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The map label for this gene is ureC

Identifier: 89054243

GI number: 89054243

Start: 1741113

End: 1742822

Strand: Direct

Name: ureC

Synonym: Jann_1752

Alternate gene names: 89054243

Gene position: 1741113-1742822 (Clockwise)

Preceding gene: 89054242

Following gene: 89054244

Centisome position: 40.32

GC content: 60.88

Gene sequence:

>1710_bases
ATGCCCACCAAAATCCCCCGTAACGACTACGCTGCCATGTATGGTCCCACGACCGGGGACCGGGTCAGGCTCGCGGATAC
GGACCTGATCATCGAAGTGGAACGCGACCTCACCACCTACGGCGAGGAGGTGAAATTCGGCGGCGGCAAGGTGATCCGCG
ACGGGATGGGGCAGAGCCAGGTCACCCGGGCGCAATGCGCCGTCGATACGGTGATCACCAACGCGCTGATCGTGGACCAT
TCCGGCATCTACAAGGCGGATGTCGGCCTCAAAGACGGGCGCATTCACAAGATCGGCAAGGCGGGCAACCCGGACACACA
GCCAAATGTCGACATCATCATCGGGCCGGGGACGGAGGCGATTGCGGGGGAGGGGCGTATTCTGACGGCGGGCGGCTTCG
ACGCGCATATCCACTTCATCTGTCCGCAACAAATCGAAGACTCTCTGCATTCGGGCATCACCACGATGCTCGGCGGCGGC
ACCGGGCCCGCCCATGGCACGCTGGCCACCACCTGCACGCCGGGGCCGTGGCACATCGGGCGAATGCTGCAATCGCTTGA
TGCGTTTCCGATGAACTTTGGTCTCTCGTGCAAGGGCAACGCCTCCCAGCCAGAGGCGCTGGTGGAAATGGTCAGCGCCG
GGGCCTGCGCGATGAAACTGCATGAGGATTGGGGCACAACGCCCGGCGCAATTGATTGCTGCCTTTCCGTGGCCGATGAA
ATGGACGTGCAGGTGATGATCCACACCGATACGCTGAACGAAAGCGGGTTCGTGGAGAATACCTTGGCCGCTATCGGCGA
CCGCACCATCCACGCGTTCCATACCGAAGGGGCAGGCGGCGGCCATGCGCCGGACATCATGAAGGTGGTGGGGTATGAGA
ATATTCTGCCATCCTCCACCAATCCCACGATGCCCTACACGGTCAACACGCTGGAAGAGCATCTGGATATGCTGATGGTG
TGTCACCACCTTGATAAGTCGATCCCGGAAGATGTGGCCTTTGCAGAATCCCGCATTCGCAAGGAAACCATCGCCGCCGA
AGATATCCTGCACGACATGGGCGCGTTTTCTGTCATGGCGTCGGACTCTCAGGCCATGGGACGGGTGGGAGAGGTCATCA
TCCGCACTTGGCAGACGGCGGACAAGATGAAGAAACAGCGGGGACGTTTGGCAGAGGAGACGGGCGACAACGACAACGCC
CGCGTGATGCGCTACATCGCCAAATATACGATCAACCCCGCGCTGGTCCATGGGATGAGCCGCGAGATCGGCAGCATCGA
GGAAGGCAAACGCGCCGATCTGGTGCTGTGGAGCCCGGCGTTTTTCGGCGTGAAGCCCGAGATGTCATTGATTGGCGGCA
CGATTGTGATGGCGCAGATGGGCGATCCCAATGCCTCCATCCCGACGCCTCAACCCGTCTATAGCAGGCCGATGTTCGGA
GCCTTCGGACGCGCCGTGGAACGCTCCGCCGTGCTGTTCGTCAGTGAGGCCGCGCAGGCCGCGGGGATCGGTGACCAGCT
TGGGCTGGCCAAGGATACGCTGGCCGTCAAAAGCACGCGCGACATCAGGAAATCTGACATGATTCACAATAGCTTCCGGC
CCGACATTCATGTCGATCCTGAAACCTATGACGTGCGCGCGAACGGAGAATTGCTGACATGCGAGCCCGCGACAGACCTG
CCTCTGGCACAGCGCTATTTCATGTATTGA

Upstream 100 bases:

>100_bases
GGGCGCCTTGTCTGATCCAGTTGTGCAGCGTTTGAACACCCTTGTCGCGACAGCCAATCCCGTGCCCATTCAAGACATTT
GCCAAGAAAGCTGAACGCCC

Downstream 100 bases:

>100_bases
TCCATGTGCAACGATGCGGCCCCGCGCTTGGGGCGCGGTGACCATGGCATGGCATCCTCTGATGATGATGCAAACAGACC
TTTGGAGAGAGAAGACGATG

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MPTKIPRNDYAAMYGPTTGDRVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQVTRAQCAVDTVITNALIVDH
SGIYKADVGLKDGRIHKIGKAGNPDTQPNVDIIIGPGTEAIAGEGRILTAGGFDAHIHFICPQQIEDSLHSGITTMLGGG
TGPAHGTLATTCTPGPWHIGRMLQSLDAFPMNFGLSCKGNASQPEALVEMVSAGACAMKLHEDWGTTPGAIDCCLSVADE
MDVQVMIHTDTLNESGFVENTLAAIGDRTIHAFHTEGAGGGHAPDIMKVVGYENILPSSTNPTMPYTVNTLEEHLDMLMV
CHHLDKSIPEDVAFAESRIRKETIAAEDILHDMGAFSVMASDSQAMGRVGEVIIRTWQTADKMKKQRGRLAEETGDNDNA
RVMRYIAKYTINPALVHGMSREIGSIEEGKRADLVLWSPAFFGVKPEMSLIGGTIVMAQMGDPNASIPTPQPVYSRPMFG
AFGRAVERSAVLFVSEAAQAAGIGDQLGLAKDTLAVKSTRDIRKSDMIHNSFRPDIHVDPETYDVRANGELLTCEPATDL
PLAQRYFMY

Sequences:

>Translated_569_residues
MPTKIPRNDYAAMYGPTTGDRVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQVTRAQCAVDTVITNALIVDH
SGIYKADVGLKDGRIHKIGKAGNPDTQPNVDIIIGPGTEAIAGEGRILTAGGFDAHIHFICPQQIEDSLHSGITTMLGGG
TGPAHGTLATTCTPGPWHIGRMLQSLDAFPMNFGLSCKGNASQPEALVEMVSAGACAMKLHEDWGTTPGAIDCCLSVADE
MDVQVMIHTDTLNESGFVENTLAAIGDRTIHAFHTEGAGGGHAPDIMKVVGYENILPSSTNPTMPYTVNTLEEHLDMLMV
CHHLDKSIPEDVAFAESRIRKETIAAEDILHDMGAFSVMASDSQAMGRVGEVIIRTWQTADKMKKQRGRLAEETGDNDNA
RVMRYIAKYTINPALVHGMSREIGSIEEGKRADLVLWSPAFFGVKPEMSLIGGTIVMAQMGDPNASIPTPQPVYSRPMFG
AFGRAVERSAVLFVSEAAQAAGIGDQLGLAKDTLAVKSTRDIRKSDMIHNSFRPDIHVDPETYDVRANGELLTCEPATDL
PLAQRYFMY
>Mature_568_residues
PTKIPRNDYAAMYGPTTGDRVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQVTRAQCAVDTVITNALIVDHS
GIYKADVGLKDGRIHKIGKAGNPDTQPNVDIIIGPGTEAIAGEGRILTAGGFDAHIHFICPQQIEDSLHSGITTMLGGGT
GPAHGTLATTCTPGPWHIGRMLQSLDAFPMNFGLSCKGNASQPEALVEMVSAGACAMKLHEDWGTTPGAIDCCLSVADEM
DVQVMIHTDTLNESGFVENTLAAIGDRTIHAFHTEGAGGGHAPDIMKVVGYENILPSSTNPTMPYTVNTLEEHLDMLMVC
HHLDKSIPEDVAFAESRIRKETIAAEDILHDMGAFSVMASDSQAMGRVGEVIIRTWQTADKMKKQRGRLAEETGDNDNAR
VMRYIAKYTINPALVHGMSREIGSIEEGKRADLVLWSPAFFGVKPEMSLIGGTIVMAQMGDPNASIPTPQPVYSRPMFGA
FGRAVERSAVLFVSEAAQAAGIGDQLGLAKDTLAVKSTRDIRKSDMIHNSFRPDIHVDPETYDVRANGELLTCEPATDLP
LAQRYFMY

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_JANSC (Q28RJ3)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509694.1
- ProteinModelPortal:   Q28RJ3
- SMR:   Q28RJ3
- STRING:   Q28RJ3
- GeneID:   3934200
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1752
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   JSP290400:JANN_1752-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61338; Mature: 61207

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 322-322 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKIPRNDYAAMYGPTTGDRVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQ
CCCCCCCCCCEEEECCCCCCEEEEECCEEEEEECCCHHHCCCEEECCCCEEEECCCCHHH
VTRAQCAVDTVITNALIVDHSGIYKADVGLKDGRIHKIGKAGNPDTQPNVDIIIGPGTEA
HHHHHHHHHHHHHHEEEEECCCCEEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCC
IAGEGRILTAGGFDAHIHFICPQQIEDSLHSGITTMLGGGTGPAHGTLATTCTPGPWHIG
CCCCCEEEEECCCCEEEEEECHHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCCCCHHHH
RMLQSLDAFPMNFGLSCKGNASQPEALVEMVSAGACAMKLHEDWGTTPGAIDCCLSVADE
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHEEEEHHHCCCCCHHHHHHHHHHCC
MDVQVMIHTDTLNESGFVENTLAAIGDRTIHAFHTEGAGGGHAPDIMKVVGYENILPSST
CCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCHHHCCCCCC
NPTMPYTVNTLEEHLDMLMVCHHLDKSIPEDVAFAESRIRKETIAAEDILHDMGAFSVMA
CCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEE
SDSQAMGRVGEVIIRTWQTADKMKKQRGRLAEETGDNDNARVMRYIAKYTINPALVHGMS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
REIGSIEEGKRADLVLWSPAFFGVKPEMSLIGGTIVMAQMGDPNASIPTPQPVYSRPMFG
HHHCCCCCCCCCCEEEECCHHCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHH
AFGRAVERSAVLFVSEAAQAAGIGDQLGLAKDTLAVKSTRDIRKSDMIHNSFRPDIHVDP
HHHHHHHHCEEEEEEHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
ETYDVRANGELLTCEPATDLPLAQRYFMY
CCEEEECCCCEEEECCCCCCCHHHHHHCC
>Mature Secondary Structure 
PTKIPRNDYAAMYGPTTGDRVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQ
CCCCCCCCCEEEECCCCCCEEEEECCEEEEEECCCHHHCCCEEECCCCEEEECCCCHHH
VTRAQCAVDTVITNALIVDHSGIYKADVGLKDGRIHKIGKAGNPDTQPNVDIIIGPGTEA
HHHHHHHHHHHHHHEEEEECCCCEEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCC
IAGEGRILTAGGFDAHIHFICPQQIEDSLHSGITTMLGGGTGPAHGTLATTCTPGPWHIG
CCCCCEEEEECCCCEEEEEECHHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCCCCHHHH
RMLQSLDAFPMNFGLSCKGNASQPEALVEMVSAGACAMKLHEDWGTTPGAIDCCLSVADE
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHEEEEHHHCCCCCHHHHHHHHHHCC
MDVQVMIHTDTLNESGFVENTLAAIGDRTIHAFHTEGAGGGHAPDIMKVVGYENILPSST
CCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCHHHCCCCCC
NPTMPYTVNTLEEHLDMLMVCHHLDKSIPEDVAFAESRIRKETIAAEDILHDMGAFSVMA
CCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEE
SDSQAMGRVGEVIIRTWQTADKMKKQRGRLAEETGDNDNARVMRYIAKYTINPALVHGMS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
REIGSIEEGKRADLVLWSPAFFGVKPEMSLIGGTIVMAQMGDPNASIPTPQPVYSRPMFG
HHHCCCCCCCCCCEEEECCHHCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHH
AFGRAVERSAVLFVSEAAQAAGIGDQLGLAKDTLAVKSTRDIRKSDMIHNSFRPDIHVDP
HHHHHHHHCEEEEEEHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
ETYDVRANGELLTCEPATDLPLAQRYFMY
CCEEEECCCCEEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA