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The map label for this gene is pepA [H]

Identifier: 89054306

GI number: 89054306

Start: 1805295

End: 1806761

Strand: Direct

Name: pepA [H]

Synonym: Jann_1815

Alternate gene names: 89054306

Gene position: 1805295-1806761 (Clockwise)

Preceding gene: 89054299

Following gene: 89054307

Centisome position: 41.81

GC content: 64.35

Gene sequence:

>1467_bases
ATGACCGACCTCATGTCCATAGACTTTGCTGAAACCGACCTCGACGCGCTGGCAGATGCGGCGGGCAAGCTGGCGATTCT
CGTCACGCCCGAGGGCAAGCTGGATCCTGCCGGTCGGCGGGTAAACCGGCTGACAAAGCAGGCAGTGGCGCGGTTGGTGG
AGTCGGATCGGTGGGAGAAGGTGAAGGCGGGCGACGGCTTTACCATGGGATTCCCTGCGGGCGTGGCAGCGGACGCCTTG
CTGGTGGTGAAGCTGGAGCGGCGCCCCACCGTCACGGAGGCCCGCAAGGCGGGCGCATCGCTGGCCAAGTTCAAGGGCAA
GGATGCGCTGACTGTTTGCGCGGGCGCATTCAACCGTACCGCTGACATCGCGTTGGGCCTGGCGCTCCGCGCCTACGGGT
TCGACGCCCATCGCACCGGAGAGAAGACGGACGCGCAGGGCGCGATGATCTATTGCGCCAAGCCCGATGAGGTGAAGCCG
GAGGCCGCAACTGCCATGGCCGTCGCCGAAGGTGTGTTCTTCACCCGCGATCTGATCAATGAGCCCGCCAACGTGCTGAC
AACGCAGGAGTTTGCCGATCGGCTGGAGGCGATGAAAGATATCGGCCTGAAGGTTGAGGTGCTGGACGAGCCTGCGCTGG
CAAAGCTGGGGATGCGCACGCTTCTGGCGGTGGGCGAAGGCTCCGAAAGCCCGTCTAAGGTTGTCGTGATGTCGTGGAAT
GGCGGCGGCGATGAAAAGCCTCTGGCGCTGATCGGCAAGGGGGTTGTGTTCGATACGGGCGGCATCAGCCTGAAGCCCGC
AGGCGGCATGGAAGACATGACGATGGATATGGGCGGCGCGGGTGTCGTGTCGGGCGTCATGCGGACGCTGGCCCTGCGCA
AGGCCAAGGCGAACGTCGTGGGCGTTGTGGGCCTGGTGGAGAACATGCCAGACGGGCGTGCCACGCGGCCCGGCGATGTC
GTCCGCTCCATGAAAGGCGACACGGTGGAGATCATCAACACCGATGCGGAGGGGCGTTTGGTCTTGTGCGATATCATGTG
GTACGCGCAGGAGCGGTTCGAGCCGTCTGGGATGATTGATCTTGCCACGCTGACCGGGGCGATCATCATCGGGTTGGGCC
ATGAGAATGCCGGCGTCTTCTCCAATTCTGACCCGTTGTCCGGTGCCTTCCTGAAGGCGGCCGACGCGGAGGGTGAGGGG
GCATGGCGGATGCCTCTGGGGGACGCCTACGACAAGATGCTGAAATCGCGCGTGGCCGATATGGCGAACGTCGGTGGTCG
GGCCGCAGGCTCCATCACAGCCGCGCAGTTCCTGCAACGGTTCGTGAAGGAGGAGACGCCTTGGATCCACCTCGATATTG
CAGGCGTGGCGAGCGTGAAGTCCGAGACCGCGCTGGCACCCAAGGGCGCGACGGGCTGGGGCGTGATGGCTTTGGACAGG
CTTGTCCGCGATAGCTATGAAGGCTGA

Upstream 100 bases:

>100_bases
GCGTTTTCAGCCCTTGCGTAGGGGCGATCTGGCCAAGCGGGGAACACCGCCCTAAGGTCTGGCGCGAATGTCACGCTTTT
CGCCCATAAGGGAGCCCTTG

Downstream 100 bases:

>100_bases
TCTATCACATGAAGAGCGGCGCGTAAGCTATGGGTGAGGCGTACTTTTATCACCTCACCCAAGCGCCGCTGGAGGTCACG
CTGCGCGTGCTGTTGGGCAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTDLMSIDFAETDLDALADAAGKLAILVTPEGKLDPAGRRVNRLTKQAVARLVESDRWEKVKAGDGFTMGFPAGVAADAL
LVVKLERRPTVTEARKAGASLAKFKGKDALTVCAGAFNRTADIALGLALRAYGFDAHRTGEKTDAQGAMIYCAKPDEVKP
EAATAMAVAEGVFFTRDLINEPANVLTTQEFADRLEAMKDIGLKVEVLDEPALAKLGMRTLLAVGEGSESPSKVVVMSWN
GGGDEKPLALIGKGVVFDTGGISLKPAGGMEDMTMDMGGAGVVSGVMRTLALRKAKANVVGVVGLVENMPDGRATRPGDV
VRSMKGDTVEIINTDAEGRLVLCDIMWYAQERFEPSGMIDLATLTGAIIIGLGHENAGVFSNSDPLSGAFLKAADAEGEG
AWRMPLGDAYDKMLKSRVADMANVGGRAAGSITAAQFLQRFVKEETPWIHLDIAGVASVKSETALAPKGATGWGVMALDR
LVRDSYEG

Sequences:

>Translated_488_residues
MTDLMSIDFAETDLDALADAAGKLAILVTPEGKLDPAGRRVNRLTKQAVARLVESDRWEKVKAGDGFTMGFPAGVAADAL
LVVKLERRPTVTEARKAGASLAKFKGKDALTVCAGAFNRTADIALGLALRAYGFDAHRTGEKTDAQGAMIYCAKPDEVKP
EAATAMAVAEGVFFTRDLINEPANVLTTQEFADRLEAMKDIGLKVEVLDEPALAKLGMRTLLAVGEGSESPSKVVVMSWN
GGGDEKPLALIGKGVVFDTGGISLKPAGGMEDMTMDMGGAGVVSGVMRTLALRKAKANVVGVVGLVENMPDGRATRPGDV
VRSMKGDTVEIINTDAEGRLVLCDIMWYAQERFEPSGMIDLATLTGAIIIGLGHENAGVFSNSDPLSGAFLKAADAEGEG
AWRMPLGDAYDKMLKSRVADMANVGGRAAGSITAAQFLQRFVKEETPWIHLDIAGVASVKSETALAPKGATGWGVMALDR
LVRDSYEG
>Mature_487_residues
TDLMSIDFAETDLDALADAAGKLAILVTPEGKLDPAGRRVNRLTKQAVARLVESDRWEKVKAGDGFTMGFPAGVAADALL
VVKLERRPTVTEARKAGASLAKFKGKDALTVCAGAFNRTADIALGLALRAYGFDAHRTGEKTDAQGAMIYCAKPDEVKPE
AATAMAVAEGVFFTRDLINEPANVLTTQEFADRLEAMKDIGLKVEVLDEPALAKLGMRTLLAVGEGSESPSKVVVMSWNG
GGDEKPLALIGKGVVFDTGGISLKPAGGMEDMTMDMGGAGVVSGVMRTLALRKAKANVVGVVGLVENMPDGRATRPGDVV
RSMKGDTVEIINTDAEGRLVLCDIMWYAQERFEPSGMIDLATLTGAIIIGLGHENAGVFSNSDPLSGAFLKAADAEGEGA
WRMPLGDAYDKMLKSRVADMANVGGRAAGSITAAQFLQRFVKEETPWIHLDIAGVASVKSETALAPKGATGWGVMALDRL
VRDSYEG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=311, Percent_Identity=40.1929260450161, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI47155554, Length=364, Percent_Identity=32.4175824175824, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790710, Length=311, Percent_Identity=47.2668810289389, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=35.423197492163, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=301, Percent_Identity=36.5448504983389, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=182, Percent_Identity=30.2197802197802, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355725, Length=287, Percent_Identity=36.2369337979094, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24661038, Length=287, Percent_Identity=36.2369337979094, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129969, Length=302, Percent_Identity=31.7880794701987, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24662227, Length=333, Percent_Identity=30.03003003003, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161077148, Length=290, Percent_Identity=32.4137931034483, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20130057, Length=290, Percent_Identity=32.4137931034483, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19922386, Length=290, Percent_Identity=33.448275862069, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI20129963, Length=300, Percent_Identity=32.3333333333333, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355645, Length=290, Percent_Identity=30, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24662223, Length=290, Percent_Identity=30, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221379063, Length=313, Percent_Identity=31.629392971246, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI221379062, Length=313, Percent_Identity=31.629392971246, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21357381, Length=313, Percent_Identity=31.629392971246, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24646701, Length=144, Percent_Identity=34.7222222222222, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646703, Length=144, Percent_Identity=34.7222222222222, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358201, Length=144, Percent_Identity=34.7222222222222, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51379; Mature: 51247

