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The map label for this gene is cry2 [H]

Identifier: 89054364

GI number: 89054364

Start: 1861653

End: 1863206

Strand: Direct

Name: cry2 [H]

Synonym: Jann_1873

Alternate gene names: 89054364

Gene position: 1861653-1863206 (Clockwise)

Preceding gene: 89054362

Following gene: 89054372

Centisome position: 43.11

GC content: 68.79

Gene sequence:

>1554_bases
ATGAAAAATGTTCTGGTTTTGTTCAAGCGTGACCTGCGCGTGCAGGACAACCCGGCGCTGGCCCTGGCCGCGTCGCGGGA
CGGGGCGGCGCTGCCCGTCTTTGTGGCCGAGCCTGAGGCCTGGGCGCAGCCCGACGCCTCCGCCCGGCAGTGGCGGTTTG
TGGCCGAAAGCCTGGAGGGGCTGCGCGCCGATCTGGCCGCACTTGGCGCGCCCCTGATCGTGCGGCGCGGCGATATGATG
GCGGTGCTTGGTGGGTTGTGCGCGACCCATGACGTCGGCGAAATCATCAGCATCGAGGAAACCGGCAACCTGTGGAGCTA
TGGCCGCGACCGTCGCCTCGCGGCCTGGGCACGGGGCGCGGGGGTGATCTGGACGGAGGTGCCGCAATTGGGCGTGCAGC
GCCGCTTGGTGAACCGCGATGGATGGGCGCGGGACCGTCAGGCGGTGATGCGGCAGGCGCAGGTGCCTGTGCCGGAGGGT
CTGCGCGGCGTGTCCGAGGAGCCGGGCAGCATCCCAGACGCCCGCGATCTGGCGCTGGCGTTCGATCCATGCCCGGGACG
GCAGGCGGGGGGCCGTGACGGGGGCCTTGCGACGCTCGCCTCCTTCCTGACGGCGCGCGGGCAAGAGTACCGCCGCGCCA
TGTCCTCGCCGCTGGACGGGGCGGCGGCCTGCTCGCGCCTCTCGCCGCATTTGGCCTGGGGGACATTGTCCTCCCGTGAG
GTGCTGCACGGCATGGCGGCCCGGCGCGCCGAGGTGAAGGGCACACGCGACGGCTGGCTCGGCTCCCTGCGCAGTTTTGA
AGCCCGCGTGGCCTGGCGCGATCACTTCATGCAAAAGCTGGAGGATCAGCCCGCGATGGAGATCCGCTGCCTGCACTCCG
CCTACGAGGACCTGCGCCCGAACGTGCCTGACGCCACGCGCCTCAGCGCTTGGGAAAAGGGCGAAACCGGCATTCCCTTC
GTGGATGCCTGCATGCGGTCGCTGATTGCCACGGGATGGATCAACTTCCGCATGCGCGCGATGCTGGCGGCCGTGGCCTC
CTACCATCTGTGGCTGGATTGGCGCAGGACTGGCCCGCATCTGGCGCGGATGTTTACGGATTATGAGCCCGGCATCCACT
GGCCGCAGATGCAAATGCAAGCGGGCACGACGGGGATGAACACGATCCGCATCTACAACCCGGTCAAGCAGGGCCTCGAC
CATGACCCGACCGGCACGTTCACCCGCACATGGTGCCCGGAATTGCGGGAGGTGCCCGATGCCTGCCTGCAAACGCCCTG
GGCCTGGGCCGAGACGGGGTCACCCGCGGCTCGCCGTCTGGGGCGTCGCTATCCGGCCCCGATTGTCGATGTGACGCAAG
CCGCCCGTGCGGCCCGGGACCGGGCATTTGCCGTGCGCCGCGGCGATGCCTTTCACCGGGAGGCGTCGGAGATTGTCACC
AAACACGCCAGCCGCAAAGATAGCGGGGCCGGGCGTCATTTCGTGAACGATAGAGAGAGAACGCGCCGATCAAAGGCGCA
GACCCCCTCGGCTCAGCTGGACCTCGGGCTATAG

