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The map label for this gene is allD [C]

Identifier: 89054632

GI number: 89054632

Start: 2149164

End: 2150150

Strand: Direct

Name: allD [C]

Synonym: Jann_2141

Alternate gene names: 89054632

Gene position: 2149164-2150150 (Clockwise)

Preceding gene: 89054631

Following gene: 89054636

Centisome position: 49.77

GC content: 64.34

Gene sequence:

>987_bases
ATGCAGATCTCCATTTCCGACATTCGCCAAACAGCTGAGGCCGCGCTTCTGGCCCACGGGGCCGGACCGTTCCAAGCTGC
CGAAGTTTCCAAGGCCGTCGCGCGGGCGGAGGAGACGGGGAATATCATCTGCGGGCTCTATTATCTTGAAAGCTATTGCA
CGCAGCTGGCGTCGGGTCGTGTTGACGGGATGGTGCAGCCGGAGGTTTCCCAACCAAAGCAGGGGGTTGTTCGGGCGAAC
GCACGGTTCGGCTTCGCGCAACCAGCCTTTGCGCGGGCCTTGCCACAGGCAATTGCCGCGGCGCGGGACGTGGGGATTGC
CACCCTGACCGTCGCTCATGCCCATACCTGCACGTCACTGGGCTATTTCACGGAACAGATCGCGGCAGGCGGTTTGATTG
GTATCGGCTTCACCAATGCCTCCGCCATCGTGGTCGCACCGGGGGGCAAGACGCCGGTTCTGGGCACGAACCCGATTGCG
ATGACGATACCGGGGGAGGATGCGCCGCTGATGCATGCTGATTTCTCCACCTCCGCGGTGGCCTTGGGCAAGATCACCAT
GGCAAAGGCGGCGGGTGAGGCGATCCCTTTGGGATGGGCCGTCGATGCGGACGGTCAGCCAACGACGGACCCGGACGCGG
CGCTGAAAGGCGCGCTCGTTAGCGCGGCAGGCCCCAAGGGGTGGGCATTCGGATTGCTGGTCGAAGTGATGGCGGCGGGA
TTGACTGGGTCGGTAAATTCAATGGACGTCAAAGGCTTGAAGCTGCCCGATGGTCCGCCCCATGATCTGGGGCAGACCTA
TATCCTGATTGATCCGGAGGCCCATGGGGGCCTCGACACCATGGCAGCGCGCCTGGCCCGCGTGGCCGATGTCGTGGCCA
GTGACGGCGGCACCGGGCGCATCCCCGGTGCGCCGCGTAGGCACATGGATCCGGTGGATGTGCCGGACGCGCTCTGGACG
TTGGTGACAGAGCTGGCGGAGGCCTAA

Upstream 100 bases:

>100_bases
AACTCGGCAAGCGGACCCAGGCGAAGGTGACGCCCCTTGCACCGGCCGTCCGGTTCCTGTTCGGTTGCGCCGATATCGAC
TGACCCGAAAGGCATCCACG

Downstream 100 bases:

>100_bases
GCCTCTTCACCGCTCTCCGTCTCTTCCCGTTTCGCGGCCGCTTTGCCGGCGAAATAGGACGCGCCCATCAGGATTGCGGT
GGCGATCAGTCGAATGGCCA

Product: malate/L-lactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MQISISDIRQTAEAALLAHGAGPFQAAEVSKAVARAEETGNIICGLYYLESYCTQLASGRVDGMVQPEVSQPKQGVVRAN
ARFGFAQPAFARALPQAIAAARDVGIATLTVAHAHTCTSLGYFTEQIAAGGLIGIGFTNASAIVVAPGGKTPVLGTNPIA
MTIPGEDAPLMHADFSTSAVALGKITMAKAAGEAIPLGWAVDADGQPTTDPDAALKGALVSAAGPKGWAFGLLVEVMAAG
LTGSVNSMDVKGLKLPDGPPHDLGQTYILIDPEAHGGLDTMAARLARVADVVASDGGTGRIPGAPRRHMDPVDVPDALWT
LVTELAEA

Sequences:

>Translated_328_residues
MQISISDIRQTAEAALLAHGAGPFQAAEVSKAVARAEETGNIICGLYYLESYCTQLASGRVDGMVQPEVSQPKQGVVRAN
ARFGFAQPAFARALPQAIAAARDVGIATLTVAHAHTCTSLGYFTEQIAAGGLIGIGFTNASAIVVAPGGKTPVLGTNPIA
MTIPGEDAPLMHADFSTSAVALGKITMAKAAGEAIPLGWAVDADGQPTTDPDAALKGALVSAAGPKGWAFGLLVEVMAAG
LTGSVNSMDVKGLKLPDGPPHDLGQTYILIDPEAHGGLDTMAARLARVADVVASDGGTGRIPGAPRRHMDPVDVPDALWT
LVTELAEA
>Mature_328_residues
MQISISDIRQTAEAALLAHGAGPFQAAEVSKAVARAEETGNIICGLYYLESYCTQLASGRVDGMVQPEVSQPKQGVVRAN
ARFGFAQPAFARALPQAIAAARDVGIATLTVAHAHTCTSLGYFTEQIAAGGLIGIGFTNASAIVVAPGGKTPVLGTNPIA
MTIPGEDAPLMHADFSTSAVALGKITMAKAAGEAIPLGWAVDADGQPTTDPDAALKGALVSAAGPKGWAFGLLVEVMAAG
LTGSVNSMDVKGLKLPDGPPHDLGQTYILIDPEAHGGLDTMAARLARVADVVASDGGTGRIPGAPRRHMDPVDVPDALWT
LVTELAEA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=289, Percent_Identity=29.757785467128, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787020, Length=287, Percent_Identity=28.2229965156794, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790000, Length=337, Percent_Identity=22.5519287833828, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17507179, Length=305, Percent_Identity=26.5573770491803, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17536633, Length=264, Percent_Identity=26.8939393939394, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24658010, Length=338, Percent_Identity=26.9230769230769, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45553211, Length=267, Percent_Identity=25.8426966292135, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667912, Length=267, Percent_Identity=25.8426966292135, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667904, Length=267, Percent_Identity=25.8426966292135, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667908, Length=267, Percent_Identity=25.8426966292135, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648360, Length=257, Percent_Identity=27.2373540856031, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 33405; Mature: 33405

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISISDIRQTAEAALLAHGAGPFQAAEVSKAVARAEETGNIICGLYYLESYCTQLASGR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCC
VDGMVQPEVSQPKQGVVRANARFGFAQPAFARALPQAIAAARDVGIATLTVAHAHTCTSL
CCCEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHH
GYFTEQIAAGGLIGIGFTNASAIVVAPGGKTPVLGTNPIAMTIPGEDAPLMHADFSTSAV
HHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEEECCCCCCEE
ALGKITMAKAAGEAIPLGWAVDADGQPTTDPDAALKGALVSAAGPKGWAFGLLVEVMAAG
EHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
LTGSVNSMDVKGLKLPDGPPHDLGQTYILIDPEAHGGLDTMAARLARVADVVASDGGTGR
CCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
IPGAPRRHMDPVDVPDALWTLVTELAEA
CCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQISISDIRQTAEAALLAHGAGPFQAAEVSKAVARAEETGNIICGLYYLESYCTQLASGR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCC
VDGMVQPEVSQPKQGVVRANARFGFAQPAFARALPQAIAAARDVGIATLTVAHAHTCTSL
CCCEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHH
GYFTEQIAAGGLIGIGFTNASAIVVAPGGKTPVLGTNPIAMTIPGEDAPLMHADFSTSAV
HHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEEECCCCCCEE
ALGKITMAKAAGEAIPLGWAVDADGQPTTDPDAALKGALVSAAGPKGWAFGLLVEVMAAG
EHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
LTGSVNSMDVKGLKLPDGPPHDLGQTYILIDPEAHGGLDTMAARLARVADVVASDGGTGR
CCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
IPGAPRRHMDPVDVPDALWTLVTELAEA
CCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]