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The map label for this gene is purM

Identifier: 89054327

GI number: 89054327

Start: 1822102

End: 1823151

Strand: Direct

Name: purM

Synonym: Jann_1836

Alternate gene names: 89054327

Gene position: 1822102-1823151 (Clockwise)

Preceding gene: 89054325

Following gene: 89054328

Centisome position: 42.2

GC content: 64.48

Gene sequence:

>1050_bases
ATGACTGACAGCAAACCGGACGCGTTGACCTATGCGGATGCGGGCGTCGATATCGACGCTGGCAACGCGCTTGTGGATCG
GATCAAGCCCGCCGCTGCCGCGACAAATCGTGCCGGTGTCATGGCGGGCCTGGGGGGCTTTGGCGCTTTGTTCGATCTCA
AGGCCGCGGGCTATGATGATCCGGTTCTTGTGGCCGCAACGGACGGTGTCGGCACCAAGCTAAAGATCGCCATCGACACG
GGCAACTTCGACACTATCGGCGTGGATCTGGTGGCCATGTGTGTCAACGATCTGGTCTGTCAGGGTGCGGAGCCGCTGTT
TTTCCTGGATTATTTCGCGACGGGCAAGCTGGATGTCGATGACGCCGCGCGTATTGTCGAAGGCATTGCGGCGGGTTGCA
AAGCCTCGGGTTGCGCGTTGATTGGCGGCGAGACGGCAGAGATGCCGGGCATGTATGCGCCCGGCGATTTTGACCTTGCG
GGCTTTTCCGTTGGCGCGATGGAGCGGGGCCGGGCGCTGCCGGACGGCGTGGCAGAGGGCGATGTGCTGCTGGGGTTGGC
GTCAGACGGCGTGCATTCCAACGGCTATTCGCTGGTGCGCCGTGTGGTGGAGCGATCCGGGCTGGCCTGGGATGCGCCCG
CACCCTTCGCGCAATCCAGTTTGGGAGAGGCACTTTTGGCCCCCACGCGCCTTTACGTGCAGCCCGCGCTGGCCGCGATC
CGTGCGGGCGGGGTCCATGCCCTGGCCCATATCACCGGTGGCGGATTGACCGAGAACATCCCCCGCGTTCTGCCCGATGG
GCTCGGCGTTGATATCGACCTGTCATCCTGGTCCCTGCCGCCGGTATTCGGCTGGCTGGCGCAGGAAGGTGCGTTGGATC
AGGCGGAGCTTCTGAAGACGTTCAACGCAGGCCTCGGCATGGTCCTCGTGGTCTCGGCGGATGCCGTCGATGGCCTGACC
TGGACATTGGAAGACGCGGGCGAAAGTGTGCACCGCATCGGCACCGTCACGGCAGGCGCGGGCGTGCGCTACTCGGGATC
GCTTGGATGA

Upstream 100 bases:

>100_bases
CGACATTCGGCCGATGACATGCGAAGTGTGGCCGTTGAGCATGGACGAGCCGCGGGTGGCCTGATACCTGAGCGGCCATC
GCCAGAGGGGGCCCTTGCAG

Downstream 100 bases:

>100_bases
GCTTGCGGGTCGCGATCCTGATCTCCGGCGGCGGGTCCAACATGGTCGCGCTGGCCCGGGACATGGTGGGCCATCACCCC
GCGCGGCCCTGTCTGGTCGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTDSKPDALTYADAGVDIDAGNALVDRIKPAAAATNRAGVMAGLGGFGALFDLKAAGYDDPVLVAATDGVGTKLKIAIDT
GNFDTIGVDLVAMCVNDLVCQGAEPLFFLDYFATGKLDVDDAARIVEGIAAGCKASGCALIGGETAEMPGMYAPGDFDLA
GFSVGAMERGRALPDGVAEGDVLLGLASDGVHSNGYSLVRRVVERSGLAWDAPAPFAQSSLGEALLAPTRLYVQPALAAI
RAGGVHALAHITGGGLTENIPRVLPDGLGVDIDLSSWSLPPVFGWLAQEGALDQAELLKTFNAGLGMVLVVSADAVDGLT
WTLEDAGESVHRIGTVTAGAGVRYSGSLG

Sequences:

>Translated_349_residues
MTDSKPDALTYADAGVDIDAGNALVDRIKPAAAATNRAGVMAGLGGFGALFDLKAAGYDDPVLVAATDGVGTKLKIAIDT
GNFDTIGVDLVAMCVNDLVCQGAEPLFFLDYFATGKLDVDDAARIVEGIAAGCKASGCALIGGETAEMPGMYAPGDFDLA
GFSVGAMERGRALPDGVAEGDVLLGLASDGVHSNGYSLVRRVVERSGLAWDAPAPFAQSSLGEALLAPTRLYVQPALAAI
RAGGVHALAHITGGGLTENIPRVLPDGLGVDIDLSSWSLPPVFGWLAQEGALDQAELLKTFNAGLGMVLVVSADAVDGLT
WTLEDAGESVHRIGTVTAGAGVRYSGSLG
>Mature_348_residues
TDSKPDALTYADAGVDIDAGNALVDRIKPAAAATNRAGVMAGLGGFGALFDLKAAGYDDPVLVAATDGVGTKLKIAIDTG
NFDTIGVDLVAMCVNDLVCQGAEPLFFLDYFATGKLDVDDAARIVEGIAAGCKASGCALIGGETAEMPGMYAPGDFDLAG
FSVGAMERGRALPDGVAEGDVLLGLASDGVHSNGYSLVRRVVERSGLAWDAPAPFAQSSLGEALLAPTRLYVQPALAAIR
AGGVHALAHITGGGLTENIPRVLPDGLGVDIDLSSWSLPPVFGWLAQEGALDQAELLKTFNAGLGMVLVVSADAVDGLTW
TLEDAGESVHRIGTVTAGAGVRYSGSLG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=56.3049853372434, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=56.3049853372434, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=56.3049853372434, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=55.8823529411765, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=44.8071216617211, Blast_Score=284, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6321203, Length=341, Percent_Identity=53.6656891495601, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24582400, Length=265, Percent_Identity=49.4339622641509, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_JANSC (Q28RA9)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509778.1
- ProteinModelPortal:   Q28RA9
- SMR:   Q28RA9
- STRING:   Q28RA9
- GeneID:   3934287
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1836
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q28RA9
- ProtClustDB:   PRK05385
- BioCyc:   JSP290400:JANN_1836-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35418; Mature: 35287

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSKPDALTYADAGVDIDAGNALVDRIKPAAAATNRAGVMAGLGGFGALFDLKAAGYDD
CCCCCCCEEEEECCCCEECCCCHHHHHHCHHHHCCCCCCCEECCCCHHHHEEECCCCCCC
PVLVAATDGVGTKLKIAIDTGNFDTIGVDLVAMCVNDLVCQGAEPLFFLDYFATGKLDVD
CEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHH
DAARIVEGIAAGCKASGCALIGGETAEMPGMYAPGDFDLAGFSVGAMERGRALPDGVAEG
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECHHHCCCCCCCCCCCC
DVLLGLASDGVHSNGYSLVRRVVERSGLAWDAPAPFAQSSLGEALLAPTRLYVQPALAAI
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
RAGGVHALAHITGGGLTENIPRVLPDGLGVDIDLSSWSLPPVFGWLAQEGALDQAELLKT
HCCCEEEEEEECCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHH
FNAGLGMVLVVSADAVDGLTWTLEDAGESVHRIGTVTAGAGVRYSGSLG
HCCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHEEEECCCCEEECCCCC
>Mature Secondary Structure 
TDSKPDALTYADAGVDIDAGNALVDRIKPAAAATNRAGVMAGLGGFGALFDLKAAGYDD
CCCCCCEEEEECCCCEECCCCHHHHHHCHHHHCCCCCCCEECCCCHHHHEEECCCCCCC
PVLVAATDGVGTKLKIAIDTGNFDTIGVDLVAMCVNDLVCQGAEPLFFLDYFATGKLDVD
CEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHH
DAARIVEGIAAGCKASGCALIGGETAEMPGMYAPGDFDLAGFSVGAMERGRALPDGVAEG
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECHHHCCCCCCCCCCCC
DVLLGLASDGVHSNGYSLVRRVVERSGLAWDAPAPFAQSSLGEALLAPTRLYVQPALAAI
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
RAGGVHALAHITGGGLTENIPRVLPDGLGVDIDLSSWSLPPVFGWLAQEGALDQAELLKT
HCCCEEEEEEECCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHH
FNAGLGMVLVVSADAVDGLTWTLEDAGESVHRIGTVTAGAGVRYSGSLG
HCCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHEEEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA