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The map label for this gene is ygeZ [C]

Identifier: 89053979

GI number: 89053979

Start: 1457551

End: 1458933

Strand: Reverse

Name: ygeZ [C]

Synonym: Jann_1488

Alternate gene names: 89053979

Gene position: 1458933-1457551 (Counterclockwise)

Preceding gene: 89053983

Following gene: 89053978

Centisome position: 33.79

GC content: 57.92

Gene sequence:

>1383_bases
ATGTTCAACACGACAGTCATTCGTAATACGAAAGTCCTAGGCGGCGCGACGCTGACCGCCATGGACATCGCAATTTCGGA
TGGGACAATCCAAGCGATCGGACCGAACCTCCCCGACGCGGGTCAGAGTATTGACGCCAGCGGTCTTGTTGCGACGCCAG
GCGGTGTCGATCCCCACGCCCATATCGAGCAACGCTCGGGCATGGGGTTGATGAATGCCGACACGTTTGAAACTGCAACA
CGCTCTGCCGCGTTAGGAGGCACTACCAGCGTCATTTCTTTCGCAGCACAGGGGAAAGGGCAGCGTTTGCAAGACGTTGT
GGGTGACTATACCGCCCGCGCGAAACGTGGAGCAATGATCGACTACGCGTTTCACCTGAGCTTATCGGACCCTGACGTGC
CGCATTTTGTTGACGATTTGCGCGCCCTCATTGCTGGAGGGCACAGATCTTTGAAGGTTTTCACGACCTACGACATTGCG
CTGAACGACGACCAGATCGAGAAGATCCTACAAGTGGCTGGCCCGGCCGGCGCATTGACATGTGTTCACGCGGAAGACGA
TACGACTTTAAGATCTGCTCGCAACATTTTGCTATCCCGTCATAAATCTCTTCCCAAGCATCACGCACAGGCGCGTCCTG
AGGCCGCCGAACGCATAGCCGTGGCCCGGATCTGTGCGATGGCCGAGCGCACGGACGCGCCGGTCATGATTTTCCATGTC
TCCTGCGCGAGCGCCGCGAAAGCCGTCGCCGATGCCCGAGCGCGGGGCGCCCCGGTTTTTGCTGAAACCTGCCCCCATTA
CTTGTTCATGACGGCTGACATTCTTGACAAACCGGGTGTCGAGGGCGCGAAGTGGATGTGCTCTCCGCCGCAACGTACGG
AAAGGGATCAAGCCGCGCTTTGGGCCGCTTTGAATGATGGGACACTCGATCTGATTTCATCCGATCACGCCCCGTACCGT
TTTGATAAGACTGGAAAACTAAAGAATGGCTTGAGCCCACCATTTCCAGATATCGCGAACGGTCTTCCCGGGTTAGAGAC
CCGGCTGCCCCTGCTGTTTGACGCGATCGTGAAACGCTCCAAGCTTCCATCGGCCGCATTTGCAGCCCTTACTGCGGGCG
CTGCCGCGGATATTTATGGTCTTCCCGGCAAGGGCCGCCTCCGACCCGGCGCGGACGCGGATATTGTGCTGTGGGATCCC
GAGAAGTCTTATACGTACGGCGCGGACGACCTGCATGACAACGTGGGCTATAATCCCTATGAAGGTCATTGTGTAACTGG
TTGGCCAGTAAATGTTTTCTTGCGCGGGCAGCGGATCGTGAGAGACGGAGCGCTCACTGCCCACCCTGGCCAAGGCCGCT
GGATTGATCGGAGACCCACATGA

Upstream 100 bases:

>100_bases
TTAATATCCACAGATTTACTCACAAGATATCTGCCCTTCTATTTTCGCCCCTTGCCTCTCTCAGGCCTACCGGACACGCT
ATGTTCAAGAAGGAGCATGC

Downstream 100 bases:

>100_bases
ACCAACGCCCGGACGCGCCCAATGAGCTGGCGATCACGTTCCTTTATTACAAGGATCTTGATAGGGCAGAGGCCTTTTAC
CGCGATGTGATGGGCTTTCC

Product: dihydropyrimidinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MFNTTVIRNTKVLGGATLTAMDIAISDGTIQAIGPNLPDAGQSIDASGLVATPGGVDPHAHIEQRSGMGLMNADTFETAT
RSAALGGTTSVISFAAQGKGQRLQDVVGDYTARAKRGAMIDYAFHLSLSDPDVPHFVDDLRALIAGGHRSLKVFTTYDIA
LNDDQIEKILQVAGPAGALTCVHAEDDTTLRSARNILLSRHKSLPKHHAQARPEAAERIAVARICAMAERTDAPVMIFHV
SCASAAKAVADARARGAPVFAETCPHYLFMTADILDKPGVEGAKWMCSPPQRTERDQAALWAALNDGTLDLISSDHAPYR
FDKTGKLKNGLSPPFPDIANGLPGLETRLPLLFDAIVKRSKLPSAAFAALTAGAAADIYGLPGKGRLRPGADADIVLWDP
EKSYTYGADDLHDNVGYNPYEGHCVTGWPVNVFLRGQRIVRDGALTAHPGQGRWIDRRPT

Sequences:

>Translated_460_residues
MFNTTVIRNTKVLGGATLTAMDIAISDGTIQAIGPNLPDAGQSIDASGLVATPGGVDPHAHIEQRSGMGLMNADTFETAT
RSAALGGTTSVISFAAQGKGQRLQDVVGDYTARAKRGAMIDYAFHLSLSDPDVPHFVDDLRALIAGGHRSLKVFTTYDIA
LNDDQIEKILQVAGPAGALTCVHAEDDTTLRSARNILLSRHKSLPKHHAQARPEAAERIAVARICAMAERTDAPVMIFHV
SCASAAKAVADARARGAPVFAETCPHYLFMTADILDKPGVEGAKWMCSPPQRTERDQAALWAALNDGTLDLISSDHAPYR
FDKTGKLKNGLSPPFPDIANGLPGLETRLPLLFDAIVKRSKLPSAAFAALTAGAAADIYGLPGKGRLRPGADADIVLWDP
EKSYTYGADDLHDNVGYNPYEGHCVTGWPVNVFLRGQRIVRDGALTAHPGQGRWIDRRPT
>Mature_460_residues
MFNTTVIRNTKVLGGATLTAMDIAISDGTIQAIGPNLPDAGQSIDASGLVATPGGVDPHAHIEQRSGMGLMNADTFETAT
RSAALGGTTSVISFAAQGKGQRLQDVVGDYTARAKRGAMIDYAFHLSLSDPDVPHFVDDLRALIAGGHRSLKVFTTYDIA
LNDDQIEKILQVAGPAGALTCVHAEDDTTLRSARNILLSRHKSLPKHHAQARPEAAERIAVARICAMAERTDAPVMIFHV
SCASAAKAVADARARGAPVFAETCPHYLFMTADILDKPGVEGAKWMCSPPQRTERDQAALWAALNDGTLDLISSDHAPYR
FDKTGKLKNGLSPPFPDIANGLPGLETRLPLLFDAIVKRSKLPSAAFAALTAGAAADIYGLPGKGRLRPGADADIVLWDP
EKSYTYGADDLHDNVGYNPYEGHCVTGWPVNVFLRGQRIVRDGALTAHPGQGRWIDRRPT

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503051, Length=465, Percent_Identity=30.1075268817204, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI62422571, Length=465, Percent_Identity=30.1075268817204, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI190194363, Length=461, Percent_Identity=30.1518438177874, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4503377, Length=462, Percent_Identity=29.6536796536797, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4503375, Length=469, Percent_Identity=29.4243070362473, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI19923821, Length=461, Percent_Identity=29.2841648590022, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4503379, Length=450, Percent_Identity=29.1111111111111, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI18105007, Length=455, Percent_Identity=26.8131868131868, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI87082175, Length=463, Percent_Identity=34.9892008639309, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786722, Length=464, Percent_Identity=30.6034482758621, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17539558, Length=465, Percent_Identity=29.247311827957, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71989490, Length=465, Percent_Identity=29.0322580645161, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI86575075, Length=471, Percent_Identity=23.1422505307856, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=446, Percent_Identity=26.2331838565022, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6322218, Length=417, Percent_Identity=27.5779376498801, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221377917, Length=467, Percent_Identity=30.8351177730193, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137462, Length=464, Percent_Identity=30.1724137931034, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24644287, Length=304, Percent_Identity=29.2763157894737, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24642586, Length=410, Percent_Identity=25.609756097561, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644289, Length=237, Percent_Identity=28.6919831223629, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859883, Length=426, Percent_Identity=27.4647887323944, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 49079; Mature: 49079

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNTTVIRNTKVLGGATLTAMDIAISDGTIQAIGPNLPDAGQSIDASGLVATPGGVDPHA
CCCCEEEECCEEECCCEEEEEEEEECCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCH
HIEQRSGMGLMNADTFETATRSAALGGTTSVISFAAQGKGQRLQDVVGDYTARAKRGAMI
HHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEE
DYAFHLSLSDPDVPHFVDDLRALIAGGHRSLKVFTTYDIALNDDQIEKILQVAGPAGALT
EEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHHCCCCCEEE
CVHAEDDTTLRSARNILLSRHKSLPKHHAQARPEAAERIAVARICAMAERTDAPVMIFHV
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEE
SCASAAKAVADARARGAPVFAETCPHYLFMTADILDKPGVEGAKWMCSPPQRTERDQAAL
CHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEHHHHCCCCCCCCCEECCCCCCCCCCHHEE
WAALNDGTLDLISSDHAPYRFDKTGKLKNGLSPPFPDIANGLPGLETRLPLLFDAIVKRS
EEEECCCEEEEEECCCCCEEECCCCCHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHC
KLPSAAFAALTAGAAADIYGLPGKGRLRPGADADIVLWDPEKSYTYGADDLHDNVGYNPY
CCCHHHHHHHHCCCCHHEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCCCCCC
EGHCVTGWPVNVFLRGQRIVRDGALTAHPGQGRWIDRRPT
CCEEEECCCEEEEEECCEEEECCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MFNTTVIRNTKVLGGATLTAMDIAISDGTIQAIGPNLPDAGQSIDASGLVATPGGVDPHA
CCCCEEEECCEEECCCEEEEEEEEECCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCH
HIEQRSGMGLMNADTFETATRSAALGGTTSVISFAAQGKGQRLQDVVGDYTARAKRGAMI
HHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEE
DYAFHLSLSDPDVPHFVDDLRALIAGGHRSLKVFTTYDIALNDDQIEKILQVAGPAGALT
EEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHHCCCCCEEE
CVHAEDDTTLRSARNILLSRHKSLPKHHAQARPEAAERIAVARICAMAERTDAPVMIFHV
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEE
SCASAAKAVADARARGAPVFAETCPHYLFMTADILDKPGVEGAKWMCSPPQRTERDQAAL
CHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEHHHHCCCCCCCCCEECCCCCCCCCCHHEE
WAALNDGTLDLISSDHAPYRFDKTGKLKNGLSPPFPDIANGLPGLETRLPLLFDAIVKRS
EEEECCCEEEEEECCCCCEEECCCCCHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHC
KLPSAAFAALTAGAAADIYGLPGKGRLRPGADADIVLWDPEKSYTYGADDLHDNVGYNPY
CCCHHHHHHHHCCCCHHEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCCCCCC
EGHCVTGWPVNVFLRGQRIVRDGALTAHPGQGRWIDRRPT
CCEEEECCCEEEEEECCEEEECCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]