Upstream 100 bases:

>100_bases
ACGGGTTGCCGGGAAGGTAGAGCGGCGGCGCGGGGGGAGCAATGGGCCGCAGGACGCACCGCGTCTTGATCATGGGGCCG
GATCTGCTACCTGTGCAGGG

Downstream 100 bases:

>100_bases
GTCCTATGCCCTGCCTCTGGTTGATGATCGAACAAATCCAACCTGGTCTCACCCGGCAGACATGTCCGGAAAGGTGCTCC
GCCCCGCATTCACCTGGGCC

Product: deoxyribodipyrimidine photo-lyase type I

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MKNVLVLFKRDLRVQDNPALALAASRDGAALPVFVAEPEAWAQPDASARQWRFVAESLEGLRADLAALGAPLIVRRGDMM
AVLGGLCATHDVGEIISIEETGNLWSYGRDRRLAAWARGAGVIWTEVPQLGVQRRLVNRDGWARDRQAVMRQAQVPVPEG
LRGVSEEPGSIPDARDLALAFDPCPGRQAGGRDGGLATLASFLTARGQEYRRAMSSPLDGAAACSRLSPHLAWGTLSSRE
VLHGMAARRAEVKGTRDGWLGSLRSFEARVAWRDHFMQKLEDQPAMEIRCLHSAYEDLRPNVPDATRLSAWEKGETGIPF
VDACMRSLIATGWINFRMRAMLAAVASYHLWLDWRRTGPHLARMFTDYEPGIHWPQMQMQAGTTGMNTIRIYNPVKQGLD
HDPTGTFTRTWCPELREVPDACLQTPWAWAETGSPAARRLGRRYPAPIVDVTQAARAARDRAFAVRRGDAFHREASEIVT
KHASRKDSGAGRHFVNDRERTRRSKAQTPSAQLDLGL

Sequences:

>Translated_517_residues
MKNVLVLFKRDLRVQDNPALALAASRDGAALPVFVAEPEAWAQPDASARQWRFVAESLEGLRADLAALGAPLIVRRGDMM
AVLGGLCATHDVGEIISIEETGNLWSYGRDRRLAAWARGAGVIWTEVPQLGVQRRLVNRDGWARDRQAVMRQAQVPVPEG
LRGVSEEPGSIPDARDLALAFDPCPGRQAGGRDGGLATLASFLTARGQEYRRAMSSPLDGAAACSRLSPHLAWGTLSSRE
VLHGMAARRAEVKGTRDGWLGSLRSFEARVAWRDHFMQKLEDQPAMEIRCLHSAYEDLRPNVPDATRLSAWEKGETGIPF
VDACMRSLIATGWINFRMRAMLAAVASYHLWLDWRRTGPHLARMFTDYEPGIHWPQMQMQAGTTGMNTIRIYNPVKQGLD
HDPTGTFTRTWCPELREVPDACLQTPWAWAETGSPAARRLGRRYPAPIVDVTQAARAARDRAFAVRRGDAFHREASEIVT
KHASRKDSGAGRHFVNDRERTRRSKAQTPSAQLDLGL
>Mature_517_residues
MKNVLVLFKRDLRVQDNPALALAASRDGAALPVFVAEPEAWAQPDASARQWRFVAESLEGLRADLAALGAPLIVRRGDMM
AVLGGLCATHDVGEIISIEETGNLWSYGRDRRLAAWARGAGVIWTEVPQLGVQRRLVNRDGWARDRQAVMRQAQVPVPEG
LRGVSEEPGSIPDARDLALAFDPCPGRQAGGRDGGLATLASFLTARGQEYRRAMSSPLDGAAACSRLSPHLAWGTLSSRE
VLHGMAARRAEVKGTRDGWLGSLRSFEARVAWRDHFMQKLEDQPAMEIRCLHSAYEDLRPNVPDATRLSAWEKGETGIPF
VDACMRSLIATGWINFRMRAMLAAVASYHLWLDWRRTGPHLARMFTDYEPGIHWPQMQMQAGTTGMNTIRIYNPVKQGLD
HDPTGTFTRTWCPELREVPDACLQTPWAWAETGSPAARRLGRRYPAPIVDVTQAARAARDRAFAVRRGDAFHREASEIVT
KHASRKDSGAGRHFVNDRERTRRSKAQTPSAQLDLGL

Specific function: Has no photolyase activity [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=488, Percent_Identity=25.2049180327869, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI4758072, Length=493, Percent_Identity=24.5436105476673, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI188536103, Length=452, Percent_Identity=24.5575221238938, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786926, Length=499, Percent_Identity=28.8577154308617, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324962, Length=289, Percent_Identity=25.9515570934256, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137248, Length=483, Percent_Identity=26.0869565217391, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585455, Length=483, Percent_Identity=26.0869565217391, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648152, Length=509, Percent_Identity=23.7721021611002, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 57315; Mature: 57315

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLVLFKRDLRVQDNPALALAASRDGAALPVFVAEPEAWAQPDASARQWRFVAESLEG
CCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCHHHCCCCCHHHHHHHHHHHHHH
LRADLAALGAPLIVRRGDMMAVLGGLCATHDVGEIISIEETGNLWSYGRDRRLAAWARGA
HHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCHHHHHCCC
GVIWTEVPQLGVQRRLVNRDGWARDRQAVMRQAQVPVPEGLRGVSEEPGSIPDARDLALA
CEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCEEEE
FDPCPGRQAGGRDGGLATLASFLTARGQEYRRAMSSPLDGAAACSRLSPHLAWGTLSSRE
ECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCCEECCCCHHH
VLHGMAARRAEVKGTRDGWLGSLRSFEARVAWRDHFMQKLEDQPAMEIRCLHSAYEDLRP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
NVPDATRLSAWEKGETGIPFVDACMRSLIATGWINFRMRAMLAAVASYHLWLDWRRTGPH
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
LARMFTDYEPGIHWPQMQMQAGTTGMNTIRIYNPVKQGLDHDPTGTFTRTWCPELREVPD
HHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEECHHHHCCCCCCCCCCCHHCCHHHHHCCH
ACLQTPWAWAETGSPAARRLGRRYPAPIVDVTQAARAARDRAFAVRRGDAFHREASEIVT
HHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KHASRKDSGAGRHFVNDRERTRRSKAQTPSAQLDLGL
HHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKNVLVLFKRDLRVQDNPALALAASRDGAALPVFVAEPEAWAQPDASARQWRFVAESLEG
CCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCHHHCCCCCHHHHHHHHHHHHHH
LRADLAALGAPLIVRRGDMMAVLGGLCATHDVGEIISIEETGNLWSYGRDRRLAAWARGA
HHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCHHHHHCCC
GVIWTEVPQLGVQRRLVNRDGWARDRQAVMRQAQVPVPEGLRGVSEEPGSIPDARDLALA
CEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCEEEE
FDPCPGRQAGGRDGGLATLASFLTARGQEYRRAMSSPLDGAAACSRLSPHLAWGTLSSRE
ECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCCEECCCCHHH
VLHGMAARRAEVKGTRDGWLGSLRSFEARVAWRDHFMQKLEDQPAMEIRCLHSAYEDLRP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
NVPDATRLSAWEKGETGIPFVDACMRSLIATGWINFRMRAMLAAVASYHLWLDWRRTGPH
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
LARMFTDYEPGIHWPQMQMQAGTTGMNTIRIYNPVKQGLDHDPTGTFTRTWCPELREVPD
HHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEECHHHHCCCCCCCCCCCHHCCHHHHHCCH
ACLQTPWAWAETGSPAARRLGRRYPAPIVDVTQAARAARDRAFAVRRGDAFHREASEIVT
HHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KHASRKDSGAGRHFVNDRERTRRSKAQTPSAQLDLGL
HHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]