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLMSIDFAETDLDALADAAGKLAILVTPEGKLDPAGRRVNRLTKQAVARLVESDRWEK
CCCCEECCCCCCCHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
VKAGDGFTMGFPAGVAADALLVVKLERRPTVTEARKAGASLAKFKGKDALTVCAGAFNRT
EECCCCEEECCCCCHHHCEEEEEEECCCCCHHHHHHCCCHHHHHCCCCCEEEEHHCCCCH
ADIALGLALRAYGFDAHRTGEKTDAQGAMIYCAKPDEVKPEAATAMAVAEGVFFTRDLIN
HHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHC
EPANVLTTQEFADRLEAMKDIGLKVEVLDEPALAKLGMRTLLAVGEGSESPSKVVVMSWN
CCHHHEEHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHEEECCCCCCCCEEEEEEEC
GGGDEKPLALIGKGVVFDTGGISLKPAGGMEDMTMDMGGAGVVSGVMRTLALRKAKANVV
CCCCCCCEEEEECCEEEECCCEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCEE
GVVGLVENMPDGRATRPGDVVRSMKGDTVEIINTDAEGRLVLCDIMWYAQERFEPSGMID
EEEHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCCCEE
LATLTGAIIIGLGHENAGVFSNSDPLSGAFLKAADAEGEGAWRMPLGDAYDKMLKSRVAD
HHEECCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHHHH
MANVGGRAAGSITAAQFLQRFVKEETPWIHLDIAGVASVKSETALAPKGATGWGVMALDR
HHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHCCCCCCCCCCCCCCCHHHHHHH
LVRDSYEG
HHHHCCCC
>Mature Secondary Structure 
TDLMSIDFAETDLDALADAAGKLAILVTPEGKLDPAGRRVNRLTKQAVARLVESDRWEK
CCCEECCCCCCCHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
VKAGDGFTMGFPAGVAADALLVVKLERRPTVTEARKAGASLAKFKGKDALTVCAGAFNRT
EECCCCEEECCCCCHHHCEEEEEEECCCCCHHHHHHCCCHHHHHCCCCCEEEEHHCCCCH
ADIALGLALRAYGFDAHRTGEKTDAQGAMIYCAKPDEVKPEAATAMAVAEGVFFTRDLIN
HHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHC
EPANVLTTQEFADRLEAMKDIGLKVEVLDEPALAKLGMRTLLAVGEGSESPSKVVVMSWN
CCHHHEEHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHEEECCCCCCCCEEEEEEEC
GGGDEKPLALIGKGVVFDTGGISLKPAGGMEDMTMDMGGAGVVSGVMRTLALRKAKANVV
CCCCCCCEEEEECCEEEECCCEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCEE
GVVGLVENMPDGRATRPGDVVRSMKGDTVEIINTDAEGRLVLCDIMWYAQERFEPSGMID
EEEHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCCCEE
LATLTGAIIIGLGHENAGVFSNSDPLSGAFLKAADAEGEGAWRMPLGDAYDKMLKSRVAD
HHEECCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHHHH
MANVGGRAAGSITAAQFLQRFVKEETPWIHLDIAGVASVKSETALAPKGATGWGVMALDR
HHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHCCCCCCCCCCCCCCCHHHHHHH
LVRDSYEG
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA