCC
TGGGCCGCATCGGCACCCCGCAGGAAATCGCCGAAGCCGTAGACCACCTGCTGCGTGCAGAATGGACAACGGGCGCCTCT
TTGGTCGTCGACGGCGGCCTCGGTCTAGGCGTCAGCTACAAGTGA

Upstream 100 bases:

>100_bases
GCCCTCGGGCATGACAAGGACGCAGTTCAGGATCCCGGCTACGTGCGGCTTCTGAAACGGGCCACCCGTGCCCTATTTCC
CCCGAACAGCGAGGACGCTC

Downstream 100 bases:

>100_bases
GTACCCAATGATAATCGAACAACGCACCTATGATTTTCACCCCGGCGCGATTCCGAAGTTCTTCAATATCTATGAGGAAA
CCGGCGCGCGCGAGTTGCAA

Product: short-chain dehydrogenase/reductase SDR

Products: D-glucono-1,5-lactone; NADH; NADPH; H+

Alternate protein names: ORF6 [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MQSIEGYSVLITGGGSGLGRGVAEDMAARGAKVTITGRRAEKLEDVAGAIGPSCAIAAGDVSIEEDRRRMIDTAVAHGGG
LQGLFNNAGNMLRGPITDLAAEDILEVMNVNVVAGMRLTGLAAPHLEEHGGAVVFVGSGHTRRAFPGASPYAASKGAVEV
LAQVLAAELGPKGIRVNCIVPGAVPTEINVRAGIAASFEDNKVRLNSMVDDHPLGRIGTPQEIAEAVDHLLRAEWTTGAS
LVVDGGLGLGVSYK

Sequences:

>Translated_254_residues
MQSIEGYSVLITGGGSGLGRGVAEDMAARGAKVTITGRRAEKLEDVAGAIGPSCAIAAGDVSIEEDRRRMIDTAVAHGGG
LQGLFNNAGNMLRGPITDLAAEDILEVMNVNVVAGMRLTGLAAPHLEEHGGAVVFVGSGHTRRAFPGASPYAASKGAVEV
LAQVLAAELGPKGIRVNCIVPGAVPTEINVRAGIAASFEDNKVRLNSMVDDHPLGRIGTPQEIAEAVDHLLRAEWTTGAS
LVVDGGLGLGVSYK
>Mature_254_residues
MQSIEGYSVLITGGGSGLGRGVAEDMAARGAKVTITGRRAEKLEDVAGAIGPSCAIAAGDVSIEEDRRRMIDTAVAHGGG
LQGLFNNAGNMLRGPITDLAAEDILEVMNVNVVAGMRLTGLAAPHLEEHGGAVVFVGSGHTRRAFPGASPYAASKGAVEV
LAQVLAAELGPKGIRVNCIVPGAVPTEINVRAGIAASFEDNKVRLNSMVDDHPLGRIGTPQEIAEAVDHLLRAEWTTGAS
LVVDGGLGLGVSYK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=32.7868852459016, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=33.6099585062241, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=31.8725099601594, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=30.5785123966942, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI19923817, Length=260, Percent_Identity=26.1538461538462, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI59889578, Length=234, Percent_Identity=32.0512820512821, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI33667109, Length=219, Percent_Identity=31.5068493150685, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI126723191, Length=175, Percent_Identity=33.1428571428571, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=30.241935483871, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=28.3400809716599, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI7705855, Length=187, Percent_Identity=28.3422459893048, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI226371731, Length=186, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI66933014, Length=253, Percent_Identity=27.6679841897233, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4758504, Length=262, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI119392083, Length=185, Percent_Identity=30.2702702702703, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=28.643216080402, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI32455239, Length=202, Percent_Identity=27.7227722772277, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI5031765, Length=202, Percent_Identity=27.7227722772277, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=30.5220883534137, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=31.3253012048193, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=30.241935483871, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=29.296875, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=30.6201550387597, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=29.8039215686275, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=29.718875502008, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI2367365, Length=255, Percent_Identity=31.7647058823529, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=30.9160305343511, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=27.2, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787526, Length=217, Percent_Identity=32.7188940092166, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786701, Length=236, Percent_Identity=28.8135593220339, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=26.7716535433071, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787820, Length=227, Percent_Identity=29.0748898678414, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=36.6141732283465, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=34.7826086956522, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=31.203007518797, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=31.4393939393939, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=32.1705426356589, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=31.9548872180451, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=31.1111111111111, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=31.2977099236641, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=255, Percent_Identity=29.4117647058824, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=32.8301886792453, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=31.6981132075472, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=30.5019305019305, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=27.9527559055118, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17565030, Length=256, Percent_Identity=30.859375, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=270, Percent_Identity=29.2592592592593, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=29.1044776119403, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538486, Length=259, Percent_Identity=29.3436293436293, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=32.2097378277154, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=32.2344322344322, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.8804780876494, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=27.7153558052434, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=267, Percent_Identity=28.8389513108614, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=269, Percent_Identity=29.368029739777, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=29.5546558704453, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=260, Percent_Identity=29.6153846153846, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=30.2040816326531, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507613, Length=206, Percent_Identity=29.6116504854369, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193210355, Length=196, Percent_Identity=28.0612244897959, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32563809, Length=206, Percent_Identity=29.6116504854369, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=245, Percent_Identity=27.3469387755102, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=33.160621761658, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=186, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322226, Length=199, Percent_Identity=24.6231155778894, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322067, Length=197, Percent_Identity=28.9340101522843, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=37.6, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=35.6275303643725, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=36.046511627907, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=35.7976653696498, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=27.7992277992278, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=29.7619047619048, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21358495, Length=199, Percent_Identity=30.1507537688442, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644337, Length=182, Percent_Identity=36.8131868131868, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=29.7619047619048, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24580925, Length=208, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28574402, Length=190, Percent_Identity=27.8947368421053, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584744, Length=190, Percent_Identity=27.8947368421053, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584752, Length=186, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.47

Molecular weight: Translated: 25992; Mature: 25992

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIEGYSVLITGGGSGLGRGVAEDMAARGAKVTITGRRAEKLEDVAGAIGPSCAIAAGD
CCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCEEEECC
VSIEEDRRRMIDTAVAHGGGLQGLFNNAGNMLRGPITDLAAEDILEVMNVNVVAGMRLTG
CCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEECCEEEC
LAAPHLEEHGGAVVFVGSGHTRRAFPGASPYAASKGAVEVLAQVLAAELGPKGIRVNCIV
CCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE
PGAVPTEINVRAGIAASFEDNKVRLNSMVDDHPLGRIGTPQEIAEAVDHLLRAEWTTGAS
CCCCCCEEEEEECEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCE
LVVDGGLGLGVSYK
EEEECCCCCCCCCC
>Mature Secondary Structure
MQSIEGYSVLITGGGSGLGRGVAEDMAARGAKVTITGRRAEKLEDVAGAIGPSCAIAAGD
CCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCEEEECC
VSIEEDRRRMIDTAVAHGGGLQGLFNNAGNMLRGPITDLAAEDILEVMNVNVVAGMRLTG
CCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEECCEEEC
LAAPHLEEHGGAVVFVGSGHTRRAFPGASPYAASKGAVEVLAQVLAAELGPKGIRVNCIV
CCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE
PGAVPTEINVRAGIAASFEDNKVRLNSMVDDHPLGRIGTPQEIAEAVDHLLRAEWTTGAS
CCCCCCEEEEEECEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCE
LVVDGGLGLGVSYK
EEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: beta-D-glucose; NAD+; NADP+

Specific reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2583128; 9831526 [H]