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The map label for this gene is kynA [H]

Identifier: 89054575

GI number: 89054575

Start: 2092650

End: 2093573

Strand: Direct

Name: kynA [H]

Synonym: Jann_2084

Alternate gene names: 89054575

Gene position: 2092650-2093573 (Clockwise)

Preceding gene: 89054574

Following gene: 89054576

Centisome position: 48.46

GC content: 60.39

Gene sequence:

>924_bases
GTGATTGAGCCGCCGATTGTGGCGTGTGATGCGAGTCCTGGACCGAGTTGTATTGGCCCAGATGAAACAGGGGAGAGTGC
CAAATGGCGGGGAGAGCGCGCGGTGACTGAGAACCCGGAAGACGACGGCGCGCGGATGTCCTTCAAGGATGCGATGAGTT
ACGGCGATTATCTGTCGCTCGATCCCATCCTGGGGGCCGCGAAACCGCTGTCGAATGCCCATGATGAGATGTTGTTTATC
ATCCAGCACCAGACGTCTGAGTTGTGGATGCGGCTGGCGCTGCACGAATTGGACGCAGCGCGCAGCGCCCTGGCACGGGG
AGAGACCGCGCCGGTCTTCAAGATGCTGGCCCGCGTGGCGCGGATTTTTGAGCAGTTGAACAACGCCTGGGACGTGCTGC
GCACCATGACGCCCTCCGATTACACCGCTTTTCGCGAAGATCTGGGACAGTCGAGCGGGTTTCAGTCACACCAATATCGG
CTCATCGAATACATCCTTGGCAATCGCAACACGGCGCTGATGCGGGTGCATGAGCATCGCGTGGATCTGCACCGGATGCT
GGCGCAGGAGCTGACGCAGCCCTCGCTTTACGACGTGGCTGTGGCGCGTCTGGGGGCGGATCTGGGTCTGGACTTGCCGA
GCGGTGCGCTTGATACGCCGCACAAGGCCGTCGCGACCATCGAGGATGCCTGGGCGCAGGTTTATCGTGATCCGGATGCC
CATTGGAGCCTCTATGAATTGGCCGAAAAGCTGGTGGACCTGGAAGATTATTTCCGCCGCTGGCGCTTCAACCACGTCAC
AACGGTCGAACGCATCATCGGGTTCAAGCGCGGCACCGGCGGGACATCGGGCGTGTCGTATTTACGCCGGATGCTGGACG
TGGAACTGTTCCCGGAACTTTGGAATGTAAGGGGGCAGCTATGA

Upstream 100 bases:

>100_bases
TATCGGCGGCGGGCATGGTCGCGGTGGTATCGGGCGTGATCCTTGCGCTGGCGTGCCTCTTTGGTCCGGCCCGGGGCCGG
GTGGGCGTGGCGGCCGGAGG

Downstream 100 bases:

>100_bases
GCCTGACGGTAAAAGAGAAATTCGTGCTGCCCGAGGGGATGATTTACTTGGACGGGAACTCGCTTGGGCCGCTGCCGGTG
GGCGTGGAGGACGCGGTGGC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MIEPPIVACDASPGPSCIGPDETGESAKWRGERAVTENPEDDGARMSFKDAMSYGDYLSLDPILGAAKPLSNAHDEMLFI
IQHQTSELWMRLALHELDAARSALARGETAPVFKMLARVARIFEQLNNAWDVLRTMTPSDYTAFREDLGQSSGFQSHQYR
LIEYILGNRNTALMRVHEHRVDLHRMLAQELTQPSLYDVAVARLGADLGLDLPSGALDTPHKAVATIEDAWAQVYRDPDA
HWSLYELAEKLVDLEDYFRRWRFNHVTTVERIIGFKRGTGGTSGVSYLRRMLDVELFPELWNVRGQL

Sequences:

>Translated_307_residues
MIEPPIVACDASPGPSCIGPDETGESAKWRGERAVTENPEDDGARMSFKDAMSYGDYLSLDPILGAAKPLSNAHDEMLFI
IQHQTSELWMRLALHELDAARSALARGETAPVFKMLARVARIFEQLNNAWDVLRTMTPSDYTAFREDLGQSSGFQSHQYR
LIEYILGNRNTALMRVHEHRVDLHRMLAQELTQPSLYDVAVARLGADLGLDLPSGALDTPHKAVATIEDAWAQVYRDPDA
HWSLYELAEKLVDLEDYFRRWRFNHVTTVERIIGFKRGTGGTSGVSYLRRMLDVELFPELWNVRGQL
>Mature_307_residues
MIEPPIVACDASPGPSCIGPDETGESAKWRGERAVTENPEDDGARMSFKDAMSYGDYLSLDPILGAAKPLSNAHDEMLFI
IQHQTSELWMRLALHELDAARSALARGETAPVFKMLARVARIFEQLNNAWDVLRTMTPSDYTAFREDLGQSSGFQSHQYR
LIEYILGNRNTALMRVHEHRVDLHRMLAQELTQPSLYDVAVARLGADLGLDLPSGALDTPHKAVATIEDAWAQVYRDPDA
HWSLYELAEKLVDLEDYFRRWRFNHVTTVERIIGFKRGTGGTSGVSYLRRMLDVELFPELWNVRGQL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=142, Percent_Identity=38.0281690140845, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI32564651, Length=127, Percent_Identity=37.7952755905512, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=127, Percent_Identity=37.7952755905512, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17530891, Length=157, Percent_Identity=38.2165605095541, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 34688; Mature: 34688

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPPIVACDASPGPSCIGPDETGESAKWRGERAVTENPEDDGARMSFKDAMSYGDYLSL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCC
DPILGAAKPLSNAHDEMLFIIQHQTSELWMRLALHELDAARSALARGETAPVFKMLARVA
CHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RIFEQLNNAWDVLRTMTPSDYTAFREDLGQSSGFQSHQYRLIEYILGNRNTALMRVHEHR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
VDLHRMLAQELTQPSLYDVAVARLGADLGLDLPSGALDTPHKAVATIEDAWAQVYRDPDA
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
HWSLYELAEKLVDLEDYFRRWRFNHVTTVERIIGFKRGTGGTSGVSYLRRMLDVELFPEL
CCHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WNVRGQL
HHHCCCC
>Mature Secondary Structure
MIEPPIVACDASPGPSCIGPDETGESAKWRGERAVTENPEDDGARMSFKDAMSYGDYLSL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCC
DPILGAAKPLSNAHDEMLFIIQHQTSELWMRLALHELDAARSALARGETAPVFKMLARVA
CHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RIFEQLNNAWDVLRTMTPSDYTAFREDLGQSSGFQSHQYRLIEYILGNRNTALMRVHEHR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
VDLHRMLAQELTQPSLYDVAVARLGADLGLDLPSGALDTPHKAVATIEDAWAQVYRDPDA
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
HWSLYELAEKLVDLEDYFRRWRFNHVTTVERIIGFKRGTGGTSGVSYLRRMLDVELFPEL
CCHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WNVRGQL
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA