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The map label for this gene is ppi [H]

Identifier: 89054408

GI number: 89054408

Start: 1905699

End: 1906202

Strand: Direct

Name: ppi [H]

Synonym: Jann_1917

Alternate gene names: 89054408

Gene position: 1905699-1906202 (Clockwise)

Preceding gene: 89054407

Following gene: 89054409

Centisome position: 44.13

GC content: 63.49

Gene sequence:

>504_bases
ATGGCCGATATCAAAGACCCGGAAAACACGATCCTGATGGAGCTGAAGGATGGCACCGTGACCATTGAGCTGCTGGCGGA
TGTGGCGCCTGAGCACACTGCGCGGATGAAGGAACTGGCGCGCGCCGGGGCCTATGACGGCGTGGTGTTCCACCGTGTGA
TCGAGGGGTTCATGGCGCAGACGGGCGACGTGCAGCACGGCAAGAAAGAGGGCGGCAATCTGCGCGCGGCGGGCACCGGC
GGGTCCGACAAGCCGGATCTTCCGGCGGAATTCTCCAAGCTGCCCCATGCGCGGGGCACCCTGGGTGCCGCGCGGTCGTC
CAACCCGAACTCGGCCAACAGTCAGTTCTTCATCAACTTCAGCGACAATGACTTCCTCAACGGGCAATACACGGTTTATG
GGCGGGTCACGTCGGGTATGGAGCATGTGGATGCGATCACGCGGGGCGAGCCGCCTGCGGACCCCGATGTGATGATCTCC
GTGAAGGTCGCCGCCGATGCGTAA

Upstream 100 bases:

>100_bases
TGTCGTCGTTTGTGACGCCGTCCGTCAACACCGCGCTGCGAGAGAAGTATCCCCGCTGAGACCACGCGGGCCGAGATTAT
GACATATAAGGAGAGCCATC

Downstream 100 bases:

>100_bases
GGCGACAGCCCCTTGGGCGGCCTTCGGGCCGCTCCTCGCTGCGCTCCTCGCCGCCGCTCCGATTGGGGCGACGGGGATCG
AGATCGACGTTGCCGGAGAG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MADIKDPENTILMELKDGTVTIELLADVAPEHTARMKELARAGAYDGVVFHRVIEGFMAQTGDVQHGKKEGGNLRAAGTG
GSDKPDLPAEFSKLPHARGTLGAARSSNPNSANSQFFINFSDNDFLNGQYTVYGRVTSGMEHVDAITRGEPPADPDVMIS
VKVAADA

Sequences:

>Translated_167_residues
MADIKDPENTILMELKDGTVTIELLADVAPEHTARMKELARAGAYDGVVFHRVIEGFMAQTGDVQHGKKEGGNLRAAGTG
GSDKPDLPAEFSKLPHARGTLGAARSSNPNSANSQFFINFSDNDFLNGQYTVYGRVTSGMEHVDAITRGEPPADPDVMIS
VKVAADA
>Mature_166_residues
ADIKDPENTILMELKDGTVTIELLADVAPEHTARMKELARAGAYDGVVFHRVIEGFMAQTGDVQHGKKEGGNLRAAGTGG
SDKPDLPAEFSKLPHARGTLGAARSSNPNSANSQFFINFSDNDFLNGQYTVYGRVTSGMEHVDAITRGEPPADPDVMISV
KVAADA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=131, Percent_Identity=34.3511450381679, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI7706339, Length=144, Percent_Identity=31.9444444444444, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI10863927, Length=136, Percent_Identity=33.0882352941176, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5031987, Length=132, Percent_Identity=35.6060606060606, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI24308049, Length=135, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786736, Length=137, Percent_Identity=37.2262773722628, Blast_Score=86, Evalue=9e-19,
Organism=Escherichia coli, GI1789763, Length=180, Percent_Identity=32.7777777777778, Blast_Score=81, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=29.9319727891156, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=139, Percent_Identity=33.8129496402878, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=139, Percent_Identity=33.8129496402878, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=133, Percent_Identity=37.593984962406, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=148, Percent_Identity=32.4324324324324, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=151, Percent_Identity=31.7880794701987, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=103, Percent_Identity=38.8349514563107, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=103, Percent_Identity=38.8349514563107, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=155, Percent_Identity=31.6129032258064, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=132, Percent_Identity=31.8181818181818, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=180, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=32.9268292682927, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17787; Mature: 17656

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKDPENTILMELKDGTVTIELLADVAPEHTARMKELARAGAYDGVVFHRVIEGFMAQ
CCCCCCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVQHGKKEGGNLRAAGTGGSDKPDLPAEFSKLPHARGTLGAARSSNPNSANSQFFINF
CCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE
SDNDFLNGQYTVYGRVTSGMEHVDAITRGEPPADPDVMISVKVAADA
CCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
ADIKDPENTILMELKDGTVTIELLADVAPEHTARMKELARAGAYDGVVFHRVIEGFMAQ
CCCCCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVQHGKKEGGNLRAAGTGGSDKPDLPAEFSKLPHARGTLGAARSSNPNSANSQFFINF
CCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE
SDNDFLNGQYTVYGRVTSGMEHVDAITRGEPPADPDVMISVKVAADA
CCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA