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The map label for this gene is kynU [H]

Identifier: 89054576

GI number: 89054576

Start: 2093570

End: 2094757

Strand: Direct

Name: kynU [H]

Synonym: Jann_2085

Alternate gene names: 89054576

Gene position: 2093570-2094757 (Clockwise)

Preceding gene: 89054575

Following gene: 89054577

Centisome position: 48.48

GC content: 63.47

Gene sequence:

>1188_bases
ATGAGCCTGACGGTAAAAGAGAAATTCGTGCTGCCCGAGGGGATGATTTACTTGGACGGGAACTCGCTTGGGCCGCTGCC
GGTGGGCGTGGAGGACGCGGTGGCGTCTATGATGCGGGAGCAATGGGGCGCGCATCTGATCAAGGGGTGGAACGTGGATG
GTTGGATGGCGCAACCCTCGCGGGTCGGGGACAGGGTAGGGCGGCTGATCGGGGCCGCTCCCGGATCTGTCGTCATGGGG
GATACGCTGTCGCTGAAGGTCTATCAGGCGCTGTCGGCTGCGTTGCAGATGCGACCGGACCGCAAGGTGGTACTGTCTGA
CAGCGGCAATTTCCCGACGGATCTGTATATGGCAGAAGGGTTGATCCGGCAGCTATCCCAGGGCCATGAGCTGCGCATCG
TCGCGCCGGACGAGGTGGCGGAGGCTATCGACGAGACCGTCGCCGCCGTCATGATCACGCAAGTGGATTACCGCACCGGC
CGTGTCCACGAAATGGATGCGATCACGGCGCGGGCCCATGCCTCCGGCGCTGTGATGATCTGGGATCTGGCCCATTCCGC
GGGGGCCATGCCGGTCAATATGGCGGCCAGCGGGGCGGAGTTTGCCGTGGGCTGCACGTACAAATACCTCAACGGTGGCC
CCGGCGCGCCCGCGTTCATCTATGTCCGCCCCGATATCGTGAACGACGTTAACCCCGCGCTGGCGGGCTGGTTGGGGCAT
GAAGCACCCTTCGCGTTTGACTTGGATTATCGCCCCGGAGAGGGGATCGAGCGGATGCGTGTGGGCACCCCGCCCGCGAT
CCAGCTGGCCGCGCTGGAGCGTGCGTTGGAGGTTTGGGACGGCGTCGATATGCAGGACTTGCGCGCCGCCTCCATTGCGC
TGTCGGAGCAATTCATCGCTGAGGTGGAGGCCAAATGTCCGCAACTGACCCTCGCAAGCCCCCGCGACGCCACCCACCGT
GGCAGCCAGGTGTCGTTCCATTTCGAGCATGGCTACGCCGCTATGCAGGCGCTGATCGCGCGCGGTGTCATCGGCGATTT
TCGGGCGCCTGACATCATGCGCTTTGGGTTCACGCCGCTCTATCTGGACCTGAACGACGTCAGCCAAGCGGTTGATATTC
TGGCAGAGATCCTGCGGGACCGACTATGGGATGCACCGGAATATACCACGCGTCAGCGGGTTACTTAA

Upstream 100 bases:

>100_bases
GGTTCAAGCGCGGCACCGGCGGGACATCGGGCGTGTCGTATTTACGCCGGATGCTGGACGTGGAACTGTTCCCGGAACTT
TGGAATGTAAGGGGGCAGCT

Downstream 100 bases:

>100_bases
AATGCTCGGCGGCAGGTTTCTACCCGCTGCCGAATGTATGTAATACAATGTTAATGTTATTACTTAAGATCTGCCTACAA
GCTGCTTAAAATTAATAATT

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSLTVKEKFVLPEGMIYLDGNSLGPLPVGVEDAVASMMREQWGAHLIKGWNVDGWMAQPSRVGDRVGRLIGAAPGSVVMG
DTLSLKVYQALSAALQMRPDRKVVLSDSGNFPTDLYMAEGLIRQLSQGHELRIVAPDEVAEAIDETVAAVMITQVDYRTG
RVHEMDAITARAHASGAVMIWDLAHSAGAMPVNMAASGAEFAVGCTYKYLNGGPGAPAFIYVRPDIVNDVNPALAGWLGH
EAPFAFDLDYRPGEGIERMRVGTPPAIQLAALERALEVWDGVDMQDLRAASIALSEQFIAEVEAKCPQLTLASPRDATHR
GSQVSFHFEHGYAAMQALIARGVIGDFRAPDIMRFGFTPLYLDLNDVSQAVDILAEILRDRLWDAPEYTTRQRVT

Sequences:

>Translated_395_residues
MSLTVKEKFVLPEGMIYLDGNSLGPLPVGVEDAVASMMREQWGAHLIKGWNVDGWMAQPSRVGDRVGRLIGAAPGSVVMG
DTLSLKVYQALSAALQMRPDRKVVLSDSGNFPTDLYMAEGLIRQLSQGHELRIVAPDEVAEAIDETVAAVMITQVDYRTG
RVHEMDAITARAHASGAVMIWDLAHSAGAMPVNMAASGAEFAVGCTYKYLNGGPGAPAFIYVRPDIVNDVNPALAGWLGH
EAPFAFDLDYRPGEGIERMRVGTPPAIQLAALERALEVWDGVDMQDLRAASIALSEQFIAEVEAKCPQLTLASPRDATHR
GSQVSFHFEHGYAAMQALIARGVIGDFRAPDIMRFGFTPLYLDLNDVSQAVDILAEILRDRLWDAPEYTTRQRVT
>Mature_394_residues
SLTVKEKFVLPEGMIYLDGNSLGPLPVGVEDAVASMMREQWGAHLIKGWNVDGWMAQPSRVGDRVGRLIGAAPGSVVMGD
TLSLKVYQALSAALQMRPDRKVVLSDSGNFPTDLYMAEGLIRQLSQGHELRIVAPDEVAEAIDETVAAVMITQVDYRTGR
VHEMDAITARAHASGAVMIWDLAHSAGAMPVNMAASGAEFAVGCTYKYLNGGPGAPAFIYVRPDIVNDVNPALAGWLGHE
APFAFDLDYRPGEGIERMRVGTPPAIQLAALERALEVWDGVDMQDLRAASIALSEQFIAEVEAKCPQLTLASPRDATHRG
SQVSFHFEHGYAAMQALIARGVIGDFRAPDIMRFGFTPLYLDLNDVSQAVDILAEILRDRLWDAPEYTTRQRVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=394, Percent_Identity=26.6497461928934, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI74101437, Length=243, Percent_Identity=24.2798353909465, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17550466, Length=392, Percent_Identity=26.7857142857143, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323261, Length=421, Percent_Identity=27.0783847980998, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 42948; Mature: 42816

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTVKEKFVLPEGMIYLDGNSLGPLPVGVEDAVASMMREQWGAHLIKGWNVDGWMAQPS
CCCCCCCEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHH
RVGDRVGRLIGAAPGSVVMGDTLSLKVYQALSAALQMRPDRKVVLSDSGNFPTDLYMAEG
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
LIRQLSQGHELRIVAPDEVAEAIDETVAAVMITQVDYRTGRVHEMDAITARAHASGAVMI
HHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHEEECCCCCCEEHHHHHHHHHCCCCCEEE
WDLAHSAGAMPVNMAASGAEFAVGCTYKYLNGGPGAPAFIYVRPDIVNDVNPALAGWLGH
EEECCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCEEEEECCHHCCCCCHHHHHHCCC
EAPFAFDLDYRPGEGIERMRVGTPPAIQLAALERALEVWDGVDMQDLRAASIALSEQFIA
CCCEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EVEAKCPQLTLASPRDATHRGSQVSFHFEHGYAAMQALIARGVIGDFRAPDIMRFGFTPL
HHHHCCCCEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHCCCCEE
YLDLNDVSQAVDILAEILRDRLWDAPEYTTRQRVT
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLTVKEKFVLPEGMIYLDGNSLGPLPVGVEDAVASMMREQWGAHLIKGWNVDGWMAQPS
CCCCCCEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHH
RVGDRVGRLIGAAPGSVVMGDTLSLKVYQALSAALQMRPDRKVVLSDSGNFPTDLYMAEG
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
LIRQLSQGHELRIVAPDEVAEAIDETVAAVMITQVDYRTGRVHEMDAITARAHASGAVMI
HHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHEEECCCCCCEEHHHHHHHHHCCCCCEEE
WDLAHSAGAMPVNMAASGAEFAVGCTYKYLNGGPGAPAFIYVRPDIVNDVNPALAGWLGH
EEECCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCEEEEECCHHCCCCCHHHHHHCCC
EAPFAFDLDYRPGEGIERMRVGTPPAIQLAALERALEVWDGVDMQDLRAASIALSEQFIA
CCCEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EVEAKCPQLTLASPRDATHRGSQVSFHFEHGYAAMQALIARGVIGDFRAPDIMRFGFTPL
HHHHCCCCEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHCCCCEE
YLDLNDVSQAVDILAEILRDRLWDAPEYTTRQRVT
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA